Activated hepatic stellate cells promote angiogenesis via interleukin-8 in hepatocellular carcinoma
Open accessAbstract
BACKGROUND: Chemokines have been recognized as important modulators of angiogenesis, and they play critical roles in the development and metastasis of hepatocellular carcinoma (HCC), although their origins and latent molecular mechanisms remain elusive. The aim of this study was to investigate how activated hepatic stellate cells (a-HSCs) promote angiogenesis in HCC. METHODS: A total of 22 HCC patients were enrolled randomly. We used immunohistochemistry, western blotting, and enzyme-linked immunosorbent assay (ELISA) to analyse the production of interleukin-8 (IL-8) in a-HSCs derived from HCC tissues. The angiogenic effects of IL-8 in vitro and in vivo were assessed by ELISA, real-time quantitative polymerase chain reaction, capillary tube formation assay, and chick embryo chorioallantoic membrane assay. RESULTS: The present study showed that IL-8 was enriched predominantly in the tumour stroma of HCC tissues and was mainly derived from a-HSCs, rather than from hepatoma cells, in vivo and in vitro. Angiogenesis was most active at the invading edge, which was close to the a-HSCs. The angiogenic effect was dramatically attenuated by an IL-8 neutralizing antibody both in vitro and in vivo. Moreover, the IL-8 neutralizing antibody down-regulated Ser727-phosphorylated STAT3 levels in hepatoma cells treated with a-HSCs conditioned medium. CONCLUSIONS: These findings reveal that a-HSCs within the stroma of HCC contribute to tumour angiogenesis via IL-8.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Tregs can paradoxically promote HSC activation through TGF-β-dependent signaling and IL-8 induction, facilitating fibrogenesis.
“While Tregs secrete anti-inflammatory cytokines like IL-10, IL-35, and TGF-β (Dikiy and Rudensky 2023), they can paradoxically promote HSC activation through TGF-β-dependent signaling pathway and IL-8 induction, thereby facilitating fibrogenesis (Dewidar et al. 2019; Langhans et al. 2013; Zhu et al. 2015).”
From The double-edged sword of regulatory T cells in MASLD: from inflammation control to fibrosis promotion (2026) · cites this paper as Zhu et al. 2015
The Results section reports that activated HSCs secrete IL-8, but the paper studies how that IL-8 promotes angiogenesis in hepatocellular carcinoma. It does not establish that Tregs activate HSCs through TGF-β-dependent signaling, induce IL-8, or thereby facilitate fibrogenesis. (LLM, conf=0.86)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Jemal, A., Bray, F., Ferlay, J., Ward, E., & Forman, D. (2011) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.20107 · Cited by 54,708 · see citing works
Tumor angiogenesis: therapeutic implications
Sherwood, L. M., Parris, E. E., & Folkman, J. (1971) · New England Journal of Medicine · doi:10.1056/nejm197111182852108 · Cited by 10,187 · see citing works
Microenvironmental regulation of tumor progression and metastasis
Quail, D. F., & Joyce, J. A. (2013) · Nature Medicine · doi:10.1038/nm.3394 · Cited by 7,994 · see citing works
Jaffe, E. A., Nachman, R., Becker, C. G., & Minick, C. (1973) · Journal of Clinical Investigation · doi:10.1172/jci107470 · Cited by 7,146 · see citing works
Kalluri, R., & Zeisberg, M. (2006) · Nature Reviews Cancer · doi:10.1038/nrc1877 · Cited by 4,538 · see citing works
