NADPH oxidase in brain injury and neurodegenerative disorders

Superoxide Dismutase

McCord, J. M., & Fridovich, I. (1969) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)63504-5 · Cited by 12,952

Copper-Zinc Superoxide Dismutase (SOD1) Is Released by Microglial Cells and Confers Neuroprotection against 6-OHDA Neurotoxicity

Polazzi, E., Mengoni, I., Caprini, M., Peña‐Altamira, E., Kurtys, E., & Monti, B. (2012) · Neurosignals · doi:10.1159/000337115 · Cited by 9,023

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

Rosen, D. R., Siddique, T., Patterson, D., Figlewicz, D. A., Sapp, P., Hentati, A., Donaldson, D., Goto, J., O'Regan, J. P., Deng, H.-X., et al. (1993) · Nature · doi:10.1038/362059a0 · Cited by 7,062

The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology

Bedard, K., & Krause, K.-H. (2007) · Physiological Reviews · doi:10.1152/physrev.00044.2005 · Cited by 6,989

Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013

Vos, T., Barber, R. M., Bell, B., Bertozzi-Villa, A., Biryukov, S., Bolliger, I., Charlson, F., Davis, A., Degenhardt, L., Dicker, D., et al. (2015) · The Lancet · doi:10.1016/s0140-6736(15)60692-4 · Cited by 6,414

Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly

Beckman, J. S., & Koppenol, W. H. (1996) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1996.271.5.c1424 · Cited by 5,513

Multiple Sclerosis

Noseworthy, J. H., Lucchinetti, C. F., Rodriguez, M., & Weinshenker, B. G. (2000) · New England Journal of Medicine · doi:10.1056/nejm200009283431307 · Cited by 3,016

Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions

Ming, G.-L., & Song, H. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.001 · Cited by 2,651

The State of US Health, 1990-2010: Burden of Diseases, Injuries, and Risk Factors

Murray, C. J. L. (2013) · JAMA · doi:10.1001/jama.2013.13805 · Cited by 2,438

Recent approaches on Huntington's disease (Review)

Palaiogeorgou, A. M., Papakonstantinou, E., Golfinopoulou, R., Sigala, M., Mitsis, Τ., Papageorgiou, L., Diakou, I., Pierouli, K., Dragoumani, K., Spandidos, D. A., et al. (2022) · Biomedical Reports · doi:10.3892/br.2022.1587 · Cited by 27

Low-Dose Radiation Therapy (LDRT) against Cancer and Inflammatory or Degenerative Diseases: Three Parallel Stories with a Common Molecular Mechanism Involving the Nucleoshuttling of the ATM Protein?

Reun, E. L., & Foray, N. (2023) · Cancers · doi:10.3390/cancers15051482 · Cited by 27

Down-regulation of NOX4 by betulinic acid protects against cerebral ischemia-reperfusion in mice

Lu, P., Zhang, C., Zhang, X., Li, H., Luo, A., Tian, Y., & Xu, H. (2017) · Current Medical Science · doi:10.1007/s11596-017-1798-5 · Cited by 24

NADPH Oxidases in Neurodegenerative Disorders: Mechanisms and Therapeutic Opportunities

Fiadeiro, M. B., Diogo, J. C., Silva, A., Kim, Y., & Cristóvão, A. C. (2024) · Antioxidants and Redox Signaling · doi:10.1089/ars.2023.0002 · Cited by 25

Glucose-Sparing Action of Ketones Boosts Functions Exclusive to Glucose in the Brain

Zilberter, Y., & Zilberter, T. (2020) · eNeuro · doi:10.1523/eneuro.0303-20.2020 · Cited by 23

Dexmedetomidine Attenuates Apoptosis and Neurological Deficits by Modulating Neuronal NADPH Oxidase 2-Derived Oxidative Stress in Neonates Following Hypoxic Brain Injury

Chen, X., Chen, D., Chen, P., Chen, A., Deng, J., Wei, J., Zeng, W., & Zheng, X. (2022) · Antioxidants · doi:10.3390/antiox11112199 · Cited by 23

NOX2 inhibition enables retention of the circadian clock in BV2 microglia and primary macrophages

Muthukumarasamy, I., Buel, S. M., Hurley, J., & Dordick, J. S. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1106515 · Cited by 23

NADPH oxidase 2 deletion enhances neurogenesis following traumatic brain injury

Wang, J., Ma, M. W., Dhandapani, K. M., & Brann, D. W. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.05.069 · Cited by 23

