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Cited by 174Physical Activity and HealthCardiovascular and exercise physiologyDiabetes, Cardiovascular Risks, and Lipoproteins

The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.

Clinical outcomes and glycaemic responses to different aerobic exercise training intensities in type II diabetes: a systematic review and meta-analysis

Open access
Grace, Aimee, Chan, Erick, Giallauria, Francesco, Graham, Petra L., Smart, Neil A.·2017·Cardiovascular Diabetology
DOI 10.1186/s12933-017-0518-6PMC PMC5351065
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Abstract

To establish if aerobic exercise training is associated with beneficial effects on clinical outcomes and glycaemic profile in people with type II diabetes. A systematic search was conducted to identify studies through a search of MEDLINE (1985 to Sept 1, 2016, Cochrane Controlled Trials Registry (1966 to Sept 1, 2016), CINAHL, SPORTDiscus and Science Citation Index. The search strategy included a mix of MeSH and free text terms for related key concepts. Searches were limited to prospective randomized or controlled trials of aerobic exercise training in humans with type II diabetes, aged >18 years, lasting >2 weeks. Our analysis included 27 studies (38 intervention groups) totalling 1372 participants, 737 exercise and 635 from control groups. The studies contain data from 39,435 patient-hours of exercise training. Our analyses showed improvements with exercise in glycosylated haemoglobin (HbA1C%) MD: −0.71%, 95% CI −1.11, −0.31; p value = 0.0005. There were significant moderator effects; for every additional week of exercise HbA1C% reduces between 0.009 and 0.04%, p = 0.002. For those exercising at vigorous intensity peak oxygen consumption (peak VO 2 ) increased a further 0.64 and 5.98 ml/kg/min compared to those doing low or moderate intensity activity. Homeostatic model assessment of insulin resistance (HOMA-IR) was also improved with exercise MD: −1.02, 95% CI −1.77, −0.28; p value = 0.007; as was fasting serum glucose MD: −12.53 mmol/l, 95% CI −18.94, −6.23; p value <0.0001; and serum MD: −10.39 IU, 95% CI −17.25, −3.53; p value = 0.003. Our analysis support existing guidelines that for those who can tolerate it, exercise at higher intensity may offer superior fitness benefits and longer program duration will optimize reductions in HbA1C%.

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Crossref · 10.1186/s12933-017-0518-6

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Fig. 1 Consort statement
Fig. 1 Consort statementCC BY · PubMed Central
Fig. 2 Change in HbA1C% exercise vs control
Fig. 2 Change in HbA1C% exercise vs controlCC BY · PubMed Central
Fig. 3 Change in HOMA-IR exercise vs control
Fig. 3 Change in HOMA-IR exercise vs controlCC BY · PubMed Central
Fig. 4 Change in peak VO2 exercise vs control
Fig. 4 Change in peak VO2 exercise vs controlCC BY · PubMed Central

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Metadata

Authors
Grace, A., Chan, E., Giallauria, F., Graham, P. L., & Smart, N. A.
Affiliations
  • University of New England (AU)
  • Griffith University (AU)
  • Federico II University Hospital (IT)
  • Macquarie University (AU)
Corresponding author
Smart, Neil A.
ORCID
Venue
Cardiovascular Diabetology
Publisher
Springer Science and Business Media LLC
Published
2017-03-14
Volume
16
Issue
1
Pages
37-37
ISSN
1475-2840 (ISSN-L)
DOI
10.1186/s12933-017-0518-6
PMC
PMC5351065
OpenAlex
W2600366653
Cited by
174
References
52
Citations by year
2026: 6 · 2025: 22 · 2024: 15 · 2023: 41 · 2022: 23 · 2021: 15 · 2020: 12 · 2019: 21 · 2018: 15 · 2017: 4
FWCI
1.75
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Cardiovascular Diabetology (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Griffith Research Online (submittedVersion, cc-by)
  • RUNE (Research UNE) (submittedVersion)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
  • Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
type 2 diabetes, aerobic exercise training, exercise intensity, glycemic control, HbA1c, insulin resistance, HOMA-IR, fasting serum glucose, peak oxygen uptake, exercise duration
MeSH terms
Blood Glucose, Diabetes Mellitus, Type 2, Physical Exertion, Humans, Body Mass Index, Randomized Controlled Trials as Topic, Treatment Outcome

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