The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Dynasore - not just a dynamin inhibitor
Open accessAbstract
Dynamin is a GTPase protein that is essential for membrane fission during clathrin-mediated endocytosis in eukaryotic cells. Dynasore is a GTPase inhibitor that rapidly and reversibly inhibits dynamin activity, which prevents endocytosis. However, comparison between cells treated with dynasore and RNA interference of genes encoding dynamin, reveals evidence that dynasore reduces labile cholesterol in the plasma membrane, and disrupts lipid raft organization, in a dynamin-independent manner. To explore the role of dynamin it is important to use multiple dynamin inhibitors, alongside the use of dynamin mutants and RNA interference targeting genes encoding dynamin. On the other hand, dynasore provides an interesting tool to explore the regulation of cholesterol in plasma membranes.
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Cites
Functional rafts in cell membranes
Simons, K., & Ikonen, E. (1997) · Nature · doi:10.1038/42408 · Cited by 9,757 · cited 1×
“Lipid rafts are membrane microdomains that are enriched in cholesterol, sphingomyelin, sphingolipids and phospholipids, and these areas of membrane differ in composition from the surrounding regions of plasma membrane [41,42].”
A Receptor-Mediated Pathway for Cholesterol Homeostasis
Brown, M. S., & Goldstein, J. L. (1986) · Science · doi:10.1126/science.3513311 · Cited by 5,703
Molecular mechanism and physiological functions of clathrin-mediated endocytosis
McMahon, H. T., & Boucrot, E. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3151 · Cited by 2,223
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Nelemans, L. C., & Gurevich, L. (2020) · Materials · doi:10.3390/ma13020366 · Cited by 173
Spoiled for Choice: Diverse Endocytic Pathways Function at the Cell Surface
Thottacherry, J. J., Sathe, M., Prabhakara, C., & Mayor, S. (2019) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100617-062710 · Cited by 122
Protein Corona Formation on Lipid Nanoparticles Negatively Affects the NLRP3 Inflammasome Activation
Debnath, M., Forster, J., Ramesh, A., & Kulkarni, A. (2023) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.3c00329 · Cited by 60
Rapid macropinocytic transfer of α-synuclein to lysosomes
Bayati, A., Banks, E., Han, C., Luo, W., Reintsch, W. E., Zorca, C. E., Shlaifer, I., Del Cid Pellitero, E., Vanderperre, B., McBride, H. M., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111102 · Cited by 57
Metadata
- Authors
- Preta, G., Cronin, J. G., & Sheldon, I. M.
- Venue
- Cell Communication and Signaling
- Published
- 2015-04-10
- Volume
- 13
- Issue
- 1
- Pages
- 24-24
- ISSN
- 1478-811X (ISSN-L)
- OpenAlex
- W2145190710
- Cited by
- 289
- References
- 3
- FWCI
- 8.94
- Type
- journal article
- Language
- en
- Open access
- gold
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