Nox4-dependent ROS production is involved in CVB3-induced myocardial apoptosis

Chi, J., Yu, S., Liu, C., Zhao, X., Zhong, J., Liang, Y., Ta, N., Yin, X., & Zhao, D. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.07.093 · Cited by 23

Nicotinamide adenine dinucleotide phosphate oxidase activation and neuronal death after ischemic stroke

Shen, J., Rastogi, R., Geng, X., & Ding, Y. (2019) · Neural Regeneration Research · doi:10.4103/1673-5374.250568 · Cited by 22

α-Ketoadipic Acid and α-Aminoadipic Acid Cause Disturbance of Glutamatergic Neurotransmission and Induction of Oxidative Stress In Vitro in Brain of Adolescent Rats

da Silva, J. C., Amaral, A. U., Cecatto, C., Wajner, A., Godoy, K. D. S., Ribeiro, R. T., Gonçalves, A. D. M., Zanatta, Â., da Rosa, M. S., Loureiro, S. O., et al. (2017) · Neurotoxicity Research · doi:10.1007/s12640-017-9735-8 · Cited by 23

Molecular Roles of NADPH Oxidase-Mediated Oxidative Stress in Alzheimer’s Disease: Isoform-Specific Contributions

Kim, J., & Moon, J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252212299 · Cited by 26

Inhibition of lysophosphatidic acid receptor 1–3 deteriorates experimental autoimmune encephalomyelitis by inducing oxidative stress

Choi, J. H., Oh, J., Lee, M. J., Bae, H., Ko, S., Nah, S.-Y., & Cho, I. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02278-w · Cited by 22

Gintonin, a Panax ginseng-derived LPA receptor ligand, attenuates kainic acid-induced seizures and neuronal cell death in the hippocampus via anti-inflammatory and anti-oxidant activities

Choi, J. H., Kwon, T. W., Jo, H.-S., Ha, Y., & Cho, I. (2022) · Journal of Ginseng Research · doi:10.1016/j.jgr.2022.11.001 · Cited by 21

NOX4-derived ROS are neuroprotective by balancing intracellular calcium stores

Gola, L., Bierhansl, L., Csatári, J., Schroeter, C. B., Korn, L., Narayanan, V., Cerina, M., Abdolahi, S., Speicher, A., Hermann, A. M., et al. (2023) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-023-04758-z · Cited by 22

Loss of synaptic ribbons is an early cause in ROS-induced acquired sensorineural hearing loss

Kurasawa, S., Mohri, H., Tabuchi, K., & Ueyama, T. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106280 · Cited by 22

New opportunities for antioxidants in amelioration of neurodegenerative diseases

Bhandari, U. R., Danish, S. M., Ahmad, S., Ikram, M., Nadaf, A., Hasan, N., Kesharwani, P., & Ahmad, F. J. (2024) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2024.111961 · Cited by 24

Mitochondrial function is impaired in the primary visual cortex in an experimental glaucoma model

Arana, A. G. H., Vitar, R. M. L., Reides, C. G., Calabró, V., Marchini, T., Lerner, S. F., Evelson, P., & Ferreira, S. M. (2021) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2021.108815 · Cited by 21

Neutrophil-Related Ratios Predict the 90-Day Outcome in Acute Ischemic Stroke Patients After Intravenous Thrombolysis

Gao, B., Pan, W., Hu, X., Huang, H., Ren, J., Yang, C., Zhou, X., Zeng, T. S., Hu, J., Li, S., et al. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.670323 · Cited by 21

NADPH-oxidase 4 gene over-expression in peripheral blood lymphocytes of the schizophrenia patients

Ershova, E. S., Шмарина, Г. В., Мартынов, А. В., Zakharova, N. V., Veiko, R. V., Umriukhin, P. E., Kostyuk, G. P., Kutsev, S. I., Veiko, N. N., & Kostyuk, S. V. (2022) · PLoS ONE · doi:10.1371/journal.pone.0269130 · Cited by 21

The Role of Microglia in Sex- and Region-Specific Blood-Brain Barrier Integrity During Nicotine Withdrawal

Kumar, M., Keady, J. V., Aryal, S. P., Hessing, M. C., Richards, C. I., & Turner, J. R. (2023) · Biological Psychiatry Global Open Science · doi:10.1016/j.bpsgos.2023.08.019 · Cited by 17

Differing Outcome of Experimental Autoimmune Encephalitis in Macrophage/Neutrophil- and T Cell-Specific gp130-Deficient Mice

