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Effects of ingesting a pre-workout dietary supplement with and without synephrine for 8 weeks on training adaptations in resistance-trained males

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Jung, Y. Peter, Earnest, Conrad P., Koozehchian, Majid, Cho, Minye, Barringer, Nick, Walker, Dillon, Rasmussen, Christopher, Greenwood, Mike +2 more·2017·Journal of the International Society of Sports Nutrition
DOI 10.1186/s12970-016-0158-3PMC PMC5234097
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Abstract

BACKGROUND: The purpose of this study was to examine whether ingesting a pre-workout dietary supplement (PWS) with and without synephrine (S) during training affects training responses in resistance-trained males. METHODS: extract containing 20 mg of synephrine (PWS + S) once per day for 8-weeks during training. Participants donated a fasting blood sample and had body composition (DXA), resting heart rate and blood pressure, cognitive function (Stroop Test), readiness to perform, bench and leg press 1 RM, and Wingate anaerobic capacity assessments determined a 0, 4, and 8-weeks of standardized training. Data were analyzed by MANOVA with repeated measures. Performance and cognitive function data were analyzed using baseline values as covariates as well as mean changes from baseline with 95% confidence intervals (CI). Blood chemistry data were also analyzed using Chi-square analysis. RESULTS: Although significant time effects were seen, no statistically significant overall MANOVA Wilks' Lambda interactions were observed among groups for body composition, resting heart and blood pressure, readiness to perform questions, 1RM strength, anaerobic sprint capacity, or blood chemistry panels. MANOVA univariate analysis and analysis of changes from baseline with 95% CI revealed some evidence that cognitive function and 1RM strength were increased to a greater degree in the PWS and/or PWS + S groups after 4- and/or 8-weeks compared to PLA responses. However, there was no evidence that PWS + S promoted greater overall training adaptations compared to the PWS group. Dietary supplementation of PWS and PWS + S did not increase the incidence of reported side effects or significantly affect the number of blood values above clinical norms compared to PLA. CONCLUSION: Results provide some evidence that 4-weeks of PWS and/or PWS + S supplementation can improve some indices of cognitive function and exercise performance during resistance-training without significant side effects in apparently health males. However, these effects were similar to PLA responses after 8-weeks of supplementation and inclusion of synephrine did not promote additive benefits. TRIAL REGISTRATION: This trial (NCT02999581) was retrospectively registered on December 16th 2016.

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Authors
Jung, Y. P., Earnest, C. P., Koozehchian, M., Cho, M., Barringer, N., Walker, D., Rasmussen, C., Greenwood, M., Murano, P. S., & Kreider, R. B.
Affiliations
Texas A&M University (US)
Corresponding author
Kreider, Richard B.
ORCID
Venue
Journal of the International Society of Sports Nutrition
Publisher
Informa UK Limited
Published
2017-01-03
Volume
14
Issue
1
Pages
1-1
ISSN
1550-2783 (ISSN-L)
DOI
10.1186/s12970-016-0158-3
PMC
PMC5234097
OpenAlex
W2571578951
Cited by
40
References
16
Citations by year
2026: 3 · 2025: 4 · 2024: 2 · 2023: 3 · 2022: 5 · 2021: 9 · 2020: 2 · 2019: 2 · 2018: 5 · 2017: 5
FWCI
4.01
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of the International Society of Sports Nutrition (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
  • OakTrust (Texas A&M University Libraries) (submittedVersion)
Funders
Nutrabolt
Topics
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
  • Health Sciences › Medicine › Pharmacology › Coffee research and impacts
Keywords
synephrine, resistance training, training effects, 1RM strength, anaerobic capacity, cognitive function, body composition, resting heart rate, blood pressure, exercise performance, resistance-trained men, serum biochemistry, adverse effects
MeSH terms
Double-Blind Method, Humans, Male, Physical Endurance, Synephrine, beta-Alanine, Treatment Outcome, Dietary Supplements, Resistance Training, Young Adult, Sports Nutritional Physiological Phenomena

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