Cited by 433Redox biology and oxidative stressNitric Oxide and Endothelin EffectsNeutrophil, Myeloperoxidase and Oxidative Mechanisms

The DOI matches its Crossref record; 417 of the 417 references it cites were found in a registry or an index.

NADPH oxidase in brain injury and neurodegenerative disorders

Open access

Ma, Merry W., Wang, Jing, Zhang, Quanguang, Wang, Ruimin, Dhandapani, Krishnan M., Vadlamudi, Ratna K., Brann, Darrell W.·2017·Molecular Neurodegeneration

DOI 10.1186/s13024-017-0150-7PMC PMC5240251

Open this paper in CoChat — free account Open PDF

Abstract

Oxidative stress is a common denominator in the pathology of neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, and multiple sclerosis, as well as in ischemic and traumatic brain injury. The brain is highly vulnerable to oxidative damage due to its high metabolic demand. However, therapies attempting to scavenge free radicals have shown little success. By shifting the focus to inhibit the generation of damaging free radicals, recent studies have identified NADPH oxidase as a major contributor to disease pathology. NADPH oxidase has the primary function to generate free radicals. In particular, there is growing evidence that the isoforms NOX1, NOX2, and NOX4 can be upregulated by a variety of neurodegenerative factors. The majority of recent studies have shown that genetic and pharmacological inhibition of NADPH oxidase enzymes are neuroprotective and able to reduce detrimental aspects of pathology following ischemic and traumatic brain injury, as well as in chronic neurodegenerative disorders. This review aims to summarize evidence supporting the role of NADPH oxidase in the pathology of these neurological disorders, explores pharmacological strategies of targeting this major oxidative stress pathway, and outlines obstacles that need to be overcome for successful translation of these therapies to the clinic.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1186/s13024-017-0150-7

Cites

417 of 417 references verified0 citation errors · 0 not checkable

Statistics

Fig. 1 a Cellular Sources of ROS. ROS can be generated intracellularly via the action of various organelles, enzymes, and processes. b Conversion of Superoxide to Secondary ROS. Once produced, superoxide can interact with various molecules to generate secondary radicals. Superoxide can react with nitric oxide to produce peroxynitrite. Superoxide dismutase can also convert superoxide into hydrogen peroxide, which can then undergo a Fenton reaction to produce hydroxyl radicals and ions. Interaction of superoxide with protons can produce hydroperoxyl radicals. These secondary radicals are highly reactive and can be neurotoxic via alterations of macromolecules and amplification of oxidative stressCC BY · PubMed Central

Fig. 2 NOX isoforms and regulatory subunits. NADPH oxidases have a primary role to generate ROS. Several components and domains make up the transmembrane active enzyme complexes of NADPH oxidase isoforms. NOX1-5 and DUOX1/DUOX2 are shown here. Upon activation, an electron will be transferred from NADPH to O2 to form superoxide. NOX4 generated superoxide undergoes rapid conversion into hydrogen peroxide, which mediates many of its downstream effects. NOX5 and the DUOX enzymes are sensitive to cellular Ca2+ concentrationsCC BY · PubMed Central

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

1 retracted

Elevated NADPH oxidase activity contributes to oxidative stress and cell death in Huntington's disease
Valencia, A., Sapp, E., Kimm, J. S., McClory, H., Reeves, P., Alexander, J. S., Ansong, K. A., Masso, N., Frosch, M. P., Kegel, K. B., et al. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds516 · Cited by 95
Retracted
Superoxide Dismutase
McCord, J. M., & Fridovich, I. (1969) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)63504-5 · Cited by 12,952
Copper-Zinc Superoxide Dismutase (SOD1) Is Released by Microglial Cells and Confers Neuroprotection against 6-OHDA Neurotoxicity
Polazzi, E., Mengoni, I., Caprini, M., Peña‐Altamira, E., Kurtys, E., & Monti, B. (2012) · Neurosignals · doi:10.1159/000337115 · Cited by 9,023
Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis
Rosen, D. R., Siddique, T., Patterson, D., Figlewicz, D. A., Sapp, P., Hentati, A., Donaldson, D., Goto, J., O'Regan, J. P., Deng, H.-X., et al. (1993) · Nature · doi:10.1038/362059a0 · Cited by 7,062
The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology
Bedard, K., & Krause, K.-H. (2007) · Physiological Reviews · doi:10.1152/physrev.00044.2005 · Cited by 6,989
Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013
Vos, T., Barber, R. M., Bell, B., Bertozzi-Villa, A., Biryukov, S., Bolliger, I., Charlson, F., Davis, A., Degenhardt, L., Dicker, D., et al. (2015) · The Lancet · doi:10.1016/s0140-6736(15)60692-4 · Cited by 6,414
Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly
Beckman, J. S., & Koppenol, W. H. (1996) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1996.271.5.c1424 · Cited by 5,513
Multiple Sclerosis
Noseworthy, J. H., Lucchinetti, C. F., Rodriguez, M., & Weinshenker, B. G. (2000) · New England Journal of Medicine · doi:10.1056/nejm200009283431307 · Cited by 3,016
Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions
Ming, G.-L., & Song, H. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.001 · Cited by 2,651
The State of US Health, 1990-2010: Burden of Diseases, Injuries, and Risk Factors
Murray, C. J. L. (2013) · JAMA · doi:10.1001/jama.2013.13805 · Cited by 2,438

