The emerging role of skeletal muscle as a modulator of lipid profile the role of exercise and nutrition
Open accessAbstract
The present article aims to discuss the hypothesis that skeletal muscle per se but mostly its muscle fiber composition could be significant determinants of lipid metabolism and that certain exercise modalities may improve metabolic dyslipidemia by favorably affecting skeletal muscle mass, fiber composition and functionality. It discusses the mediating role of nutrition, highlights the lack of knowledge on mechanistic aspects of this relationship and proposes possible experimental directions in this field.
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Increased accumulation of intramuscular lipids in obese individuals results from reduced fatty acid oxidation caused by metabolic inflexibility due to diminished type I muscle fibers.
“As such, it has been suggested that the increased accumulation of intramuscular lipids in obese individuals results from reduced fatty acid oxidation, which is caused by metabolic inflexibility due to a diminished type I muscle fibers [52].”
From Mitochondrial Adaptation in Skeletal Muscle: Impact of Obesity, Caloric Restriction, and Dietary Compounds (2024) · cites this paper as [52]
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Research works printed but not linked: 1
- [58]Lieber R. Skeletal muscle structure, function, and plasticity. 2nd ed. Batimore: Lippincott, Williams & Wilkins; 2010.
Cited by
Sorted by citations
Jun, L., Tao, Y.-X., Geetha, T., & Babu, J. R. (2024) · Current Nutrition Reports · doi:10.1007/s13668-024-00555-7 · Cited by 27 · see citing works
- Authors
- Nomikos, T., Methenitis, S., & Panagiotakos, D. B.
- Affiliations
- Harokopio University of Athens (GR)
- National and Kapodistrian University of Athens (GR)
- Corresponding author
- Nomikos, Tzortzis
- Venue
- Lipids in Health and Disease
- Published
- 2022-08-30
- Volume
- 21
- Issue
- 1
- Pages
- 81-81
- ISSN
- 1476-511X (ISSN-L)
- PMC
- PMC9425975
- OpenAlex
- W4293538590
- Cited by
- 23
- References
- 62
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 5 · 2023: 6 · 2022: 1
- FWCI
- 4.96
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Lipids in Health and Disease (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- skeletal muscle, lipid metabolism, muscle fiber composition, physical activity, nutrition, lipid profile, muscle mass, exercise modalities
- MeSH terms
- Lipids, Exercise, Muscle, Skeletal, Muscle Fibers, Skeletal, Lipid Metabolism
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