Cited by 162Health Systems, Economic Evaluations, Quality of LifeHealth Policy Implementation ScienceHealthcare Quality and Management

The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index; 2 of the 34 sources its claims cite were checked for support.

Use of health economic evaluation in the implementation and improvement science fields—a systematic literature review

Open access
Roberts, Sarah Louise Elin, Healey, Andy, Sevdalis, Nick·2019·Implementation Science

Abstract

BACKGROUND: Economic evaluation can inform whether strategies designed to improve the quality of health care delivery and the uptake of evidence-based practices represent a cost-effective use of limited resources. We report a systematic review and critical appraisal of the application of health economic methods in improvement/implementation research. METHOD: A systematic literature search identified 1668 papers across the Agris, Embase, Global Health, HMIC, PsycINFO, Social Policy and Practice, MEDLINE and EconLit databases between 2004 and 2016. Abstracts were screened in Rayyan database, and key data extracted into Microsoft Excel. Evidence was critically appraised using the Quality of Health Economic Studies (QHES) framework. RESULTS: Thirty studies were included-all health economic studies that included implementation or improvement as a part of the evaluation. Studies were conducted mostly in Europe (62%) or North America (23%) and were largely hospital-based (70%). The field was split between improvement (N = 16) and implementation (N = 14) studies. The most common intervention evaluated (43%) was staffing reconfiguration, specifically changing from physician-led to nurse-led care delivery. Most studies (N = 19) were ex-post economic evaluations carried out empirically-of those, 17 were cost effectiveness analyses. We found four cost utility analyses that used economic modelling rather than empirical methods. Two cost-consequence analyses were also found. Specific implementation costs considered included costs associated with staff training in new care delivery pathways, the impacts of new processes on patient and carer costs and the costs of developing new care processes/pathways. Over half (55%) of the included studies were rated 'good' on QHES. Study quality was boosted through inclusion of appropriate comparators and reporting of incremental analysis (where relevant); and diminished through use of post-hoc subgroup analysis, limited reporting of the handling of uncertainty and justification for choice of discount rates. CONCLUSIONS: The quantity of published economic evaluations applied to the field of improvement and implementation research remains modest; however, quality is overall good. Implementation and improvement scientists should work closely with health economists to consider costs associated with improvement interventions and their associated implementation strategies. We offer a set of concrete recommendations to facilitate this endeavour.

Overview

AI snapshot

Written from the paper’s full text.

TL;DR

This systematic review identified 30 studies (2004–2016) applying health economic evaluation to implementation and improvement science, finding modest quantity but overall good quality. It recommends closer collaboration with health economists and better capture of implementation/hidden costs, plus greater use of ex-ante and hybrid evaluative designs.

Key findings

  • From 1668 records, 30 studies were included: 16 improvement and 14 implementation studies. Most were European (62%) or North American (23%) and hospital-based (70%).
  • The most common intervention was staffing reconfiguration in 13 studies (43%), specifically changing from physician-led to nurse-led care. Nineteen studies were ex-post empirical economic evaluations, including 17 cost-effectiveness analyses; four cost-utility analyses used economic modelling, and two were cost-consequence analyses.
  • QHES appraisal covered 22 papers: average score was 76/100, 13 studies (62%) scored >75, and one scored 100. The abstract reports over half (55%) were rated “good.” Improvement studies performed better than implementation studies.
  • Only six of 30 studies explicitly assessed implementation-related “hidden” costs such as training, development, and monitoring; three included rollout/scaling scenarios, and one considered funding sources.

Methods

  • Systematic literature search across Agris, Embase, Global Health, HMIC, PsycINFO, Social Policy and Practice, MEDLINE, and EconLit, covering publications after 2003 through 16 March 2016; 1668 papers were screened in Rayyan and extracted into Microsoft Excel.
  • Inclusion required English-language completed studies in public health/primary/secondary/tertiary care with implementation or improvement aspects, quantifiable patient/service outcomes, and specified economic methods; cost-only studies, protocols, methodological papers, and conference abstracts were excluded.
  • Methodological quality was assessed with the Quality of Health Economic Studies (QHES) framework, scoring 16 criteria out of 100, with ≥75 considered “good.”

