Recent Progress in Extracellular Vesicle-Based Carriers for Targeted Drug Delivery in Cancer Therapy
Open accessAbstract
Extracellular vesicles (EVs) are small, membrane-based vesicles released by cells that play a critical role in various physiological and pathological processes. They act as vehicles for transporting a variety of endogenous cargo molecules, enabling intercellular communication. Due to their natural properties, EVs have emerged as a promising “cell-free therapy” strategy for treating various diseases, including cancer. They serve as excellent carriers for different therapeutics, including nucleic acids, proteins, small molecules, and other nanomaterials. Modifying or engineering EVs can improve the efficacy, targeting, specificity, and biocompatibility of EV-based therapeutics for cancer therapy. In this review, we comprehensively outline the biogenesis, isolation, and methodologies of EVs, as well as their biological functions. We then focus on specific applications of EVs as drug carriers in cancer therapy by citing prominent recent studies. Additionally, we discuss the opportunities and challenges for using EVs as pharmaceutical drug delivery vehicles. Ultimately, we aim to provide theoretical and technical support for the development of EV-based carriers for cancer treatment.
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Various cargoes can be indirectly loaded into EVs by engineering the parent cells through co-incubation or gene transfection.
“Various cargoes can be indirectly loaded into EVs by engineering the parent cells through co-incubation or gene transfection [216].”
From Extracellular vesicles as nanotheranostic platforms for targeted neurological disorder interventions (2024) · cites this paper as [216]
Surface membranes of EVs released from parent cells can be modified by gene engineering of the parent cells via transfection.
“The surface membranes of EVs released from parent cells can be modified by gene engineering of the parent cells via transfection [216].”
From Extracellular vesicles as nanotheranostic platforms for targeted neurological disorder interventions (2024) · cites this paper as [216]
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Harnessing the Potential of Exosomes in Therapeutic Interventions for Brain Disorders
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- Authors
- Tang, Y., Liu, X., Sun, M., Xiong, S., Xiao, N., Li, J., He, X., & Xie, J.
- Affiliations
- Southwest University (CN)
- Chongqing University of Technology (CN)
- Chongqing Key Laboratory of Medicinal Chemistry and Molecular Pharmacology, Chongqing University of Technology, Chongqing 400054, China
- Corresponding author
- He, Xiao
- Xie, Jing
- Venue
- Pharmaceutics
- Publisher
- MDPI AG
- Published
- 2023-07-07
- Volume
- 15
- Issue
- 7
- Pages
- 1902
- ISSN
- 1999-4923 (ISSN-L)
- PMC
- PMC10384044
- OpenAlex
- W4383819251
- Cited by
- 24
- References
- 186
- Citations by year
- 2026: 3 · 2025: 15 · 2024: 6
- FWCI
- 0.63
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Pharmaceutics (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Science and Technology Research Program of the Chongqing Education Commission of China (KJQN202201168, cstc2021-jcyj-msxmX0382, cstc2021jcyj-msxmX0344, KJQN202101140, 2020TJZ018, cstc2021jcyjmsxmX0342, CYS21072)
- Scientific Research Foundation of Chongqing University of Technology (KJQN202201168, cstc2021-jcyj-msxmX0382, cstc2021jcyj-msxmX0344, KJQN202101140, 2020TJZ018, cstc2021jcyjmsxmX0342, CYS21072)
- Natural Science Foundation Project of CQCSTC (KJQN202201168, cstc2021-jcyj-msxmX0382, cstc2021jcyj-msxmX0344, KJQN202101140, 2020TJZ018, cstc2021jcyjmsxmX0342, CYS21072)
- Science and Technology Research Program of Chongqing Municipal Education Commission (KJQN202201168, cstc2021-jcyj-msxmX0382, cstc2021jcyj-msxmX0344, KJQN202101140, 2020TJZ018, cstc2021jcyjmsxmX0342, CYS21072)
- Science and Technology Talents in Banan District of Chongqing (KJQN202201168, cstc2021-jcyj-msxmX0382, cstc2021jcyj-msxmX0344, KJQN202101140, 2020TJZ018, cstc2021jcyjmsxmX0342, CYS21072)
- Graduate Scientific Research and Innovation Foundation of Chongqing, China (KJQN202201168, cstc2021-jcyj-msxmX0382, cstc2021jcyj-msxmX0344, KJQN202101140, 2020TJZ018, cstc2021jcyjmsxmX0342, CYS21072)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Keywords
- extracellular vesicles, targeted drug delivery, cancer therapy, cell-free therapy, EV engineering, EV biogenesis, EV isolation, intercellular communication
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