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Nanoparticle-allergen interactions mediate human allergic responses: protein corona characterization and cellular responses

Radauer-Preiml, Isabella, Andosch, Ancuela, Hawranek, Thomas, Luetz-Meindl, Ursula, Wiederstein, Markus, Horejs-Hoeck, Jutta, Himly, Martin, Boyles, Matthew, Duschl, Albert·2015·Particle and Fibre Toxicology
DOI 10.1186/s12989-016-0113-0PMC PMC4715273
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Graphical Abstract Cross-linking of IgE receptors and degranulation of human basophils due to epitope alignment of nanoparticle-coated allergens.
Graphical Abstract Cross-linking of IgE receptors and degranulation of human basophils due to epitope alignment of nanoparticle-coated allergens.CC BY · PubMed Central
Fig. 1 Characterization of AuNPs and AuNP-allergen conjugates. a TEM imaging and TEM negative staining. b Size distribution by intensity obtained from DLS measurements. c Hyperspectral images of AuNPs compared to AuNP-allergen conjugates. d HPLC analysis of allergens before and after the conjugation with AuNPs
Fig. 1 Characterization of AuNPs and AuNP-allergen conjugates. a TEM imaging and TEM negative staining. b Size distribution by intensity obtained from DLS measurements. c Hyperspectral images of AuNPs compared to AuNP-allergen conjugates. d HPLC analysis of allergens before and after the conjugation with AuNPsCC BY · PubMed Central
Fig. 2 3D models of AuNP-allergen conjugates. a Conjugation degree of allergen molecules on a single AuNP. b Preferred orientations arrangements of allergen molecules as determined by modelling the interaction with the AuNP surface via electrostatic forces (from +5 kT/e in blue to -5 kT/e in red). c Currently known allergen epitopes (in orange) accessible for biologic reactions, based on modelled data
Fig. 2 3D models of AuNP-allergen conjugates. a Conjugation degree of allergen molecules on a single AuNP. b Preferred orientations arrangements of allergen molecules as determined by modelling the interaction with the AuNP surface via electrostatic forces (from +5 kT/e in blue to -5 kT/e in red). c Currently known allergen epitopes (in orange) accessible for biologic reactions, based on modelled dataCC BY · PubMed Central
Fig. 3 BAT of allergic patients against Bet v 1. The experiments were performed with 9 donors. The patients’ whole blood was treated with 0.048-50 ng free Bet v 1 (blue squares) or the respective amount of AuNP-Bet v 1 conjugates (violet triangles). Donor 2, 3, 4 and 7 showed a higher activation upon stimulation with AuNP-Bet v 1 conjugates, whereas Donor 5, 6 and 9 were less activated by the AuNP-Bet v 1 conjugates. Donor 8 displayed no difference in the activation pattern. Donor 1 was not used for the determination of the C50 value
Fig. 3 BAT of allergic patients against Bet v 1. The experiments were performed with 9 donors. The patients’ whole blood was treated with 0.048-50 ng free Bet v 1 (blue squares) or the respective amount of AuNP-Bet v 1 conjugates (violet triangles). Donor 2, 3, 4 and 7 showed a higher activation upon stimulation with AuNP-Bet v 1 conjugates, whereas Donor 5, 6 and 9 were less activated by the AuNP-Bet v 1 conjugates. Donor 8 displayed no difference in the activation pattern. Donor 1 was not used for the determination of the C50 valueCC BY · PubMed Central
Fig. 4 BAT of allergic patients against Der p 1. The experiments were performed with 5 donors. The patients’ whole blood was treated with 0.04-50 ng free Der p 1 (blue squares) or the respective amount of AuNP-Der p 1 conjugates (violet triangles). Donor 2, 3, 4 and 5 were higher activated by the AuNP-Der p 1 conjugates compared to the allergen alone. Donor 1 was not used for the determination of the C50 value
Fig. 4 BAT of allergic patients against Der p 1. The experiments were performed with 5 donors. The patients’ whole blood was treated with 0.04-50 ng free Der p 1 (blue squares) or the respective amount of AuNP-Der p 1 conjugates (violet triangles). Donor 2, 3, 4 and 5 were higher activated by the AuNP-Der p 1 conjugates compared to the allergen alone. Donor 1 was not used for the determination of the C50 valueCC BY · PubMed Central