Role of angiogenesis in tumor growth and metastasis
Folkman, J. (2002) · Seminars in Oncology · doi:10.1016/s0093-7754(02)70065-1 · Cited by 2,862 · see citing works
Transplacental Carcinogenesis by Stilbestrol
Folkman, J. (1971) · New England Journal of Medicine · doi:10.1056/nejm197108122850711 · Cited by 2,640 · see citing works
Role of angiogenesis in tumor growth and metastasis
Folkman, J. (2002) · Seminars in Oncology · doi:10.1053/sonc.2002.37263 · Cited by 2,424 · see citing works
The Biology of Chemokines and their Receptors
Rossi, D., & Zlotnik, A. (2000) · Annual Review of Immunology · doi:10.1146/annurev.immunol.18.1.217 · Cited by 2,410 · see citing works
The Interleukin-8 Pathway in Cancer
Waugh, D. J. J., & Wilson, C. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-4843 · Cited by 2,103 · see citing works
Tumor angiogenesis: molecular pathways and therapeutic targets
Weis, S. M., & Cheresh, D. A. (2011) · Nature Medicine · doi:10.1038/nm.2537 · Cited by 1,726 · see citing works
The Chemokine Superfamily Revisited
Zlotnik, A., & Yoshie, O. (2012) · Immunity · doi:10.1016/j.immuni.2012.05.008 · Cited by 1,239 · see citing works
Structure and Functional Expression of a Human Interleukin-8 Receptor
Holmes, W. E., Lee, J., Kuang, W.-J., Rice, G. C., & Wood, W. I. (1991) · Science · doi:10.1126/science.1840701 · Cited by 1,088 · see citing works
Ras-induced interleukin-8 expression plays a critical role in tumor growth and angiogenesis
Sparmann, A., & Bar‐Sagi, D. (2004) · Cancer Cell · doi:10.1016/j.ccr.2004.09.028 · Cited by 854 · see citing works
The role of interleukin-8 and its receptors in gliomagenesis and tumoral angiogenesis
Brat, D. J., Bellail, A. C., & Meir, E. G. V. (2005) · Neuro-Oncology · doi:10.1215/s1152851704001061 · Cited by 760 · see citing works
Hepatic stellate cells in liver development, regeneration, and cancer
Yin, C., Evason, K. J., Asahina, K., & Stainier, D. Y. R. (2013) · Journal of Clinical Investigation · doi:10.1172/jci66369 · Cited by 719 · see citing works
The role of stroma in pancreatic cancer: Diagnostic and therapeutic implications
Erkan, M., Hausmann, S., Michalski, C. W., Fingerle, A. A., Dobritz, M., Kleeff, J., & Friess, H. (2012) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2012.115 · Cited by 662 · see citing works
Fernández, M., Semela, D., Bruix, J., Colle, I. O., Pinzani, M., & Bosch, J. (2009) · Journal of Hepatology · doi:10.1016/j.jhep.2008.12.011 · Cited by 598 · see citing works
HCC and angiogenesis: possible targets and future directions
Zhu, A. X., Duda, D. G., Sahani, D. V., & Jain, R. K. (2011) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2011.30 · Cited by 565 · see citing works
Microvessel Density as a Prognostic Factor in Women with Breast Cancer
Uzzan, B., Nicolas, P., Cucherat, M., & Perret, G. Y. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-1957 · Cited by 470 · see citing works
Induction of interleukin-8 preserves the angiogenic response in HIF-1α–deficient colon cancer cells
Mizukami, Y., Jo, W., Duerr, E., Gala, M. K., Li, J., Zhang, X., Zimmer, M. A., Iliopoulos, O., Zukerberg, L. R., Kohgo, Y., et al. (2005) · Nature Medicine · doi:10.1038/nm1294 · Cited by 405 · see citing works
Martı́n, D., Galisteo, R., & Gutkind, J. S. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.c800207200 · Cited by 387 · see citing works