Holz, K., Prinz, M., Brendecke, S. M., Hölscher, A., Deng, F., Mitrücker, H.-W., Rose‐John, S., & Hölscher, C. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00836 · Cited by 21

Tetrahydroxystilbene Glucoside Suppresses NAPDH Oxidative Stress to Mitigate Apoptosis and Autophagy Induced by Cerebral Ischemia/Reperfusion Injury in Mice

Feng, Y., Wei, X., Dong, L., Hu, X., Huang, D., & Wang, K. (2019) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2019/3913981 · Cited by 21

KRIT1 loss-mediated upregulation of NOX1 in stromal cells promotes paracrine pro-angiogenic responses

Finetti, F., Schiavo, I., Ercoli, J., Zotta, A., Boda, E., Retta, S. F., & Trabalzini, L. (2020) · Cellular Signalling · doi:10.1016/j.cellsig.2020.109527 · Cited by 21

Role of ALK5/SMAD2/3 signaling in the regulation of NOX expression in cerebral ischemia/reperfusion injury

Lou, Z., Wang, A., Duan, X., Hu, G., Zuo, M., & Yang, Z. (2018) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2018.6377 · Cited by 20

Early Celastrol Administration Prevents Ketamine-Induced Psychotic-Like Behavioral Dysfunctions, Oxidative Stress and IL-10 Reduction in The Cerebellum of Adult Mice

Schiavone, S., Tucci, P., Trabace, L., & Morgese, M. G. (2019) · Molecules · doi:10.3390/molecules24213993 · Cited by 20

Prolyl oligopeptidase inhibition reduces oxidative stress via reducing NADPH oxidase activity by activating protein phosphatase 2A

Eteläinen, T. S., Kulmala, V., Svarcbahs, R., Jäntti, M. H., & Myöhänen, T. T. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.04.001 · Cited by 22

Cigarette smoke-induced pulmonary impairment is associated with social recognition memory impairments and alterations in microglial profiles within the suprachiasmatic nucleus of the hypothalamus

Luca, S. N. D., Chan, S. M. H., Dobric, A., Wang, H., Seow, H. J., Brassington, K., Mou, K., Alateeq, R., Akhtar, A., Bozinovski, S., et al. (2023) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2023.02.005 · Cited by 20

Reversal of β -Amyloid-Induced Microglial Toxicity In Vitro by Activation of Fpr2/3

Wickstead, E. S., Karim, H. A., Manuel, R. E., Biggs, C. S., Getting, S. J., & McArthur, S. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/2139192 · Cited by 20

MicroRNA-126a-5p Exerts Neuroprotective Effects on Ischemic Stroke via Targeting NADPH Oxidase 2

Tan, Y., Zhou, F., Yang, D., Zhang, X., Zeng, M., & Wan, L. (2021) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s293611 · Cited by 20

What Is the Role of Ferroptosis in Neurodegeneration?

Benarroch, E. E. (2023) · Neurology · doi:10.1212/wnl.0000000000207730 · Cited by 26

MiRNA-99a alleviates inflammation and oxidative stress in lipopolysaccharide-stimulated PC-12 cells and rats post spinal cord injury

Wang, R., Liu, Y., & Li, J. (2022) · Bioengineered · doi:10.1080/21655979.2022.2031386 · Cited by 19

Ketamine administration induces early and persistent neurochemical imbalance and altered NADPH oxidase in mice

Schiavone, S., Morgese, M. G., Bové, M., Colia, A. L., Maffione, A. B., Tucci, P., Trabace, L., & Cuomo, V. (2019) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2019.109750 · Cited by 19

Activation of the phagocyte NADPH oxidase/NOX2 and myeloperoxidase in the mouse brain during pilocarpine-induced temporal lobe epilepsy and inhibition by ketamine

Tannich, F., Tlili, A., Pintard, C., Chniguir, A., Eto, B., Dang, P. M., Souilem, O., & Benna, J. E. (2019) · Inflammopharmacology · doi:10.1007/s10787-019-00655-9 · Cited by 19

Urban air pollution induces alterations in redox metabolism and mitochondrial dysfunction in mice brain cortex

Calabró, V., Garcés, M., Cáceres, L., Magnani, N., Marchini, T., Freire, A., Vico, T. A., Martinefski, M., Vanasco, V., Tripodi, V. P., et al. (2021) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2021.108875 · Cited by 19

Dexmedetomidine Protects Against Chemical Hypoxia-Induced Neurotoxicity in Differentiated PC12 Cells Via Inhibition of NADPH Oxidase 2-Mediated Oxidative Stress

