The DOI matches its Crossref record; 226 of the 226 references it cites were found in a registry or an index.
Platelet integrin αIIbβ3: signal transduction, regulation, and its therapeutic targeting
Open accessAbstract
Integrins are a family of transmembrane glycoprotein signaling receptors that can transmit bioinformation bidirectionally across the plasma membrane. Integrin αIIbβ3 is expressed at a high level in platelets and their progenitors, where it plays a central role in platelet functions, hemostasis, and arterial thrombosis. Integrin αIIbβ3 also participates in cancer progression, such as tumor cell proliferation and metastasis. In resting platelets, integrin αIIbβ3 adopts an inactive conformation. Upon agonist stimulation, the transduction of inside-out signals leads integrin αIIbβ3 to switch from a low- to high-affinity state for fibrinogen and other ligands. Ligand binding causes integrin clustering and subsequently promotes outside-in signaling, which initiates and amplifies a range of cellular events to drive essential platelet functions such as spreading, aggregation, clot retraction, and thrombus consolidation. Regulation of the bidirectional signaling of integrin αIIbβ3 requires the involvement of numerous interacting proteins, which associate with the cytoplasmic tails of αIIbβ3 in particular. Integrin αIIbβ3 and its signaling pathways are considered promising targets for antithrombotic therapy. This review describes the bidirectional signal transduction of integrin αIIbβ3 in platelets, as well as the proteins responsible for its regulation and therapeutic agents that target integrin αIIbβ3 and its signaling pathways.
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Cites
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Huang, J., Zhang, L., Wan, D., Zhou, L., Zheng, S., Lin, S., & Qiao, Y. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00544-0 · Cited by 962
Self-citationSARS-CoV-2 binds platelet ACE2 to enhance thrombosis in COVID-19
Zhang, S., Liu, Y., Wang, X., Yang, L., Li, H., Wang, Y., Liu, M., Zhao, X., Xie, Y., Yang, Y., et al. (2020) · Journal of Hematology & Oncology · doi:10.1186/s13045-020-00954-7 · Cited by 657
Advance in peptide-based drug development: delivery platforms, therapeutics and vaccines
Xiao, W., Jiang, W., Chen, Z., Huang, Y., Mao, J., Zheng, W., Hu, Y., & Shi, J. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-02107-5 · Cited by 449
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Metadata
- Authors
- Huang, J., Li, X., Shi, X., Zhu, M., Wang, J., Huang, S., Huang, X., Wang, H., Li, L., Deng, H., Zhou, Y., Mao, J., Long, Z., Ma, Z., Ye, W., Pan, J., Xi, X., & Jin, J.
- Venue
- Journal of Hematology & Oncology
- Published
- 2019-03-07
- Volume
- 12
- Issue
- 1
- Pages
- 26-26
- ISSN
- 1756-8722 (ISSN-L)
- OpenAlex
- W2923030606
- Cited by
- 377
- References
- 226
- FWCI
- 20.65
- Type
- journal article
- Language
- en
- Open access
- gold
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- Huang, J., Li, X., Shi, X., Zhu, M., Wang, J., Huang, S., Huang, X., Wang, H., Li, L., Deng, H., Zhou, Y., Mao, J., Long, Z., Ma, Z., Ye, W., Pan, J., Xi, X., & Jin, J. (2019). Platelet integrin αIIbβ3: signal transduction, regulation, and its therapeutic targeting. Journal of Hematology & Oncology. https://doi.org/10.1186/s13045-019-0709-6
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