Cancer Stem Cell Metabolism

Hallmarks of Cancer: The Next Generation

Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590 · see citing works

Association of reactive oxygen species levels and radioresistance in cancer stem cells

Diehn, M., Cho, R. W., Lobo, N. A., Kalisky, T., Dorie, M. J., Kulp, A. N., Qian, D., Lam, J. S., Ailles, L. E., Wong, M., et al. (2009) · Nature · doi:10.1038/nature07733 · Cited by 2,555 · see citing works

Identification of Selective Inhibitors of Cancer Stem Cells by High-Throughput Screening

Gupta, P. B., Önder, T. T., Jiang, G., Tao, K. X., Kuperwasser, C., Weinberg, R. A., & Lander, E. S. (2009) · Cell · doi:10.1016/j.cell.2009.06.034 · Cited by 2,386 · see citing works

HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells

Shi, L. Z., Wang, R., Huang, G., Vogel, P., Neale, G., Green, D. R., & Chi, H. (2011) · Journal of Experimental Medicine · doi:10.1084/jem.20110278 · Cited by 1,803 · see citing works

PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis

LeBleu, V. S., O’Connell, J. T., Herrera, K. N. G., Wikman, H., Pantel, K., Haigis, M. C., de Carvalho, F. M., Damascena, A. S., Chinen, L. T. D., Rocha, R. M., et al. (2014) · Nature Cell Biology · doi:10.1038/ncb3039 · Cited by 1,412 · see citing works

BCL-2 Inhibition Targets Oxidative Phosphorylation and Selectively Eradicates Quiescent Human Leukemia Stem Cells

Lagadinou, E. D., Sach, A., Callahan, K. P., Rossi, R. M., Neering, S. J., Minhajuddin, M., Ashton, J. M., Pei, S., Grose, V., O’Dwyer, K. M., et al. (2013) · Cell stem cell · doi:10.1016/j.stem.2012.12.013 · Cited by 1,410 · see citing works

Oxidative stress inhibits distant metastasis by human melanoma cells

Piskounova, E., Agathocleous, M., Murphy, M. M., Hu, Z., Huddlestun, S. E., Zhao, Z., Leitch, A. M., Johnson, T. M., DeBerardinis, R. J., & Morrison, S. J. (2015) · Nature · doi:10.1038/nature15726 · Cited by 1,269 · see citing works

Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function

Viale, A., Pettazzoni, P., Lyssiotis, C. A., Ying, H., Sánchez, N., Marchesini, M., Carugo, A., Green, T., Seth, S., Giuliani, V., et al. (2014) · Nature · doi:10.1038/nature13611 · Cited by 1,259 · see citing works

Breast Cancer Stem Cells Transition between Epithelial and Mesenchymal States Reflective of their Normal Counterparts

Liu, S., Cong, Y., Wang, D., Sun, Y., Deng, L., Liu, Y., Martin-Trevino, R., Li, S., McDermott, S., Landis, M. D., et al. (2014) · Stem Cell Reports · doi:10.1016/j.stemcr.2013.11.009 · Cited by 1,044 · see citing works

Tackling the cancer stem cells — what challenges do they pose?

Pattabiraman, D. R., & Weinberg, R. A. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4253 · Cited by 985 · see citing works

Somatic Oxidative Bioenergetics Transitions into Pluripotency-Dependent Glycolysis to Facilitate Nuclear Reprogramming

Folmes, C. D. L., Nelson, T. J., Martinez‐Fernandez, A., Arrell, D. K., Lindor, J. Z., Dzeja, P. P., Ikeda, Y., Pérez-Terzic, C. M., & Terzic, A. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.06.011 · Cited by 980 · see citing works

Germline BRCA1 Mutations and a Basal Epithelial Phenotype in Breast Cancer

Foulkes, W. D. (2003) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djg050 · Cited by 970 · see citing works

A low level of reactive oxygen species selects for primitive hematopoietic stem cells that may reside in the low-oxygenic niche

Jang, Y.-Y., & Sharkis, S. J. (2007) · Blood · doi:10.1182/blood-2007-05-087759 · Cited by 894 · see citing works

mtDNA mutations increase tumorigenicity in prostate cancer

Petros, J. A., Baumann, A. K., Ruiz‐Pesini, E., Amin, M. B., Sun, C. Q., Hall, J., Lim, S.-D., Issa, M. M., Flanders, W. D., Hosseini, S. H., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408894102 · Cited by 834 · see citing works

Loss of FBP1 by Snail-Mediated Repression Provides Metabolic Advantages in Basal-like Breast Cancer

