Smoking and hormones in health and endocrine disorders
Abstract
Smoking has multiple effects on hormone secretion, some of which are associated with important clinical implications. These effects are mainly mediated by the pharmacological action of nicotine and also by toxins such as thiocyanate. Smoking affects pituitary, thyroid, adrenal, testicular and ovarian function, calcium metabolism and the action of insulin. The major salient clinical effects are the increased risk and severity of Graves’ hyperthyroidism and opthalmopathy, osteoporosis and reduced fertility. Smoking also contributes to the development of insulin resistance and hence type 2 diabetes mellitus. An important concern is also the effect of smoking on the foetus and young children. Passive transfer of thiocyanate can cause disturbance of thyroid size and function. Furthermore, maternal smoking causes increased catecholamine production, which may contribute to under perfusion of the foetoplacental unit.
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Various studies have shown significantly increased, decreased, and unchanged levels of total testosterone in male smokers.
“Various studies have shown significantly increased, decreased, and unchanged levels of total testosterone in male smokers (41).”
From Clinical and Biochemical Assessment of Hypogonadism in Men With Type 2 Diabetes (2007) · cites this paper as [41]
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Toxic effects of smokeless tobacco on female reproductive health: A review
Laldinsangi, C. (2022) · Current Research in Toxicology · doi:10.1016/j.crtox.2022.100066 · Cited by 27 · see citing works
Erectile Dysfunction in Opioid Users: Lack of Association with Serum Testosterone
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- Authors
- Kapoor, D., & Jones, T. H.
- Affiliations
- Barnsley Hospital NHS Foundation Trust (GB)
- ORCID
- Jones, T H
- Venue
- European Journal of Endocrinology
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-04
- Volume
- 152
- Issue
- 4
- Pages
- 491-499
- ISSN
- 0804-4643 (ISSN-L)
- 1479-683X
- OpenAlex
- W2118044470
- Cited by
- 291
- References
- 122
- Citations by year
- 2026: 4 · 2025: 12 · 2024: 10 · 2023: 13 · 2022: 15 · 2021: 13 · 2020: 12 · 2019: 12 · 2018: 10 · 2017: 13 · 2016: 22 · 2015: 21 · 2014: 18 · 2013: 19 · 2012: 17
- FWCI
- 1.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Keywords
- smoking, nicotine, thiocyanate, hormone secretion, pituitary function, thyroid function, adrenal function, testicular function, ovarian function, calcium metabolism, insulin resistance, type 2 diabetes, Graves' hyperthyroidism, Graves' ophthalmopathy, osteoporosis, fertility, passive smoking, fetal development, catecholamines
- MeSH terms
- Adrenal Cortex Hormones, Adrenal Gland Diseases, Bone and Bones, Endocrine System Diseases, Female, Health, Hormones, Humans, Insulin Resistance, Male, Parathyroid Hormone, Pituitary Hormones, Gonadal Steroid Hormones, Smoking, Thyroid Diseases
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