Hepatocellular carcinoma-associated fibroblasts trigger NK cell dysfunction via PGE2 and IDO
Li, T., Yang, Y., Hua, X., Wang, G., Liu, W., Jia, C., Tai, Y., Zhang, Q., & Chen, G. (2011) · Cancer Letters · doi:10.1016/j.canlet.2011.12.020 · Cited by 329 · see citing works
Activated hepatic stellate cells promote tumorigenicity of hepatocellular carcinoma
Amann, T., Bataille, F., Spruß, T., Mühlbauer, M., Gäbele, E., Schölmerich, J., Kiefer, P., Bosserhoff, A., & Hellerbrand, C. (2009) · Cancer Science · doi:10.1111/j.1349-7006.2009.01087.x · Cited by 277 · see citing works
Compromised lymphocytes infiltrate hepatocellular carcinoma
Unitt, E., Rushbrook, S., Marshall, A., Davies, S. E., Gibbs, P., Morris, L. S., Coleman, N., & Alexander, G. (2005) · Hepatology · doi:10.1002/hep.20644 · Cited by 267 · see citing works
Tang, K. H., Ma, S., Lee, T. K., Chan, Y. P., Kwan, P. S., Tong, C. M., Ng, I. O., Man, K., To, K., Lai, P. B. S., et al. (2011) · Hepatology · doi:10.1002/hep.24739 · Cited by 251 · see citing works
Recent advances reveal IL-8 signaling as a potential key to targeting breast cancer stem cells
Singh, J. K., Simões, B. M., Howell, S. J., Farnie, G., & Clarke, R. B. (2013) · Breast Cancer Research · doi:10.1186/bcr3436 · Cited by 250 · see citing works
Tumor stroma: a complexity dictated by the hypoxic tumor microenvironment
Casazza, A., Conza, G. D., Wenes, M., Finisguerra, V., Deschoemaeker, S., & Mazzone, M. (2013) · Oncogene · doi:10.1038/onc.2013.121 · Cited by 241 · see citing works
Coulouarn, C., Corlu, A., Glaise, D., Guénon, I., Thorgeirsson, S. S., & Clément, B. (2012) · Cancer Research · doi:10.1158/0008-5472.can-11-3317 · Cited by 222 · see citing works
Angiopoietin-2: An Attractive Target for Improved Antiangiogenic Tumor Therapy
Gerald, D., Chintharlapalli, S. R., Augustin, H. G., & Benjamin, L. E. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-4697 · Cited by 202 · see citing works
The tumor microenvironment in hepatocellular carcinoma (Review)
Libra, M. (2012) · International Journal of Oncology · doi:10.3892/ijo.2012.1408 · Cited by 188 · see citing works
Rationale and Means to Target Pro-Inflammatory Interleukin-8 (CXCL8) Signaling in Cancer
Campbell, L. M., Maxwell, P. J., & Waugh, D. J. J. (2013) · Pharmaceuticals · doi:10.3390/ph6080929 · Cited by 142 · see citing works
Stellate cells and the development of liver cancer: Therapeutic potential of targeting the stroma
Coulouarn, C., & Clément, B. (2014) · Journal of Hepatology · doi:10.1016/j.jhep.2014.02.003 · Cited by 142 · see citing works
Role of the microenvironment in hepatocellular carcinoma development and progression
Wu, S., Ma, Y., Fang, Y., Liu, L., Fu, D., & Shen, X. (2011) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2011.06.010 · Cited by 131 · see citing works
Huang, Y.-Q., Li, J., Hu, L., Lee, M., & Karpatkin, S. (2002) · Blood · doi:10.1182/blood.v99.5.1646 · Cited by 125 · see citing works
Li, T., Yi, S., Liu, W., Jia, C., Wang, G., Hua, X., Tai, Y., Zhang, Q., & Chen, G. (2013) · Medical Oncology · doi:10.1007/s12032-013-0663-z · Cited by 116 · see citing works
Thrombin Up-regulates Cathepsin D which Enhances Angiogenesis, Growth, and Metastasis
Hu, L., Roth, J., Brooks, P. C., Luty, J., & Karpatkin, S. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-6276 · Cited by 113 · see citing works
