The DOI matches its Crossref record; 77 of the 77 references it cites were found in a registry or an index.
Engineering microbial consortia by division of labor
Open accessAbstract
During microbial applications, metabolic burdens can lead to a significant drop in cell performance. Novel synthetic biology tools or multi-step bioprocessing (e.g., fermentation followed by chemical conversions) are therefore needed to avoid compromised biochemical productivity from over-burdened cells. A possible solution to address metabolic burden is Division of Labor (DoL) via natural and synthetic microbial consortia. In particular, consolidated bioprocesses and metabolic cooperation for detoxification or cross feeding (e.g., vitamin C fermentation) have shown numerous successes in industrial level applications. However, distributing a metabolic pathway among proper hosts remains an engineering conundrum due to several challenges: complex subpopulation dynamics/interactions with a short time-window for stable production, suboptimal cultivation of microbial communities, proliferation of cheaters or low-producers, intermediate metabolite dilution, transport barriers between species, and breaks in metabolite channeling through biosynthesis pathways. To develop stable consortia, optimization of strain inoculations, nutritional divergence and crossing feeding, evolution of mutualistic growth, cell immobilization, and biosensors may potentially be used to control cell populations. Another opportunity is direct integration of non-bioprocesses (e.g., microbial electrosynthesis) to power cell metabolism and improve carbon efficiency. Additionally, metabolic modeling and 13 C-metabolic flux analysis of mixed culture metabolism and cross-feeding offers a computational approach to complement experimental research for improved consortia performance.
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Construction of microbial consortia for microbial degradation of complex compounds
Cao, Z., Yan, W., Ding, M., & Yuan, Y. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.1051233 · Cited by 274
Biotechnological basis of microbial consortia for the removal of pesticides from the environment
Bhatt, P., Bhatt, K., Sharma, A., Zhang, W., Mishra, S., & Chen, S. (2021) · Critical Reviews in Biotechnology · doi:10.1080/07388551.2020.1853032 · Cited by 248
Microbial consortia of biological products: Do they have a future?
Nunes, P. S. O., Lacerda-Junior, G. V., Mascarin, G. M., Guimarães, R. A., Medeiros, F. H. V., Arthurs, S., & Bettiol, W. (2024) · Biological Control · doi:10.1016/j.biocontrol.2024.105439 · Cited by 140
Construction of stable microbial consortia for effective biochemical synthesis
Jiang, Y., Wu, R., Zhang, W., Xin, F., & Jiang, M. (2023) · Trends in Biotechnology · doi:10.1016/j.tibtech.2023.05.008 · Cited by 86
Metadata
- Authors
- Roell, G. W., Zha, J., Carr, R. R., Koffas, M. A., Fong, S. S., & Tang, Y. J.
- Venue
- Microbial Cell Factories
- Published
- 2019-02-08
- Volume
- 18
- Issue
- 1
- Pages
- 35-35
- ISSN
- 1475-2859 (ISSN-L)
- OpenAlex
- W2913553075
- Cited by
- 313
- References
- 77
- FWCI
- 9.09
- Type
- journal article
- Language
- en
- Open access
- gold
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