The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
The immune response to influenza in older humans: beyond immune senescence
Open accessAbstract
Despite widespread influenza vaccination programs, influenza remains a major cause of morbidity and mortality in older adults. Age-related changes in multiple aspects of the adaptive immune response to influenza have been well-documented including a decline in antibody responses to influenza vaccination and changes in the cell-mediated response associated with immune senescence. This review will focus on T cell responses to influenza and influenza vaccination in older adults, and how increasing frailty or coexistence of multiple (≥2) chronic conditions contributes to the loss of vaccine effectiveness for the prevention of hospitalization. Further, dysregulation of the production of pro- and anti-inflammatory mediators contributes to a decline in the generation of an effective CD8 T cell response needed to clear influenza virus from the lungs. Current influenza vaccines provide only a weak stimulus to this arm of the adaptive immune response and rely on re-stimulation of CD8 T cell memory related to prior exposure to influenza virus. Efforts to improve vaccine effectiveness in older adults will be fruitless until CD8 responses take center stage.
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Cites
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Mechanisms underlying T cell ageing
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Cited by
In vivo antiviral host transcriptional response to SARS-CoV-2 by viral load, sex, and age
Lieberman, N. A. P., Peddu, V., Xie, H., Shrestha, L., Huang, M.-L., Mears, M. C., Cajimat, M. N., Bente, D. A., Shi, P.-Y., Bovier, F., et al. (2020) · PLOS Biology · doi:10.1371/journal.pbio.3000849 · Cited by 267
The Impact of Immune System Aging on Infectious Diseases
Quiros-Roldan, E., Sottini, A., Natali, P. G., & Imberti, L. (2024) · Microorganisms · doi:10.3390/microorganisms12040775 · Cited by 133
“Aging appears to affect DCs, in terms of a decrease in number, activity, and migration, determining poorer viral clearance as well as clinical outcomes and susceptibility to complications, which have been correlated to the levels of circulating inflammatory cytokines [134].”
Aging induces B cell defects and decreased antibody responses to influenza infection and vaccination
Frasca, D., & Blomberg, B. B. (2020) · Immunity & Ageing · doi:10.1186/s12979-020-00210-z · Cited by 130
D’Souza, S. S., Zhang, Y., Bailey, J. T., Fung, I. T. H., Kuentzel, M. L., Chittur, S. V., & Yang, Q. (2021) · Aging Cell · doi:10.1111/acel.13470 · Cited by 32
Metadata
- Authors
- McElhaney, J. E., Verschoor, C. P., Andrew, M. K., Haynes, L., Kuchel, G. A., & Pawelec, G.
- Venue
- Immunity & Ageing
- Published
- 2020-05-07
- Volume
- 17
- Issue
- 1
- Pages
- 10-10
- ISSN
- 1742-4933 (ISSN-L)
- OpenAlex
- W3027752479
- Cited by
- 165
- References
- 14
- FWCI
- 14.90
- Type
- journal article
- Language
- en
- Open access
- gold
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- McElhaney, J. E., Verschoor, C. P., Andrew, M. K., Haynes, L., Kuchel, G. A., & Pawelec, G. (2020). The immune response to influenza in older humans: beyond immune senescence. Immunity & Ageing. https://doi.org/10.1186/s12979-020-00181-1
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