Loss of phosphatase and tensin homolog or phosphoinositol-3 kinase activation and response to trastuzumab or lapatinib in human epidermal growth factor receptor 2-overexpressing locally advanced breast cancers

Dave, Bhuvanesh; Migliaccio, Ilenia; Gutierrez, M. Carolina; Wu, Meng-Fen; Chamness, Gary C.; Wong, Helen; Narasanna, Archana; Chakrabarty, Anindita; Hilsenbeck, Susan G.; Huang, Jian; Rimawi, Mothaffar; Schiff, Rachel; Arteaga, Carlos; Osborne, C. Kent; Chang, Jenny C.

doi:10.1200/jco.2009.27.7814

Cited by 252HER2/EGFR in Cancer ResearchPI3K/AKT/mTOR signaling in cancerLung Cancer Treatments and Mutations

Loss of phosphatase and tensin homolog or phosphoinositol-3 kinase activation and response to trastuzumab or lapatinib in human epidermal growth factor receptor 2-overexpressing locally advanced breast cancers

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Dave, Bhuvanesh, Migliaccio, Ilenia, Gutierrez, M. Carolina, Wu, Meng-Fen, Chamness, Gary C., Wong, Helen, Narasanna, Archana, Chakrabarty, Anindita +7 more·2011·Journal of Clinical Oncology

DOI 10.1200/jco.2009.27.7814PMC PMC3058274

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Abstract

PURPOSE: Phosphatase and tensin homolog (PTEN) loss or activating mutations of phosphoinositol-3 (PI3) kinase (PIK3CA) may be associated with trastuzumab resistance. Trastuzumab, the humanized human epidermal growth factor receptor 2 (HER2) monoclonal antibody, and lapatinib, an epidermal growth factor receptor/HER2 tyrosine kinase inhibitor, are both established treatments for HER2-overexpressing breast cancers. Understanding of the cellular response to HER2-targeted therapies is needed to tailor treatments and to identify patients less likely to benefit. METHODS: We evaluated the effect of trastuzumab or lapatinib in three HER2-overexpressing cell lines. We confirmed the in vitro observations in two neoadjuvant clinical trials in patients with HER2 overexpression; 35 patients received trastuzumab as a single agent for the first 3 weeks, then docetaxel every 3 weeks for 12 weeks (trastuzumab regimen), whereas 49 patients received lapatinib as a single agent for 6 weeks, followed by trastuzumab/docetaxel for 12 weeks before primary surgery (lapatinib regimen). Apoptosis, Ki67, p-MAPK, p-AKT, and PTEN were assessed by immunohistochemistry. Genomic DNA was sequenced for PIK3CA mutations. RESULTS: Under low PTEN conditions, in vitro data indicate that lapatinib alone and in combination with trastuzumab was effective in decreasing p-MAPK and p-AKT levels, whereas trastuzumab was ineffective. In the clinical trials, we confirmed that low PTEN or activating mutation in PIK3CA conferred resistance to the trastuzumab regimen (P = .015), whereas low PTEN tumors were associated with a high pathologic complete response rate (P = .007). CONCLUSION: Activation of PI3 kinase pathway is associated with trastuzumab resistance, whereas low PTEN predicted for response to lapatinib. These observations support clinical trials with the combination of both agents.

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Patients with 'hot spot' PIK3CA mutations and undetectable or low PTEN measured by IHC exhibited a poorer outcome after treatment with chemotherapy and trastuzumab compared to patients without those alterations.
“Patients with ‘hot spot’ PIK3CA mutations and undetectable or low PTEN measured by IHC, exhibited a poorer outcome after treatment with chemotherapy and trastuzumab compared to patients without those alterations (Berns et al., 2007; Dave et al., 2011; Esteva et al., 2010).”
