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Functional roles and networks of non-coding RNAs in the pathogenesis of neurodegenerative diseases
Open accessAbstract
Recent transcriptome analyses have revealed that noncoding RNAs (ncRNAs) are broadly expressed in mammalian cells and abundant in the CNS, with tissue and cell type-specific expression patterns. Moreover, ncRNAs have been found to intricately and dynamically regulate various signaling pathways in neurodegeneration. As such, some antisense transcripts and microRNAs are known to directly affect neurodegeneration in disease contexts. The functions of ncRNAs in pathogenesis are unique for each disorder, as are the pertinent networks of ncRNA/miRNA/mRNA that mediate these functions. Thus, further understanding of ncRNA biogenesis and effects might aid the discovery of diagnostic biomarkers or development of effective therapeutics for neurodegenerative disorders. Here, we review the ncRNAs that have so far been identified in major neurodegenerative disease etiology and the mechanisms that link ncRNAs with disease-specific phenotypes, such as HTT aggregation in HD, α-synuclein in PD, and Aβ plaques and hyperphosphorylated Tau in AD. We also summarize the known lncRNA/miRNA/mRNA networks that participate in neurodegenerative diseases, and we discuss ncRNA-related treatments shown to delay disease onset and prolong lifespan in rodent models.
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“ncRNAs may influence the pathophysiology of depression by regulating neuronal function, neurotransmitter release, and microglia (Fig. 4).213,221,222”
From Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential (2023) · cites this paper as [222]
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Metadata
- Authors
- Wu, Y.-Y., & Kuo, H.-C.
- Affiliations
- Institute of Cellular and Organismic Biology, Academia Sinica (TW)
- National Taiwan University (TW)
- Corresponding author
- Kuo, Hung-Chih
- ORCID
- Wu, Yi-Ying
- Venue
- Journal of Biomedical Science
- Published
- 2020-04-07
- Volume
- 27
- Issue
- 1
- Pages
- 49-49
- ISSN
- 1021-7770 (ISSN-L)
- 1423-0127
- PMC
- PMC7140545
- OpenAlex
- W3015066166
- Cited by
- 213
- References
- 161
- Citations by year
- 2026: 8 · 2025: 22 · 2024: 39 · 2023: 54 · 2022: 35 · 2021: 43 · 2020: 11
- FWCI
- 3.95
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- Journal of Biomedical Science (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Academia Sinica (AS-106-TP-B13, AS-SUMMIT-108)
- Ministry of Science and Technology (MOST 106-0210-01-15-02, 108-3114-Y-001-002, MOST 107-0210-01-19-01)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- non-coding RNA, neurodegenerative diseases, long non-coding RNA, microRNA, antisense transcripts, lncRNA-miRNA-mRNA network, Huntington's disease, alpha-synuclein, Parkinson's disease, Alzheimer's disease, amyloid plaques, tau hyperphosphorylation, disease biomarkers
- MeSH terms
- Animals, Humans, Biomarkers, Neurodegenerative Diseases, Gene Expression Profiling, RNA, Untranslated, Mice, Rats
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