The DOI matches its Crossref record; 61 of the 61 references it cites were found in a registry or an index.
Functional exosome-mediated co-delivery of doxorubicin and hydrophobically modified microRNA 159 for triple-negative breast cancer therapy
Open accessAbstract
Exosomes (Exo) hold great promise as endogenous nanocarriers that can deliver biological information between cells. However, Exo are limited in terms of their abilities to target specific recipient cell types. We developed a strategy to isolate Exo exhibiting increased binding to integrin α v β 3 . Binding occurred through a modified version of a disintegrin and metalloproteinase 15 (A15) expressed on exosomal membranes (A15-Exo), which facilitated co-delivery of therapeutic quantities of doxorubicin (Dox) and cholesterol-modified miRNA 159 (Cho-miR159) to triple-negative breast cancer (TNBC) cells, both in vitro and in vivo. The targeted A15-Exo were derived from continuous protein kinase C activation in monocyte-derived macrophages. These cell-derived Exo displayed targeting properties and had a 2.97-fold higher production yield. In vitro, A15-Exo co-loaded with Dox and Cho-miR159 induced synergistic therapeutic effects in MDA-MB-231 cells. In vivo, miR159 and Dox delivery in a vesicular system effectively silenced the TCF-7 gene and exhibited improved anticancer effects, without adverse effects. Therefore, our data demonstrate the synergistic efficacy of co-delivering miR159 and Dox by targeted Exo for TNBC therapy.
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Cited by
Liang, G., Zhu, Y., Ali, D. J., Tian, T., Xu, H., Si, K., Sun, B., Chen, B., & Xiao, Z. (2020) · Journal of Nanobiotechnology · doi:10.1186/s12951-019-0563-2 · Cited by 619
Exosome engineering: Current progress in cargo loading and targeted delivery
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Exosome-Based Drug Delivery: Translation from Bench to Clinic
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Engineering blood exosomes for tumor-targeting efficient gene/chemo combination therapy
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Metadata
- Authors
- Gong, C., Tian, J., Wang, Z., Gao, Y., Wu, X., Ding, X., Qiang, L., Li, G., Han, Z., Yuan, Y., & Gao, S.
- Venue
- Journal of Nanobiotechnology
- Published
- 2019-09-03
- Volume
- 17
- Issue
- 1
- Pages
- 93-93
- ISSN
- 1477-3155 (ISSN-L)
- OpenAlex
- W2971629072
- Cited by
- 339
- References
- 61
- FWCI
- 10.38
- Type
- journal article
- Language
- en
- Open access
- gold
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- CoChat. (2026). Citation check: Functional exosome-mediated co-delivery of doxorubicin and hydrophobically modified microRNA 159 for triple-negative breast cancer therapy. https://app.cochat.ai/papers/10.1186/s12951-019-0526-7
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- Gong, C., Tian, J., Wang, Z., Gao, Y., Wu, X., Ding, X., Qiang, L., Li, G., Han, Z., Yuan, Y., & Gao, S. (2019). Functional exosome-mediated co-delivery of doxorubicin and hydrophobically modified microRNA 159 for triple-negative breast cancer therapy. Journal of Nanobiotechnology. https://doi.org/10.1186/s12951-019-0526-7
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