The DOI matches its Crossref record; 297 of the 297 references it cites were found in a registry or an index.
Advancements in nanoparticle-based treatment approaches for skin cancer therapy
Open accessAbstract
Skin cancer has emerged as the fifth most commonly reported cancer in the world, causing a burden on global health and the economy. The enormously rising environmental changes, industrialization, and genetic modification have further exacerbated skin cancer statistics. Current treatment modalities such as surgery, radiotherapy, conventional chemotherapy, targeted therapy, and immunotherapy are facing several issues related to cost, toxicity, and bioavailability thereby leading to declined anti-skin cancer therapeutic efficacy and poor patient compliance. In the context of overcoming this limitation, several nanotechnological advancements have been witnessed so far. Among various nanomaterials, nanoparticles have endowed exorbitant advantages by acting as both therapeutic agents and drug carriers for the remarkable treatment of skin cancer. The small size and large surface area to volume ratio of nanoparticles escalate the skin tumor uptake through their leaky vasculature resulting in enhanced therapeutic efficacy. In this context, the present review provides up to date information about different types and pathology of skin cancer, followed by their current treatment modalities and associated drawbacks. Furthermore, it meticulously discusses the role of numerous inorganic, polymer, and lipid-based nanoparticles in skin cancer therapy with subsequent descriptions of their patents and clinical trials. Graphical Abstract
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1 retracted
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Cited by
Hasan, N., Nadaf, A., Imran, M., Jiba, U., Sheikh, A., Almalki, W. H., Almujri, S. S., Mohammed, Y. H., Kesharwani, P., & Ahmad, F. J. (2023) · Molecular Cancer · doi:10.1186/s12943-023-01854-3 · Cited by 322
Self-citationHu, D., Li, Y., Li, R., Wang, M., Zhou, K., He, C., Wei, Q., & Qian, Z. (2024) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2024.10.015 · Cited by 153
Afkhami, H., Mahmoudvand, G., Fakouri, A., Shadab, A., Mahjoor, M., & Komeili Movahhed, T. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1255697 · Cited by 27
El-Readi, M. Z., Abdulkarim, M. A., Abdellatif, A. A. H., Elzubeir, M. E., Refaat, B., Althubiti, M., Almaimani, R. A., Mukhtar, M. H., Al-Moraya, I. S., & Eid, S. Y. (2025) · Drug Development and Industrial Pharmacy · doi:10.1080/03639045.2024.2302557 · Cited by 11
Metadata
- Authors
- Zeng, L., Gowda, B. H. J., Ahmed, M. G., Abourehab, M. A. S., Chen, Z.-S., Zhang, C., Li, J., & Kesharwani, P.
- Venue
- Molecular Cancer
- Published
- 2023-01-12
- Volume
- 22
- Issue
- 1
- Pages
- 10-10
- ISSN
- 1476-4598 (ISSN-L)
- OpenAlex
- W4315700889
- Cited by
- 365
- References
- 297
- FWCI
- 31.44
- Type
- journal article
- Language
- en
- Open access
- gold
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- Zeng, L., Gowda, B. H. J., Ahmed, M. G., Abourehab, M. A. S., Chen, Z.-S., Zhang, C., Li, J., & Kesharwani, P. (2023). Advancements in nanoparticle-based treatment approaches for skin cancer therapy. Molecular Cancer. https://doi.org/10.1186/s12943-022-01708-4
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