The DOI matches its Crossref record; 142 of the 142 references it cites were found in a registry or an index.
Analysis of the role of the Hippo pathway in cancer
Open accessAbstract
Cancer is a serious health issue in the world due to a large body of cancer-related human deaths, and there is no current treatment available to efficiently treat the disease as the tumor is often diagnosed at a serious stage. Moreover, Cancer cells are often resistant to chemotherapy, radiotherapy, and molecular-targeted therapy. Upon further knowledge of mechanisms of tumorigenesis, aggressiveness, metastasis, and resistance to treatments, it is necessary to detect the disease at an earlier stage and for a better response to therapy. The hippo pathway possesses the unique capacity to lead to tumorigenesis. Mutations and altered expression of its core components (MST1/2, LATS1/2, YAP and TAZ) promote the migration, invasion, malignancy of cancer cells. The biological significance and deregulation of it have received a large body of interests in the past few years. Further understanding of hippo pathway will be responsible for cancer treatment. In this review, we try to discover the function of hippo pathway in different diversity of cancers, and discuss how Hippo pathway contributes to other cellular signaling pathways. Also, we try to describe how microRNAs, circRNAs, and ZNFs regulate hippo pathway in the process of cancer. It is necessary to find new therapy strategies for cancer.
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4 retracted
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Circular RNAs are a large class of animal RNAs with regulatory potency
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Cited by
Mesenchymal stem/stromal cells in cancer therapy
Lan, T., Luo, M., & Wei, X. (2021) · Journal of Hematology & Oncology · doi:10.1186/s13045-021-01208-w · Cited by 374
Transcription factors: Bridge between cell signaling and gene regulation
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Rho-kinase as a target for cancer therapy and its immunotherapeutic potential
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Metadata
- Authors
- Han, Y.
- Venue
- Journal of Translational Medicine
- Published
- 2019-04-08
- Volume
- 17
- Issue
- 1
- Pages
- 116-116
- ISSN
- 1479-5876 (ISSN-L)
- OpenAlex
- W2945535500
- Cited by
- 287
- References
- 142
- FWCI
- 17.29
- Type
- journal article
- Language
- en
- Open access
- gold
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