Hepatic stellate cells: central modulators of hepatic carcinogenesis
Thompson, A., Conroy, K. P., & Henderson, N. C. (2015) · BMC Gastroenterology · doi:10.1186/s12876-015-0291-5 · Cited by 102 · see citing works
Estradiol Increases IL-8 Secretion of Normal Human Breast Tissue and Breast Cancer In Vivo
Bendrik, C., & Dabrosin, C. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.182.1.371 · Cited by 89 · see citing works
Maxwell, P. J., Coulter, J. A., Walker, S. M., McKechnie, M., Neisen, J., McCabe, N., Kennedy, R. D., Salto‐Tellez, M., Albanese, C., & Waugh, D. J. J. (2012) · European Urology · doi:10.1016/j.eururo.2012.08.032 · Cited by 84 · see citing works
Holmes, W. E., Lee, J., Kuang, W.-J., Rice, G. C., & Wood, W. I. (2009) · PubMed · Cited by 84 · see citing works
Hepatic stellate cells stimulate HCC cell migration via laminin-5 production
Santamato, A., Fransvea, E., Dituri, F., Caligiuri, A., Quaranta, M., Niimi, T., Pinzani, M., Antonaci, S., & Giannelli, G. (2011) · Clinical Science · doi:10.1042/cs20110002 · Cited by 76 · see citing works
Shi, C.-J., Washington, M., Chaturvedi, R., Drosos, Y., Revetta, F. L., Weaver, C. J., Buzhardt, E., Yull, F. E., Blackwell, T. S., Sosa-Pineda, B., et al. (2014) · Laboratory Investigation · doi:10.1038/labinvest.2014.10 · Cited by 74 · see citing works
Ushijima, C., Tsukamoto, S., Yamazaki, K., Yoshino, I., Sugio, K., & Sugimachi, K. (2001) · Lung Cancer · doi:10.1016/s0169-5002(01)00246-x · Cited by 73 · see citing works
Multi-faceted roles for CXC-chemokines in prostate cancer progression
Waugh, D. J. J. (2008) · Frontiers in bioscience · doi:10.2741/3025 · Cited by 58 · see citing works
Zhang, M., Ye, Y., Wang, F., Zhu, J., Zhao, Q., Zheng, Y., Gu, Y., Xie, C., Huang, Z., Tai, Q., et al. (2014) · Journal of Translational Medicine · doi:10.1186/1479-5876-12-60 · Cited by 18 · see citing works
Self-citation[Role of hepatic stellate cells in the angiogenesis of hepatoma].
Jung, J.-O., Gwak, G., Lim, Y., Kim, C. Y., & Lee, H.-S. (2003) · PubMed · Cited by 14 · see citing works
Zhang, M., Wang, F., Zhu, J., Zheng, Y., Zhao, Q., GU, Y.-R., Zhang, Q., Chong, Y., & Gao, Z. (2012) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2012.767 · Cited by 13 · see citing works
Self-citationTumor microenvironment revisited
Berns, A. J. M., & Pandolfi, P. P. (2014) · EMBO Reports · doi:10.1002/embr.201438794 · Cited by 9 · see citing works
Zhang, M., Wang, F., Chong, Y., Tai, Q., Zhao, Q., Zheng, Y., Peng, L., Lin, S., & Gao, Z. (2014) · Journal of Translational Medicine · doi:10.1186/s12967-014-0308-9 · Cited by 7 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Angiogenesis in hepatocellular carcinoma: mechanisms and anti-angiogenic therapies
Yao, C., Wu, S., Kong, J., Sun, Y., Bai, Y., Zhu, R., Li, Z., Sun, W., & Zheng, L. (2023) · Cancer Biology and Medicine · doi:10.20892/j.issn.2095-3941.2022.0449 · Cited by 157 · see citing works
Hepatic Stellate Cells and Hepatocarcinogenesis
Barry, A. E., Baldeosingh, R., Lamm, R. J., Patel, K., Zhang, K., Dominguez, D. A., Kirton, K. J., Shah, A. P., & Dang, H. T. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00709 · Cited by 155 · see citing works
Xiao, P. G., Long, X., Zhang, L., Ye, Y., Guo, J., Liu, P., Zhang, R., Ning, J., Yu, W., Wei, F., et al. (2018) · OncoImmunology · doi:10.1080/2162402x.2018.1440166 · Cited by 153 · see citing works
