Middle East Respiratory Syndrome Coronavirus (MERS-CoV) origin and animal reservoir
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Middle East Respiratory Syndrome-Coronavirus (MERS-CoV) is a novel coronavirus discovered in 2012 and is responsible for acute respiratory syndrome in humans. Though not confirmed yet, multiple surveillance and phylogenetic studies suggest a bat origin. The disease is heavily endemic in dromedary camel populations of East Africa and the Middle East. It is unclear as to when the virus was introduced to dromedary camels, but data from studies that investigated stored dromedary camel sera and geographical distribution of involved dromedary camel populations suggested that the virus was present in dromedary camels several decades ago. Though bats and alpacas can serve as potential reservoirs for MERS-CoV, dromedary camels seem to be the only animal host responsible for the spill over human infections.
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The proximal reservoir of MERS-CoV is dromedary camels.
“The proximal reservoir of MERS-CoV, the virus that causes Middle East respiratory syndrome, is dromedary camels (Camelus dromedarius).56”
From The Lancet Commission on lessons for the future from the COVID-19 pandemic (2022) · cites this paper as [56]
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- Authors
- Mohd, H. A., Al-Tawfiq, J. A., & Memish, Z. A.
- Affiliations
- Ministry of Health (SA)
- Alfaisal University (SA)
- Corresponding author
- Memish, Ziad A.
- Venue
- Virology Journal
- Published
- 2016-06-03
- Volume
- 13
- Issue
- 1
- Pages
- 87-87
- ISSN
- 1743-422X (ISSN-L)
- PMC
- PMC4891877
- OpenAlex
- W2411425451
- Cited by
- 316
- References
- 41
- Citations by year
- 2026: 5 · 2025: 18 · 2024: 15 · 2023: 31 · 2022: 40 · 2021: 64 · 2020: 77 · 2019: 26 · 2018: 19 · 2017: 14 · 2016: 7
- FWCI
- 3.38
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Virology Journal (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- IUScholarWorks (Indiana University) (submittedVersion, cc-by)
- Zenodo (CERN European Organization for Nuclear Research) (submittedVersion, cc-by)
- Topics
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Virus Infections Studies
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Zoonotic diseases and public health
- Keywords
- MERS-CoV, zoonotic transmission, reservoir hosts, Camelus dromedarius, bats, alpaca, viral origin, phylogenetic analysis, seroprevalence, zoonotic spillover
- MeSH terms
- Africa, Animals, Camelids, New World, Camelus, Chiroptera, Disease Reservoirs, Humans, Zoonoses, Coronavirus Infections, Disease Transmission, Infectious, Middle East Respiratory Syndrome Coronavirus
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