The DOI matches its Crossref record; 95 of the 95 references it cites were found in a registry or an index.
Circular RNAs function as ceRNAs to regulate and control human cancer progression
Open accessAbstract
Circular RNAs (circRNAs) are connected at the 3' and 5' ends by exon or intron cyclization, forming a complete ring structure. circRNA is more stable and conservative than linear RNA and abounds in various organisms. In recent years, increasing numbers of reports have found that circRNA plays a major role in the biological functions of a network of competing endogenous RNA (ceRNA). circRNAs can compete together with microRNAs (miRNAs) to influence the stability of target RNAs or their translation, thus, regulating gene expression at the transcriptional level. circRNAs are involved in biological processes such as tumor cell proliferation, apoptosis, invasion, and migration as ceRNAs. circRNAs, therefore, represent promising candidates for clinical diagnosis and treatment. Here, we review the progress in studying the role of circRNAs as ceRNAs in tumors and highlight the participation of circRNAs in signal transduction pathways to regulate cellular functions.
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Cites
3 retracted
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RetractedHMGA2 functions as a competing endogenous RNA to promote lung cancer progression
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Circular RNAs are a large class of animal RNAs with regulatory potency
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Role of the tumor microenvironment in PD-L1/PD-1-mediated tumor immune escape
Jiang, X., Wang, J., Deng, X., Xiong, F., Ge, J., Xiang, B., Wu, X., Ma, J., Zhou, M., Li, X., et al. (2019) · Molecular Cancer · doi:10.1186/s12943-018-0928-4 · Cited by 1,457
Self-citationCircular RNA-protein interactions: functions, mechanisms, and identification
Huang, A., Zheng, H., Wu, Z., Chen, M., & Huang, Y. (2020) · Theranostics · doi:10.7150/thno.42174 · Cited by 907
Circbank: a comprehensive database for circRNA with standard nomenclature
Liu, M., Wang, Q., Shen, J., Yang, B. B., & Ding, X. (2019) · RNA Biology · doi:10.1080/15476286.2019.1600395 · Cited by 554
Role of metabolism in cancer cell radioresistance and radiosensitization methods
Tang, L., Wei, F., Wu, Y., He, Y., Shi, L., Xiong, F., Gong, Z., Guo, C., Li, X., Deng, H., et al. (2018) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-018-0758-7 · Cited by 409
Self-citationEpigenetics in hepatocellular carcinoma
Nagaraju, G. P., Dariya, B., Kasa, P., Peela, S., & El-Rayes, B. F. (2022) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.07.017 · Cited by 339
Metadata
- Authors
- Zhong, Y., Du, Y., Yang, X., Mo, Y., Fan, C., Xiong, F., Ren, D., Ye, X., Li, C., Wang, Y., Wei, F., Guo, C., Wu, X., Li, X., Li, Y., Li, G., Zeng, Z., & Xiong, W.
- Venue
- Molecular Cancer
- Published
- 2018-04-07
- Volume
- 17
- Issue
- 1
- Pages
- 79-79
- ISSN
- 1476-4598 (ISSN-L)
- OpenAlex
- W2795917193
- Cited by
- 1,007
- References
- 95
- FWCI
- 44.02
- Type
- journal article
- Language
- en
- Open access
- gold
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- Zhong, Y., Du, Y., Yang, X., Mo, Y., Fan, C., Xiong, F., Ren, D., Ye, X., Li, C., Wang, Y., Wei, F., Guo, C., Wu, X., Li, X., Li, Y., Li, G., Zeng, Z., & Xiong, W. (2018). Circular RNAs function as ceRNAs to regulate and control human cancer progression. Molecular Cancer. https://doi.org/10.1186/s12943-018-0827-8
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