Fasting-mimicking diet and markers/risk factors for aging, diabetes, cancer, and cardiovascular disease
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A periodic fasting diet improves markers of metabolic dysfunction, particularly in people already at risk.
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Fasting exerts extensive antitumor effects in various cancers, including colorectal cancer.
“Evidence suggests that fasting exerts extensive antitumor effects in various cancers, including colorectal cancer (CRC).”
From RETRACTED ARTICLE: Fasting inhibits aerobic glycolysis and proliferation in colorectal cancer via the Fdft1-mediated AKT/mTOR/HIF1α pathway suppression (2020) · cites this paper as [11]
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Bonkowski, M. S., Dominici, F. P., Arum, O., Rocha, J. S., Al-Regaiey, K., Westbrook, R., Spong, A., Panici, J. A., Masternak, M. M., Kopchick, J. J., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004567 · Cited by 125 · see citing works
RetractedAlberti, K. G. M. M., Eckel, R. H., Grundy, S. M., Zimmet, P. Z., Cleeman, J. I., Donato, K. A., Fruchart, J.-C., James, W. P. T., Loria, C. M., & Smith, S. C. (2009) · Circulation · doi:10.1161/circulationaha.109.192644 · Cited by 14,860 · see citing works
Diagnosis and Classification of Diabetes Mellitus
American Diabetes Association (2010) · Diabetes Care · doi:10.2337/dc11-s062 · Cited by 14,019 · see citing works
Ford, E. S., Giles, W. H., & Dietz, W. H. (2002) · JAMA · doi:10.1001/jama.287.3.356 · Cited by 6,698 · see citing works
Pearson, T. A., Mensah, G. A., Alexander, R. W., Anderson, J. L., Cannon, R. O., Criqui, M., Fadl, Y. Y., Fortmann, S. P., Hong, Y., Myers, G. L., et al. (2003) · Circulation · doi:10.1161/01.cir.0000052939.59093.45 · Cited by 6,401 · see citing works
Diagnosis and classification of diabetes mellitus
American Diabetes Association (2014) · Diabetes Care · doi:10.2337/dc14-s081 · Cited by 5,974 · see citing works
Extending Healthy Life Span—From Yeast to Humans
Fontana, L., Partridge, L., & Longo, V. D. (2010) · Science · doi:10.1126/science.1172539 · Cited by 3,023 · see citing works
Self-citationPearsonT, A., MensahG, A., & AlexanderR, W. (2003) · Journal of Cardiopulmonary Rehabilitation · doi:10.1097/00008483-200305000-00016 · Cited by 2,937 · see citing works
Metabolic Syndrome and Risk of Incident Cardiovascular Events and Death
Gami, A. S., Witt, B. J., Howard, D. E., Erwin, P. J., Gami, L. A., Somers, V. K., & Montori, V. M. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.09.032 · Cited by 1,888 · see citing works
Triglycerides and Cardiovascular Disease: A Scientific Statement From the American Heart Association
Miller, M., Stone, N. J., Ballantyne, C., Bittner, V., Criqui, M. H., Ginsberg, H. N., Goldberg, A. C., Howard, W. J., Jacobson, M. S., Kris-Etherton, P. M., et al. (2011) · Circulation · doi:10.1161/cir.0b013e3182160726 · Cited by 1,871 · see citing works
Renehan, A. G., Zwahlen, M., Minder, C., O'Dwyer, S. T., Shalet, S. M., & Egger, M. (2004) · The Lancet · doi:10.1016/s0140-6736(04)16044-3 · Cited by 1,697 · see citing works
Fasting: molecular mechanisms and clinical applications
Longo, V. D., & Mattson, M. P. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2013.12.008 · Cited by 1,425 · see citing works
Self-citationFasting, Circadian Rhythms, and Time-Restricted Feeding in Healthy Lifespan
Longo, V. D., & Panda, S. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.06.001 · Cited by 1,013 · see citing works
Self-citationLevine, M. E., Suarez, J. A., Brandhorst, S., Balasubramanian, P., Cheng, C.-W., Madia, F., Fontana, L., Mirisola, M. G., Guevara-Aguirre, J., Wan, J., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.02.006 · Cited by 910 · see citing works
Self-citationLevine, M. E. (2012) · The Journals of Gerontology Series A · doi:10.1093/gerona/gls233 · Cited by 897 · see citing works
Brandhorst, S., Choi, I. Y., Wei, M., Cheng, C. W., Sedrakyan, S., Navarrete, G., Dubeau, L., Yap, L. P., Park, R., Vinciguerra, M., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.05.012 · Cited by 850 · see citing works