Chen, X.-H., Chen, D.-T., Huang, X.-M., Chen, Y.-H., Pan, J.-H., Zheng, X., & Zeng, W. (2018) · Neurotoxicity Research · doi:10.1007/s12640-018-9938-7 · Cited by 19

NADPH Oxidase 3: Beyond the Inner Ear

Herb, M. (2024) · Antioxidants · doi:10.3390/antiox13020219 · Cited by 19

Targeting integrated stress response regulates microglial M1/M2 polarization and attenuates neuroinflammation following surgical brain injury in rat

Huang, T., Luo, L., Jiang, S., Chen, C., He, H., Liang, C., Li, W., Wang, H., Zhu, L., Wang, K., et al. (2021) · Cellular Signalling · doi:10.1016/j.cellsig.2021.110048 · Cited by 18

Autophagy hub-protein p62 orchestrates oxidative, endoplasmic reticulum stress, and inflammatory responses post-ischemia, exacerbating stroke outcome

Quan, X., Yang, Y., Liu, X., Kaltwasser, B., Pillath‐Eilers, M., Walkenfort, B., Voortmann, S., Yusuf, A. M., Hagemann, N., Wang, C., et al. (2025) · Redox Biology · doi:10.1016/j.redox.2025.103700 · Cited by 17

Oxidative stress in phenylketonuria—evidence from human studies and animal models, and possible implications for redox signaling

Bortoluzzi, V. T., Filho, C. S. D., & Wannmacher, C. M. D. (2021) · Metabolic Brain Disease · doi:10.1007/s11011-021-00676-w · Cited by 17

Nox2 underpins microvascular inflammation and vascular contributions to cognitive decline

Alfieri, A., Koudelka, J., Li, M., Scheffer, S., Duncombe, J., Caporali, A., Kalaria, R. N., Smith, C., Shah, A. M., & Horsburgh, K. J. (2022) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x221077766 · Cited by 17

Knockout of Sirt2 alleviates traumatic brain injury in mice

Wang, W., Gong, Q.-Y., Cai, L., Yao, J., Yang, D.-X., Yuan, F., Chen, H., & Tian, H.-L. (2022) · Neural Regeneration Research · doi:10.4103/1673-5374.346457 · Cited by 18

Exosomal miR-370-3p increases the permeability of blood-brain barrier in ischemia/reperfusion stroke of brain by targeting MPK1

Gu, C., Mo, W., Wang, K., Gao, M., Chen, J., Zhang, F., & Shen, J. (2023) · Aging · doi:10.18632/aging.204573 · Cited by 18

Genetically targeted chemical assembly

Zhang, A., Jiang, Y., Loh, K. Y., Bao, Z., & Deisseroth, K. A. (2023) · Nature Reviews Bioengineering · doi:10.1038/s44222-023-00110-z · Cited by 18

NOX2 in Alzheimer's and Parkinson's disease

Dustin, C. M., Shiva, S. S., Vazquez, A. L., Saeed, A., Pascoal, T. A., Cifuentes-Pagano, E., & Pagano, P. J. (2024) · Redox Biology · doi:10.1016/j.redox.2024.103433 · Cited by 19

Oxidized low-density lipoprotein receptor 1: a novel potential therapeutic target for intracerebral hemorrhage

He, Z., Zhang, H.-Y., Lü, X., Hao, Y.-H., & Tang, L. (2021) · Neural Regeneration Research · doi:10.4103/1673-5374.332157 · Cited by 16

A Chlorophyll-Derived Phylloxanthobilin Is a Potent Antioxidant That Modulates Immunometabolism in Human PBMC

Karg, C., Parráková, L., Fuchs, D., Schennach, H., Kräutler, B., Moser, S., & Gostner, J. (2022) · Antioxidants · doi:10.3390/antiox11102056 · Cited by 14

Meloxicam Targets COX-2/NOX1/NOX4/Nrf2 Axis to Ameliorate the Depression-like Neuropathology Induced by Chronic Restraint Stress in Rats

Arab, H. H., Khames, A., Mohammad, M. K., Alsufyani, S. E., Ashour, A. M., El‐Sheikh, A. A. K., Darwish, H. W., & Gad, A. M. (2023) · Pharmaceuticals · doi:10.3390/ph16060848 · Cited by 16

8e Protects against Acute Cerebral Ischemia by Inhibition of PI3Kγ-Mediated Superoxide Generation in Microglia