Dong, C., Yuan, T., Wu, Y., Wang, Y., Fan, T. W. ‐., Miriyala, S., Lin, Y., Yao, J., Shi, J., Kang, T., et al. (2013) · Cancer Cell · doi:10.1016/j.ccr.2013.01.022 · Cited by 806 · see citing works

Re: Germline BRCA1 Mutations and a Basal Epithelial Phenotype in Breast Cancer

van der Groep, P., Bouter, A., van der Zanden, R. A., Menko, F. H., Buerger, H., Verheijen, R. H. M., van der Wall, E., & van Diest, P. J. (2004) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djh114 · Cited by 798 · see citing works

Mitochondrial genome acquisition restores respiratory function and tumorigenic potential of cancer cells without mitochondrial DNA

Tan, A. S., Baty, J. W., Dong, L.-F., Bezawork-Geleta, A., Endaya, B., Goodwin, J., Bajzikova, M., Kovarova, J., Peterka, M., Yan, B., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2014.12.003 · Cited by 785 · see citing works

MYC/PGC-1α Balance Determines the Metabolic Phenotype and Plasticity of Pancreatic Cancer Stem Cells

Sancho, P., Burgos-Ramos, E., Tavera, A., Bou Kheir, T., Jagust, P., Schoenhals, M., Barneda, D., Sellers, K., Campos-Olivas, R., Graña, O., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.08.015 · Cited by 722 · see citing works

PGC1α Expression Defines a Subset of Human Melanoma Tumors with Increased Mitochondrial Capacity and Resistance to Oxidative Stress

Vazquez, F., Lim, J.-H., Chim, H., Bhalla, K., Girnun, G., Pierce, K., Clish, C. B., Granter, S. R., Widlund, H. R., Spiegelman, B. M., et al. (2013) · Cancer Cell · doi:10.1016/j.ccr.2012.11.020 · Cited by 715 · see citing works

Macrophages and cancer: from mechanisms to therapeutic implications

Ostuni, R., Kratochvill, F., Murray, P. J., & Natoli, G. (2015) · Trends in Immunology · doi:10.1016/j.it.2015.02.004 · Cited by 685 · see citing works

Overcoming Intrinsic Multidrug Resistance in Melanoma by Blocking the Mitochondrial Respiratory Chain of Slow-Cycling JARID1Bhigh Cells

Roesch, A., Vultur, A., Bogeski, I., Wang, H., Zimmermann, K. M., Speicher, D., Körbel, C., Laschke, M. W., Gimotty, P. A., Philipp, S. E., et al. (2013) · Cancer Cell · doi:10.1016/j.ccr.2013.05.003 · Cited by 670 · see citing works

Antiangiogenic agents increase breast cancer stem cells via the generation of tumor hypoxia

Conley, S. J., Gheordunescu, E., Kakarala, P., Newman, B., Korkaya, H., Heath, A. N., Clouthier, S. G., & Wicha, M. S. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1018866109 · Cited by 663 · see citing works

The Senescence‐Related Mitochondrial/Oxidative Stress Pathway is Repressed in Human Induced Pluripotent Stem Cells

Prigione, A., Fauler, B., Lurz, R., Lehrach, H., & Adjaye, J. (2010) · Stem Cells · doi:10.1002/stem.404 · Cited by 617 · see citing works

Breast cancer stem cells, cytokine networks, and the tumor microenvironment

Körkaya, H., Liu, S., & Wicha, M. S. (2011) · Journal of Clinical Investigation · doi:10.1172/jci57099 · Cited by 616 · see citing works

Ketones and lactate “fuel” tumor growth and metastasis

Bonuccelli, G., Tsirigos, A., Whitaker‐Menezes, D., Pavlides, S., Pestell, R. G., Chiavarina, B., Frank, P. G., Flomenberg, N., Howell, A., Martinez‐Outschoorn, U., et al. (2010) · Cell Cycle · doi:10.4161/cc.9.17.12731 · Cited by 578 · see citing works

A Mitochondrial Switch Promotes Tumor Metastasis

Porporato, P. E., Payen, V. L., Pérez‐Escuredo, J., Saedeleer, C. J. D., Danhier, P., Copetti, T., Dhup, S., Tardy, M., Vazeille, T., Bouzin, C., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.06.043 · Cited by 571 · see citing works

PDK1-Dependent Metabolic Reprogramming Dictates Metastatic Potential in Breast Cancer

Dupuy, F., Tabariès, S., Andrzejewski, S., Dong, Z., Blagih, J., Annis, M. G., Omeroglu, A., Gao, D., Leung, S., Amir, E., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.08.007 · Cited by 558 · see citing works

HIF1α induced switch from bivalent to exclusively glycolytic metabolism during ESC‐to‐EpiSC/hESC transition