Self-citationFlurkey, K., Papaconstantinou, J., Miller, R. A., & Harrison, D. E. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.111158898 · Cited by 826 · see citing works
Harvie, M. N., Pegington, M., Mattson, M. P., Frystyk, J., Dillon, B., Evans, G., Cuzick, J., Jebb, S. A., Martin, B., Cutler, R. G., et al. (2011) · International Journal of Obesity · doi:10.1038/ijo.2010.171 · Cited by 804 · see citing works
Developmental Origins of Health and Disease
Gillman, M. W. (2005) · New England Journal of Medicine · doi:10.1056/nejme058187 · Cited by 756 · see citing works
Guevara‐Aguirre, J., Balasubramanian, P., Guevara‐Aguirre, M., Wei, M., Madia, F., Cheng, C., Hwang, D., Martín‐Montalvo, A., Saavedra, J., Ingles, S. A., et al. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3001845 · Cited by 735 · see citing works
Self-citationChoi, I. Y., Piccio, L. M., Childress, P., Bollman, B., Ghosh, A., Brandhorst, S., Suarez, J., Michalsen, A., Cross, A. H., Morgan, T. E., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.05.009 · Cited by 505 · see citing works
Self-citationCheng, C., Adams, G. B., Perin, L., Wei, M., Zhou, X., Lam, B. S., Sacco, S. D., Mirisola, M. G., Quinn, D. I., Dorff, T. B., et al. (2014) · Cell stem cell · doi:10.1016/j.stem.2014.04.014 · Cited by 484 · see citing works
Self-citationDunn, S. E., Kari, F. W., French, J. E., Leininger, J. R., Travlos, G. S., Wilson, R., & Barrett, J. C. (1997) · PubMed · Cited by 439 · see citing works
Chan, J. M. (2002) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/94.14.1099 · Cited by 433 · see citing works
Harvie, M., Wright, C., Pegington, M., McMullan, D., Mitchell, E., Martin, B., Cutler, R. G., Evans, G., Whiteside, S., Maudsley, S., et al. (2013) · British Journal Of Nutrition · doi:10.1017/s0007114513000792 · Cited by 431 · see citing works
Fontana, L., Weiss, E. P., Villareal, D. T., Klein, S., & Holloszy, J. O. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2008.00417.x · Cited by 396 · see citing works
Brabant, G. E., Mühlen, A. V. Z., Wüster, C. C., Ranke, M. B., Kratzsch, J., Kieß, W., Ketelslegers, J., Wilhelmsen, L., Hulthén, L., Saller, B., et al. (2003) · Hormone Research in Paediatrics · doi:10.1159/000071871 · Cited by 360 · see citing works
Ikeno, Y., Bronson, R. T., Hubbard, G. B., Lee, S., & Bartke, A. (2003) · The Journals of Gerontology Series A · doi:10.1093/gerona/58.4.b291 · Cited by 298 · see citing works
Fasting followed by vegetarian diet in patients with rheumatoid arthritis: a systematic review
Müller, F. (2001) · Scandinavian Journal of Rheumatology · doi:10.1080/030097401750065256 · Cited by 285 · see citing works
Fasting blood glucose and cancer risk in a cohort of more than 140,000 adults in Austria
Rapp, K., Schroeder, J. C., Klenk, J., Ulmer, H., Concin, H., Diem, G., Oberaigner, W., & Weiland, S. K. (2006) · Diabetologia · doi:10.1007/s00125-006-0207-6 · Cited by 271 · see citing works
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Fontana, L., Kennedy, B. K., Longo, V. D., Seals, D. R., & Melov, S. (2014) · Nature · doi:10.1038/511405a · Cited by 266 · see citing works
Self-citationStocks, T., Rapp, K., Bjørge, T., Manjer, J., Ulmer, H., Selmer, R. M., Lukanova, A., Johansen, D., Concin, H., Tretli, S., et al. (2009) · PLoS Medicine · doi:10.1371/journal.pmed.1000201 · Cited by 243 · see citing works
Wycherley, T. P., Noakes, M., Clifton, P. M., Cleanthous, X., Keogh, J. B., & Brinkworth, G. D. (2010) · Diabetes Care · doi:10.2337/dc09-1974 · Cited by 240 · see citing works
Sonntag, W. E., Lynch, C. D., Cefalu, W. T., Ingram, R. L., Bennett, S. A., Thornton, P. L., & Khan, A. S. (1999) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/54.12.b521 · Cited by 229 · see citing works
Hays, R. D., Kravitz, R. L., Mazel, R. M., Sherbourne, C. D., DiMatteo, M. R., Rogers, W. H., & Greenfield, S. (1994) · Journal of Behavioral Medicine · doi:10.1007/bf01858007 · Cited by 193 · see citing works
Fletcher, O., Gibson, L., Johnson, N., Altmann, D. R., Holly, J. M. P., Ashworth, A., Peto, J., & dos‐Santos‐Silva, I. (2005) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.2.14.1 · Cited by 137 · see citing works
Intermittent fasting: A “new” historical strategy for controlling seizures?