Sharma, R., Deacon, S. E., Nowak, D., George, S. E., Szymonik, M., Tang, A. A.-S., Tomlinson, D. C., Davies, A. G., McPherson, M. J., & Wälti, C. (2016) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2016.02.028 · Cited by 135 · see citing works
Kabir, T. D., Ganda, C., Brown, R. A. M., Beveridge, D. J., Richardson, K. L., Chaturvedi, V., Candy, P. A., Epis, M. R., Wintle, L. C., Kalinowski, F. C., et al. (2017) · Hepatology · doi:10.1002/hep.29478 · Cited by 120 · see citing works
Regulation and functional roles of chemokines in liver diseases
Cao, S., Liu, M., Sehrawat, T. S., & Shah, V. H. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-021-00444-2 · Cited by 105 · see citing works
Yin, Z., Jiang, K., Li, R. Q., Dong, C., & Wang, L. (2018) · Molecular Cancer · doi:10.1186/s12943-018-0926-6 · Cited by 74 · see citing works
Hepatocellular Carcinoma: Molecular Pathogenesis and Therapeutic Advances
Cucarull, B., Tutusaus, A., Rider, P., Hernáez-Alsina, T., Cuño-Gómiz, C., de Frutos, P. G., Colell, A., Marı́, M., & Morales, A. (2022) · Cancers · doi:10.3390/cancers14030621 · Cited by 73 · see citing works
Macrophage MerTK promotes profibrogenic cross-talk with hepatic stellate cells via soluble mediators
Pastore, M., Caligiuri, A., Raggi, C., Navari, N., Piombanti, B., Maira, G. D., Rovida, E., Piccinni, M., Lombardelli, L., Logiodice, F., et al. (2022) · JHEP Reports · doi:10.1016/j.jhepr.2022.100444 · Cited by 64 · see citing works
Zou, J., Lin, Z., Jiao, W., Chen, J., Lin, L., Zhang, F., Zhang, X., & Zhao, J. (2022) · Scientific Reports · doi:10.1038/s41598-022-20566-0 · Cited by 58 · see citing works
Estevez, J., Chen, V. L., Podlaha, O., Li, B., Le, A. K., Vutien, P., Chang, E. T., Rosenberg‐Hasson, Y., Jiang, Z., Pflanz, S., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-11975-7 · Cited by 56 · see citing works
Liver metastasis in uveal melanoma — treatment options and clinical outcome
Kaštelan, S., Zimak, D. M., Ivanković, M., Marković, I., & Antunica, A. G. (2022) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2702072 · Cited by 53 · see citing works
Kostallari, E., & Shah, V. H. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-11093-2_9 · Cited by 49 · see citing works
Ehrlich Ascites carcinoma mice model for studying liver inflammation and fibrosis
Gowda, N. G. S., Shiragannavar, V. D., Prabhuswamimath, S. C., Tuladhar, S., Chidambaram, S. B., & Santhekadur, P. K. (2022) · Advances in Cancer Biology - Metastasis · doi:10.1016/j.adcanc.2022.100029 · Cited by 47 · see citing works
Zhang, N., Gou, Y., Liang, S., Chen, N., Liu, Y., He, Q., & Zhang, J. (2021) · Journal of Immunology Research · doi:10.1155/2021/4973589 · Cited by 45 · see citing works
Therapeutic modulators of hepatic stellate cells for hepatocellular carcinoma
Ruan, Q., Wang, H., Burke, L. J., Bridle, K. R., Li, X., Zhao, C., Crawford, D. H., Roberts, M. S., & Liang, X. (2020) · International Journal of Cancer · doi:10.1002/ijc.32899 · Cited by 43 · see citing works
Shen, P., Jia, Y., Zhou, W., Zheng, W., Wu, Y., Qu, S., Du, S., Wang, S., Shi, H., Sun, J., et al. (2023) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2023.04.010 · Cited by 42 · see citing works
Mogler, C., König, C., Wieland, M. J., Runge, A., Besemfelder, E., Komljenovic, D., Longerich, T., Schirmacher, P., & Augustin, H. G. (2017) · EMBO Molecular Medicine · doi:10.15252/emmm.201607222 · Cited by 40 · see citing works