Zhou, W., Choi, M. P., Margineantu, D. H., Margaretha, L., Hesson, J., Cavanaugh, C., Blau, C. A., Horwitz, M. S., Hockenbery, D. M., Ware, C. B., et al. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.71 · Cited by 555 · see citing works

Metabolic state of glioma stem cells and nontumorigenic cells

Vlashi, E., Lagadec, C. H., Vergnes, L., Matsutani, T., Masui, K., Poulou, M., Popescu, R., Donna, L. D., Evers, P. D., Dekmezian, C., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1106704108 · Cited by 555 · see citing works

Asymmetric apportioning of aged mitochondria between daughter cells is required for stemness

Katajisto, P., Döhla, J., Chaffer, C. L., Pentinmikko, N., Marjanovic, N. D., Iqbal, S., Zoncu, R., Chen, W. W., Weinberg, R. A., & Sabatini, D. M. (2015) · Science · doi:10.1126/science.1260384 · Cited by 536 · see citing works

Brain tumor initiating cells adapt to restricted nutrition through preferential glucose uptake

Flavahan, W. A., Wu, Q., Hitomi, M., Rahim, N., Kim, Y., Sloan, A. E., Weil, R. J., Nakano, I., Sarkaria, J. N., Stringer, B. W., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3510 · Cited by 504 · see citing works

Antibiotics that target mitochondria effectively eradicate cancer stem cells, across multiple tumor types: Treating cancer like an infectious disease

Lamb, R., Ózsvári, B., Lisanti, C., Tanowitz, H. B., Howell, A., Martinez‐Outschoorn, U., Sotgia, F., & Lisanti, M. P. (2015) · Oncotarget · doi:10.18632/oncotarget.3174 · Cited by 475 · see citing works

Preferential transfer of mitochondria from endothelial to cancer cells through tunneling nanotubes modulates chemoresistance

Pasquier, J., Guerrouahen, B. S., Althawadi, H., Ghiabi, P., Maleki, M., Abu-Kaoud, N., Jacob, A., Mirshahi, M., Galas, L., Rafii, S., et al. (2013) · Journal of Translational Medicine · doi:10.1186/1479-5876-11-94 · Cited by 469 · see citing works

Endosymbiotic theory for organelle origins

Zimorski, V., Ku, C., Martin, W. F., & Gould, S. B. (2014) · Current Opinion in Microbiology · doi:10.1016/j.mib.2014.09.008 · Cited by 453 · see citing works

Imp2 controls oxidative phosphorylation and is crucial for preserving glioblastoma cancer stem cellsPreprint

Janiszewska, M., Suvà, M. L., Riggi, N., Houtkooper, R. H., Auwerx, J. H., Clément‐Schatlo, V., Radovanovic, I., Rheinbay, E., Provero, P., & Stamenkovic, I. (2012) · Genes & Development · doi:10.1101/gad.188292.112 · Cited by 451 · see citing works

Tumor-associated macrophages: unwitting accomplices in breast cancer malignancy

Scalise, C. B., Yeh, E. S., & Soloff, A. C. (2016) · npj Breast Cancer · doi:10.1038/npjbcancer.2015.25 · Cited by 445 · see citing works

Mitochondrial control by DRP1 in brain tumor initiating cells

Xie, Q., Wu, Q., Horbinski, C., Flavahan, W. A., Yang, K., Zhou, W., Dombrowski, S. M., Huang, Z., Fang, X., Shi, Y., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.3960 · Cited by 415 · see citing works

Versatile functions for IL-6 in metabolism and cancer

Mauer, J., Denson, J. L., & Brüning, J. C. (2015) · Trends in Immunology · doi:10.1016/j.it.2014.12.008 · Cited by 405 · see citing works

Therapeutic Implications of Cellular Heterogeneity and Plasticity in Breast Cancer

Brooks, M., Burness, M. L., & Wicha, M. S. (2015) · Cell stem cell · doi:10.1016/j.stem.2015.08.014 · Cited by 373 · see citing works

Ovarian Cancer Spheroid Cells with Stem Cell-Like Properties Contribute to Tumor Generation, Metastasis and Chemotherapy Resistance through Hypoxia-Resistant Metabolism

Liao, J., Qian, F., Tchabo, N. E., Mhawech-Fauceglia, P. Y., Beck, A. F., Zikun, Q., Wang, X., Huss, W. J., Lele, S., Morrison, C. D., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0084941 · Cited by 365 · see citing works

Ketones and lactate increase cancer cell “stemness,” driving recurrence, metastasis and poor clinical outcome in breast cancer

Martinez‐Outschoorn, U., di Prisco, M., Ertel, A., Tsirigos, A., Lin, Z., Pavlides, S., Wang, C., Flomenberg, N., Knudsen, E. S., Howell, A., et al. (2011) · Cell Cycle · doi:10.4161/cc.10.8.15330 · Cited by 341 · see citing works