Wang, L., Wang, X., Li, T., Zhang, Y., & Ji, H. (2018) · Molecules · doi:10.3390/molecules23112828 · Cited by 16

Nociception in a Progressive Multiple Sclerosis Model in Mice Is Dependent on Spinal TRPA1 Channel Activation

Ritter, C. D. S., Dalenogare, D. P., de Almeida, A. S., Pereira, V. L., Pereira, G. C., Fialho, M. F. P., Lückemeyer, D. D., Antoniazzi, C. T. D. D., Kudsi, S. Q., Ferreira, J., et al. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-01891-9 · Cited by 16

Antiglycoxidative properties of amantadine – a systematic review and comprehensive in vitro study

Nesterowicz, M., Żendzian‐Piotrowska, M., Ładny, J. R., Zalewska, A., & Maciejczyk, M. (2022) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756366.2022.2137161 · Cited by 16

Therapeutic potential of NOX inhibitors in neuropsychiatric disorders

Kaur, P., Khan, H., Grewal, A. K., Dua, K., & Singh, T. G. (2023) · Psychopharmacology · doi:10.1007/s00213-023-06424-5 · Cited by 15

The phosphokinase activity of IRE1ɑ prevents the oxidative stress injury through miR ‐25/Nox4 pathway after ICH

Liao, Y., Huang, J., Wang, Z., Yang, Z., Shu, Y., Gan, S., Wang, Z., & Lu, W. (2023) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14537 · Cited by 15

Current Small Molecule–Based Medicinal Chemistry Approaches for Neurodegeneration Therapeutics

Sanghai, N., Vuong, B., Berk, A. B., Afridi, M. S. K., & Tranmer, G. K. (2024) · ChemMedChem · doi:10.1002/cmdc.202300705 · Cited by 15

CB1 Receptor Activation Provides Neuroprotection in an Animal Model of Glutamate‐Induced Excitotoxicity Through a Reduction of NOX ‐2 Activity and Oxidative Stress

Martínez‐Torres, A. M., & Morán, J. (2024) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70099 · Cited by 15

Redox Regulation of Microglial Inflammatory Response: Fine Control of NLRP3 Inflammasome through Nrf2 and NOX4

Palomino‐Antolín, A., Decouty‐Pérez, C., Farré‐Alins, V., Narros‐Fernández, P., López-Rodríguez, A. B., Álvarez‐Rubal, M., Valencia, I., Lopez-Munoz, F. J., Ramos, E., Cuadrado, A., et al. (2023) · Antioxidants · doi:10.3390/antiox12091729 · Cited by 14

Cofilactin rod formation mediates inflammation-induced neurite degeneration

Uruk, G., Mocanu, E., Shaw, A. E., Bamburg, J. R., & Swanson, R. A. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.113914 · Cited by 14

A Combination of 5-(3′,4′-Dihydroxyphenyl)-γ-Valerolactone and Curcumin Synergistically Reduces Neuroinflammation in Cortical Microglia by Targeting the NLRP3 Inflammasome and the NOX2/Nrf2 Signaling Pathway

Marcolin, E., Chemello, C., Piovan, A., Barbierato, M., Morazzoni, P., Ragazzi, E., & Zusso, M. (2025) · Nutrients · doi:10.3390/nu17081316 · Cited by 15

Ataxia Telangiectasia Mutated Protein Kinase: A Potential Master Puppeteer of Oxidative Stress‐Induced Metabolic Recycling

Blignaut, M., Harries, S., Lochner, A., & Huisamen, B. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/8850708 · Cited by 14

Aged Mouse Hippocampus Exhibits Signs of Chronic Hypoxia and an Impaired HIF-Controlled Response to Acute Hypoxic Exposures

Snyder, B., Wu, H., Tillman, B., & Floyd, T. F. (2022) · Cells · doi:10.3390/cells11030423 · Cited by 13

The Interaction of Sio 2 Nanoparticles with The Neuronal Cell Membrane: Activation of Ionic Channels and Calcium Influx

Distasi, C., Dionisi, M., Ruffinatti, F. A., Gilardino, A., Bardini, R., Antoniotti, S., Catalano, F., Bassino, E., Munaron, L., Martra, G., et al. (2019) · Nanomedicine · doi:10.2217/nnm-2018-0256 · Cited by 14

Periorbital Nociception in a Progressive Multiple Sclerosis Mouse Model Is Dependent on TRPA1 Channel Activation

