The DOI matches its Crossref record; 241 of the 241 references it cites were found in a registry or an index.
EMT and stemness: flexible processes tuned by alternative splicing in development and cancer progression
Open accessAbstract
Epithelial-to-mesenchymal transition (EMT) is associated with metastasis formation as well as with generation and maintenance of cancer stem cells. In this way, EMT contributes to tumor invasion, heterogeneity and chemoresistance. Morphological and functional changes involved in these processes require robust reprogramming of gene expression, which is only partially accomplished at the transcriptional level. Alternative splicing is another essential layer of gene expression regulation that expands the cell proteome. This step in post-transcriptional regulation of gene expression tightly controls cell identity between epithelial and mesenchymal states and during stem cell differentiation. Importantly, dysregulation of splicing factor function and cancer-specific splicing isoform expression frequently occurs in human tumors, suggesting the importance of alternative splicing regulation for cancer biology.In this review, we briefly discuss the role of EMT programs in development, stem cell differentiation and cancer progression. Next, we focus on selected examples of key factors involved in EMT and stem cell differentiation that are regulated post-transcriptionally through alternative splicing mechanisms. Lastly, we describe relevant oncogenic splice-variants that directly orchestrate cancer stem cell biology and tumor EMT, which may be envisioned as novel targets for therapeutic intervention.
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Cited by
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Specificity, versatility, and control of TGF-β family signaling
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Extracellular Matrix Alterations in Metastatic Processes
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Metadata
- Authors
- Pradella, D., Naro, C., Sette, C., & Ghigna, C.
- Venue
- Molecular Cancer
- Published
- 2017-01-30
- Volume
- 16
- Issue
- 1
- Pages
- 8-8
- ISSN
- 1476-4598 (ISSN-L)
- OpenAlex
- W2577277874
- Cited by
- 326
- References
- 241
- FWCI
- 11.26
- Type
- journal article
- Language
- en
- Open access
- gold
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- Pradella, D., Naro, C., Sette, C., & Ghigna, C. (2017). EMT and stemness: flexible processes tuned by alternative splicing in development and cancer progression. Molecular Cancer. https://doi.org/10.1186/s12943-016-0579-2
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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