Metabolic reprogramming of cancer-associated fibroblasts by TGF-β drives tumor growth: Connecting TGF-β signaling with “Warburg-like” cancer metabolism and L-lactate production

Guido, C., Whitaker‐Menezes, D., Capparelli, C., Balliet, R. M., Zhao, L., Pestell, R. G., Howell, A., Aquila, S., Andò, S., Martinez‐Outschoorn, U., et al. (2012) · Cell Cycle · doi:10.4161/cc.21384 · Cited by 316 · see citing works

Cancer stem cells from epithelial ovarian cancer patients privilege oxidative phosphorylation, and resist glucose deprivation

Pastò, A., Bellio, C., Pilotto, G., Ciminale, V., Silic‐Benussi, M., Guzzo, G., Rasola, A., Frasson, C., Nardo, G., Zulato, E., et al. (2014) · Oncotarget · doi:10.18632/oncotarget.2010 · Cited by 293 · see citing works

Modulation of Glucose Metabolism by CD44 Contributes to Antioxidant Status and Drug Resistance in Cancer Cells

Tamada, M., Nagano, O., Tateyama, S., Ohmura, M., Yae, T., Ishimoto, T., Sugihara, E., Onishi, N., Yamamoto, T., Yanagawa, H., et al. (2012) · Cancer Research · doi:10.1158/0008-5472.can-11-3024 · Cited by 275 · see citing works

Breast cancer stem cells rely on fermentative glycolysis and are sensitive to 2-deoxyglucose treatment

Ciavardelli, D., Rossi, C., Barcaroli, D., Volpe, S., Consalvo, A., Zucchelli, M., Cola, A. D., Scavo, E., Carollo, R., D'Agostino, D., et al. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.285 · Cited by 270 · see citing works

Mitochondrial biogenesis is required for the anchorage-independent survival and propagation of stem-like cancer cells

Luca, A. D., Fiorillo, M., Peiris‐Pagès, M., Ózsvári, B., Smith, D. L., Sánchez‐Alvarez, R., Martinez‐Outschoorn, U., Cappello, A. R., Pezzi, V., Lisanti, M. P., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.4401 · Cited by 262 · see citing works

Loss of phosphatase and tensin homolog or phosphoinositol-3 kinase activation and response to trastuzumab or lapatinib in human epidermal growth factor receptor 2-overexpressing locally advanced breast cancers

Dave, B., Migliaccio, I., Gutierrez, M. C., Wu, M.-F., Chamness, G. C., Wong, H., Narasanna, A., Chakrabarty, A., Hilsenbeck, S. G., Huang, J., et al. (2011) · Journal of Clinical Oncology · doi:10.1200/jco.2009.27.7814 · Cited by 252 · see citing works

Metabolic Alterations in Highly Tumorigenic Glioblastoma Cells

Zhou, Y., Zhou, Y., Shingu, T., Feng, L., Chen, Z., Ogasawara, M. A., Keating, M. J., Kondo, S., & Huang, P. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.260935 · Cited by 250 · see citing works

Proteomic and transcriptomic profiling reveals a link between the PI3K pathway and lower estrogen-receptor (ER) levels and activity in ER+ breast cancer

Creighton, C. J., Fu, X., Hennessy, B. T., Casa, A. J., Zhang, Y., Gonzalez-Angulo, A. M., Lluch, A. M., Gray, J. W., Brown, P. H., Hilsenbeck, S. G., et al. (2010) · Breast Cancer Research · doi:10.1186/bcr2594 · Cited by 250 · see citing works

Dual Inhibition of Tumor Energy Pathway by 2-Deoxyglucose and Metformin Is Effective against a Broad Spectrum of Preclinical Cancer Models

Cheong, J., Park, E. S., Liang, J., Dennison, J. B., Tsavachidou, D., Nguyen-Charles, C., Cheng, K. W., Hall, H. S., Zhang, D., Lu, Y., et al. (2011) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-11-0497 · Cited by 244 · see citing works

TrkA overexpression enhances growth and metastasis of breast cancer cells

Lagadec, C. H., Meignan, S., Adriaenssens, É., Foveau, B., Vanhecke, E., Romon, R., Toillon, R., Oxombre, B., Hondermarck, H., & Bourhis, X. L. (2009) · Oncogene · doi:10.1038/onc.2009.61 · Cited by 238 · see citing works

HIF1-alpha functions as a tumor promoter in cancer-associated fibroblasts, and as a tumor suppressor in breast cancer cells