Dalenogare, D. P., Ritter, C. D. S., Bellinaso, F. R. A., Kudsi, S. Q., Pereira, G. C., Fialho, M. F. P., Lückemeyer, D. D., Antoniazzi, C. T. D. D., Landini, L., Ferreira, J., et al. (2021) · Pharmaceuticals · doi:10.3390/ph14080831 · Cited by 14

Cadmium-induced lung injury is associated with oxidative stress, apoptosis, and altered SIRT1 and Nrf2/HO-1 signaling; protective role of the melatonin agonist agomelatine

Alruhaimi, R. S., Hassanein, E. H. M., Bin-Jumah, M. N., & Mahmoud, A. M. (2023) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-023-02754-5 · Cited by 13

Individual susceptibility has a major impact on strong association between oxidative stress, defence systems and Parkinson's disease

Karahalıl, B., Salihoğlu, E. M., Elkama, A., Orhan, G., Saygın, E., & Yardım-Akaydin, S. (2021) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.13659 · Cited by 13

Effects of head-only or whole-body exposure to very low doses of 4He (1000 MeV/n) particles on neuronal function and cognitive performance

Rabin, B. M., Poulose, S. M., Bielinski, D. F., & Shukitt‐Hale, B. (2019) · Life Sciences in Space Research · doi:10.1016/j.lssr.2019.02.001 · Cited by 13

Aberrant neuronal excitation promotes neuroinflammation in the primary motor cortex of ischemic stroke mice

Li, T., Guo, X., Zhao, Y., Cheng, Y., Xin, D., Song, Y., Liu, D.-X., & Wang, Z. (2025) · Acta Pharmacologica Sinica · doi:10.1038/s41401-025-01518-6 · Cited by 14

Polydopamine nanoparticle-enhanced stem cell spheroid-derived decellularized extracellular matrix with antioxidant and tissue-adhesive properties for brain repair

Yang, P., Kao, Y., Lin, Y.-P., Chen, G. H., Ho, C.-H., Liu, S., Huang, S.-C., Lee, P.-Y., Chen, L., & Huang, C. (2025) · Biomaterials · doi:10.1016/j.biomaterials.2025.123530 · Cited by 12

Modeling Ischemia-Reperfusion Injury in Stroke Using the BBB Chip

Wu, Y., Zhang, M., Wang, P., Liu, H., Zhang, X., & Qin, J. (2025) · ACS Omega · doi:10.1021/acsomega.5c06071 · Cited by 14

α-Lipoic Acid Reduces Ceramide Synthesis and Neuroinflammation in the Hypothalamus of Insulin-Resistant Rats, While in the Cerebral Cortex Diminishes the β-Amyloid Accumulation

Maciejczyk, M., Żebrowska, E., Nesterowicz, M., Supruniuk, E., Choromańska, B., Chabowski, A., Żendzian‐Piotrowska, M., & Zalewska, A. (2022) · Journal of Inflammation Research · doi:10.2147/jir.s358799 · Cited by 12

The Role of Cardiolipin in Brain Bioenergetics, Neuroinflammation, and Neurodegeneration

Bradshaw, P. C., Aldridge, J. L., Jamerson, L. E., McNeal, C., Pearson, A. C., & Frasier, C. R. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04630-6 · Cited by 12

Microglial NOX2 as a therapeutic target in traumatic brain injury: Mechanisms, consequences, and potential for neuroprotection

Bano, N., Khan, S., Ahamad, S., Dar, N. J., Alanazi, H. H., Nazir, A., & Bhat, S. A. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102735 · Cited by 13

Effects of iron accumulation and its chelation on oxidative stress in intracortical implants

Franklin, M. E., Grant, J. L., Lee, G. M., Álvarez-Ciara, A., Bennett, C., Mattis, S., Gallardo, N., Corrales, N., Cui, X. T., Capadona, J. R., et al. (2025) · Acta Biomaterialia · doi:10.1016/j.actbio.2025.05.026 · Cited by 13

Nitrosative Stress Is Associated with Dopaminergic Dysfunction in the HIV-1 Transgenic Rat

Shah, S., Maric, D., Denaro, F., Ibrahim, W. G., Mason, R. P., Kumar, A., Hammoud, D. A., & Reid, W. C. (2019) · American Journal Of Pathology · doi:10.1016/j.ajpath.2019.03.004 · Cited by 12

Utility of serum NOX4 as a potential prognostic biomarker for aneurysmal subarachnoid hemorrhage

Pan, J., Lao, L., Shen, J. F., Huang, S.-C., Zhang, T., Fan, W., Yan, M., Gu, J., & Liu, W. (2021) · Clinica Chimica Acta · doi:10.1016/j.cca.2021.02.007 · Cited by 12

Intertwined associations between oxidative and nitrosative stress and endocannabinoid system pathways: Relevance for neuropsychiatric disorders

Morris, G., Walder, K. R., Berk, M., Carvalho, A. F., Marx, W., Bortolasci, C. C., Yung, A. R., Puri, B. K., & Maes, M. H. J. (2021) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2021.110481 · Cited by 13

Microorganism-Derived Molecules as Enzyme Inhibitors to Target Alzheimer’s Diseases Pathways

Nguyen, T. H., Wang, S., & Nguyen, V. B. (2023) · Pharmaceuticals · doi:10.3390/ph16040580 · Cited by 12

Appoptosin Mediates Lesions Induced by Oxidative Stress Through the JNK-FoxO1 Pathway

Zhang, C., Tan, Z., Xie, Y., Zhao, Y., Huang, T. Y., Lu, Z. C., Luo, H., Can, D., Xu, H., Zhang, Y., et al. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00243 · Cited by 12

Recent Advances in Fluorescence Imaging of Bioactive Molecules in Neurons and in Vivo

Wang, X., Li, P., Zhang, W., & Tang, B. (2019) · Chinese Journal of Analytical Chemistry · doi:10.1016/s1872-2040(19)61191-6 · Cited by 12

The significance of oxidative stress in the pathophysiology of Long COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)

Walker, M., Hall, K. H., Peppercorn, K., & Tate, W. P. (2022) · Medical Research Archives · doi:10.18103/mra.v10i9.3050 · Cited by 13

Protective Potentials of Alpha-Lipoic Acid against Ionizing Radiation-Induced Brain Damage in Rats

Xu, J., Alameri, A. A., Zabibah, R. S., Gabr, G. A., Ramírez‐Coronel, A. A., Bagheri, H., & Abedi‐Firouzjah, R. (2023) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2023/4999306 · Cited by 11

Reactive oxygen species and oxidative stress

Touyz, R. M., & Camargo, L. L. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-85492-4.00032-6 · Cited by 11

Deciphering the mechanisms underlying the neuroprotective potential of kaempferol: a comprehensive investigation

Chaubey, S., & Singh, L. (2024) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-024-03515-8 · Cited by 12

MicroRNA‐454 modulates the oxidative stress and neuronal apoptosis after cerebral ischemia/reperfusion injury via targeting NADPH oxidase 4 (NOX4)

Zhang, T., Han, H., Zhou, Y., Liu, Z., Ma, T., & Cao, X. (2022) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.23153 · Cited by 11

Neuroprotective effect of angiotensin-(1–7) against rotenone-induced oxidative damage in CATH.a neurons

Zhou, Y., Li, M., Zhu, D., Jiang, T., Gao, Q., Tang, X.-H., Zhang, S.-G., Lu, J., & Zhang, Y. (2018) · Toxicology in Vitro · doi:10.1016/j.tiv.2018.04.005 · Cited by 11

Oxidative Stress and Intracranial Hypertension after Aneurysmal Subarachnoid Hemorrhage

Hao, G., Ocak, P. E., & Mo, J. (2022) · Antioxidants · doi:10.3390/antiox11122423 · Cited by 11

ATR-IR and EPR spectroscopy for detecting the alterations in cortical synaptosomes induced by aluminium stress

Ahmed, G. A.-R., Khalil, S., hotaby, W. E., Abbas, L., Sherif, H. H. A., Abdel‐Rahman, E. A., Saber, S. H., Hassan, M. A. E., Hassan, M. H., & Ali, S. S. (2019) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2019.117535 · Cited by 11

Mitochondrial Dysfunction Contributes To Zinc-induced Neurodegeneration: a Link with NADPH Oxidase

Chauhan, A. K. S., Mittra, N., Singh, G., & Singh, C. (2022) · Journal of Molecular Neuroscience · doi:10.1007/s12031-022-02008-8 · Cited by 11

Harnessing the power of iridium AIEgens for NAD(P)H detection in aqueous medium and living cells

Gupta, A., Gautam, A., Patra, S., Kunwar, A., & Sasmal, P. K. (2025) · Chemical Communications · doi:10.1039/d5cc01124h · Cited by 10

Involvement of Reactive Oxygen Species in Prostate Cancer and Its Disparity in African Descendants

Liou, G., C’lay-Pettis, R., & Kavuri, S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25126665 · Cited by 10

Novel Approaches of Oxidative Stress Mechanisms in the Multiple Sclerosis Pathophysiology and Therapy

Adamczyk, B., Niedziela, N., & Adamczyk-Sowa, M. H. (2017) · Codon Publications eBooks · doi:10.15586/codon.multiplesclerosis.2017.ch10 · Cited by 10

Regulation of Superoxide by BAP31 through Its Effect on p22phox and Keap1/Nrf2/HO‐1 Signaling Pathway in Microglia

Liu, X., Yuan, Q., Li, G., Jia, C., Liu, J., Yang, Y., Wang, X., Hou, Y., & Wang, B. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/1457089 · Cited by 11

Hypoxia and interleukin-1-primed mesenchymal stem/stromal cells as novel therapy for stroke

Salaudeen, M. A., Allan, S. M., & Pinteaux, E. (2023) · Human Cell · doi:10.1007/s13577-023-00997-1 · Cited by 9

Exploring the mechanisms of chrysin in combating Alzheimer's disease: therapeutic perspectives

Singh, T. G., SHARMA, A. K., & Devi, S. (2024) · Journal of Applied Pharmaceutical Science · doi:10.7324/japs.2024.162341 · Cited by 9

Dietary Moringa oleifera mitigates Fluconazole-Induced immunological and spleen-histological alterations in Catfish (Clarias gariepinus)

Basry, D. M., Mansour, S., & Sayed, A. E. H. (2024) · BMC Veterinary Research · doi:10.1186/s12917-024-04173-x · Cited by 9

Monitoring in real time and far-red imaging of H2O2 dynamics with subcellular resolution

Lee, J. D., Nguyen, A., Gibbs, C. E., Jin, Z. R., Wang, Y., Moghadasi, A., Wait, S. J., Choi, H., Evitts, K. M., Asencio, A., et al. (2025) · Nature Chemical Biology · doi:10.1038/s41589-025-01891-7 · Cited by 13

Microglia energy metabolism: A new perspective on Alzheimer's disease treatment

Wu, Q.-L., Yang, X., Luo, J.-X., Liu, L., Zhou, Y., & Lu, M. (2025) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2025.123585 · Cited by 12

Mechanisms of delayed ischemia/reperfusion evoked ROS generation in the hippocampal CA1 zone of adult mouse brain slices

Medvedeva, Y. V., Sharman, E. H., & Weiss, J. H. (2025) · Scientific Reports · doi:10.1038/s41598-025-07070-x · Cited by 9

Peripheral and central effects of NADPH oxidase inhibitor, mitoapocynin, in a rat model of diisopropylfluorophosphate (DFP) toxicity

Meyer, C., Rao, N. S., Vasanthi, S. S., Pereira, B., Gage, M., Putra, M. R. E., Holtkamp, C., Huss, J., & Thippeswamy, T. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1195843 · Cited by 9

Association of NOS1 gene polymorphisms with cerebral palsy in a Han Chinese population: a case-control study

Yu, T., Xia, L., Bi, D., Wang, Y., Shang, Q., Zhu, D., Song, J., Wang, Y., Wang, X., Zhu, C., et al. (2018) · BMC Medical Genomics · doi:10.1186/s12920-018-0374-6 · Cited by 9

The Role of NADPH Oxidase in Neuronal Death and Neurogenesis after Acute Neurological Disorders

Lee, S. H., Lee, M., Ko, D. G., Choi, B. Y., & Suh, S. W. (2021) · Antioxidants · doi:10.3390/antiox10050739 · Cited by 32

NADPH oxidases: novel therapeutic targets for neurodegenerative diseases

Gao, H., Zhou, H., & Hong, J. (2012) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2012.03.008 · Cited by 219

The Role of NADPH Oxidases and Oxidative Stress in Neurodegenerative Disorders

Tarafdar, A., & Pula, G. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19123824 · Cited by 373

NADPH oxidases in Parkinson’s disease: a systematic review

Bélarbi, K., Cuvelier, E., Destée, A., Gressier, B., & Chartier‐Harlin, M. (2017) · Molecular Neurodegeneration · doi:10.1186/s13024-017-0225-5 · Cited by 161

NADPH Oxidases in Neurodegenerative Disorders: Mechanisms and Therapeutic Opportunities

Fiadeiro, M. B., Diogo, J. C., Silva, A., Kim, Y., & Cristóvão, A. C. (2024) · Antioxidants and Redox Signaling · doi:10.1089/ars.2023.0002 · Cited by 25