The DOI matches its Crossref record; 270 of the 270 references it cites were found in a registry or an index.
Vaginal microbiota and the potential of Lactobacillus derivatives in maintaining vaginal health
Open accessAbstract
Human vagina is colonised by a diverse array of microorganisms that make up the normal microbiota and mycobiota. Lactobacillus is the most frequently isolated microorganism from the healthy human vagina, this includes Lactobacillus crispatus, Lactobacillus gasseri, Lactobacillus iners, and Lactobacillus jensenii. These vaginal lactobacilli have been touted to prevent invasion of pathogens by keeping their population in check. However, the disruption of vaginal ecosystem contributes to the overgrowth of pathogens which causes complicated vaginal infections such as bacterial vaginosis (BV), sexually transmitted infections (STIs), and vulvovaginal candidiasis (VVC). Predisposing factors such as menses, pregnancy, sexual practice, uncontrolled usage of antibiotics, and vaginal douching can alter the microbial community. Therefore, the composition of vaginal microbiota serves an important role in determining vagina health. Owing to their Generally Recognised as Safe (GRAS) status, lactobacilli have been widely utilised as one of the alternatives besides conventional antimicrobial treatment against vaginal pathogens for the prevention of chronic vaginitis and the restoration of vaginal ecosystem. In addition, the effectiveness of Lactobacillus as prophylaxis has also been well-founded in long-term administration. This review aimed to highlight the beneficial effects of lactobacilli derivatives (i.e. surface-active molecules) with anti-biofilm, antioxidant, pathogen-inhibition, and immunomodulation activities in developing remedies for vaginal infections. We also discuss the current challenges in the implementation of the use of lactobacilli derivatives in promotion of human health. In the current review, we intend to provide insights for the development of lactobacilli derivatives as a complementary or alternative medicine to conventional probiotic therapy in vaginal health.
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Cited by
Das, S., Bhattacharjee, M. J., Mukherjee, A. K., & Khan, M. R. (2023) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2022.2049696 · Cited by 51
The Role of Fatty Acid Metabolites in Vaginal Health and Disease: Application to Candidiasis
Baldewijns, S., Sillen, M., Palmans, I., Vandecruys, P., Van Dijck, P., & Demuyser, L. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.705779 · Cited by 44
Sekito, T., Wada, K., Ishii, A., Iwata, T., Matsubara, T., Tomida, S., Watanabe, M., Araki, M., & Sadahira, T. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1187479 · Cited by 19
Li, D., Yang, C., Xu, X., Li, S., Luo, G., Zhang, C., Wang, Z., Sun, D., Cheng, J., & Zhang, Q. (2023) · Environmental Pollution · doi:10.1016/j.envpol.2023.121375 · Cited by 14
Urogenital colonization and pathogenicity of E. Coli in the vaginal microbiota during pregnancy
Boutouchent, N., Vu, T. N. A., Landraud, L., & Kennedy, S. P. (2024) · Scientific Reports · doi:10.1038/s41598-024-76438-2 · Cited by 14
Metadata
- Authors
- Chee, W. J. Y., Chew, S. Y., & Than, L. T. L.
- Venue
- Microbial Cell Factories
- Published
- 2020-11-07
- Volume
- 19
- Issue
- 1
- Pages
- 203-203
- ISSN
- 1475-2859 (ISSN-L)
- OpenAlex
- W3094904088
- Cited by
- 657
- References
- 270
- FWCI
- 33.79
- Type
- journal article
- Language
- en
- Open access
- gold
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