Cited by 24Extracellular vesicles in diseaseNanoparticle-Based Drug DeliveryNanoplatforms for cancer theranostics

Recent Progress in Extracellular Vesicle-Based Carriers for Targeted Drug Delivery in Cancer Therapy

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Tang, Yaqin, Liu, Xingyou, Sun, Meng, Xiong, Su, Xiao, Nianting, Li, Jianchao, He, Xiao, Xie, Jing·2023·Pharmaceutics

Abstract

Extracellular vesicles (EVs) are small, membrane-based vesicles released by cells that play a critical role in various physiological and pathological processes. They act as vehicles for transporting a variety of endogenous cargo molecules, enabling intercellular communication. Due to their natural properties, EVs have emerged as a promising “cell-free therapy” strategy for treating various diseases, including cancer. They serve as excellent carriers for different therapeutics, including nucleic acids, proteins, small molecules, and other nanomaterials. Modifying or engineering EVs can improve the efficacy, targeting, specificity, and biocompatibility of EV-based therapeutics for cancer therapy. In this review, we comprehensively outline the biogenesis, isolation, and methodologies of EVs, as well as their biological functions. We then focus on specific applications of EVs as drug carriers in cancer therapy by citing prominent recent studies. Additionally, we discuss the opportunities and challenges for using EVs as pharmaceutical drug delivery vehicles. Ultimately, we aim to provide theoretical and technical support for the development of EV-based carriers for cancer treatment.

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Crossref · 10.3390/pharmaceutics15071902

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Authors
Tang, Y., Liu, X., Sun, M., Xiong, S., Xiao, N., Li, J., He, X., & Xie, J.
Affiliations
  • Southwest University (CN)
  • Chongqing University of Technology (CN)
  • Chongqing Key Laboratory of Medicinal Chemistry and Molecular Pharmacology, Chongqing University of Technology, Chongqing 400054, China
Corresponding author
  • He, Xiao
  • Xie, Jing
Venue
Pharmaceutics
Publisher
MDPI AG
Published
2023-07-07
Volume
15
Issue
7
Pages
1902
ISSN
1999-4923 (ISSN-L)
OpenAlex
W4383819251
Cited by
24
References
186
Citations by year
2026: 3 · 2025: 15 · 2024: 6
FWCI
0.63
Type
journal article
Language
en
Open access
Locations
  • Pharmaceutics (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Science and Technology Research Program of the Chongqing Education Commission of China (KJQN202201168, cstc2021-jcyj-msxmX0382, cstc2021jcyj-msxmX0344, KJQN202101140, 2020TJZ018, cstc2021jcyjmsxmX0342, CYS21072)
  • Scientific Research Foundation of Chongqing University of Technology (KJQN202201168, cstc2021-jcyj-msxmX0382, cstc2021jcyj-msxmX0344, KJQN202101140, 2020TJZ018, cstc2021jcyjmsxmX0342, CYS21072)
  • Natural Science Foundation Project of CQCSTC (KJQN202201168, cstc2021-jcyj-msxmX0382, cstc2021jcyj-msxmX0344, KJQN202101140, 2020TJZ018, cstc2021jcyjmsxmX0342, CYS21072)
  • Science and Technology Research Program of Chongqing Municipal Education Commission (KJQN202201168, cstc2021-jcyj-msxmX0382, cstc2021jcyj-msxmX0344, KJQN202101140, 2020TJZ018, cstc2021jcyjmsxmX0342, CYS21072)
  • Science and Technology Talents in Banan District of Chongqing (KJQN202201168, cstc2021-jcyj-msxmX0382, cstc2021jcyj-msxmX0344, KJQN202101140, 2020TJZ018, cstc2021jcyjmsxmX0342, CYS21072)
  • Graduate Scientific Research and Innovation Foundation of Chongqing, China (KJQN202201168, cstc2021-jcyj-msxmX0382, cstc2021jcyj-msxmX0344, KJQN202101140, 2020TJZ018, cstc2021jcyjmsxmX0342, CYS21072)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
Keywords
extracellular vesicles, targeted drug delivery, cancer therapy, cell-free therapy, EV engineering, EV biogenesis, EV isolation, intercellular communication

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