The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Drug resistance and Cancer stem cells
Open accessAbstract
Therapy resistance is a major problem when treating cancer patients as cancer cells develop mechanisms that counteract the effect of therapeutic compounds, leading to fit and more aggressive clones that contribute to poor prognosis. Therapy resistance can be both intrinsic and/or acquired. These are multifactorial events, and some are related to factors including adaptations in cancer stem cells (CSCs), epithelial-mesenchymal transition (EMT), deregulation of key signaling pathways, drug efflux through ABC transporters, acquired mutations, evading apoptosis, and activation of DNA damage response among others. Among these factors, CSCs represent the major source of therapy resistance. CSCs are a subset of tumor cells that are capable of self-renewal and multilineage progenitor expansion that are known to be intrinsically resistant to anticancer treatments. Multiple clones of CSCs pre-exist, and some can adopt and expand easily to changes in the tumor microenvironment (TME) and/or in response to radio- and chemotherapy. A combination of both intrinsic and extrinsic factors contributes to CSC-mediated therapy resistance. In this review, we will focus on CSCs and therapy resistance as well as suggest strategies to eliminate CSCs and, therefore, overcome resistance.
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Cited by
Unveiling the mechanisms and challenges of cancer drug resistance
Khan, S. U., Fatima, K., Aisha, S., & Malik, F. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-023-01302-1 · Cited by 417
scDrugMap: benchmarking large foundation models for drug response prediction
Wang, Q., Pan, Y., Zhou, M., Tang, Z., Wang, Y., Wang, G., & Song, Q. (2025) · Nature Communications · doi:10.1038/s41467-025-67481-2 · Cited by 12
Pan-cancer analyses suggest kindlin-associated global mechanochemical alterations
Chowdhury, D., Mistry, A., Maity, D., Bhatia, R., Priyadarshi, S., Wadan, S., Chakraborty, S., & Haldar, S. (2024) · Communications Biology · doi:10.1038/s42003-024-06044-5 · Cited by 5
Metadata
- Authors
- Li, Y., Wang, Z., Ajani, J. A., & Song, S.
- Venue
- Cell Communication and Signaling
- Published
- 2021-02-15
- Volume
- 19
- Issue
- 1
- Pages
- 19-19
- ISSN
- 1478-811X (ISSN-L)
- OpenAlex
- W3129607550
- Cited by
- 331
- References
- 12
- FWCI
- 17.20
- Type
- journal article
- Language
- en
- Open access
- gold
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