Fig. 5 BAT of allergic patients against Phl p 5. The experiments were performed with 8 donors. The patients’ whole blood was treated with 0.078-50 ng free Phl p 5 (blue squares) or the respective amount of AuNP-Phl p 5 conjugates (violet triangles). Donor 8 showed a higher activation upon stimulation with AuNP-Phl p 5 conjugates, whereas donor 9 was activated to a lesser degree. Donor 4 and 6 did not show a difference in their activation profile. Donor 1, 2, 3 and 5 were not used for the determination of the C50 value
Fig. 5 BAT of allergic patients against Phl p 5. The experiments were performed with 8 donors. The patients’ whole blood was treated with 0.078-50 ng free Phl p 5 (blue squares) or the respective amount of AuNP-Phl p 5 conjugates (violet triangles). Donor 8 showed a higher activation upon stimulation with AuNP-Phl p 5 conjugates, whereas donor 9 was activated to a lesser degree. Donor 4 and 6 did not show a difference in their activation profile. Donor 1, 2, 3 and 5 were not used for the determination of the C50 valueCC BY · PubMed Central
Fig. 6 Determination of protease activity of free Der p 1 versus AuNP-Der p 1 conjugates. a Enzymatic activity assay of 30 ng AuNP-Der p 1 conjugates compared to 50 and 100 ng free Der p 1. b Stability of conjugates addressed by enzymatic activity of 30 ng AuNP-Der p 1 conjugates upon storage at 4 °C. In conjugates the given values refer to amount of coupled allergen. c TEER measurements of A549 cells to monitor the formation of a tight cell layer. d TEER measurements of A549 cells exposed to controls, free Der p 1 and AuNP-Der p 1 conjugates (*, p < 0.05). e Permeation of Fluorescein through a tight monolayer of A549 cells exposed to controls, free Der p 1 and AuNP-Der p 1 conjugates (*, p < 0.05)
Fig. 6 Determination of protease activity of free Der p 1 versus AuNP-Der p 1 conjugates. a Enzymatic activity assay of 30 ng AuNP-Der p 1 conjugates compared to 50 and 100 ng free Der p 1. b Stability of conjugates addressed by enzymatic activity of 30 ng AuNP-Der p 1 conjugates upon storage at 4 °C. In conjugates the given values refer to amount of coupled allergen. c TEER measurements of A549 cells to monitor the formation of a tight cell layer. d TEER measurements of A549 cells exposed to controls, free Der p 1 and AuNP-Der p 1 conjugates (*, p < 0.05). e Permeation of Fluorescein through a tight monolayer of A549 cells exposed to controls, free Der p 1 and AuNP-Der p 1 conjugates (*, p < 0.05)CC BY · PubMed Central

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  1. Oberdorster G. Safety assessment for nanotechnology and nanomedicine: concepts of nanotoxicology. J Intern Med. 2010;267(1):89–105. doi: 10.1111/j.1365-2796.2009.02187.x . · DOI
  2. Oberdörster G, Stone V, Donaldson K. Toxicology of nanoparticles: A historical perspective. Nanotoxicology. 2007;1(1):2–25. doi: 10.1080/17435390701314761 . · DOI
  3. Seaton A, Tran L, Aitken R. Nanoparticles, human health hazard and regulation. J R Soc Interface. 2010;7 Suppl 1:S119–29. doi: 10.1098/rsif.2009.0252.focus . · DOI
  4. Mahon E, Salvati A, Baldelli Bombelli F, Lynch I, Dawson KA. Designing the nanoparticle-biomolecule interface for “targeting and therapeutic delivery”. J Control Release. 2012;161(2):164–74. doi: 10.1016/j.jconrel.2012.04.009 . · DOI
  5. Borm PJ, Robbins D, Haubold S, Kuhlbusch T, Fissan H, Donaldson K, et al. The potential risks of nanomaterials: a review carried out for ECETOC. Part Fibre Toxicol. 2006;3:11. doi: 10.1186/1743-8977-3-11 . · DOI
  6. Saptarshi SR, Duschl A, Lopata AL. Interaction of nanoparticles with proteins: relation to bio-reactivity of the nanoparticle. J Nanobiotechnol. 2013;11:26. doi: 10.1186/1477-3155-11-26 . · DOI
  7. Nel AE, Madler L, Velegol D, Xia T, Hoek EM, Somasundaran P, et al. Understanding biophysicochemical interactions at the nano-bio interface. Nat Mater. 2009;8(7):543–57. doi: 10.1038/nmat2442 . · DOI · Paper page
  8. Kreyling WG, Semmler-Behnke M, Seitz J, Scymczak W, Wenk A, Mayer P, et al. Size dependence of the translocation of inhaled iridium and carbon nanoparticle aggregates from the lung of rats to the blood and secondary target organs. Inhal Toxicol. 2009;21 Suppl 1:55–60. doi: 10.1080/08958370902942517 . · DOI
  9. Nemmar A, Hoet PH, Vanquickenborne B, Dinsdale D, Thomeer M, Hoylaerts MF, et al. Passage of inhaled particles into the blood circulation in humans. Circulation. 2002;105(4):411–4. · DOI · Paper page