Show all 417 references

Sorted by citations

Items 301–400 of 433

Adolescent traumatic brain injury leads to incremental neural impairment in middle-aged mice: role of persistent oxidative stress and neuroinflammation
Chen, Z., Wang, P., Cheng, H., Wang, N., Wu, M., Wang, Z., Wang, Z., Dong, W., Guan, D., Wang, L., et al. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1292014 · Cited by 11
Valproic Acid Inhibits Endoplasmic Reticulum Stress and Reduces Ferroptosis After Traumatic Brain Injury
Chen, J., Li, L., Huang, L., Zhao, C., & Ruan, Z. (2024) · Dose-Response · doi:10.1177/15593258241303646 · Cited by 8
Combination therapies and other therapeutic approaches targeting the NLRP3 inflammasome and neuroinflammatory pathways: a promising approach for traumatic brain injury
Montazeri-Khosh, Z., Ebrahimpour, A., Keshavarz, M., Sheybani‐Arani, M., & Samiei, A. (2025) · Immunopharmacology and Immunotoxicology · doi:10.1080/08923973.2024.2444956 · Cited by 8
Functional characteristics, intercellular interactions and pathophysiological associations of astrocytes in Parkinson’s disease
Li, Z., Cao, M., Yin, Z., Li, X., Wang, Q., Dong, P., & Zhou, C. (2025) · PeerJ · doi:10.7717/peerj.19998 · Cited by 10
Thymoquinone Attenuates Retinal Expression of Mediators and Markers of Neurodegeneration in a Diabetic Animal Model
Alkharfy, K. M., Ahmad, A., Siddiquei, M. M., Mohammad, G., & El‐Asrar, A. M. A. (2022) · Current Molecular Pharmacology · doi:10.2174/1874467215666220113105300 · Cited by 8
Altered Blood and Brain Expression of Inflammation and Redox Genes in Alzheimer’s Disease, Common to APPV717I × TAUP301L Mice and Patients
Cucoș, C. A., Milanesi, E., Dobre, M., Musat, I. A., Manda, G., & Cuadrado, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105799 · Cited by 8
Effect of Vitamin E on Transcriptomic Alterations in Alzheimer’s Disease
Ekeuku, S. O., Murshid, N. M., Shukri, S. N., Sahardi, N. F. N. M., & Makpol, S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241512372 · Cited by 9
GLP-1(7–36) protected against oxidative damage and neuronal apoptosis in the hippocampal CA region after traumatic brain injury by regulating ERK5/CREB
Wang, S., Liu, A., Xu, C., Hou, J., & Hong, J. K. (2024) · Molecular Biology Reports · doi:10.1007/s11033-024-09244-8 · Cited by 8
Advances in brain ischemia mechanisms and treatment approaches: Recent insights and inflammation-driven risks
Kim, D., Morikawa, S., Nakagawa, T., Okano, H., & Kase, Y. (2025) · Experimental Neurology · doi:10.1016/j.expneurol.2025.115177 · Cited by 8
Proteomic profile differentiating between mesial temporal lobe epilepsy with and without hippocampal sclerosis
Furukawa, A., Kakita, A., Chiba, Y., Kitaura, H., Fujii, Y., Fukuda, M., Kameyama, S., & Shimada, A. (2020) · Epilepsy Research · doi:10.1016/j.eplepsyres.2020.106502 · Cited by 8
NADPH Oxidase: a Possible Therapeutic Target for Cognitive Impairment in Experimental Cerebral Malaria
Simhadri, P. K., & Babu, P. P. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02598-1 · Cited by 7
NOX4 Deficiency Exacerbates the Impairment of Cystatin C-Dependent Hippocampal Neurogenesis by a Chronic High Fat Diet
Jiranugrom, P., Yoo, I. D., Park, M. W., Ryu, J. H., Moon, J., & Yi, S. S. (2020) · Genes · doi:10.3390/genes11050567 · Cited by 8
The NADPH Oxidase Inhibitor, Mitoapocynin, Mitigates DFP-Induced Reactive Astrogliosis in a Rat Model of Organophosphate Neurotoxicity
Meyer, C., Grego, E., Vasanthi, S. S., Rao, N. S., Massey, N., Holtkamp, C., Huss, J., Showman, L. J., Narasimhan, B., & Thippeswamy, T. (2023) · Antioxidants · doi:10.3390/antiox12122061 · Cited by 7
Excitotoxic neuronal death requires superoxide entry into neurons through volume-regulated anion channels
Harris, K., Won, S. J., Uruk, G., Mai, N., Ogut, D., Zhao, Y., Xie, L., Baxter, P. S., Everaerts, K., Sah, R., et al. (2025) · Science Advances · doi:10.1126/sciadv.adw0424 · Cited by 7
Neuroprotective Potential of Polydatin Against Motor Abnormalities and Dopaminergic Neuronal Loss in Rotenone Induced Parkinson Model
Ahmed, M. R., Shaikh, M. A., Baloch, N. A., Nazir, S., Abrar, H., & Ulhaq, H. S. I. (2018) · International Journal of Morphology · doi:10.4067/s0717-95022018000200584 · Cited by 7
OGA Inhibition Alters Energetics and Nutrient Sensing in Alzheimer’s Disease Cytoplasmic Hybrids
Flax, J., Wilkins, H., Miller, R., Griffith, S., Cork, G. K., Qiang, A., Thompson, J. A., Swerdlow, R. H., & Slawson, C. M. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-200996 · Cited by 7