Chiavarina, B., Whitaker‐Menezes, D., Migneco, G., Martinez‐Outschoorn, U., Pavlides, S., Howell, A., Tanowitz, H. B., Casimiro, M. C., Wang, C., Pestell, R. G., et al. (2010) · Cell Cycle · doi:10.4161/cc.9.17.12908 · Cited by 222 · see citing works

Metabolic regulation of cancer cell side population by glucose through activation of the Akt pathway

Liu, P.-P., Liao, J., Tang, Z.-J., Wu, W.-J., Yang, J., Zeng, Z.-L., Hu, Y., Wang, P., Ju, H., Xu, R., et al. (2013) · Cell Death and Differentiation · doi:10.1038/cdd.2013.131 · Cited by 219 · see citing works

Bacteria-Eradicating Therapy With Doxycycline in Ocular Adnexal MALT Lymphoma: A Multicenter Prospective Trial

Ferreri, A. J. M., Ponzoni, M., Guidoboni, M., et al. (2006) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djj373 · Cited by 210 · see citing works

The role of the Crabtree effect and an endogenous fuel in the energy metabolism of resting and proliferating thymocytes

Guppy, M., Greiner, E. F., & Brand, K. (1993) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1993.tb17637.x · Cited by 209 · see citing works

Cyclin D1 repression of nuclear respiratory factor 1 integrates nuclear DNA synthesis and mitochondrial function

Wang, C., Li, Z., Lu, Y., Du, R., Katiyar, S., Yang, J., Fu, M., Leader, J. E., Quong, A. A., Novikoff, P. M., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603363103 · Cited by 208 · see citing works

High mitochondrial mass identifies a sub-population of stem-like cancer cells that are chemo-resistant

Farnie, G., Sotgia, F., & Lisanti, M. P. (2015) · Oncotarget · doi:10.18632/oncotarget.5401 · Cited by 206 · see citing works

Mitochondria as new therapeutic targets for eradicating cancer stem cells: Quantitative proteomics and functional validation via MCT1/2 inhibition

Lamb, R., Harrison, H., Hulit, J., et al. (2014) · Oncotarget · doi:10.18632/oncotarget.2789 · Cited by 190 · see citing works

Cyclin D1 Determines Mitochondrial Function InVivo

Sakamaki, T., Casimiro, M. C., Ju, X., Quong, A. A., Katiyar, S., Liu, M., Jiao, X., Li, A., Zhang, X., Lu, Y., et al. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.02074-05 · Cited by 184 · see citing works

Tumor Macroenvironment and Metabolism

Zoughbi, W. A., Huang, J., Paramasivan, G. S., Till, H., Pichler, M., Guertl‐Lackner, B., & Höefler, G. (2014) · Seminars in Oncology · doi:10.1053/j.seminoncol.2014.02.005 · Cited by 160 · see citing works

Mitochondrial retrograde signaling induces epithelial–mesenchymal transition and generates breast cancer stem cells

Guha, M., Srinivasan, S., Ruthel, G. T., Kashina, A., Carstens, R. P., Mendoza, A., Khanna, C., Winkle, T. V., & Avadhani, N. G. (2013) · Oncogene · doi:10.1038/onc.2013.467 · Cited by 154 · see citing works

Mevalonate Metabolism Regulates Basal Breast Cancer Stem Cells and Is a Potential Therapeutic Target

Ginestier, C., Monville, F., Wicinski, J., Cabaud, O., Cervera, N., Josselin, E., Finetti, P., Guillé, A., Gaelle, L., Viens, P., et al. (2012) · Stem Cells · doi:10.1002/stem.1122 · Cited by 152 · see citing works

Autophagy in Cancer Stem Cells: A Potential Link Between Chemoresistance, Recurrence, and Metastasis

Ojha, R., Bhattacharyya, S., & Singh, S. K. (2015) · BioResearch open access · doi:10.1089/biores.2014.0035 · Cited by 150 · see citing works

TPO-Induced Metabolic Reprogramming Drives Liver Metastasis of Colorectal Cancer CD110+ Tumor-Initiating Cells

Wu, Z., Wei, D., Gao, W., Xu, Y., Hu, Z., Ma, Z., Gao, C., Zhu, X., & Li, Q. (2015) · Cell Stem Cell · doi:10.1016/j.stem.2015.05.016 · Cited by 149 · see citing works

Mitochondrial targeted catalase suppresses invasive breast cancer in mice

Goh, J., Enns, L. C., Fatemie, S., Hopkins, H. C., Morton, J., Pettan-Brewer, C., & Ladiges, W. (2011) · BMC Cancer · doi:10.1186/1471-2407-11-191 · Cited by 148 · see citing works

Metformin Represses Self-Renewal of the Human Breast Carcinoma Stem Cells via Inhibition of Estrogen Receptor-Mediated OCT4 Expression

