Sex differences in the management of persons with dementia following a subnational primary care policy intervention
Open accessAbstract
BACKGROUND: The influence of sex and gender on the risk of dementia, its clinical presentation and progression is increasingly being recognized. However, current dementia strategies have not explicitly considered sex and gender differences in the management of dementia to ensure equitable care. The objective of this study was to examine the moderating effect of sex on the quality of care following the implementation of the Quebec Alzheimer Plan (QAP). METHODS: We conducted a secondary analysis of the evaluation of the QAP consisting of a retrospective chart review of 945 independent, randomly-selected patient charts of males and females 75+ years old with dementia and a visit to one of 13 participating Family Medicine Groups before (October 2011-July 2013) and after (October 2014 - July 2015). The quality of dementia care score, based on Canadian and international recommendations and consensus guidelines, consisted of documented assessments in 10 domains. We used a mixed linear regression model to measure the interaction between sex and the implementation of the QAP on the quality of dementia care score, adjusting for age and number of medications. RESULTS: We found that improvements in the quality of dementia care following the QAP were larger for men than women (mean difference = 4.97; 95%CI: 0.08, 9.85). We found that men had a larger improvement in four indicators (driving assessments, dementia medication management, Alzheimer Society referrals, and functional status evaluation), while women had a smaller improvement in three (home care needs, behavioural and psychological symptoms of dementia, and weight). Men were prescribed fewer anticholinergics post-QAP, while women were prescribed more. Cognitive testing improved in men but decreased for women following the QAP; the opposite was observed for caregiver needs. CONCLUSION: While the overall quality of care improved after the implementation of the QAP, this study reveals differences in dementia management between men and women. While we identified areas of inequalities in the care received, it is unclear whether this represents inequities in access to care and health outcomes. Future research should focus on better understanding sex and gender-specific needs in dementia to bridge this gap and better inform dementia strategies.
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Sex, rurality, and neighborhood income quintile have been previously tied to inequalities in access to care that could be exacerbated by the COVID-19 pandemic.
“Sex, rurality, and income quintile were chosen as strata as they have been previously tied to inequalities in access to care that could be exacerbated by the pandemic.13 , 14”
From Impact of the COVID-19 pandemic on home care services among community-dwelling adults with dementia (2021) · cites this paper as [13]
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Cites
Dementia prevention, intervention, and care
Livingston, G., Sommerlad, A., Orgeta, V., Costafreda, S. G., Huntley, J., Ames, D., Ballard, C., Banerjee, S., Burns, A., Cohen-Mansfield, J., et al. (2017) · The Lancet · doi:10.1016/s0140-6736(17)31363-6 · Cited by 6,072 · see citing works
Kessler, R. (1993) · Journal of Affective Disorders · doi:10.1016/0165-0327(93)90026-g · Cited by 2,207 · see citing works
World Development Report 2012: Gender equality and development
Wong, Y.-N. (2012) · Forum for Development Studies · doi:10.1080/08039410.2012.722769 · Cited by 1,457 · see citing works
Canadian Institutes of Health Research
Cooney-Birch, J. (2019) · Palgrave Macmillan UK eBooks · doi:10.1057/978-1-349-95943-3_219 · Cited by 1,457 · see citing works
Thompson, A. E., Anisimowicz, Y., Miedema, B. B., Hogg, W. E., Wodchis, W. P., & Aubrey‐Bassler, K. (2016) · BMC Family Practice · doi:10.1186/s12875-016-0440-0 · Cited by 1,171 · see citing works
Recent global trends in the prevalence and incidence of dementia, and survival with dementia
Prince, M., Ali, G.-C., Guerchet, M., Prina, A. M., Albanese, E., & Wu, Y.-T. (2016) · Alzheimer's Research & Therapy · doi:10.1186/s13195-016-0188-8 · Cited by 876 · see citing works
Understanding the impact of sex and gender in Alzheimer’s disease: A call to action
Nebel, R. A., Aggarwal, N. T., Barnes, L. L., Gallagher, A., Goldstein, J. M., Kantarci, K., Mallampalli, M. P., Mormino, E. C., Scott, L., Yu, W. H., et al. (2018) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2018.04.008 · Cited by 839 · see citing works
Sex and gender differences in health: Science & Society Series on Sex and Science
Regitz‐Zagrosek, V. (2012) · The EMBO Reports · doi:10.1038/embor.2012.87 · Cited by 572 · see citing works
Gender differences in determinants and consequences of health and illness.