Hepatic Stellate Cell: A Potential Target for Hepatocellular Carcinoma
Wu, M., Miao, H., Fu, R., Zhang, J., & Zheng, W. (2020) · Current Molecular Pharmacology · doi:10.2174/1874467213666200224102820 · Cited by 31 · see citing works
Khan, M. G. M., Ghosh, A., Variya, B. C., Santharam, M. A., Ihsan, A. U., Ramanathan, S., & Ilangumaran, S. (2020) · BMC Cancer · doi:10.1186/s12885-020-07285-3 · Cited by 30 · see citing works
Cancer Stem Cell and Hepatic Stellate Cells in Hepatocellular Carcinoma
Quiroz-Reyes, A. G., Lozano-Sepúlveda, S. A., Martínez-Acuña, N., Islas, J. F., González, P. D., Heredia-Torres, T. G., Roacho-Pérez, J. A., & Garza-Treviño, E. N. (2023) · Technology in Cancer Research & Treatment · doi:10.1177/15330338231163677 · Cited by 29 · see citing works
Zhang, Y. L., Li, X., Chen, H., Li, J., Guo, X., Fang, Y., Chen, L., Li, K., Zhang, Y., Kong, F., et al. (2024) · Advanced Science · doi:10.1002/advs.202404089 · Cited by 28 · see citing works
Immunological aspect of the liver and metastatic uveal melanoma
Terai, M., Mastrangleo, M. J., & Sato, T. (2017) · Journal of Cancer Metastasis and Treatment · doi:10.20517/2394-4722.2017.39 · Cited by 28 · see citing works
Fu, S., Chen, X. '., Lin, H.-J. L., & Lin, J. (2018) · International Journal of Oncology · doi:10.3892/ijo.2018.4389 · Cited by 28 · see citing works
Peng, S., Chen, Y., Gong, Y., Li, Z., Xie, R., Lin, Y., Zou, B., Li, J., & Zeng, L. (2019) · Cytokine · doi:10.1016/j.cyto.2019.03.012 · Cited by 27 · see citing works
IL‑17A promotes CXCR2‑dependent angiogenesis in a mouse model of liver cancer
Liu, L., Sun, H., Wu, S., Tan, H., Sun, Y. S., Liu, X., Si, S., Xu, L., Huang, J., Zhou, W., et al. (2019) · Molecular Medicine Reports · doi:10.3892/mmr.2019.10310 · Cited by 27 · see citing works
Anti-Angiogenic Effects of Natural Compounds in Diet-Associated Hepatic Inflammation
Novi, S., Vestuto, V., Campiglia, P., Tecce, N., Bertamino, A., & Tecce, M. F. (2023) · Nutrients · doi:10.3390/nu15122748 · Cited by 26 · see citing works
Angiogenesis of hepatocellular carcinoma: An immunohistochemistry study
Fodor, D., Jung, I., Turdean, S. G., Satala, C.-B., & Gurzu, S. (2019) · World Journal of Hepatology · doi:10.4254/wjh.v11.i3.294 · Cited by 25 · see citing works
Miller, H., Czigány, Z., Lurje, I., Reichelt, S., Bednarsch, J., Strnad, P., Trautwein, C., Roderburg, C., Tacke, F., Gaisa, N. T., et al. (2020) · Cancers · doi:10.3390/cancers12123826 · Cited by 23 · see citing works
Cho, Y., Park, M. J., Kim, K., Park, J. Y., Kim, J., Kim, W., & Yoon, J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21020472 · Cited by 18 · see citing works
Odagiri, N., Matsubara, T., Higuchi, M., Takada, S., Urushima, H., Sato-Matsubara, M., Teranishi, Y., Yoshizato, K., Kawada, N., & Ikeda, K. (2019) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-018-3466-x · Cited by 17 · see citing works
Systematic review of the roles of interleukins in hepatocellular carcinoma
Hu, Y., Xuefeng, Y., & Jianhua, X. (2020) · Clinica Chimica Acta · doi:10.1016/j.cca.2020.03.001 · Cited by 17 · see citing works
Lü, Y., Xu, J., Chen, S., Zhou, Z., & Lin, N. (2017) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmx100 · Cited by 14 · see citing works