From ERBB Receptors: From Oncogene Discovery to Basic Science to Mechanism-Based Cancer Therapeutics (2014) · cites this paper as Dave et al., 2011

Trastuzumab plus Adjuvant Chemotherapy for Operable HER2-Positive Breast Cancer
Romond, E. H., Perez, E. A., Bryant, J., Suman, V. J., Geyer, C. E., Davidson, N. E., Tan-Chiu, E., Martino, S., Paik, S., Kaufman, P. A., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa052122 · Cited by 5,355 · see citing works
THE USE OF CONFIDENCE OR FIDUCIAL LIMITS ILLUSTRATED IN THE CASE OF THE BINOMIAL
Clopper, C. J., & Pearson, E. S. (1934) · Biometrika · doi:10.1093/biomet/26.4.404 · Cited by 5,106 · see citing works
Lapatinib plus Capecitabine for HER2-Positive Advanced Breast Cancer
Geyer, C. E., Forster, J. K., Lindquist, D. L., Chan, S. Y. T., Romieu, C. G., Pieńkowski, T., Jagiełło-Gruszfeld, A., Crown, J. P., Chan, A., Kaufman, B., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa064320 · Cited by 3,419 · see citing works
Prognostic and predictive factors in breast cancer by immunohistochemical analysis.
Allred, D. C., Harvey, J. M., Berardo, M. D., & Gm, C. (1998) · PubMed · Cited by 2,143 · see citing works
PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients
Nagata, Y., Lan, K.-H., Zhou, X., Tan, M., Esteva, F. J., Sahin, A. A., Klos, K. S., Li, P., Monia, B. P., Nguyen, N. T., et al. (2004) · Cancer Cell · doi:10.1016/j.ccr.2004.06.022 · Cited by 1,858 · see citing works
Intrinsic Resistance of Tumorigenic Breast Cancer Cells to Chemotherapy
Li, X., Lewis, M. T., Huang, J., Gutiérrez, C., Osborne, C. K., Wu, M.-F., Hilsenbeck, S. G., Pavlick, A. C., Zhang, X., Chamness, G. C., et al. (2008) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djn123 · Cited by 1,789 · see citing works
Self-citation
A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer
Berns, K., Horlings, H. M., Hennessy, B. T., Madiredjo, M., Hijmans, E. M., Beelen, K., Linn, S. C., Gonzalez-Angulo, A. M., Stemke-Hale, K., Hauptmann, M., et al. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.08.030 · Cited by 1,627 · see citing works
Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab
Cho, H., Mason, K., Ramyar, K. X., Stanley, A. M., Gabelli, S. B., Denney, D. W., & Leahy, D. J. (2003) · Nature · doi:10.1038/nature01392 · Cited by 1,615 · see citing works
Lapatinib Combined With Letrozole Versus Letrozole and Placebo As First-Line Therapy for Postmenopausal Hormone Receptor–Positive Metastatic Breast Cancer
Johnston, S. R. D., Pippen, J., Pivot, X. B., Lichinitser, M., Sadeghi, S., Dieras, V. C., Gómez, H., Romieu, G., Manikhas, A., Kennedy, M. J., et al. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2009.23.3734 · Cited by 1,016 · see citing works
Insulin-like growth factor-I receptor/human epidermal growth factor receptor 2 heterodimerization contributes to trastuzumab resistance of breast cancer cells
Nahta, R., Yuan, L. X. H., Zhang, B., Kobayashi, R., & Esteva, F. J. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-3841 · Cited by 793 · see citing works
Anti-tumor activity of GW572016: a dual tyrosine kinase inhibitor blocks EGF activation of EGFR/erbB2 and downstream Erk1/2 and AKT pathways
Xia, W., Mullin, R. J., Keith, B. R., Liu, L.-H., Ma, H., Rusnak, D. W., Owens, G., Alligood, K. J., & Spector, N. L. (2002) · Oncogene · doi:10.1038/sj.onc.1205794 · Cited by 664 · see citing works
Phosphatidylinositol 3-kinase hyperactivation results in lapatinib resistance that is reversed by the mTOR/phosphatidylinositol 3-kinase inhibitor NVP-BEZ235
Eichhorn, P. J. A., Gili, M., Scaltriti, M., Serra, V., Guzman, M., Nijkamp, W., Beijersbergen, R. L., Valero, V., Seoane, J., Bernards, R., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-1740 · Cited by 499 · see citing works
Lapatinib plus Capecitabine for HER2-Positive Advanced Breast Cancer
(2007) · New England Journal of Medicine · doi:10.1056/nejmx070016 · Cited by 350 · see citing works
The characterization of novel, dual ErbB-2/EGFR, tyrosine kinase inhibitors: potential therapy for cancer.