Hartman, A. L., Rubenstein, J. E., & Kossoff, E. H. (2012) · Epilepsy Research · doi:10.1016/j.eplepsyres.2012.10.011 · Cited by 117 · see citing works
Allen, N. E., Roddam, A. W., Allen, D., Fentiman, I., Silva, I. D. S., Peto, J., Holly, J. M. P., & Key, T. J. (2005) · British Journal of Cancer · doi:10.1038/sj.bjc.6602471 · Cited by 114 · see citing works
Recent Update to the US Cholesterol Treatment Guidelines
Nayor, M. G., & Vasan, R. S. (2016) · Circulation · doi:10.1161/circulationaha.116.021407 · Cited by 103 · see citing works
Brandhorst, S., Wei, M., Hwang, S., Morgan, T. E., & Longo, V. D. (2013) · Experimental Gerontology · doi:10.1016/j.exger.2013.02.016 · Cited by 88 · see citing works
Self-citationInsulin, insulin-like growth factors, insulin resistance, and neoplasia
Pollak, M. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.3.820s · Cited by 80 · see citing works
Florakis, D., Diamanti‐Kandarakis, E., Katsikis, I., Nassis, G. P., Karkanaki, A., Georgopoulos, N. A., & Panidis, D. (2007) · International Journal of Obesity · doi:10.1038/sj.ijo.0803777 · Cited by 53 · see citing works
Increased activity of surviving locus ceruleus neurons in Alzheimer's disease
Moser (1999) · Pure Amsterdam UMC · doi:10.1002/1531-8249(199901)45:1
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- Authors
- Wei, M., Brandhorst, S., Shelehchi, M., Mirzaei, H., Cheng, C. W., Budniak, J., Groshen, S., Mack, W. J., Guen, E., Di Biase, S., Cohen, P., Morgan, T. E., Dorff, T., Hong, K., Michalsen, A., Laviano, A., & Longo, V. D.
- Affiliations
- University of Southern California (US)
- Longevity Institute, School of Gerontology, and Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA.
- Charité – Universitätsmedizin Berlin (DE)
- Sapienza University of Rome (IT)
- Corresponding author
- Wei, Min
- Brandhorst, Sebastian
- Longo, Valter D.
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2017-02-15
- Volume
- 9
- Issue
- 377
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC6816332
- OpenAlex
- W2588251211
- Cited by
- 553
- References
- 43
- Citations by year
- 2026: 29 · 2025: 52 · 2024: 75 · 2023: 66 · 2022: 67 · 2021: 75 · 2020: 76 · 2019: 47 · 2018: 43 · 2017: 23
- FWCI
- 38.23
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- Funders
- NIH (UL1TR001855)
- Topics
- Health Sciences › Medicine › Physiology › Dietary Effects on Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Keywords
- fasting-mimicking diet, caloric restriction, healthy aging, age-related diseases, diabetes risk, cancer risk, cardiovascular risk, insulin-like growth factor I, fat loss, blood pressure, fasting blood glucose, cholesterol, C-reactive protein, triglycerides, unsaturated fat, dietary adherence, disease prevention
- MeSH terms
- Adult, Aging, Cardiovascular Diseases, Diabetes Mellitus, Diet, Fasting, Female, Follow-Up Studies, Humans, Male, Neoplasms, Risk Factors, Biomarkers
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