Jung, J., Park, S., Lee, S., Seo, M., Trosko, J. E., & Kang, K. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028068 · Cited by 145 · see citing works

Mitochondrial mass, a new metabolic biomarker for stem-like cancer cells: Understanding WNT/FGF-driven anabolic signaling

Lamb, R., Bonuccelli, G., Ózsvári, B., Peiris‐Pagès, M., Fiorillo, M., Smith, D. L., Bevilacqua, G., Mazzanti, C. M., McDonnell, L. A., Naccarato, A. G., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.5852 · Cited by 145 · see citing works

Energy Metabolism Characterization of a Novel Cancer Stem Cell‐ L ike Line 3 AB ‐ OS

Palorini, R., Votta, G., Balestrieri, C., Monestiroli, A., Olivieri, S., Vento, R., & Chiaradonna, F. (2013) · Journal of Cellular Biochemistry · doi:10.1002/jcb.24671 · Cited by 139 · see citing works

Metabolic differences in breast cancer stem cells and differentiated progeny

Vlashi, E., Lagadec, C. H., Vergnes, L., Reue, K., Frohnen, P., Chan, M., Alhiyari, Y. M., Dratver, M. B., & Pajonk, F. (2014) · Breast Cancer Research and Treatment · doi:10.1007/s10549-014-3051-2 · Cited by 139 · see citing works

Mitochondrially targeted anti-cancer agents

Biasutto, L., Dong, L., Zoratti, M., & Neužil, J. (2010) · Mitochondrion · doi:10.1016/j.mito.2010.06.004 · Cited by 125 · see citing works

Cytokine production and inflammation drive autophagy in the tumor microenvironment

Martinez‐Outschoorn, U., Whitaker‐Menezes, D., Zhao, L., Flomenberg, N., Howell, A., Pestell, R. G., Lisanti, M. P., & Sotgia, F. (2011) · Cell Cycle · doi:10.4161/cc.10.11.15674 · Cited by 123 · see citing works

Targeting Unique Metabolic Properties of Breast Tumor Initiating Cells

Feng, W., Gentles, A. J., Nair, R. V., Huang, M., Lin, Y., Lee, C. Y., Cai, S., Scheeren, F. A., Kuo, A. H., & Diehn, M. (2014) · Stem Cells · doi:10.1002/stem.1662 · Cited by 110 · see citing works

The secretome of colon cancer stem cells contains drug-metabolizing enzymes

Emmink, B. L., Verheem, A., van Houdt, W. J., Steller, E. J. A., Govaert, K. M., Pham, T. V., Piersma, S. R., Rinkes, I. H. M. B., Jiménez, C. R., & Kranenburg, O. (2013) · Journal of Proteomics · doi:10.1016/j.jprot.2013.06.027 · Cited by 108 · see citing works

Salinomycin induces apoptosis in cisplatin-resistant colorectal cancer cells by accumulation of reactive oxygen species

Zhou, J., Li, P., Xue, X., et al. (2013) · Toxicology Letters · doi:10.1016/j.toxlet.2013.07.022 · Cited by 101 · see citing works

Inhibition of glutamine metabolism counteracts pancreatic cancer stem cell features and sensitizes cells to radiotherapy

Li, D., Fu, Z., Chen, R., Zhao, X., Zhou, Y., Zeng, B., Yu, M., Zhou, Q., Lin, Q., Gao, W., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.5150 · Cited by 97 · see citing works

The Intercellular Metabolic Interplay between Tumor and Immune Cells

Wang, T., Liu, G., & Wang, R. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00358 · Cited by 95 · see citing works

Salinomycin Promotes Anoikis and Decreases the CD44+/CD24- Stem-Like Population via Inhibition of STAT3 Activation in MDA-MB-231 Cells

An, H., Kim, J. Y., Oh, E., Lee, N., Cho, Y., & Seo, J. H. (2015) · PLoS ONE · doi:10.1371/journal.pone.0141919 · Cited by 89 · see citing works

Sub-Sets of Cancer Stem Cells Differ Intrinsically in Their Patterns of Oxygen Metabolism

Gammon, L., Biddle, A., Heywood, H. K., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062493 · Cited by 88 · see citing works

Metformin and prostate cancer stem cells: a novel therapeutic target

Mayer, M., Klotz, L. H., & Venkateswaran, V. K. (2015) · Prostate Cancer and Prostatic Diseases · doi:10.1038/pcan.2015.35 · Cited by 83 · see citing works

Metabolic reprogramming and two-compartment tumor metabolism

Chiavarina, B., Martinez‐Outschoorn, U., Whitaker‐Menezes, D., Howell, A., Tanowitz, H. B., Pestell, R. G., Sotgia, F., & Lisanti, M. P. (2012) · Cell Cycle · doi:10.4161/cc.21643 · Cited by 81 · see citing works