Self-citationXu, F., Yi, J., Wang, F., Wang, W., Wang, Z., Xue, J., & Luan, X. (2017) · Oncology Letters · doi:10.3892/ol.2017.7215 · Cited by 13 · see citing works
Linking fatty liver diseases to hepatocellular carcinoma by hepatic stellate cells
Chen, L., Ye, X.-S., Yang, L., Zhao, J., You, J., & Feng, Y. (2024) · Journal of the National Cancer Center · doi:10.1016/j.jncc.2024.01.002 · Cited by 12 · see citing works
khooy, M. J. M., Farasat, M., Salmi, M. S., & Mirzaei, H. (2023) · Phytotherapy Research · doi:10.1002/ptr.7716 · Cited by 12 · see citing works
Du, Y., & Gao, Y. (2020) · BMC Cancer · doi:10.1186/s12885-020-07391-2 · Cited by 11 · see citing works
Niu, J., Wang, Y., Wang, J., Liu, B., & Hu, X. (2016) · Aging · doi:10.18632/aging.101146 · Cited by 11 · see citing works
Cells in the liver microenvironment regulate the process of liver metastasis
Wang, P., Jie, Y., Yao, L., Sun, Y., Jiang, D., Zhang, S., Wang, X., & Fan, Y. (2024) · Cell Biochemistry and Function · doi:10.1002/cbf.3969 · Cited by 8 · see citing works
Biomarkers for the detection of circulating tumor cells
Gostomczyk, K., Drozd, M., Marsool, M. D. M., Pandey, A., Tugas, K., Chacon, J., Tayyab, H., Ullah, A., Borowczak, J., & Szylberg, Ł. (2025) · Experimental Cell Research · doi:10.1016/j.yexcr.2025.114555 · Cited by 7 · see citing works
The sub-molecular characterization identification for cervical cancer
Mo, X., Wang, N., He, Z., Kang, W., Wang, L., Han, X., & Yang, L. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e16873 · Cited by 6 · see citing works
Moadab, A., Valizadeh, M. R., Nazari, A., & Khorramdelazad, H. (2024) · BMC Immunology · doi:10.1186/s12865-024-00612-4 · Cited by 6 · see citing works
Carson, J. P., Robinson, M. W., Ramm, G. A., & Gobert, G. N. (2022) · Experimental Parasitology · doi:10.1016/j.exppara.2022.108255 · Cited by 5 · see citing works
Pion, E., Haerteis, S., & Aung, T. (2022) · Methods in molecular biology · doi:10.1007/978-1-0716-2703-7_11 · Cited by 5 · see citing works
Okimoto, S., Tashiro, H., Iwako, H., Kuroda, S., Kobayashi, T., Hinoi, T., & Ohdan, H. (2020) · Hepatology Research · doi:10.1111/hepr.13558 · Cited by 4 · see citing works
Resistance to antiangiogenic treatments: A review
Koltai, T., Reshkin, S. J., & Cardone, R. A. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-90190-1.00014-7 · Cited by 3 · see citing works
Azad, A. I., Gutiérrez, F., & Gores, G. J. (2025) · Cells · doi:10.3390/cells15010069 · Cited by 2 · see citing works
Liver cancer in ovo models for preclinical testing
Garcia, P., Wang, Y., Viallet, J. P., Mehdi, N. E. H., Montaut, É., Decaens, T., Emadali, A., & Jílková, Z. M. (2024) · The FASEB Journal · doi:10.1096/fj.202401416r · Cited by 2 · see citing works
Hassen, M. T., Ahmed, N. J., & MOHAMED, H. K. (2020) · International Journal of Pharmacy and Pharmaceutical Sciences · doi:10.22159/ijpps.2020v12i9.38813 · Cited by 2 · see citing works
Lee, S. E., Jo, M. G., Park, S. W., Kim, H. J., Yun, S. P., & Kim, J.-W. (2026) · Animal Cells and Systems · doi:10.1080/19768354.2026.2630463 · Cited by 2 · see citing works
“…secrete anti-inflammatory cytokines like IL-10, IL-35, and TGF-β (Dikiy and Rudensky 2023), they can para-doxically promote HSC activation through TGF-β-dependent signaling pathway and IL-8 induction, thereby facilitating fibrogenesis (Dewidar et al. 2019; Langhans et al. 2013; Zhu et al. 2015).”
