The DOI matches its Crossref record; 146 of the 146 references it cites were found in a registry or an index.
Extracellular vesicles-mediated intercellular communication: roles in the tumor microenvironment and anti-cancer drug resistance
Open accessAbstract
The tumor microenvironment represents a complex network, in which tumor cells not only communicate with each other but also with stromal and immune cells. Current research has demonstrated the vital role of the tumor microenvironment in supporting tumor phenotype via a sophisticated system of intercellular communication through direct cell-to-cell contact or by classical paracrine signaling loops of cytokines or growth factors. Recently, extracellular vesicles have emerged as an important mechanism of cellular interchange of bioactive molecules. Extracellular vesicles isolated from tumor and stromal cells have been implicated in various steps of tumor progression, such as proliferation, angiogenesis, metastasis, and drug resistance. Inhibition of extracellular vesicles secretion, and thus of the transfer of oncogenic molecules, holds promise for preventing tumor growth and drug resistance. This review focuses on the role of extracellular vesicles in modulating the tumor microenvironment by addressing different aspects of the bidirectional interactions among tumor and tumor-associated cells. The contribution of extracellular vesicles to drug resistance will also be discussed as well as therapeutic strategies targeting extracellular vesicles production for the treatment of cancer.
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Cites
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The multi-factorial nature of clinical multidrug resistance in cancer
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Li, M., Zhang, X., Wang, M., Wang, Y., Qian, J., Xing, X., Wang, Z., You, Y., Guo, K., Chen, J., et al. (2022) · Cancer Communications · doi:10.1002/cac2.12364 · Cited by 181
Cancer‐Associated Fibroblasts Suppress Cancer Development: The Other Side of the Coin
Wang, Z., Yang, Q., Tan, Y., Tang, Y., Ye, J., Yuan, B., & Yu, W. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.613534 · Cited by 81
Recent Progress in Extracellular Vesicle-Based Carriers for Targeted Drug Delivery in Cancer Therapy
Tang, Y., Liu, X., Sun, M., Xiong, S., Xiao, N., Li, J., He, X., & Xie, J. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15071902 · Cited by 24
Metadata
- Authors
- Maacha, S., Bhat, A. A., Jimenez, L., Raza, A., Haris, M., Uddin, S., & Grivel, J.-C.
- Venue
- Molecular Cancer
- Published
- 2019-03-30
- Volume
- 18
- Issue
- 1
- Pages
- 55-55
- ISSN
- 1476-4598 (ISSN-L)
- OpenAlex
- W2939856144
- Cited by
- 572
- References
- 146
- FWCI
- 15.11
- Type
- journal article
- Language
- en
- Open access
- gold
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- Maacha, S., Bhat, A. A., Jimenez, L., Raza, A., Haris, M., Uddin, S., & Grivel, J.-C. (2019). Extracellular vesicles-mediated intercellular communication: roles in the tumor microenvironment and anti-cancer drug resistance. Molecular Cancer. https://doi.org/10.1186/s12943-019-0965-7
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