Discovery of a NADPH oxidase inhibitor, (E)-3-cyclohexyl-5-(4-((2-hydroxyethyl)(methyl)amino)benzylidene)-1-methyl-2-thioxoimidazolidin-4-oneone, as a novel therapeutic for Parkinson's disease
Shim, S., Jeong, D. U., Kim, H., Kim, C. Y., Park, H., Jin, Y., Kim, K., Lee, H. J., Kim, D. H., Bae, Y. S., et al. (2022) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2022.114854 · Cited by 7
Biochemical regulatory processes in the control of oxidants and antioxidants production in the brain of rats with iron and copper chronic overloads
Saporito-Magriñá, C., Lairion, F., Musacco-Sebio, R., Fuda, J., Torti, H., & Repetto, M. G. (2022) · JBIC Journal of Biological Inorganic Chemistry · doi:10.1007/s00775-022-01960-5 · Cited by 6
Improved Synthesis of Effective 3-(Indolin-6-yl)-4-(N-pyrazole-sulfonamide)-1H-pyrrolo[2,3-b]pyridine-Based Inhibitors of NADPH Oxidase 2
Potapov, K. V., Platonov, D. N., Belyy, A. Y., Novikov, M. A., Tomilov, Y. V., Anashkina, A. A., Mukhina, K. A., Kechko, O. I., Solyev, P. N., Новиков, Р. А., et al. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26083647 · Cited by 7
A dual-responsive fluorescent probe for simultaneous detection of H2S and SO2 and its application in an oxidative stress model of neuronal cells
Gu, B., Zhao, L., Liu, M., He, C., Wang, Y., Chen, J., Yu, G., & Gao, Y. (2025) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2025.109291 · Cited by 6
Role of the Polyol Pathway in Locomotor Recovery and Wallerian Degeneration after Spinal Cord Contusion Injury
Zeman, R. J., Wen, X., Ouyang, N., Brown, A. M., & Etlinger, J. D. (2021) · Neurotrauma Reports · doi:10.1089/neur.2021.0018 · Cited by 6
Mechanical Stretching-Induced Traumatic Brain Injury Is Mediated by the Formation of GSK-3β-Tau Complex to Impair Insulin Signaling Transduction
Cheng, P., Wu, Y., Wong, T., Sun, G., & Tseng, C. (2021) · Biomedicines · doi:10.3390/biomedicines9111650 · Cited by 6
Protective effect of exogenous peroxiredoxin 6 and thymic peptide thymulin on BBB conditions in an experimental model of multiple sclerosis
Lunin, S. M., Novoselova, E. G., Glushkova, O. V., Parfenyuk, S. B., Kuzekova, A. A., Novoselova, T. V., Sharapov, M. G., Mubarakshina, E. K., Goncharov, R. G., & Khrenov, M. O. (2023) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2023.109729 · Cited by 7
Neuronal NADPH oxidase is required for neurite regeneration of Aplysia bag cell neurons
Alam, S. M. S., Watanabe, Y., Steeno, B. L., Dutta, S., Szilagyi, H., Wei, A., & Suter, D. M. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.15977 · Cited by 6
Neuroprotective effects of Olea europaea L. leaf extract on neuroinflammation and memory impairment induced by toluene and noise exposure: Assessing brain changes in rat
Attia, T. B., Horchani, M., Salhi, M., Ali, R. B., Jannet, H. B., Kacem, L. B. H., May, M. V. E., López‐Maldonado, E. A., & Mhamdi, A. (2024) · Journal of Functional Foods · doi:10.1016/j.jff.2024.106489 · Cited by 8
Impact of endurance training on mitochondrial H2O2 production and NRF2 levels in different rat organs
Gałgański, Ł., Wojcicki, K., Jarmuszkiewicz, W., & Zoladz, J. A. (2025) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2025.1653162 · Cited by 5
Molecular Targets for Intracranial Aneurysm Treatment
Hutchinson, H. J., Rezk, R., Farag, M., Hanna, A. G., & Lucke-Wold, B. P. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262010053 · Cited by 5
Isoamericanin A improves lipopolysaccharide ‐induced memory impairment in mice through suppression of the nicotinamide adenine dinucleotide phosphateoxidase‐dependent nuclear factor kappa B signaling pathway
Yang, Y., Chen, R., Che, Y., Yao, X., Fang, M., Wang, Y., Zhou, D., Li, N., & Hou, Y. (2023) · Phytotherapy Research · doi:10.1002/ptr.7858 · Cited by 5
Ser/Thr protein kinase Bβ-NADPH oxidase 2 signaling in thromboinflammation
Li, J., & Cho, J. (2017) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000365 · Cited by 5
Exploring a shared genetic signature and immune infiltration between spontaneous intracerebral hemorrhage and Helicobacter pylori infection
Liu, X., Li, M., Han, Q., Zhengyao, Z., Wang, Q., Su, D., Fan, M., & Chen, T. (2023) · Microbial Pathogenesis · doi:10.1016/j.micpath.2023.106067 · Cited by 5
Breast cancer 1 (BRCA1) protection in altered gene expression and neurodevelopmental disorders due to physiological and ethanol-enhanced reactive oxygen species formation