  10. Weinberg EG. The Wao White Book on allergy 2011–2012. Curr Allergy Clin Im. 2011;24(3):156–7.
  11. Hammad H, Lambrecht BN. Dendritic cells and epithelial cells: linking innate and adaptive immunity in asthma. Nat Rev Immunol. 2008;8(3):193–204. doi: 10.1038/nri2275 . · DOI
  12. Zhou B, Comeau MR, De Smedt T, Liggitt HD, Dahl ME, Lewis DB, et al. Thymic stromal lymphopoietin as a key initiator of allergic airway inflammation in mice. Nat Immunol. 2005;6(10):1047–53. doi: 10.1038/ni1247 . · DOI
  13. Ziegler SF, Artis D. Sensing the outside world: TSLP regulates barrier immunity. Nat Immunol. 2010;11(4):289–93. doi: 10.1038/ni.1852 . · DOI
  14. Dullaers M, De Bruyne R, Ramadani F, Gould HJ, Gevaert P, Lambrecht BN. The who, where, and when of IgE in allergic airway disease. J Allergy Clin Immunol. 2012;129(3):635–45. doi: 10.1016/j.jaci.2011.10.029 . · DOI · Paper page
  15. He SH, Zhang HY, Zeng XN, Chen D, Yang PC. Mast cells and basophils are essential for allergies: mechanisms of allergic inflammation and a proposed procedure for diagnosis. Acta Pharmacol Sin. 2013;34(10):1270–83. doi: 10.1038/aps.2013.88 . · DOI
  16. Holgate ST. The epidemic of allergy and asthma. Nature. 1999;402(6760 Suppl):B2–4. · DOI
  17. Skoner DP. Allergic rhinitis: definition, epidemiology, pathophysiology, detection, and diagnosis. J Allergy Clin Immunol. 2001;108(1 Suppl):S2–8. · DOI
  18. D’Amato G, Cecchi L, Bonini S, Nunes C, Annesi-Maesano I, Behrendt H, et al. Allergenic pollen and pollen allergy in Europe. Allergy. 2007;62(9):976–90. doi: 10.1111/j.1398-9995.2007.01393.x . · DOI · Paper page
  19. Calderon MA, Linneberg A, Kleine-Tebbe J, De Blay F, Hernandez Fernandez de Rojas D, Virchow JC, et al. Respiratory allergy caused by house dust mites: What do we really know? J Allergy Clin Immunol. 2014. doi: 10.1016/j.jaci.2014.10.012 . · DOI
  20. Zock JP, Heinrich J, Jarvis D, Verlato G, Norback D, Plana E, et al. Distribution and determinants of house dust mite allergens in Europe: the European Community Respiratory Health Survey II. J Allergy Clin Immunol. 2006;118(3):682–90. doi: 10.1016/j.jaci.2006.04.060 . · DOI
  21. Knox RB, Suphioglu C, Taylor P, Desai R, Watson HC, Peng JL, et al. Major grass pollen allergen Lol p 1 binds to diesel exhaust particles: implications for asthma and air pollution. Clin Exp Allergy. 1997;27(3):246–51. · DOI
  22. Tsien A, Diaz-Sanchez D, Ma J, Saxon A. The organic component of diesel exhaust particles and phenanthrene, a major polyaromatic hydrocarbon constituent, enhances IgE production by IgE-secreting EBV-transformed human B cells in vitro. Toxicol Appl Pharmacol. 1997;142(2):256–63. doi: 10.1006/taap.1996.8063 . · DOI
  23. Diaz-Sanchez D, Tsien A, Fleming J, Saxon A. Combined diesel exhaust particulate and ragweed allergen challenge markedly enhances human in vivo nasal ragweed-specific IgE and skews cytokine production to a T helper cell 2-type pattern. J Immunol. 1997;158(5):2406–13. · DOI
  24. Takano H, Yanagisawa R, Ichinose T, Sadakane K, Yoshino S, Yoshikawa T, et al. Diesel exhaust particles enhance lung injury related to bacterial endotoxin through expression of proinflammatory cytokines, chemokines, and intercellular adhesion molecule-1. Am J Respir Crit Care Med. 2002;165(9):1329–35. doi: 10.1164/rccm.2108122 . · DOI