Limitations

  • The authors state that strict inclusion criteria may have limited the number of studies identified and synthesised; they excluded cost-only studies and non-English papers, making criteria stricter than prior reviews.
  • The authors state they cannot rule out whether early-phase economic analyses are not being done or are simply not reported in academic publications.
  • Evident from the text: QHES appraisal excluded literature reviews, meta-analyses, and commentaries, so quality conclusions apply to 22 of 30 included papers; comparison with Hoomans et al. is limited because the two reviews used different quality appraisal frameworks.

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Integrity signals

Registry

Crossref · 10.1186/s13012-019-0901-7

Cites

41 of 41 references verified0 citation errors · 0 not checkable

Statistics

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Figures

Fig. 1 Consort diagram
Fig. 1 Consort diagramCC BY · PubMed Central
Fig. 2 Quality appraisal of economic evidence—distribution of QHES instrument scores
Fig. 2 Quality appraisal of economic evidence—distribution of QHES instrument scoresCC BY · PubMed Central

Verification

Claims the paper makes

39 Own result · 15 Not checked yet · 9 Own method · 8 Own interpretation · 5 No basis given · 1 Partly supported · accuracy not yet measured

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  • Probably not a substantial claim. 19
  • It may state two separate claims as one. 17
  • The quote only partly states this claim. 1
31 of 31
  • The paper relies on this without support.

    The relationship between implementation outcomes, service outcomes and patient outcomes is central to understanding the benefits and costs and overall cost-effectiveness of an intervention.

    “The relationship between implementation outcomes, service outcomes and patient outcomes is central to understanding the benefits and costs and overall cost-effectiveness of an intervention.”
  • The paper relies on this without support.

    Economic evaluation can inform choices over whether and how resources should be allocated to improve services and for implementing evidence into health care practice.

    “Economic evaluation can inform choices over whether and how resources should be allocated to improve services and for implementing evidence into health care practice.”
2 of 2

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Citations

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Research works printed but not linked: 1

  1. Elmagarmid A, Fedorowicz Z, Hammady H, Ilyas I, Khabsa M, Ouzzani M. Rayyan: a systematic reviews web app for exploring and filtering searches for eligible studies for Cochrane reviews. In: Evidence-informed public health: opportunities and challenges. Abstracts of the 22nd Cochrane colloquium. Hyderabad: Wiley; 2014. p. 21–6.

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Metadata

Authors
Roberts, S. L. E., Healey, A., & Sevdalis, N.
Affiliations
King's College London (GB)
Corresponding author
Roberts, Sarah Louise Elin
Venue
Implementation Science
Published
2019-07-15
Volume
14
Issue
1
Pages
72-72
ISSN
1748-5908 (ISSN-L)
OpenAlex
W2959993899
Cited by
161
References
41
Citations by year
2026: 14 · 2025: 20 · 2024: 22 · 2023: 26 · 2022: 30 · 2021: 26 · 2020: 21 · 2019: 1
FWCI
5.42
Type
journal article
Language
en
Open access
Locations
  • Implementation Science (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Research Portal (King's College London) (publishedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
  • Minerva Access (University of Melbourne) (submittedVersion, cc-by)
Funders
National Institute for Health Research
Topics
  • Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Health Systems, Economic Evaluations, Quality of Life
  • Health Sciences › Health Professions › General Health Professions › Health Policy Implementation Science
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Healthcare Quality and Management
Keywords
health economic evaluation, implementation research, improvement science, cost-effectiveness analysis, nurse-led care, implementation costs, cost-utility analysis, cost-consequence analysis, hospital care delivery
MeSH terms
Implementation Science, Cost-Benefit Analysis, Delivery of Health Care, Humans, Models, Economic, Evidence-Based Practice, Quality Improvement

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