Rusnak, D. W., Affleck, K., Cockerill, S. G., Stubberfield, C. R., Harris, R., Pagé, M., Smith, K. J., Guntrip, S. B., Carter, M. C., Shaw, R. J., et al. (2001) · PubMed · Cited by 294 · see citing works
Anti-epidermal growth factor receptor monoclonal antibody 225 up-regulates p27KIP1 and induces G1 arrest in prostatic cancer cell line DU145.
Peng, D., Fan, Z., Yang, L., DeBlasio, T., Scher, H. I., & Mendelsohn, J. M. (1996) · PubMed · Cited by 280 · see citing works
Neoadjuvant Trastuzumab Induces Apoptosis in Primary Breast Cancers
Mohsin, S. K., Weiss, H. L., Gutierrez, M. C., Chamness, G. C., Schiff, R., DiGiovanna, M. P., Wang, C.-X., Hilsenbeck, S. G., Osborne, C. K., Allred, D. C., et al. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.00.661 · Cited by 244 · see citing works
Self-citation
Correction: IGF-IR/HER-2 Contributes to Trastuzumab Resistance
(2008) · Cancer Research · doi:10.1158/0008-5472.can-68-22-cor1 · Cited by 230 · see citing works
Akt/Protein Kinase B Isoforms Are Differentially Regulated by Epidermal Growth Factor Stimulation
Okano, J., Gaslightwala, I., Birnbaum, M. J., Rustgi, A. K., & Nakagawa, H. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004112200 · Cited by 214 · see citing works
Residual metastatic axillary lymph nodes following neoadjuvant chemotherapy predict disease-free survival in patients with locally advanced breast cancer
Kuerer, H. M., Newman, L. A., Buzdar, A. U., Hunt, K. K., Dhingra, K., Buchholz, T. A., Binkley, S. M., Ames, F. C., Feig, B. W., Ross, M. I., et al. (1998) · The American Journal of Surgery · doi:10.1016/s0002-9610(98)00253-0 · Cited by 152 · see citing works
Lapatinib Antitumor Activity Is Not Dependent upon Phosphatase and Tensin Homologue Deleted on Chromosome 10 in ErbB2-Overexpressing Breast Cancers
Xia, W., Husain, I., Liu, L.-H., Bacus, S. S., Saini, S., Spohn, J., Pry, K. J., Westlund, R. E., Stein, S. H., & Spector, N. L. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-2101 · Cited by 146 · see citing works
Signal transduction pathways activated and required for mammary carcinogenesis in response to specific oncogenes
Amundadottir, L. T., & Leder, P. (1998) · Oncogene · doi:10.1038/sj.onc.1201829 · Cited by 135 · see citing works
Tumor-inhibitory monoclonal antibodies to the HER-2/Neu receptor induce differentiation of human breast cancer cells.