Drake, D. M., Zhen, D., Kerrebijn, I., Or, B., Gao, S. W., Afsharian, K., Tran, J., Bhatia, S., Cheng, A., & Wells, P. G. (2023) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2023.08.006 · Cited by 5
Electrochemical micro- and nanobiosensors for in vivo reactive oxygen/nitrogen species measurement in the brain
Beigloo, F., Khoshkar-Vandi, S. A., Pourmand, E., Heydari, M., Molaabasi, F., Gharib, N., Zare, Y., Rhee, K. Y., & Park, S. (2023) · Nanotechnology Reviews · doi:10.1515/ntrev-2023-0124 · Cited by 6
Basic Properties of Anthocyanin for Pain Management
Widyadharma, I. P. E., Soejitno, A., Jawi, M., Purwata, T. E., Suprapta, D. N., & Sudewi, A. A. R. (2020) · Open Access Macedonian Journal of Medical Sciences · doi:10.3889/oamjms.2020.4539 · Cited by 5
OxInflammation in Alzheimer’s disease
Cervellati, C., Zuliani, G., & Valacchi, G. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.374144 · Cited by 5
Oxidative Stress in Neurodegenerative Diseases
Alami, M., Fülöp, T., Boumezough, K., Khalil, A., Zerif, E., & Berrougui, H. (2024) · Springer eBooks · doi:10.1007/978-3-031-69962-7_4 · Cited by 6
Ferroptosis in Nervous System Diseases
Wan, J., Yang, X., & Wang, J. (2019) · Springer eBooks · doi:10.1007/978-3-030-26780-3_10 · Cited by 5
Far-red and sensitive sensor for monitoring real time H 2 O 2 dynamics with subcellular resolution and in multi-parametric imaging applicationsPreprint
Lee, J. D., Nguyen, A., Jin, Z. R., Moghadasi, A., Gibbs, C. E., Wait, S. J., Evitts, K. M., Asencio, A., Bremner, S. B., Zuniga, S., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.02.06.579232 · Cited by 5
Oxidative stress promotes intervertebral disc degeneration through NAT10-mediated IKKβ N4-acetylcytidine modification
Wang, Z., Chen, S., Guo, W., Zhang, W., Mao, C., Tang, X., & Wei, J. (2025) · Cellular Signalling · doi:10.1016/j.cellsig.2025.111918 · Cited by 4
Neuroprotective Effect of Mixed Mushroom Mycelia Extract on Neurotoxicity and Neuroinflammation via Regulation of ROS-Induced Oxidative Stress in PC12 and BV2 Cells
Lee, S.-S., Ko, D.-H., Kim, S.-Y., Lee, G.-Y., Han, S. Y., Park, J.-Y., Park, M. S., Kim, H., Kim, Y.-E., & Yoo, Y. C. (2025) · Cells · doi:10.3390/cells14130977 · Cited by 4
Reprogramming brain-resident macrophages: from disease drivers to therapeutic allies in neurological disorders
Zhao, P., Li, S., Liu, Q., Peng, X.-C., Liu, L., Yang, F.-Y., Wang, C., Qian, F., & Tang, F.-R. (2026) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2026.1726194 · Cited by 6
Modulation of Innate Immune Memory Dynamics by Subcellular Reactive Oxygen Species
Geng, S., Lin, R., Wu, Y., Wang, J., & Li, L. (2023) · Antioxidants and Redox Signaling · doi:10.1089/ars.2023.0304 · Cited by 5
Mito-Apocynin Protects Against Kainic Acid-Induced Excitotoxicity by Ameliorating Mitochondrial Impairment
Lin, M., Wu, H., Wan, X., Liu, N., Jiang, Y., Sheng, Y.-C., Wang, J., Xu, H., Xue, J., Qin, Z., et al. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-04827-3 · Cited by 4
Artificial intelligence: Ways and means for central nervous system (CNS) delivery
Patel, S., Patel, K., & Patel, A. K. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-23841-3.00015-7 · Cited by 4
Therapeutic correlation of NOX4 and diabetes-mediated neurodegeneration
Tiwari, C., Khan, H., Grewal, A. K., & Singh, T. G. (2023) · Obesity Medicine · doi:10.1016/j.obmed.2023.100515 · Cited by 4
Fasudil mediates neuroprotection in ischemia/reperfusion by modulating the ROCK-PPARα-NOX axis
Yang, X., & Wang, G. (2023) · Acta Cirúrgica Brasileira · doi:10.1590/acb387023 · Cited by 4
Neither Excessive Nitric Oxide Accumulation nor Acute Hyperglycemia Affects the N-Acetylaspartate Network in Wistar Rat Brain Cells
Zyśk, M., Pikuł, P., Kowalski, R. G., Lewandowski, K. C., Sakowicz‐Burkiewicz, M., & Pawełczyk, T. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228541 · Cited by 4
Expression and Roles of Free Radicals and Reactive Oxygen Species in Hearing Loss
Lee, J. M., Cha, Y. J., Oh, Y. J., Kim, H. O., Kim, S. S., Kim, Y., Yon, D. K., & Yeo, S. G. (2025) · Antioxidants · doi:10.3390/antiox14121397 · Cited by 4
Acrylamide-Induced Neuroendocrine Disruption in Adult Male Zebrafish (Danio rerio): Mechanistic Insights into Locomotor, Neuronal, and Reproductive Impairments
Banerjee, S., Samanta, A., Ghosh, S., Das, S., & Maitra, S. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05471-7 · Cited by 3