CRLX101, an investigational camptothecin-containing nanoparticle-drug conjugate, targets cancer stem cells and impedes resistance to antiangiogenic therapy in mouse models of breast cancer

Conley, S. J., Baker, T. L., Burnett, J., Theisen, R., Lazarus, D. D., Peters, C. G., Clouthier, S. G., Eliasof, S. D., & Wicha, M. S. (2015) · Breast Cancer Research and Treatment · doi:10.1007/s10549-015-3349-8 · Cited by 70 · see citing works

The nutritional phenome of EMT-induced cancer stem-like cells

Cuyàs, E., Corominas-Faja, B., & Menéndez, J. A. (2014) · Oncotarget · doi:10.18632/oncotarget.2147 · Cited by 69 · see citing works

EMT-induced metabolite signature identifies poor clinical outcome

Bhowmik, S. K., Ramirez‐Peña, E., Arnold, J. M., Putluri, V., Sphyris, N., Michailidis, G. C., Putluri, N., Ambs, S., Sreekumar, A., & Mani, S. A. (2015) · Oncotarget · doi:10.18632/oncotarget.4765 · Cited by 66 · see citing works

Resistance to cytotoxic chemotherapy-induced apoptosis in side population cells of human oral squamous cell carcinoma cell line Ho-1-N-1

Azuma, M. (2009) · International Journal of Oncology · doi:10.3892/ijo_00000337 · Cited by 55 · see citing works

c-mycand N-mycpromote active stem cell metabolism and cycling as architects of the developing brain

Wey, A., & Knoepfler, P. S. (2010) · Oncotarget · doi:10.18632/oncotarget.116 · Cited by 54 · see citing works

Metabolic activation of mitochondria in glioma stem cells promotes cancer development through a reactive oxygen species-mediated mechanism

Yuan, S., Lu, Y., Yang, J., Chen, G., Kim, S., Feng, L., Ogasawara, M. A., Hammoudi, N., Lu, W., Zhang, H., et al. (2015) · Stem Cell Research & Therapy · doi:10.1186/s13287-015-0174-2 · Cited by 51 · see citing works

The metabolic landscape of cancer stem cells

Dando, I., Pozza, E. D., Biondani, G., Cordani, M., Palmieri, M., & Donadelli, M. (2015) · IUBMB Life · doi:10.1002/iub.1426 · Cited by 50 · see citing works

The control of mitochondrial DNA replication during development and tumorigenesis

Lee, W., & John, J. C. S. (2015) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12873 · Cited by 50 · see citing works

Cells, Stem Cells, and Cancer Stem Cells

Aguilar-Gallardo, C., & Simón, C. (2013) · Seminars in Reproductive Medicine · doi:10.1055/s-0032-1331792 · Cited by 48 · see citing works

Role of HER3 expression and PTEN loss in patients with HER2-overexpressing metastatic breast cancer (MBC) who received taxane plus trastuzumab treatment

Park, Y. H., Jung, H. A., Choi, M. K., Chang, W., Choi, Y., Do, I.-G., Ahn, J. S., & Im, Y.-H. (2013) · British Journal of Cancer · doi:10.1038/bjc.2013.757 · Cited by 47 · see citing works

Metabolism in embryonic and cancer stemness

Jang, H., Yang, J., Lee, E., & Cheong, J. (2015) · Archives of Pharmacal Research · doi:10.1007/s12272-015-0558-y · Cited by 43 · see citing works

Modeling of Cancer Stem Cell State Transitions Predicts Therapeutic Response

Sehl, M. E., Shimada, M., Landeros, A., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0135797 · Cited by 38 · see citing works

Clinical Significance of PTEN and p-Akt Co-Expression in HER2-Positive Metastatic Breast Cancer Patients Treated with Trastuzumab-Based Therapies

Fabi, A., Metro, G., Benedetto, A. D., Nisticò, C., Vici, P., Melucci, E., Antoniani, B., Perracchio, L., Sperduti, I., Milella, M., et al. (2010) · Oncology · doi:10.1159/000312656 · Cited by 35 · see citing works

Azithromycin enhances the favorable results of paclitaxel and cisplatin in patients with advanced non-small cell lung cancer

Chu, D.-J., Yao, D. E., Zhuang, Y. F., et al. (2014) · Genetics and Molecular Research · doi:10.4238/2014.april.14.8 · Cited by 34 · see citing works

A quantitative proteomics analysis of MCF7 breast cancer stem and progenitor cell populations