Bacus, S. S., Stancovski, I., Huberman, E., Chin, D., Hurwitz, E., Mills, G. B., Ullrich, A., Sela, M., & Yarden, Y. (1992) · PubMed · Cited by 101 · see citing works
The ins and outs of virulence gene expression: Mg2 as a regulatory signal
Groisman, E. A. (1998) · BioEssays · doi:10.1002/(sici)1521-1878(199801)20:1 · Cited by 100 · see citing works
A phase II, open-label, multicenter study of GW572016 in patients with trastuzumab-refractory metastatic breast cancer
Blackwell, K., Kaplan, E., Franco, S. X., Marcom, P. K., Maleski, J. E., Sorensen, M. J., & Berger, M. S. (2004) · Journal of Clinical Oncology · doi:10.1200/jco.2004.22.90140.3006 · Cited by 96 · see citing works
Uncommon Presentations of Hodgkin's Disease
Simpson, L., Taylor, S. G., & Piotrowski, A. (2003) · Journal of Clinical Oncology · doi:10.1200/jco.2004.02.144 · Cited by 59 · see citing works
Inhibitors of epidermal growth factor receptor kinase and of cyclin-dependent kinase 2 activation induce growth arrest, differentiation, and apoptosis of human papilloma virus 16-immortalized human keratinocytes.
Ben‐Bassat, H., Rosenbaum-Mitrani, S., Hartzstark, Z., Shlomai, Z., Kleinberger-Doron, N., Gazit, A., Plowman, G. D., Levitzki, R., Tsvieli, R., & Levitzki, A. (1997) · PubMed · Cited by 52 · see citing works
Clinical summary of 67 heavily pre-treated patients with metastatic carcinomas treated with GW572016 in a phase Ib study
Dees, E. C., Burris, H. A., Hurwitz, H. I., Dowlati, A., Smith, D. A., Koch, K., Stead, A. G., Mangum, S., Harris, J., & Spector, N. (2004) · Journal of Clinical Oncology · doi:10.1200/jco.2004.22.90140.3188 · Cited by 15 · see citing works
Detection of c-erbB-2 amplification in breast cancer by in situ hybridization
Smith, K. L., Robbins, P., Dawkins, H. J. S., Papadimitriou, J. M., Carrello, S., Harvey, J. M., & Sterrett, G. F. (1993) · The Breast · doi:10.1016/0960-9776(93)90006-2 · Cited by 7 · see citing works

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Lapatinib with trastuzumab for HER2-positive early breast cancer (NeoALTTO): a randomised, open-label, multicentre, phase 3 trial
Baselga, J. M., Bradbury, I., Eidtmann, H., Cosimo, S. D., de Azambuja, E., Aura, C. M., Gómez, H., Dinh, P., Fauria, K., Dooren, V. V., et al. (2012) · The Lancet · doi:10.1016/s0140-6736(11)61847-3 · Cited by 1,317 · see citing works
ERBB Receptors: From Oncogene Discovery to Basic Science to Mechanism-Based Cancer Therapeutics
Arteaga, C. L., & Engelman, J. A. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.02.025 · Cited by 1,048 · see citing works
Self-citation
Cancer Stem Cell Metabolism
Peiris-Pagès, M., Martinez-Outschoorn, U. E., Pestell, R. G., Sotgia, F., & Lisanti, M. P. (2016) · Breast Cancer Research · doi:10.1186/s13058-016-0712-6 · Cited by 465 · see citing works
Mutations in the phosphatidylinositol 3-kinase pathway: role in tumor progression and therapeutic implications in breast cancer
Miller, T. W., Rexer, B. N., Garrett, J. T., & Arteaga, C. L. (2011) · Breast Cancer Research · doi:10.1186/bcr3039 · Cited by 465 · see citing works
Self-citation
Molecular Heterogeneity and Response to Neoadjuvant Human Epidermal Growth Factor Receptor 2 Targeting in CALGB 40601, a Randomized Phase III Trial of Paclitaxel Plus Trastuzumab With or Without Lapatinib
Carey, L., Berry, D. A., Cirrincione, C., Barry, W. T., Pitcher, B. N., Harris, L. N., Ollila, D. W., Krop, I. E., Henry, N. L., Weckstein, D. J., et al. (2015) · Journal of Clinical Oncology · doi:10.1200/jco.2015.62.1268 · Cited by 421 · see citing works