Valente, L. C., Riechelmann-Casarin, L., Esteves, L. L. P., Bacil, G. P., da Silva, T. C., Vinken, M., Cogliati, B., Friedman, S. L., Columbano, A., Barbisan, L. F., et al. (2025) · Archives of Toxicology · doi:10.1007/s00204-025-04167-0 · Cited by 1 · see citing works
The role of medicinal plants in the management of hepatocellular carcinoma and its metastasis
Nagar, M. K., Sudha, D., & Vairappan, B. (2025) · Exploration of Digestive Diseases · doi:10.37349/edd.2025.100588 · Cited by 1 · see citing works
Pastore, M., Raggi, C., Navari, N., Piombanti, B., Maira, G. D., Rovida, E., Piccinni, M., Lombardelli, L., Logiodice, F., Rombouts, K., et al. (2022) · Journal of Hepatology · doi:10.1016/s0168-8278(22)01283-1 · Cited by 1 · see citing works
Marchewka, Z., Szymańska, B., & Piwowar, A. (2019) · Diagnostyka Laboratoryjna · doi:10.5604/01.3001.0013.7692
Păsărică, M. A., Maria, D. C. D., Gruia, I., Murgoi, G., Schmitzer, S., & Grigorescu, A. C. (2021) · Oncolog-Hematolog ro · doi:10.26416/onhe.57.4.2021.5796
Comanzo, C. G., Fagalde, F. B., Vera, M. C., Bustos, L. O., Palma, N. F., Capiglioni, A. M., Hesse, L. D., Pisani, G. B., Ferretti, A. C., Ceballos, M. P., et al. (2026) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/j.jpet.2026.104301
Wen, X., Xue, T.-Y., Yang, Y.-H., Mai, Y.-P., Wang, Q.-S., Wang, X.-X., Chen, D.-B., Chen, H., & Wang, Z.-X. (2026) · World Journal of Hepatology · doi:10.4254/wjh.119664
Xu, G., Li, F., Li, Z., Wang, L., Chen, J., & Zhang, T. (2026) · Journal of Radiation Research and Applied Sciences · doi:10.1016/j.jrras.2026.102624
- Authors
- Zhu, B., Lin, N., Zhang, M., Zhu, Y., Cheng, H., Chen, S., Ling, Y., Pan, W., & Xu, R.
- Affiliations
- Sun Yat-sen University (CN)
- Anhui Medical University (CN)
- Corresponding author
- Xu, Ruiyun
- Venue
- Journal of Translational Medicine
- Published
- 2015-11-22
- Volume
- 13
- Issue
- 1
- Pages
- 365-365
- ISSN
- 1479-5876 (ISSN-L)
- PMC
- PMC4655083
- OpenAlex
- W2177730560
- Cited by
- 58
- References
- 50
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 5 · 2023: 6 · 2022: 9 · 2021: 3 · 2020: 10 · 2019: 5 · 2018: 4 · 2017: 6 · 2016: 2
- FWCI
- 2.37
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Journal of Translational Medicine (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81272642)
- Natural Science Foundation of Guangdong Province (2014A030313144, 2014A030313067)
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Health Sciences › Medicine › Hepatology › Hepatocellular Carcinoma Treatment and Prognosis
- Keywords
- hepatocellular carcinoma, hepatic stellate cells, angiogenesis, interleukin-8, chemokines, tumor stroma, STAT3 phosphorylation
- MeSH terms
- Animals, Chick Embryo, Enzyme-Linked Immunosorbent Assay, Carcinoma, Hepatocellular, Humans, Liver Neoplasms, Neovascularization, Pathologic, Interleukin-8, Hepatic Stellate Cells, Antibodies, Neutralizing
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