Overcoming Oxidative Stress in Parkinson’s Disease: NADPH Oxidase 4 (NOX4) as a Potential Therapeutic Target
Xu, X., Wang, Q., Liu, Z., Li, J., Wang, S., & Qian, L. (2026) · Antioxidants · doi:10.3390/antiox15050571 · Cited by 4
C-Phycocyanin and Phycocyanobilin for neuroprotection: a deep dive into the biological processes involved
Pentón‐Rol, G., Marín‐Prida, J., Sarduy-Chávez, R. D. L. C., & Hernández-González, I. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-23763-8.00016-6 · Cited by 3
Metoprolol exacerbates dementia in scopolamine-induced cognitive impairment in rats: A potential role of NADPH oxidase
Sharaf, A. M., Muhammad, R. N., Khalifa, H. O., Kandil, E. A., & Ahmed, L. A. (2025) · Neuropharmacology · doi:10.1016/j.neuropharm.2025.110657 · Cited by 3
Disease models in cerebral cavernous malformations
Glading, A., Finetti, F., & Trabalzini, L. (2019) · Drug Discovery Today Disease Models · doi:10.1016/j.ddmod.2019.10.009 · Cited by 3
Antioxidative Strategy in Traumatic Brain Injury: Role of Low-Molecular-Weight Antioxidants
Bulama, I., Saidu, U. F., Suleiman, N., Abbas, A. Y., SAİDU, Y., Yakubu, Y., Ismail, N. J., & Bilbis, L. S. (2024) · Gaziantep Islam Science and Technology University · doi:10.46871/eams.1346139 · Cited by 3
Exploring different mechanisms of reactive oxygen species formation in hypoxic conditions at the hippocampal CA3 area
Alves, J. L., Quinta-Ferreira, R. M., Quinta-Ferreira, M. E., & Matias, C. M. (2025) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2025.112517 · Cited by 3
Tolfenamic acid inhibits ROS-generating oxidase Nox1-regulated p53 activity in intrastriatal injection of malonic acid rats
Yang, X. P., Zhang, H., Qu, T., Wang, Y., Zhong, Y., Yan, Y., Ji, X., Chi, T., Liu, P., & Zou, L. (2022) · The Journal of Physiological Sciences · doi:10.1186/s12576-022-00842-4 · Cited by 2
A small-molecular photoacoustic probe for reversible and ratiometric imaging oxidative stress dynamics in acute liver injury mice
Liu, H., Zhou, Y. M., Gao, H., Xu, H., & Liu, Z. (2025) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2025.126551 · Cited by 2
Remote ischemic conditioning as a potential therapy for Parkinson’s Disease: Inhibiting TLR4-Driven neuroinflammation and oxidative damage
Cai, L., Ding, Y., Tekreeti, A. A., Li, F., Zhu, Y., Geng, X., & Ji, X. (2025) · Brain Research · doi:10.1016/j.brainres.2025.149920 · Cited by 2
Imidazolium-tethered red-emissive iridium AIEgen for sensitive detection of NAD(P)H in aqueous and cellular media
Gautam, A., Gupta, A., Chauhan, D., Kunwar, A., & Sasmal, P. K. (2026) · Journal of Materials Chemistry B · doi:10.1039/d5tb02044a · Cited by 2
Multiomics Investigation of Hypertension and White Matter Hyperintensity as a Source of Vascular Dementia or a Comorbidity to Alzheimer’s Disease
Pathak, G. A., Barber, R. C., & Phillips, N. (2021) · Current Alzheimer Research · doi:10.2174/1567205018666210422133547 · Cited by 2
Posttraumatic epilepsy: clinical, diagnostic and therapeutic features
Евгеньевич, М. Н., Литвинова, А. А., Kovalev, P. S., Maslova, N. N., Юрьева, Н. В., & Хамцова, Е. И. (2022) · Epilepsy and Paroxysmal Conditions · doi:10.17749/2077-8333/epi.par.con.2021.100 · Cited by 2
Knockout of neutrophil cytosolic factor 1 ameliorates neuroinflammation and motor deficit after traumatic brain injury
Gao, T.-X., Liang, Y., Li, J., Zhao, D., Dong, B.-J., Xu, C., Zhao, W., Li, X., & Zhao, C. (2024) · Experimental Neurology · doi:10.1016/j.expneurol.2024.114983 · Cited by 2
Neuroprotective Effect of Benzyl Ferulate on Ischemia/Reperfusion Injury via Regulating NOX2 and NOX4 in Rats
Xiang, Y., Mao, L., Dai, Z.-H., Liu, X.-H., & Yang, Z. (2024) · Advances in Pharmacological and Pharmaceutical Sciences · doi:10.1155/2024/5534135 · Cited by 2
Targeting PTGS2/NF-κB Pathway: MG-132’s Role in Reducing Ischemic Stroke Injury
Wang, Y., Huang, Y., Wang, Y., Zheng, Y.-X., Gao, Y.-R., Wu, M., Gao, F.-H., Wang, H., Liu, K., & Lin, Y. (2025) · Biochemical Genetics · doi:10.1007/s10528-025-11155-7 · Cited by 2
Serum Nox1 and Gper Levels in Patients With Generalized Anxiety Disorder: A Cross‐Sectional Study in Turkiye
Hurşıtoğlu, O., Kurutaş, E. B., Uygur, Ö. F., Öztürk, N., Uygur, H., Sağlam, F., & Strawbridge, R. (2025) · Brain and Behavior · doi:10.1002/brb3.70645 · Cited by 3
Increased Ribosome Biogenesis and Increased Oxidative Stress in Blood Leukocytes of Patients With Catatonic Schizophrenia Compared With Paranoid Schizophrenia