Therapeutic Implications of Cellular Heterogeneity and Plasticity in Breast Cancer
Brooks, M., Burness, M. L., & Wicha, M. S. (2015) · Cell stem cell · doi:10.1016/j.stem.2015.08.014 · Cited by 373 · see citing works
Intrinsic and Acquired Resistance to HER2-Targeted Therapies in HER2 Gene-Amplified Breast Cancer: Mechanisms and Clinical Implications
Rexer, B. N., & Arteaga, C. L. (2012) · Critical Reviews™ in Oncogenesis · doi:10.1615/critrevoncog.v17.i1.20 · Cited by 372 · see citing works
Self-citation
Targeted therapies for breast cancer
Higgins, M. J., & Baselga, J. M. (2011) · Journal of Clinical Investigation · doi:10.1172/jci57152 · Cited by 368 · see citing works
Combination of everolimus with trastuzumab plus paclitaxel as first-line treatment for patients with HER2-positive advanced breast cancer (BOLERO-1): a phase 3, randomised, double-blind, multicentre trial
Hurvitz, S. A., André, F., Jiang, Z., Shao, Z., Mano, M. S., Neciosup, S. P., Tseng, L.-M., Zhang, Q., Shen, K., Liu, D., et al. (2015) · The Lancet Oncology · doi:10.1016/s1470-2045(15)00051-0 · Cited by 306 · see citing works
Antitumour immunity regulated by aberrant ERBB family signalling
Kumagai, S., Koyama, S., & Nishikawa, H. (2021) · Nature reviews. Cancer · doi:10.1038/s41568-020-00322-0 · Cited by 279 · see citing works
Multicenter Phase II Study of Neoadjuvant Lapatinib and Trastuzumab With Hormonal Therapy and Without Chemotherapy in Patients With Human Epidermal Growth Factor Receptor 2–Overexpressing Breast Cancer: TBCRC 006
Rimawi, M. F., Mayer, I. A., Forero, A., Nanda, R., Goetz, M. P., Rodriguez, A. A., Pavlick, A. C., Wang, T., Hilsenbeck, S. G., Gutiérrez, C., et al. (2013) · Journal of Clinical Oncology · doi:10.1200/jco.2012.44.8027 · Cited by 273 · see citing works
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Rimawi, M. F., Schiff, R., & Osborne, C. K. (2015) · Annual Review of Medicine · doi:10.1146/annurev-med-042513-015127 · Cited by 267 · see citing works
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Dillon, L. M., & Miller, T. W. (2014) · Current Drug Targets · doi:10.2174/1389450114666140106100909 · Cited by 240 · see citing works
Resistance mechanisms to anti-HER2 therapies in HER2-positive breast cancer: Current knowledge, new research directions and therapeutic perspectives
Vernieri, C., Milano, M., Brambilla, M., Mennitto, A., Maggi, C., Cona, M. S., Prisciandaro, M., Fabbroni, C., Celio, L., Mariani, G., et al. (2019) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2019.05.001 · Cited by 245 · see citing works
PIK3CA Mutations Are Associated With Decreased Benefit to Neoadjuvant Human Epidermal Growth Factor Receptor 2–Targeted Therapies in Breast Cancer
Majewski, I. J., Nuciforo, P. G., Mittempergher, L., Bosma, A. J., Eidtmann, H., Holmes, E. M., Sotiriou, C. P., Fumagalli, D., Jimenez, J., Aura, C. M., et al. (2015) · Journal of Clinical Oncology · doi:10.1200/jco.2014.55.2158 · Cited by 237 · see citing works
Increased signalling of EGFR and IGF1R, and deregulation of PTEN/PI3K/Akt pathway are related with trastuzumab resistance in HER2 breast carcinomas
Gallardo, A., Lerma, E., Escuín, D., Tibau, A., Muñoz, J., Ojeda, B., Barnadas, A., Adrover, E., Sánchez-Tejada, L., Giner, D., et al. (2012) · British Journal of Cancer · doi:10.1038/bjc.2012.85 · Cited by 229 · see citing works