Vlassoff, C. (2007) · PubMed Central · Cited by 494 · see citing works
Gender, psychosocial factors and the use of medical services: a longitudinal analysis
Green, C. A., & Pope, C. R. (1999) · Social Science & Medicine · doi:10.1016/s0277-9536(98)00440-7 · Cited by 472 · see citing works
Gender Differences in Utilization of Preventive Care Services in the United States
Vaidya, V., Partha, G., & Karmakar, M. (2011) · Journal of Women s Health · doi:10.1089/jwh.2011.2876 · Cited by 441 · see citing works
World Trade Organization (2012) · World Trade Report · doi:10.30875/ac42f7b8-en · Cited by 332 · see citing works
Driving Life Expectancy of Persons Aged 70 Years and Older in the United States
Foley, D. J., Heimovitz, H. K., Guralnik, J. M., & Brock, D. B. (2002) · American Journal of Public Health · doi:10.2105/ajph.92.8.1284 · Cited by 329 · see citing works
Greater cognitive deterioration in women than men with Alzheimer's disease: A meta analysis
Irvine, K., Laws, K. R., Gale, T. M., & Kondel, T. K. (2012) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/13803395.2012.712676 · Cited by 290 · see citing works
Tschanz, J. T., Corcoran, C. D., Schwartz, S., Treiber, K., Green, R. C., Norton, M. C., Mielke, M. M., Piercy, K., Steinberg, M., Rabins, P. V., et al. (2011) · The American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e3181faec23 · Cited by 244 · see citing works
Physical Aggression in Dementia Patients and Its Relationship to Depression
Lyketsos, C. G., Steele, C., Galik, E., Rosenblatt, A., Steinberg, M., Warren, A., & Sheppard, J.-M. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.1.66 · Cited by 199 · see citing works
Katz, S. J. (2000) · JAMA · doi:10.1001/jama.284.23.3022 · Cited by 192 · see citing works
Introduction to the Assessing Care of Vulnerable Elders‐3 Quality Indicator Measurement Set
Wenger, N. S., Roth, C. P., Shekelle, P., & the ACOVE Investigators (2007) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2007.01328.x · Cited by 187 · see citing works
Women's Health Research: Progress, Pitfalls, and Promise
Taylor, J. S. (2011) · Health Care For Women International · doi:10.1080/07399332.2011.562837 · Cited by 132 · see citing works
Nelis, S. M., Wu, Y., Matthews, F. E., Martyr, A., Quinn, C., Rippon, I., Rusted, J. M., Thom, J. M., Kopelman, M. D., Hindle, J. V., et al. (2018) · Age and Ageing · doi:10.1093/ageing/afy155 · Cited by 116 · see citing works
Bartlett, R. L., Gjernes, T. K. O., Lotherington, A. T., & Obstefelder, A. (2016) · Health & Social Care in the Community · doi:10.1111/hsc.12340 · Cited by 107 · see citing works
Age and gender interactions on verbal memory performance
Kramer, J. H., Yaffe, K. S., Lengenfelder, J., & Delis, D. C. (2003) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617703910113 · Cited by 105 · see citing works
Sex differences in inappropriate prescribing among elderly veterans.
Bierman, A., Pugh, M., Dhalla, I., Amuan, M. E., Fincke, B. G., Rosen, A. K., & Berlowitz, D. (2007) · The American Journal of Geriatric Pharmacotherapy · doi:10.1016/j.amjopharm.2007.06.005 · Cited by 98 · see citing works
Zuidema, S. U., de Jonghe, J. F. M., Verhey, F. R. J., & Koopmans, R. T. C. M. (2009) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.2225 · Cited by 97 · see citing works
Redesigning Systems Of Care For Older Adults With Alzheimer’s Disease
Callahan, C. M., Sachs, G. A., LaMantia, M. A., Unroe, K. T., Arling, G. W., & Boustani, M. A. (2014) · Health Affairs · doi:10.1377/hlthaff.2013.1260 · Cited by 90 · see citing works
Gambassi, G., Lapane, K. L., Landi, F., Sgadari, A., Mor, V., & Bernabei, R. (1999) · Neurology · doi:10.1212/wnl.53.3.508 · Cited by 86 · see citing works
What does the medical record reveal about functional status?
