Cited by 23Cardiovascular and exercise physiologyMuscle metabolism and nutritionAdipose Tissue and Metabolism

The emerging role of skeletal muscle as a modulator of lipid profile the role of exercise and nutrition

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Nomikos, Tzortzis, Methenitis, Spyridon, Panagiotakos, Demosthenes B·2022·Lipids in Health and Disease

Abstract

The present article aims to discuss the hypothesis that skeletal muscle per se but mostly its muscle fiber composition could be significant determinants of lipid metabolism and that certain exercise modalities may improve metabolic dyslipidemia by favorably affecting skeletal muscle mass, fiber composition and functionality. It discusses the mediating role of nutrition, highlights the lack of knowledge on mechanistic aspects of this relationship and proposes possible experimental directions in this field.

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Crossref · 10.1186/s12944-022-01692-0

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  • Increased accumulation of intramuscular lipids in obese individuals results from reduced fatty acid oxidation caused by metabolic inflexibility due to diminished type I muscle fibers.

    “As such, it has been suggested that the increased accumulation of intramuscular lipids in obese individuals results from reduced fatty acid oxidation, which is caused by metabolic inflexibility due to a diminished type I muscle fibers [52].”

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Research works printed but not linked: 1

  1. [58]Lieber R. Skeletal muscle structure, function, and plasticity. 2nd ed. Batimore: Lippincott, Williams & Wilkins; 2010.

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Authors
Nomikos, T., Methenitis, S., & Panagiotakos, D. B.
Affiliations
  • Harokopio University of Athens (GR)
  • National and Kapodistrian University of Athens (GR)
Corresponding author
Nomikos, Tzortzis
Venue
Lipids in Health and Disease
Published
2022-08-30
Volume
21
Issue
1
Pages
81-81
ISSN
1476-511X (ISSN-L)
OpenAlex
W4293538590
Cited by
23
References
62
Citations by year
2026: 4 · 2025: 7 · 2024: 5 · 2023: 6 · 2022: 1
FWCI
4.96
Type
journal article
Language
en
Open access
Locations
  • Lipids in Health and Disease (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Keywords
skeletal muscle, lipid metabolism, muscle fiber composition, physical activity, nutrition, lipid profile, muscle mass, exercise modalities
MeSH terms
Lipids, Exercise, Muscle, Skeletal, Muscle Fibers, Skeletal, Lipid Metabolism

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