Mechanisms Underlying the Action and Synergism of Trastuzumab and Pertuzumab in Targeting HER2-Positive Breast Cancer
Nami, B., Maadi, H., & Wang, Z. (2018) · Cancers · doi:10.3390/cancers10100342 · Cited by 192 · see citing works
Mechanisms behind the Resistance to Trastuzumab in HER2-Amplified Breast Cancer and Strategies to Overcome It
Luque-Cabal, M., García‐Teijido, P., Fernández-Pérez, Y., Sánchez‐Lorenzo, L., & Vázquez, I. P. (2016) · Clinical Medicine Insights Oncology · doi:10.4137/cmo.s34537 · Cited by 182 · see citing works
De-escalation strategies in HER2-positive early breast cancer (EBC): final analysis of the WSG-ADAPT HER2+/HR− phase II trial: efficacy, safety, and predictive markers for 12 weeks of neoadjuvant dual blockade with trastuzumab and pertuzumab ± weekly paclitaxel
Nitz, U. A., Gluz, O., Christgen, M., Grischke, E. ‐., Augustin, D., Küemmel, S., Braun, M., Potenberg, J., Kohls, A., Krauss, K., et al. (2017) · Annals of Oncology · doi:10.1093/annonc/mdx494 · Cited by 167 · see citing works
Targeted therapy for breast cancer and molecular mechanisms of resistance to treatment
Gu, G., Dustin, D., & Fuqua, S. A. (2016) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2016.11.005 · Cited by 163 · see citing works
Gastric cancer: somatic genetics as a guide to therapy
Zhang, X., & Zhang, P.-Y. (2016) · Journal of Medical Genetics · doi:10.1136/jmedgenet-2016-104171 · Cited by 159 · see citing works
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Fumagalli, D., Venet, D., Ignatiadis, M., Azim, H. A., Maetens, M., Rothé, F., Salgado, R., Bradbury, I., Pusztai, L., Harbeck, N., et al. (2016) · JAMA Oncology · doi:10.1001/jamaoncol.2016.3824 · Cited by 151 · see citing works
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Wang, L., Zhang, Q., Zhang, J., Sun, S., Guo, H., Jia, Z. Y., Wang, B., Shao, Z., Wang, Z., & Hu, X. (2011) · BMC Cancer · doi:10.1186/1471-2407-11-248 · Cited by 146 · see citing works
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Bazzichetto, C., Conciatori, F., Pallocca, M., Falcone, I., Fanciulli, M., Cognetti, F., Milella, M., & Ciuffreda, L. (2019) · Cancers · doi:10.3390/cancers11040435 · Cited by 145 · see citing works
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Xia, W., Petricoin, E., Zhao, S., Liu, L.-H., Osada, T., Cheng, Q., Wulfkuhle, J. D., Gwin, W. R., Yang, X., Gallagher, R. I., et al. (2013) · Breast Cancer Research · doi:10.1186/bcr3480 · Cited by 143 · see citing works
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Rexer, B. N., Ham, A.-J. L., Rinehart, C., Hill, S., de Matos Granja-Ingram, N., González-Angulo, A. M., Mills, G. B., Dave, B., Chang, J. C., Liebler, D. C., et al. (2011) · Oncogene · doi:10.1038/onc.2011.130 · Cited by 139 · see citing works
Self-citation
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Jensen, J. D., Knoop, A. S., Lænkholm, A., Grauslund, M., Jensen, M., Santoni‐Rugiu, E., Andersson, M., & Ewertz, M. (2011) · Annals of Oncology · doi:10.1093/annonc/mdr546 · Cited by 135 · see citing works
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Kim, J., Fox, C., Peng, S., Pusung, M., Pectasides, E., Matthée, E., Hong, Y. S., Do, I., Jang, J., Thorner, A. R., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci75200 · Cited by 133 · see citing works
Trastuzumab-resistant cells rely on a HER2-PI3K-FoxO-survivin axis and are sensitive to PI3K inhibitors