Bogardus, S. T., Towle, V. R., Williams, C. S., Desai, M. M., & Inouye, S. K. (2001) · Journal of General Internal Medicine · doi:10.1111/j.1525-1497.2001.00625.x · Cited by 78 · see citing works
Women's health research: progress, pitfalls, and promise
(2011) · Choice Reviews Online · doi:10.5860/choice.48-6314 · Cited by 74 · see citing works
Sex and gender differences in polypharmacy in persons with dementia: A scoping review
Trenaman, S. C., Rideout, M., & Andrew, M. K. (2019) · SAGE Open Medicine · doi:10.1177/2050312119845715 · Cited by 35 · see citing works
Forbes, D. A., Jansen, L., Markle‐Reid, M., Hawranik, P. G., Morgan, D., Henderson, S. R., Leipert, B. D., Peacock, S., & Kingston, D. E. (2008) · PubMed · Cited by 32 · see citing works
Rosenwax, L. K., McNamara, B. A., & Zilkens, R. (2008) · Health & Social Care in the Community · doi:10.1111/j.1365-2524.2008.00795.x · Cited by 20 · see citing works
Vedel, I., Sourial, N., Arsenault‐Lapierre, G., Godard‐Sebillotte, C., & Bergman, H. (2019) · CMAJ Open · doi:10.9778/cmajo.20190053 · Cited by 20 · see citing works
Meta-analysis of Driving Cessation and Dementia: Does Sex Matter?
Baines, N., Au, B., Rapoport, M. J., Naglie, G., & Tierney, M. C. (2016) · The Journals of Gerontology Series B · doi:10.1093/geronb/gbw158 · Cited by 17 · see citing works
Le Plan Alzheimer québécois, un plan basé sur les soins primaires
Arsenault‐Lapierre, G., Godard‐Sebillotte, C., Sourial, N., Couturier, Y., Bouchard, P., Rojas‐Rozo, L., Pilon, C., Bergman, H., & Vedel, I. (2020) · Santé Publique · doi:10.3917/spub.204.0375 · Cited by 16 · see citing works
Initial Cholinesterase Inhibitor Therapy Dose and Serious Events in Older Women and Men
Rochon, P. A., Gruneir, A., Gill, S. S., Wu, W., Zhu, L., Herrmann, N., Bell, C. M., Austin, P. C., Stall, N. M., McCarthy, L. M., et al. (2018) · Journal of the American Geriatrics Society · doi:10.1111/jgs.15442 · Cited by 15 · see citing works
Potentially inappropriate prescriptions of anticholinergics drugs in Alzheimer's disease patients
Valladales‐Restrepo, L. F., Lengua, M. D., & Machado‐Alba, J. E. (2019) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/ggi.13748 · Cited by 13 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- [5]World Health Organization. Women and Health: Today’s Evidence Tomorrows Agenda. Geneva: WHO Press; 2009.
- [33]Third Canadian Consensus Conference on diagnosis and treatment of dementia Montreal2007 [Available from: http://www.cccdtd.ca/pdfs/Final_Recommendations_CCCDTD_2007.pdf.
Cited by
Sorted by citations
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Jones, A., Maclagan, L. C., Schumacher, C., Wang, X., Jaakkimainen, R. L., Guan, J., Swartz, R. H., & Bronskill, S. E. (2021) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2021.08.031 · Cited by 38 · see citing works
Sex-Specific Associations of Diabetes With Brain Structure and Function in a Geriatric Population
Thomas, E. G., Rhodius‐Meester, H. F. M., Exalto, L. G., Peters, S. A. E., van Bloemendaal, L., Ponds, R., & Muller, M. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.885787 · Cited by 25 · see citing works
Patient triage system for supporting the operation of dispatch centres and rescue teams
Nimmolrat, A., Sutham, K., & Thinnukool, O. (2021) · BMC Medical Informatics and Decision Making · doi:10.1186/s12911-021-01440-x · Cited by 22 · see citing works
Considering inequities in national dementia strategies: breadth, depth, and scope
Godard‐Sebillotte, C., Navani, S., Hacker, G., & Vedel, I. (2024) · International Journal for Equity in Health · doi:10.1186/s12939-024-02166-8 · Cited by 14 · see citing works
Aguzzoli, E., Walbaum, M., Knapp, M. R. J., Castro‐Aldrete, L., Chadha, A. S., & Cyhlarova, E. (2025) · Archives of Public Health · doi:10.1186/s13690-025-01626-z · Cited by 10 · see citing works
Noguchi, T., Nakagawa, T., Sugimoto, T., Komatsu, A., Kuroda, Y., Uchida, K., Ono, R., Arai, H., Sakurai, T., & Saito, T. (2024) · Journal of Epidemiology · doi:10.2188/jea.je20230343 · Cited by 6 · see citing works
Neuropsychiatric symptoms in patients with possible vascular cognitive impairment, does sex matter?