Ershova, E. S., Вейко, Н. Н., Agafonova, O. N., Мартынов, А. В., Veiko, R. V., Porokhovnik, L. N., Салимова, Т. А., Kostyuk, G. P., Zakharova, N. V., & Kostyuk, S. V. (2025) · Frontiers in Bioscience-Landmark · doi:10.31083/fbl39426 · Cited by 2
Green tea’s secret weapon: a review on the protective effects of epigallocatechin-3-gallate against ischemia/reperfusion damage
Wang, Y., Cao, Y., & Zhao, Y. (2025) · Pharmacological Reports · doi:10.1007/s43440-025-00781-y · Cited by 2
Genetic Factors and Long-term Treatment-Related Neurocognitive Deficits, Anxiety, and Depression in Childhood Leukemia Survivors: An Exome-Wide Association Study
Petrykey, K., Lippé, S., Sultan, S., Robaey, P., Drouin, S., Bertout, L., Beaulieu, P., St-Onge, P., Baedke, J. L., Yasui, Y., et al. (2023) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-23-0634 · Cited by 3
Free Radicals in Oxidative Stress, Aging, and Neurodegenerative Disorders
Biney, R. P., Mpofana, T., & Kasanga, E. A. (2018) · Advances in medical diagnosis, treatment, and care (AMDTC) book series · doi:10.4018/978-1-5225-5282-6.ch003 · Cited by 2
ANTIOXIDANT EFFECT OF FLAVONOIDS IN NEURODEGENERATIVE DISEASES
Bulboacă, A. E., Bolboaca, S. D., Stănescu, I., Sfrângeu, C. A., & Bulboacă, A. (2017) · Romanian Journal of Neurology · doi:10.37897/rjn.2017.2.2 · Cited by 1
Saikogenin F From Bupleurum smithii Ameliorates Learning and Memory Impairment via Antiinflammation Effect in an Alzheimer’s Disease Mouse Model
Chen, Z., Li, J., Zhao, X.-X., Yang, X.-H., Li, J., Zou, B., Zang, W.-B., Ma, R., Wang, Y., & Yao, Y. (2022) · Natural Product Communications · doi:10.1177/1934578x221111029 · Cited by 1
Metabolic correction of neurodegenerative pathologies: the role of macronutrients and timing
Zilberter, Y., & Zilberter, T. (2023) · Exploration of neuroscience · doi:10.37349/en.2023.00013 · Cited by 1
Penehyclidine hydrochloride improves cognitive function of rats with brain injury via CAMP/CREB signaling pathway
Wang, Y., Zhao, W., Zhu, S., & Wei, L. (2024) · Cellular and Molecular Biology · doi:10.14715/cmb/2024.70.5.32 · Cited by 1
Fabrication and optimization of verapamil-loaded PEGylated nanoparticles for management of traumatic brain injury: a comparative evaluation
Amin, O. M., Khalifa, M. K. A., El-Fattah, M. A. A., Allam, A., Aboutaleb, A. S., & Al‐Najjar, A. H. (2025) · Pharmaceutical Development and Technology · doi:10.1080/10837450.2025.2592102 · Cited by 1
Mechanisms to medicines: navigating drug repurposing strategies in Alzheimer’s disease
Khan, S. A., Raza, K., Tiwari, P., El‐Tanani, M., Rabbani, S. A., & Parvez, S. (2026) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2025.1676065 · Cited by 1
Uncovering the metabolic variations of sulfur dioxide in the brain of Parkinson’s disease and air pollution: From imaging to therapeutic evaluations
Ke, J., Zang, S., & HU, F. (2026) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2026.142478 · Cited by 1
Integrated proteomic and metabolomic analyses implicate redox-metabolic pathways in PTSD-associated multisystem disease and accelerated aging
Kuan, P. F., Mann, F. D., Yang, X., Kotov, R., Clouston, S., Ilkayeva, O., Muehlbauer, M. J., Newgard, C. B., & Luft, B. J. (2026) · Nature Communications · doi:10.1038/s41467-026-74757-8 · Cited by 1
From Defense to Disease: NADPH Oxidase in Cellular Function and Dysregulation
Prasad, A., Kushwaha, R., Alugoju, P., Pospíšil, P., & Rathi, D. (2026) · Journal of Immunology Research · doi:10.1155/jimr/2847417 · Cited by 1
The type 1 and type 3 immune responses underlying the tissue inflammation associated with NOX2 deficiency
Cheng, W.-T., Lin, M.-S., Chan, T., Wu, C., & Shieh, C. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1848916 · Cited by 1
Cognitive dysfunction in Parkinson's disease: Hippocampal vulnerability and redox-driven mechanisms.
Curto, A. R., Silva, A. A., Fiadeiro, M. B., Pereira, D., & Cristóvão, A. C. (2026) · Redox Biology · doi:10.1016/j.redox.2026.104318 · Cited by 1
Beneficial Effects of Some Nutraceuticals Containing Glucosamine and Antioxidant against CCL4 Induced Brain Injury in Rats
Nasr, S. A., Ahmed-Farid, O. O. A., & Zein-El-Abedeen, E.-S. A. (2019) · Open Journal of Applied Sciences · doi:10.4236/ojapps.2020.101001 · Cited by 1
Post-treatment with apocynin at a lower dose regulates the UPR branch of eIF2α and XBP-1 pathways after stroke