Nie, S., McDermott, S., Deol, Y. S., Tan, Z., Wicha, M. S., & Lubman, D. M. (2015) · PROTEOMICS · doi:10.1002/pmic.201500002 · Cited by 30 · see citing works

Hypoxia-resistant profile implies vulnerability of cancer stem cells to physiological agents, which suggests new therapeutic targets

Cipolleschi, M. G., Marzi, I., Santini, R., Fredducci, D., Vinci, M. C., D’Amico, M., Rovida, E., Stivarou, T., Torre, E., Sbarba, P. D., et al. (2013) · Cell Cycle · doi:10.4161/cc.27031 · Cited by 28 · see citing works

Gene expression signatures of breast cancer stem and progenitor cells do not exhibit features of Warburg metabolism

Gordon, N. T., Skinner, A. M., Pommier, R. F., Schillace, R. V., O’Neill, S., Peckham, J. L., Muller, P., Condron, M. E., Donovan, C., Naik, A. M., et al. (2015) · Stem Cell Research & Therapy · doi:10.1186/s13287-015-0153-7 · Cited by 23 · see citing works

Corrigendum to “Tumor Macroenvironment and Metabolism” [Seminars in Oncology, Vol 41, No 2, April 2014, pp 281–295]

Zoughbi, W. A., Huang, J., Paramasivan, G. S., Till, H., Pichler, M., Guertl‐Lackner, B., & Höefler, G. (2014) · Seminars in Oncology · doi:10.1053/j.seminoncol.2014.07.005 · Cited by 14 · see citing works

Cancer stem cells revisited

Batlle, E., & Clevers, H. (2017) · Nature Medicine · doi:10.1038/nm.4409 · Cited by 2,769 · see citing works

ROS signaling under metabolic stress: cross-talk between AMPK and AKT pathway

Zhao, Y., Hu, X., Liu, Y., Dong, S., Wen, Z., He, W., Zhang, S., Huang, Q., & Shi, M. (2017) · Molecular Cancer · doi:10.1186/s12943-017-0648-1 · Cited by 735 · see citing works

Tumor cell plasticity in targeted therapy-induced resistance: Mechanisms and new strategies

Shi, Z.-D., Pang, K., Wu, Z.-X., Dong, Y., Hao, L., Qin, J.-X., Wang, W., Chen, Z.-S., & Han, C.-H. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01383-x · Cited by 256 · see citing works

Targeting glutaminase 1 attenuates stemness properties in hepatocellular carcinoma by increasing reactive oxygen species and suppressing Wnt/beta-catenin pathway

Li, B., Cao, Y., Meng, G., Qian, L., Xu, T., Yan, C., Luo, O., Wang, S., Wei, J., Ding, Y., et al. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2018.11.063 · Cited by 245 · see citing works

Extracellular Matrix Cues Regulate Mechanosensing and Mechanotransduction of Cancer Cells

Mierke, C. T. (2024) · Cells · doi:10.3390/cells13010096 · Cited by 146 · see citing works

Hypoxia Signaling in Cancer: From Basics to Clinical Practice

Sebestyén, A., Kopper, L., Dankó, T., & Tímár, J. (2021) · Pathology and Oncology Research · doi:10.3389/pore.2021.1609802 · Cited by 110 · see citing works

Metabolic plasticity and cancer stem cell metabolism: Exploring the glycolysis-OXPHOS switch as a mechanism for resistance and tumorigenesis

Keoh, L. Q., Chiu, C.-F., & Ramasamy, T. S. (2025) · Stem Cell Reviews and Reports · doi:10.1007/s12015-025-10956-y · Cited by 66 · see citing works

Abstracts exchange: European Journal of Surgical Oncology

(1996) · Annals of Surgical Oncology · doi:10.1007/bf02305806

ASO Author Reflections: Investigating the Relationship Between Patient Primary Language and Surgical Oncology Outcomes

Woods, A. P., & Drake, F. T. (2022) · Annals of Surgical Oncology · doi:10.1245/s10434-022-12396-1 · Cited by 1 · see citing works

ASO Visual Abstract: Application and Match Rates in the Complex General Surgical Oncology Match

Silvestre, J., Smith, J. R., Nasef, K. E., et al. (2022) · Annals of Surgical Oncology · doi:10.1245/s10434-022-12793-6

Controversies in Gynaecologic Oncology

Maheshwari, A., & Gupta, S. (2017) · Indian Journal of Gynecologic Oncology · doi:10.1007/s40944-017-0153-x · Cited by 1 · see citing works

Society of Surgical Oncology SSO 2023 - International Conference on Surgical Cancer Care

Jehan, F., Song, C., Azim, A., et al. (2023) · Annals of Surgical Oncology · doi:10.1245/s10434-023-13332-7 · Cited by 3 · see citing works