Cited by 297Extracellular vesicles in diseaseMesenchymal stem cell researchCancer Cells and Metastasis

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Mesenchymal stem cell-derived exosomes in cancer therapy resistance: recent advances and therapeutic potential

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Lin, Zhengjun, Wu, Yanlin, Xu, Yiting, Li, Guoqing, Li, Zhihong, Liu, Tang·2022·Molecular Cancer

DOI 10.1186/s12943-022-01650-5PMC PMC9468526

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Abstract

Mesenchymal stem cells (MSCs) are multipotent stromal cells that can be obtained from various human tissues and organs. They can differentiate into a wide range of cell types, including osteoblasts, adipocytes and chondrocytes, thus exhibiting great potential in regenerative medicine. Numerous studies have indicated that MSCs play critical roles in cancer biology. The crosstalk between tumour cells and MSCs has been found to regulate many tumour behaviours, such as proliferation, metastasis and epithelial-mesenchymal transition (EMT). Multiple lines of evidence have demonstrated that MSCs can secrete exosomes that can modulate the tumour microenvironment and play important roles in tumour development. Notably, very recent works have shown that mesenchymal stem cell-derived exosomes (MSC-derived exosomes) are critically involved in cancer resistance to chemotherapy agents, targeted-therapy drugs, radiotherapy and immunotherapy. In this review, we systematically summarized the emerging roles and detailed molecular mechanisms of MSC-derived exosomes in mediating cancer therapy resistance, thus providing novel insights into the clinical applications of MSC-derived exosomes in cancer management.

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Fig. 1 Overview of MSC-derived exosomes. A Biogenesis of exosomes. The biogenesis of exosomes comprises endocytosis, MVB formation, and exosome secretion into the extracellular microenvironment through merging with the plasma membrane. B Characteristics and contents of exosomes. C Exosome purification methodsCC BY · PubMed Central

Fig. 2 MSC-derived exosomes in cancer therapy resistance. MSC-derived exosomes participate in cancer drug resistance, immunotherapy and radiotherapy resistance through complex mechanisms, including evasion of apoptosis, modulation of cancer stem cells, and regulation of cancer dormancyCC BY · PubMed Central

Fig. 3 Applications of MSC-derived exosomes in cancer therapy. MSC-derived exosomes can be employed to deliver functional RNAs including miRNAs and siRNA to enhance the drug sensitivity, and deliver anticancer drugs such as chemotherapeutic agents. Moreover, MSC-derived exosomes are capable of repairing radiotherapy-induced damage through complex mechanisms, including promotion of cellular proliferation, promotion of angiogenesis capability, inhibition of inflammation and oxidation, and reduction of the pathogenesis of fibrosisCC BY · PubMed Central

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Authors: Lin, Z., Wu, Y., Xu, Y., Li, G., Li, Z., & Liu, T.
Affiliations: Central South University (CN)
Second Xiangya Hospital of Central South University (CN)
Corresponding author: Li, Zhihong
Liu, Tang
ORCID: Lin, Zhengjun
Wu, Yanlin
Xu, Yiting
Li, Guoqing
Li, Zhihong
Liu, Tang
Venue: Molecular Cancer
Publisher: Springer Science and Business Media LLC
Published: 2022-09-13
Volume: 21
Issue: 1
Pages: 179-179
ISSN: 1476-4598 (ISSN-L)
DOI: 10.1186/s12943-022-01650-5
PMC: PMC9468526
OpenAlex: W4295750964
Cited by: 297
References: 158
Citations by year: 2026: 50 · 2025: 115 · 2024: 81 · 2023: 48 · 2022: 2
FWCI: 6.40
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0 (tdm)
creativecommons.org/licenses/by/4.0 (vor)
Locations: Molecular Cancer (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: National Natural Science Foundation of China (82072441, 2022JJ10095, 81871783)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
Keywords: mesenchymal stem cells, exosomes, cancer therapy resistance, tumor microenvironment, chemoresistance, targeted therapy resistance, radiotherapy resistance, immunotherapy resistance, epithelial-mesenchymal transition, metastasis, regenerative medicine
MeSH terms: Humans, Neoplasms, Adipocytes, Exosomes, Tumor Microenvironment, Mesenchymal Stem Cells

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Mesenchymal stem cell-derived exosomes in cancer therapy resistance: recent advances and therapeutic potential

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