  25. Gomez S, Gamazo C, San Roman B, Grau A, Espuelas S, Ferrer M, et al. A novel nanoparticulate adjuvant for immunotherapy with Lolium perenne. J Immunol Methods. 2009;348(1–2):1–8. http://dx.doi.org/10.1016/j.jim.2009.06.005 . · DOI
  26. Licciardi M, Montana G, Bondi ML, Bonura A, Scialabba C, Melis M, et al. An allergen-polymeric nanoaggregate as a new tool for allergy vaccination. Int J Pharm. 2014;465(1–2):275–83. http://dx.doi.org/10.1016/j.ijpharm.2014.01.031 . · DOI
  27. Nouri HR, Varasteh A, Jaafari MR, Davies JM, Sankian M. Induction of a Th1 immune response and suppression of IgE via immunotherapy with a recombinant hybrid molecule encapsulated in liposome–protamine–DNA nanoparticles in a model of experimental allergy. Immunol Res. 2015;62(3):280–91. doi: 10.1007/s12026-015-8659-8 . · DOI
  28. Pali-Scholl I, Szollosi H, Starkl P, Scheicher B, Stremnitzer C, Hofmeister A, et al. Protamine nanoparticles with CpG-oligodeoxynucleotide prevent an allergen-induced Th2-response in BALB/c mice. Eur J Pharm Biopharm. 2013;85(3, Part A):656–64. http://dx.doi.org/10.1016/j.ejpb.2013.03.003 . · DOI
  29. Salem AK. A promising CpG adjuvant-loaded nanoparticle-based vaccine for treatment of dust mite allergies. Immunotherapy. 2014;6(11):1161–3. doi: 10.2217/imt.14.97 . · DOI
  30. Chuang HC, Hsiao TC, Wu CK, Chang HH, Lee CH, Chang CC, et al. Allergenicity and toxicology of inhaled silver nanoparticles in allergen-provocation mice models. Int J Nanomedicine. 2013;8:4495–506. doi: 10.2147/IJN.S52239 . · DOI
  31. Brandenberger C, Rowley NL, Jackson-Humbles DN, Zhang Q, Bramble LA, Lewandowski RP, et al. Engineered silica nanoparticles act as adjuvants to enhance allergic airway disease in mice. Part Fibre Toxicol. 2013;10:26. doi: 10.1186/1743-8977-10-26 . · DOI
  32. Ilves M, Palomaki J, Vippola M, Lehto M, Savolainen K, Savinko T, et al. Topically applied ZnO nanoparticles suppress allergen induced skin inflammation but induce vigorous IgE production in the atopic dermatitis mouse model. Part Fibre Toxicol. 2014;11:38. doi: 10.1186/s12989-014-0038-4 . · DOI
  33. Jonasson S, Gustafsson A, Koch B, Bucht A. Inhalation exposure of nano-scaled titanium dioxide (TiO2) particles alters the inflammatory responses in asthmatic mice. Inhal Toxicol. 2013;25(4):179–91. · DOI
  34. Lefebvre DE, Pearce B, Fine JH, Chomyshyn E, Ross N, Halappanavar S, et al. In vitro enhancement of mouse T Helper 2 cell sensitization to ovalbumin allergen by carbon black nanoparticles. Toxicol Sci. 2014;138(2):322–32. doi: 10.1093/toxsci/kfu010 . · DOI
  35. Nygaard UC, Samuelsen M, Marioara CD, Lovik M. Carbon nanofibers have IgE adjuvant capacity but are less potent than nanotubes in promoting allergic airway responses. BioMed Res Int. 2013;2013:476010. doi: 10.1155/2013/476010 . · DOI
  36. Su CL, Chen TT, Chang CC, Chuang KJ, Wu CK, Liu WT, et al. Comparative proteomics of inhaled silver nanoparticles in healthy and allergen provoked mice. Int J Nanomedicine. 2013;8:2783–99. doi: 10.2147/IJN.S46997 . · DOI
