Glycemic variability determined with a continuous glucose monitoring system can predict prognosis after acute coronary syndrome
Open accessAbstract
BACKGROUND: Impaired glucose metabolism is an established risk factor for coronary artery disease. Previous studies revealed that glycemic variability (GV) is also important for glucose metabolism in patients with acute coronary syndrome (ACS). We explored the association between GV and prognosis in patients with ACS. METHODS: A total of 417 patients with ACS who received reperfusion wore a continuous glucose monitoring system (CGMS) in a stable phase after admission and were monitored for at least 24 consecutive h. The mean amplitude of glycemic excursion (MAGE) was calculated as a marker of GV. We divided into two groups based on the highest tertile levels of MAGE (MAGE = 52 mg/dl). The groups were followed up for a median of 39 months [IQR 24-50 months]. The primary endpoint was the incidence of major adverse cardiovascular and cerebrovascular events (MACCE). RESULT: During follow-up, 66 patients experienced MACCE (5 patients had cardiovascular death, 14 had recurrence of ACS, 27 had angina requiring revascularization, 8 had acute decompensated heart failure, and 16 had a stroke). MACCE was more frequently observed in the high MAGE group (23.5% vs. 11.6%, p = 0.002). In multivariate analysis, high MAGE was an independent predictive factor of poor prognosis for MACCE (odds ratio, 1.84; 95% confidence interval, 1.01-3.36; p = 0.045). CONCLUSION: Glycemic variability determined with a CGMS is a predictor of prognosis in patients with ACS without severe DM. Trial registration UMIN 000010620. Registered April 1st 2012.
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In patients with acute coronary syndrome who underwent percutaneous coronary intervention, glycemic variability was an independent predictive factor of poor prognosis.
“They reported that GV was an independent predictive factor of poor prognosis”
From Glycemic variability and cardiovascular disease in patients with type 2 diabetes (2021) · cites this paper as [50]
In patients with acute coronary syndrome who underwent percutaneous coronary intervention, the high glycemic variability group had significantly lower event-free survival rates.
“with the high GV group having significantly lower event-free survival rates.”
From Glycemic variability and cardiovascular disease in patients with type 2 diabetes (2021) · cites this paper as [50]
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Glycemic variability and cardiovascular disease in patients with type 2 diabetes
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- Authors
- Takahashi, H., Iwahashi, N., Kirigaya, J., Kataoka, S., Minamimoto, Y., Gohbara, M., Abe, T., Okada, K., Matsuzawa, Y., Konishi, M., Maejima, N., Hibi, K., Kosuge, M., Ebina, T., Tamura, K., & Kimura, K.
- Affiliations
- Yokohama City University Medical Center (JP)
- Yokohama City University (JP)
- Corresponding author
- Iwahashi, Noriaki
- ORCID
- Venue
- Cardiovascular Diabetology
- Published
- 2018-08-18
- Volume
- 17
- Issue
- 1
- Pages
- 116-116
- ISSN
- 1475-2840 (ISSN-L)
- PMC
- PMC6098663
- OpenAlex
- W2886713969
- Cited by
- 86
- References
- 32
- Citations by year
- 2026: 6 · 2025: 8 · 2024: 9 · 2023: 12 · 2022: 12 · 2021: 15 · 2020: 13 · 2019: 10 · 2017: 1
- FWCI
- 7.56
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Cardiovascular Diabetology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- glycemic variability, acute coronary syndrome, continuous glucose monitoring, mean amplitude of glycemic excursions, prognosis, major adverse cardiac and cerebrovascular events, reperfusion therapy, non-diabetic patients, glucose metabolism
- MeSH terms
- Aged, Blood Glucose, Cerebrovascular Disorders, Female, Heart Failure, Humans, Japan, Male, Middle Aged, Predictive Value of Tests, Prospective Studies, Recurrence, Risk Factors, Time Factors, Blood Glucose Self-Monitoring, Biomarkers, Myocardial Reperfusion, Incidence, Treatment Outcome, Risk Assessment, Glucose Metabolism Disorders, Acute Coronary Syndrome
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