Exalto, L. G., Boomsma, J. M. F., Sep, Y. C. P., Leeuwis, A. E., Scheltens, P., Biessels, G. J., & van der Flier, W. M. (2022) · Cerebral Circulation - Cognition and Behavior · doi:10.1016/j.cccb.2022.100152 · Cited by 4 · see citing works
Béland, B., Perera, T., Lee, A., Greenfield, J., Korngut, L. W., & Jewett, G. (2024) · Muscle & Nerve · doi:10.1002/mus.28210 · Cited by 3 · see citing works
Gengeswaran, N., Brandwood, A., Anderson, N. N., Ramlakhan, J. U., & Gagliardi, A. R. (2024) · Dementia · doi:10.1177/14713012241244982 · Cited by 2 · see citing works
Salzwedel, M., Zuidema, S. U., Kort, H. S. M., & Janus, S. I. M. (2025) · Journal of Applied Gerontology · doi:10.1177/07334648241310708 · Cited by 2 · see citing works
Abzhandadze, T., Hoang, M. T., Raaschou, P., Norgren, J., Mo, M., Molnár, C., Xu, H., Kananen, L., Åkerman, M., Religa, D., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-03055-y · Cited by 2 · see citing works
Martineau, A., Conant, M., Barnett, K. M., Norman, M., Lanza, E., Snowball, E., Forget, M., Bruneau, M., Couture, V., Nguyên, Q. D., et al. (2026) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/cjn.2026.10609 · Cited by 1 · see citing works
Jaul, E., Factor, H., & Meiron, O. (2023) · Research Square · doi:10.21203/rs.3.rs-3573907/v1
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Thomas, E. G. (2025) · doi:10.5463/thesis.1107
Godard‐Sebillotte, C., Navani, S., Hacker, G., & Vedel, I. (2024) · Figshare · doi:10.6084/m9.figshare.25621939
Gendersensible Gerontopsychiatrie
Seethaler, M., Lopez, A. S., & Scheuber, P. (2026) · Nervenheilkunde · doi:10.1055/a-2773-7663
- Authors
- Sourial, N., Arsenault-Lapierre, G., Margo-Dermer, E., Henein, M., & Vedel, I.
- Affiliations
- Centre Hospitalier de l’Université de Montréal (CA)
- McGill University (CA)
- Jewish General Hospital (CA)
- Corresponding author
- Sourial, Nadia
- Venue
- International Journal for Equity in Health
- Published
- 2020-10-06
- Volume
- 19
- Issue
- 1
- Pages
- 175-175
- ISSN
- 1475-9276 (ISSN-L)
- PMC
- PMC7539425
- OpenAlex
- W3091909259
- Cited by
- 17
- References
- 36
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 5 · 2023: 2 · 2022: 2 · 2021: 2
- FWCI
- 1.09
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- International Journal for Equity in Health (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- The Canadian Consortium on Neurodegeneration in Aging
- Fonds de Recherche du Québec - Santé
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Sex and Gender in Healthcare
- Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
- Keywords
- dementia care, sex differences, gender differences, primary care policy, quality of care, health equity, older adults, behavioral and psychological symptoms of dementia, caregiver needs, cognitive assessment, home care needs
- MeSH terms
- Aged, Dementia, Female, Health Policy, Humans, Male, Primary Health Care, Quebec, Retrospective Studies, Sex Factors
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