The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Type I Interferon signaling controls the accumulation and transcriptomes of monocytes in the aged lung
Abstract
Aging is paradoxically associated with a deteriorated immune defense (immunosenescence) and increased basal levels of tissue inflammation (inflammaging). The lung is particularly sensitive to the effects of aging. The immune cell mechanisms underlying physiological lung aging remain poorly understood. Here we reveal that aging leads to increased interferon signaling and elevated concentrations of chemokines in the lung, which is associated with infiltration of monocytes into the lung parenchyma. scRNA‐seq identified a novel Type‐1 interferon signaling dependent monocyte subset (MO‐ifn) that upregulated IFNAR1 expression and exhibited greater transcriptomal changes with aging than the other monocytes. Blockade of type‐1 interferon signaling by treatment with anti‐IFNAR1 neutralizing antibodies rapidly ablated MO‐ifn cells. Treatment with anti‐IFNAR1 antibodies also reduced airway chemokine concentrations and repressed the accumulation of the overall monocyte population in the parenchyma of the aged lung. Together, our work suggests that physiological aging is associated with increased basal level of airway monocyte infiltration and inflammation in part due to elevated type‐1 interferon signaling.
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“Blockade of the common type-1 interferon receptor IFNAR1 reverses the accumulation of monocytes in the aging mouse lung 268 .”
From Hallmarks of aging: An expanding universe (2023) · cites this paper as [268]
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Type I interferons in infectious disease
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The many roles of chemokines and chemokine receptors in inflammation
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Monocyte differentiation and antigen-presenting functions
Jakubzick, C. V., Randolph, G. J., & Henson, P. M. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2017.28 · Cited by 910 · cited 1×
“In addition to their capacity to differentiate into phagocytes and dendritic cells, monocytes might be important sources of proinflammatory cytokines and by themselves possess the capability to present antigen (Bassler et al., 2019; Jakubzick et al., 2017).”
BackgroundAging-induced type I interferon response at the choroid plexus negatively affects brain function
Baruch, K., Deczkowska, A., David, E., Castellano, J. M., Miller, O., Kertser, A., Berkutzki, T., Barnett-Itzhaki, Z., Bezalel, D., Wyss-Coray, T., et al. (2014) · Science · doi:10.1126/science.1252945 · Cited by 615
Monocyte Cytokine Production in an Elderly Population: Effect of Age and Inflammation
Roubenoff, R., Harris, T. B., Abad, L. W., Wilson, P. W. F., Dallal, G. E., & Dinarello, C. A. (1998) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/53a.1.m20 · Cited by 418 · cited 1×
“…reduced metabolic fitness, and altered responses to pattern recognition receptor (Alvarez- Rodriguez et al., 2012; De Martinis et al., 2004; Hearps et al., 2012; Merino et al., 2011; Nyugen et al., 2010; Pence & Yarbro, 2018, 2019; Roubenoff et al., 1998; Saare et al., 2020; Seidler et al., 2010).”
BackgroundSeidler, S., Zimmermann, H. W., Bartneck, M., Trautwein, C., & Tacke, F. (2010) · BMC Immunology · doi:10.1186/1471-2172-11-30 · Cited by 390
Impaired functions of peripheral blood monocyte subpopulations in aged humans
Nyugen, J., Agrawal, S., Gollapudi, S., & Gupta, S. (2010) · Journal of Clinical Immunology · doi:10.1007/s10875-010-9448-8 · Cited by 249
Complement Factor H Inhibits CD47-Mediated Resolution of Inflammation
Calippe, B., Augustin, S., Beguier, F., Charles-Messance, H., Poupel, L., Conart, J.-B., Hu, S. J., Lavalette, S., Fauvet, A., Rayes, J., et al. (2017) · Immunity · doi:10.1016/j.immuni.2017.01.006 · Cited by 168
Innate immune responses in the ageing lung.
Boe, D. M., Boule, L. A., & Kovacs, E. J. (2016) · Clinical and Experimental Immunology · doi:10.1111/cei.12881 · Cited by 156
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Sorted by citations
Hallmarks of aging: An expanding universe
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2023) · Cell · doi:10.1016/j.cell.2022.11.001 · Cited by 6,549
Meta-hallmarks of aging and cancer
López-Otín, C., Pietrocola, F., Roiz-Valle, D., Galluzzi, L., & Kroemer, G. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2022.11.001 · Cited by 529
Metadata
- Authors
- D’Souza, S. S., Zhang, Y., Bailey, J. T., Fung, I. T. H., Kuentzel, M. L., Chittur, S. V., & Yang, Q.
- Affiliations
- Department of Immunology and Microbial Disease Albany Medical College Albany NY USA
- Center for Functional Genomics University at Albany‐SUNY Rensselaer NY USA
- ORCID
- Yang, Qi
- Venue
- Aging Cell
- Publisher
- Wiley
- Published
- 2021-09-21
- Volume
- 20
- Issue
- 10
- ISSN
- 1474-9718
- 1474-9726
- PMC
- PMC8520712
- Cited by
- 32
- References
- 13
- Language
- en
- Funders
- National Institutes of Health (R01HL155021)
- National Heart, Lung, and Blood Institute (R01HL137813)
- National Institute on Aging (R01AG057782)
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