  37. Wan H, Winton HL, Soeller C, Tovey ER, Gruenert DC, Thompson PJ, et al. Der p 1 facilitates transepithelial allergen delivery by disruption of tight junctions. J Clin Invest. 1999;104(1):123–33. doi: 10.1172/JCI5844 . · DOI · Paper page
  38. Ackaert C, Kofler S, Horejs-Hoeck J, Zulehner N, Asam C, von Grafenstein S, et al. The impact of nitration on the structure and immunogenicity of the major birch pollen allergen Bet v 1.0101. PLoS One. 2014;9(8):e104520. doi: 10.1371/journal.pone.0104520 . · DOI
  39. Cromwell O, Suck R, Kahlert H, Nandy A, Weber B, Fiebig H. Transition of recombinant allergens from bench to clinical application. Methods. 2004;32(3):300–12. doi: 10.1016/j.ymeth.2003.08.009 . · DOI
  40. Himly M, Nony E, Chabre H, Van Overtvelt L, Neubauer A, van Ree R, et al. Standardization of allergen products: 1. Detailed characterization of GMP-produced recombinant Bet v 1.0101 as biological reference preparation. Allergy. 2009;64(7):1038–45. doi: 10.1111/j.1398-9995.2009.01957.x . · DOI
  41. Pettersen EF, Goddard TD, Huang CC, Couch GS, Greenblatt DM, Meng EC, et al. UCSF Chimera—A visualization system for exploratory research and analysis. J Comput Chem. 2004;25(13):1605–12. doi: 10.1002/jcc.20084 . · DOI
  42. Chruszcz M, Chapman MD, Vailes LD, Stura EA, Saint-Remy JM, Minor W, et al. Crystal structures of mite allergens Der f 1 and Der p 1 reveal differences in surface-exposed residues that may influence antibody binding. J Mol Biol. 2009;386(2):520–30. doi: 10.1016/j.jmb.2008.12.049 . · DOI
  43. Kofler S, Asam C, Eckhard U, Wallner M, Ferreira F, Brandstetter H. Crystallographically mapped ligand binding differs in high and low IgE binding isoforms of birch pollen allergen bet v 1. J Mol Biol. 2012;422(1):109–23. doi: 10.1016/j.jmb.2012.05.016 . · DOI
  44. Dolinsky TJ, Czodrowski P, Li H, Nielsen JE, Jensen JH, Klebe G, et al. PDB2PQR: expanding and upgrading automated preparation of biomolecular structures for molecular simulations. Nucleic Acids Res. 2007;35 suppl 2:W522–5. doi: 10.1093/nar/gkm276 . · DOI
  45. Dolinsky TJ, Nielsen JE, McCammon JA, Baker NA. PDB2PQR: an automated pipeline for the setup of Poisson–Boltzmann electrostatics calculations. Nucleic Acids Res. 2004;32(Web Server issue):W665–7. doi: 10.1093/nar/gkh381 . · DOI
  46. Sitkoff D, Sharp KA, Honig B. Accurate calculation of hydration free energies using macroscopic solvent models. J Phys Chem. 1994;98(7):1978–88. doi: 10.1021/j100058a043 . · DOI
  47. Baker NA, Sept D, Joseph S, Holst MJ, McCammon JA. Electrostatics of nanosystems: Application to microtubules and the ribosome. Proc Natl Acad Sci U S A. 2001;98(18):10037–41. doi: 10.1073/pnas.181342398 . · DOI
  48. Brar SK, Verma M. Measurement of nanoparticles by light-scattering techniques. TrAC Trends Anal Chem. 2011;30(1):4–17. doi: 10.1016/j.trac.2010.08.008 . · DOI
  49. de Halleux S, Stura E, VanderElst L, Carlier V, Jacquemin M, Saint-Remy JM. Three-dimensional structure and IgE-binding properties of mature fully active Der p 1, a clinically relevant major allergen. J Allergy Clin Immunol. 2006;117(3):571–6. doi: 10.1016/j.jaci.2005.11.032 . · DOI
  50. Dell'Orco D, Lundqvist M, Oslakovic C, Cedervall T, Linse S. Modeling the time evolution of the nanoparticle-protein corona in a body fluid. PLoS One. 2010;5(6):e10949. doi: 10.1371/journal.pone.0010949 . · DOI