Nakka, V. P., Gogada, R., Simhadri, P. K., Qadeer, M. A., & Phanithi, P. B. (2022) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2022.02.003 · Cited by 1
CYBA allelic variants are associated with severity and recovery in Guillain–Barré syndrome
Törnell, A., Lagerström, N., Mossberg, N., Kiffin, R., Farman, H. H., Lycke, J., Andersen, O., Axelsson, M., Hellstrand, K., & Martner, A. (2023) · Journal of the Peripheral Nervous System · doi:10.1111/jns.12571 · Cited by 1
Effect of Vitamin E on Lipid Peroxidation and Oxidative Stress in Traumatic Brain Injury-Induced Rats
Usman, B., Sajo, M. U., Adam, M. K., Mshelia, P. A., Bulama, I., & Sanda, K. A. (2023) · Asian Journal of Research in Animal and Veterinary Sciences · doi:10.9734/ajravs/2023/v6i4262 · Cited by 1
Cytokines in Neurodegenerative Disorders
Pahan, K. (2024) · Springer eBooks · doi:10.1007/978-3-031-68237-7_12 · Cited by 1
Free Radicals in Oxidative Stress, Aging, and Neurodegenerative Disorders
Biney, R. P., Mpofana, T., & Kasanga, E. A. (2022) · IGI Global eBooks · doi:10.4018/978-1-6684-5295-0.ch015 · Cited by 1
Investigation of novel mitoNEET ligand NL-1 as a therapeutic for cerebral ischemia and reperfusion injury
Saralkar, P. A. (2021) · doi:10.33915/etd.8144 · Cited by 1
Near-infrared light reduces β-amyloid-stimulated microglial toxicity and enhances survival of neurons: Mechanisms of light therapy for Alzheimer's diseasePreprint
Stepanov, Y. V., Golovynska, I., Zhang, R., Golovynskyi, S., Stepanova, L. I., Gorbach, O. I., Dovbynchuk, T., Garmanchuk, L., Ohulchanskyy, T. Y., & Qu, J. (2022) · Research Square · doi:10.21203/rs.3.rs-1377965/v1 · Cited by 1
Neurodegeneration and neuroinflammation are linked, but independent of α -synuclein inclusions, in a seeding/spreading mouse model of Parkinson’s diseasePreprint
Garcia, P., Wemheuer, W. M., Huarte, O. U., Schmit, K. J., Masuch, A., Brioschi, S., Weihofen, A., Koncina, E., Coowar, D., Heurtaux, T., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.08.05.237750 · Cited by 2
Approach Towards The Development Of Novel Disease Modifying Therapeutics For Parkinson's Disease
Luo, D. (2017) · Human Biology
Aging exacerbates myelin disruption and axon injury following demyelination
Michaels, N. J. (2019) · doi:10.11575/prism/36466
Temporal and spatial effects of shock overpressure on blood-brain barrier permeability in blast-induced traumatic brain injury
Kuriakose, M. (2018)
Neurodegeneration and Neuroinflammation are Linked, but Independent of α-Synuclein Inclusions, in a Seeding/Spreading Mouse Model of Parkinson’s DiseasePreprint
Garcia, P., Wemheuer, W. M., Huarte, O. U., Schmit, K. J., Masuch, A., Brioschi, S., Weihofen, A., Koncina, E., Coowar, D., Heurtaux, T., et al. (2020) · doi:10.21203/rs.3.rs-29977/v1
Ginsenoside Rg1 alleviates Aβ deposition and neuronal damage by inhibiting NLRP1 inflammasome activation in APP/PS1 micePreprint
Zhang, H., Su, Y., Sun, Z., Chen, M., Han, Y., Li, Y., Dong, X., Ding, S., Fang, Z., Li, W., et al. (2020) · Research Square · doi:10.21203/rs.3.rs-49467/v1
Clinical Neurologic Issues in Cerebrovascular Monitoring
Bleck, T. P. (2021) · Springer eBooks · doi:10.1007/978-3-030-73387-2_56
Do MTHFR C677T Genetic Polymorphism Influence in the Pathogenesis of Amyotrophic Lateral Sclerosis?Preprint
Azevedo, R. M., Santos, K. D. F., de Oliveira, R. P. D., Pereira, J. C., Bento, D. D. C. P., Reis, Â. A. D. S., & Santos, R. D. S. (2021) · Research Square · doi:10.21203/rs.3.rs-939291/v1
Five Genes as Diagnostic Markers of Ischemic Stroke and Their Correlation with Immune InfiltrationPreprint
Wang, M., Zhang, R., Guan, Q., Yao, Y., & Han, L. (2021) · Research Square · doi:10.21203/rs.3.rs-936536/v1
NADPH Oxidase Nox1 do hospedeiro contribui para a manutenção do microambiente redox e crescimento do melanoma.
de Morais, P. F. (2020) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.42.2020.tde-30092020-153153
Novel therapeutic approaches targeting oxidative stress in mood disorders
Bambokian, A., Gomes, F. A., Sjaarda, C. P., Soares, C. N., Milev, R. V., & Brietzke, E. M. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-90905-1.00001-8
Papel de las especies reactivas de oxígeno producidas por NADPH-Oxidasa en el proceso neuroinflamatorio inducido por daño excitotóxico
Sánchez-Evangelista, G. (2021) · doi:10.24275/uami.00000028p
Reconstrucción metabólica a escala genómica de una neurona humana : aplicación a lesión traumática cerebral
Cruz, A. M. P. (2020) · doi:10.11144/javeriana.10554.51054

