Cited by 168Diabetes Management and ResearchDiabetes Treatment and ManagementDiabetes, Cardiovascular Risks, and Lipoproteins

Comprehensive elaboration of glycemic variability in diabetic macrovascular and microvascular complications

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Sun, Bao, Luo, Zhiying, Zhou, Jiecan·2021·Cardiovascular Diabetology

Abstract

Diabetes mellitus is the major risk factor for the development of macrovascular and microvascular complications. It is increasingly recognized that glycemic variability (GV), referring to oscillations in blood glucose levels and representing either short-term or long-term GV, is involved in the pathogenesis of diabetic complications and has emerged as a possible independent risk factor for them. In this review, we summarize the metrics and measurement of GV in clinical practice, as well as comprehensively elaborate the role and related mechanisms of GV in diabetic macrovascular and microvascular complications, aiming to provide the mechanism-based therapeutic strategies for clinicians to manage diabetes mellitus.

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Crossref · 10.1186/s12933-020-01200-7

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  • Glycaemic variability is associated with both microvascular and macrovascular complications, with reduced quality of life, and increasing the psychological burden of diabetes management.

    “This glycaemic variability, is associated with both microvascular and macrovascular complications, with reduced quality of life, and increasing in the psychological burden of diabetes management [98–100].”

    From Diabetic gastroparesis: pathophysiology and impact on insulin timing choices (2026) · cites this paper as [100]

    The ‘Relevant mechanisms of GV in diabetic macrovascular and microvascular complications’ section reports an association between glycaemic variability and both types of vascular complication. The passages on management discuss glycaemic control, but the copy does not link glycaemic variability to reduced quality of life or increased psychological burden; searches for those terms found no such passage. Page numbers were not available in the copy. (LLM, conf=0.88)

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Authors
Sun, B., Luo, Z., & Zhou, J.
Affiliations
  • Central South University (CN)
  • First Affiliated Hospital of University of South China (CN)
Corresponding author
  • Luo, Zhiying
  • Zhou, Jiecan
Venue
Cardiovascular Diabetology
Published
2021-01-07
Volume
20
Issue
1
Pages
9-9
ISSN
1475-2840 (ISSN-L)
OpenAlex
W3121117564
Cited by
168
References
122
Citations by year
2026: 26 · 2025: 27 · 2024: 40 · 2023: 33 · 2022: 33 · 2021: 9
FWCI
4.41
Type
journal article
Language
en
Open access
Locations
  • Cardiovascular Diabetology (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, other-oa)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Natural Science Foundation of Hunan Province (2020JJ5513)
  • Scientific Research Fund Project of Hunan Provincial Health Commission (20201973)
  • Scientific Research Fund of Hunan Provincial Education Department (19A418)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
glycemic variability, diabetes mellitus, macrovascular complications, microvascular complications, risk factors, treatment options
MeSH terms
Glycemic Control, Animals, Blood Glucose, Diabetes Mellitus, Diabetic Angiopathies, Glycated Hemoglobin, Humans, Hypoglycemic Agents, Risk Factors, Biomarkers, Treatment Outcome, Risk Assessment

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