  51. Arbos P, Arangoa MA, Campanero MA, Irache JM. Quantification of the bioadhesive properties of protein-coated PVM/MA nanoparticles. Int J Pharm. 2002;242(1–2):129–36. · DOI
  52. Brancolini G, Kokh DB, Calzolai L, Wade RC, Corni S. Docking of ubiquitin to gold nanoparticles. ACS Nano. 2012;6(11):9863–78. doi: 10.1021/nn303444b . · DOI
  53. Calzolai L, Franchini F, Gilliland D, Rossi F. Protein--nanoparticle interaction: identification of the ubiquitin--gold nanoparticle interaction site. Nano Lett. 2010;10(8):3101–5. doi: 10.1021/nl101746v . · DOI
  54. Brancolini G, Corazza A, Vuano M, Fogolari F, Mimmi MC, Bellotti V, et al. Probing the influence of citrate-capped gold nanoparticles on an amyloidogenic protein. ACS Nano. 2015;9(3):2600–13. doi: 10.1021/nn506161j . · DOI
  55. Brewer SH, Glomm WR, Johnson MC, Knag MK, Franzen S. Probing BSA binding to citrate-coated gold nanoparticles and surfaces. Langmuir. 2005;21(20):9303–7. doi: 10.1021/la050588t . · DOI
  56. Hoffmann HJ, Santos AF, Mayorga C, Nopp A, Eberlein B, Ferrer M, et al. The clinical utility of basophil activation testing in diagnosis and monitoring of allergic disease. Allergy. 2015;70(11):1393–405. doi: 10.1111/all.12698 . · DOI
  57. MacGlashan Jr DW. Basophil activation testing. J Allergy Clin Immunol. 2013;132(4):777–87. doi: 10.1016/j.jaci.2013.06.038 . · DOI
  58. Siracusa MC, Kim BS, Spergel JM, Artis D. Basophils and allergic inflammation. J Allergy Clin Immunol. 2013;132(4):789–801. doi: 10.1016/j.jaci.2013.07.046 . quiz 788. · DOI
  59. Christensen LH, Holm J, Lund G, Riise E, Lund K. Several distinct properties of the IgE repertoire determine effector cell degranulation in response to allergen challenge. J Allergy Clin Immunol. 2008;122(2):298–304. · DOI
  60. McGowan EC, Saini S. Update on the performance and application of basophil activation tests. Curr Allergy Asthma Rep. 2013;13(1):101–9. doi: 10.1007/s11882-012-0324-x . · DOI
  61. Stone KD, Prussin C, Metcalfe DD. IgE, mast cells, basophils, and eosinophils. J Allergy Clin Immunol. 2010;125(2):S73–80. · DOI
  62. Gepp B, Lengger N, Bublin M, Hemmer W, Breiteneder H, Radauer C. Chimeras of Bet v 1 and Api g 1 reveal heterogeneous IgE responses in patients with birch pollen allergy. J Allergy Clin Immunol. 2014;134(1):188–94. doi: 10.1016/j.jaci.2013.12.1073 . · DOI
  63. Knol EF. Requirements for effective IgE cross‐linking on mast cells and basophils. Mol Nutr Food Res. 2006;50(7):620–4. · DOI
  64. Chapman MD, Heymann PW, Platts-Mills TA. Epitope mapping of two major inhalant allergens, Der p I and Der f I, from mites of the genus Dermatophagoides. J Immunol. 1987;139(5):1479–84. · DOI
  65. Dai YC, Chuang WJ, Chua KY, Shieh CC, Wang JY. Epitope mapping and structural analysis of the anti-Der p 1 monoclonal antibody: insight into therapeutic potential. J Mol Med. 2011;89(7):701–12. doi: 10.1007/s00109-011-0744-4 . · DOI
  66. Focke-Tejkl M, Campana R, Reininger R, Lupinek C, Blatt K, Valent P, et al. Dissection of the IgE and T-cell recognition of the major group 5 grass pollen allergen Phl p 5. J Allergy Clin Immunol. 2014;133(3):836–45. doi: 10.1016/j.jaci.2013.08.038 . e11. · DOI