Authors: Ma, M. W., Wang, J., Zhang, Q., Wang, R., Dhandapani, K. M., Vadlamudi, R. K., & Brann, D. W.
Affiliations: Augusta University (US)
The University of Texas at San Antonio Health Science Center (US)
Corresponding author: Brann, Darrell W.
ORCID: Ma, Merry W.
Wang, Jing
Zhang, Quanguang
Wang, Ruimin
Dhandapani, Krishnan M.
Vadlamudi, Ratna K.
Brann, Darrell W.
Venue: Molecular Neurodegeneration
Publisher: Springer Science and Business Media LLC
Published: 2017-01-17
Volume: 12
Issue: 1
Pages: 7-7
ISSN: 1750-1326 (ISSN-L)
DOI: 10.1186/s13024-017-0150-7
PMC: PMC5240251
OpenAlex: W2574254633
Cited by: 432
References: 417
Citations by year: 2026: 21 · 2025: 45 · 2024: 43 · 2023: 59 · 2022: 44 · 2021: 67 · 2020: 49 · 2019: 38 · 2018: 40 · 2017: 26
FWCI: 3.92
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (tdm)
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Molecular Neurodegeneration (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Funders: U.S. Department of Veterans Affairs (5l101BX001117)
National Institute of Neurological Disorders and Stroke (5R01NS050730, R01NS088058)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Keywords: NADPH oxidase, oxidative stress, neurodegenerative diseases, brain injury, ischemic brain injury, traumatic brain injury, NOX1, NOX2, NOX4, neuroprotection, antioxidant therapy, Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, multiple sclerosis
MeSH terms: Animals, Brain Injuries, Humans, NADPH Oxidases, Neurodegenerative Diseases

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

NADPH oxidase in brain injury and neurodegenerative disorders

Abstract

Overview

Integrity signals

Figures

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks