The DOI matches its Crossref record; 126 of the 126 references it cites were found in a registry or an index.
Taurine: the appeal of a safe amino acid for skeletal muscle disorders
Open accessAbstract
Taurine is a natural amino acid present as free form in many mammalian tissues and in particular in skeletal muscle. Taurine exerts many physiological functions, including membrane stabilization, osmoregulation and cytoprotective effects, antioxidant and anti-inflammatory actions as well as modulation of intracellular calcium concentration and ion channel function. In addition taurine may control muscle metabolism and gene expression, through yet unclear mechanisms. This review summarizes the effects of taurine on specific muscle targets and pathways as well as its therapeutic potential to restore skeletal muscle function and performance in various pathological conditions. Evidences support the link between alteration of intracellular taurine level in skeletal muscle and different pathophysiological conditions, such as disuse-induced muscle atrophy, muscular dystrophy and/or senescence, reinforcing the interest towards its exogenous supplementation. In addition, taurine treatment can be beneficial to reduce sarcolemmal hyper-excitability in myotonia-related syndromes. Although further studies are necessary to fill the gaps between animals and humans, the benefit of the amino acid appears to be due to its multiple actions on cellular functions while toxicity seems relatively low. Human clinical trials using taurine in various pathologies such as diabetes, cardiovascular and neurological disorders have been performed and may represent a guide-line for designing specific studies in patients of neuromuscular diseases.
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Physiological actions of taurine
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Physiological role of taurine – from organism to organelle
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Cited by
CLC Chloride Channels and Transporters: Structure, Function, Physiology, and Disease
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Effects of taurine on gut microbiota and metabolism in mice
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Effects of taurine supplementation following eccentric exercise in young adults
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Is taurine an aging biomarker?
Fernandez, M. E., Bernier, M., Price, N. L., Camandola, S., Aon, M. A., Vaughan, K., Mattison, J. A., Preston, J. D., Jones, D. P., Tanaka, T., et al. (2025) · Science · doi:10.1126/science.adl2116 · Cited by 33
The Effect of Taurine on the Recovery from Eccentric Exercise-Induced Muscle Damage in Males
McLeay, Y., Stannard, S., & Barnes, M. (2017) · Antioxidants · doi:10.3390/antiox6040079 · Cited by 32
Metadata
- Authors
- De Luca, A., Pierno, S., & Camerino, D. C.
- Venue
- Journal of Translational Medicine
- Published
- 2015-07-25
- Volume
- 13
- Issue
- 1
- Pages
- 243-243
- ISSN
- 1479-5876 (ISSN-L)
- OpenAlex
- W1960300958
- Cited by
- 253
- References
- 126
- FWCI
- 10.02
- Type
- journal article
- Language
- en
- Open access
- gold
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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