  67. Levin M, Davies AM, Liljekvist M, Carlsson F, Gould HJ, Sutton BJ, et al. Human IgE against the major allergen Bet v 1--defining an epitope with limited cross-reactivity between different PR-10 family proteins. Clin Exp Allergy. 2014;44(2):288–99. doi: 10.1111/cea.12230 . · DOI
  68. Szalai K, Fuhrmann J, Pavkov T, Scheidl M, Wallmann J, Bramswig KH, et al. Mimotopes identify conformational B-cell epitopes on the two major house dust mite allergens Der p 1 and Der p 2. Mol Immunol. 2008;45(5):1308–17. doi: 10.1016/j.molimm.2007.09.012 . · DOI
  69. Takai T, Kato T, Yasueda H, Okumura K, Ogawa H. Analysis of the structure and allergenicity of recombinant pro- and mature Der p 1 and Der f 1: major conformational IgE epitopes blocked by prodomains. J Allergy Clin Immunol. 2005;115(3):555–63. doi: 10.1016/j.jaci.2004.11.024 . · DOI
  70. Furmonaviciene R, Tighe PJ, Clark MR, Sewell HF, Shakib F. The use of phage-peptide libraries to define the epitope specificity of a mouse monoclonal anti-Der p 1 antibody representative of a major component of the human immunoglobulin E anti-Der p 1 response. Clin Exp Allergy. 1999;29(11):1563–71. · DOI
  71. Lynch I, Salvati A, Dawson KA. Protein-nanoparticle interactions: What does the cell see? Nat Nanotechnol. 2009;4(9):546–7. doi: 10.1038/nnano.2009.248 . · DOI
  72. Monopoli MP, Aberg C, Salvati A, Dawson KA. Biomolecular coronas provide the biological identity of nanosized materials. Nat Nanotechnol. 2012;7(12):779–86. doi: 10.1038/nnano.2012.207 . · DOI · Paper page
  73. Bessot J, Pauli G. Mite allergens: an overview. Eur Ann Allergy Clin Immunol. 2011;43(5):141.
  74. Schlinkert P, Casals E, Boyles M, Tischler U, Hornig E, Tran N, et al. The oxidative potential of differently charged silver and gold nanoparticles on three human lung epithelial cell types. J Nanobiotechnol. 2015;13(1):1. doi: 10.1186/s12951-014-0062-4 . · DOI
  75. El-Sayed M, Ginski M, Rhodes C, et al. Transepithelial transport of poly(amidoamine) dendrimers across Caco-2 cell monolayers. J Control Release. 2002;81(3):355–65. · DOI

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Metadata

Authors
Radauer-Preiml, I., Andosch, A., Hawranek, T., Luetz-Meindl, U., Wiederstein, M., Horejs-Hoeck, J., Himly, M., Boyles, M., & Duschl, A.
Venue
Particle and Fibre Toxicology
Publisher
Springer Science and Business Media LLC
Published
2015-12
Volume
13
Issue
1
ISSN
1743-8977
DOI
10.1186/s12989-016-0113-0
PMC
PMC4715273
Cited by
56
References
3
Language
en
Funders
Seventh Framework Programme (BE) (263147)

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This page
CoChat. (2026). Citation check: Nanoparticle-allergen interactions mediate human allergic responses: protein corona characterization and cellular responses. https://app.cochat.ai/papers/10.1186/s12989-016-0113-0
The paper
Radauer-Preiml, I., Andosch, A., Hawranek, T., Luetz-Meindl, U., Wiederstein, M., Horejs-Hoeck, J., Himly, M., Boyles, M., & Duschl, A. (2015). Nanoparticle-allergen interactions mediate human allergic responses: protein corona characterization and cellular responses. Particle and Fibre Toxicology. https://doi.org/10.1186/s12989-016-0113-0