Chakrabarty, A., Bhola, N. E., Sutton, C., Ghosh, R., Kuba, M. G., Dave, B., Chang, J. C., & Arteaga, C. L. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-2440 · Cited by 130 · see citing works
Self-citation
Spatial Proximity to Fibroblasts Impacts Molecular Features and Therapeutic Sensitivity of Breast Cancer Cells Influencing Clinical Outcomes
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Self-citation
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Zheng, Q., Zhang, M., Zhou, F., Zhang, L., & Meng, X. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.599965 · Cited by 124 · see citing works
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Self-citation
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Self-citation
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Moody, S. E., Schinzel, A. C., Singh, S., Izzo, F., Strickland, M. R., Luo, L. Y., Thomas, S. R., Boehm, J. S., Kim, S. Y., Wang, Z. C., et al. (2014) · Oncogene · doi:10.1038/onc.2014.153 · Cited by 110 · see citing works
PIK3R1 underexpression is an independent prognostic marker in breast cancer
Čížková, M., Vacher, S., Meseure, D., Trassard, M., Susini, A., Mlcuchova, D., Callens, C., Rouleau, É., Spyratos, F., Lidereau, R., et al. (2013) · BMC Cancer · doi:10.1186/1471-2407-13-545 · Cited by 111 · see citing works
Intrinsic Subtypes, PIK3CA Mutation, and the Degree of Benefit From Adjuvant Trastuzumab in the NSABP B-31 Trial
Pogue–Geile, K. L., Song, N., Jeong, J., Gavin, P. G., Kim, S.-R., Blackmon, N. L., Finnigan, M., Rastogi, P., Fehrenbacher, L., Mamounas, E. P., et al. (2015) · Journal of Clinical Oncology · doi:10.1200/jco.2014.56.2439 · Cited by 111 · see citing works
The Phosphoinositide-3-Kinase-Akt-mTOR Pathway as a Therapeutic Target in Breast Cancer
Lauring, J. D., Park, B. H., & Wolff, A. C. (2013) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2013.0086 · Cited by 111 · see citing works
Prospective Biomarker Analysis of the Randomized CHER-LOB Study Evaluating the Dual Anti-HER2 Treatment With Trastuzumab and Lapatinib Plus Chemotherapy as Neoadjuvant Therapy for HER2-Positive Breast Cancer
Guarneri, V., Dieci, M. V., Frassoldati, A., Maiorana, A., Ficarra, G., Bettelli, S. R., Tagliafico, E., Bicciato, S., Generali, D., Cagossi, K., et al. (2015) · The Oncologist · doi:10.1634/theoncologist.2015-0138 · Cited by 109 · see citing works
Notch-1-PTEN-ERK1/2 signaling axis promotes HER2+ breast cancer cell proliferation and stem cell survival
Baker, A. T., Wyatt, D. L., Bocchetta, M., Li, J., Filipović, A., Green, A. R., Peiffer, D. S., Fuqua, S. A. W., Miele, L., Albain, K. S., et al. (2018) · Oncogene · doi:10.1038/s41388-018-0251-y · Cited by 108 · see citing works
Myeloid PTEN promotes chemotherapy-induced NLRP3-inflammasome activation and antitumour immunity
Huang, Y., Wang, H., Hao, Y., Lin, H., Dong, M., Ye, J., Song, L., Wang, Y., Li, Q., Shan, B., et al. (2020) · Nature Cell Biology · doi:10.1038/s41556-020-0510-3 · Cited by 109 · see citing works
Impact of PTEN protein expression on benefit from adjuvant trastuzumab in early-stage human epidermal growth factor receptor 2-positive breast cancer in the North Central Cancer Treatment Group N9831 trial
Perez, E. A., Dueck, A. C., McCullough, A. E., Chen, B., Geiger, X. J., Jenkins, R. B., Lingle, W. L., Davidson, N. E., Martino, S., Kaufman, P. A., et al. (2013) · Journal of Clinical Oncology · doi:10.1200/jco.2012.42.2642 · Cited by 106 · see citing works
Trastuzumab Emtansine: A Novel Antibody–Drug Conjugate for HER2-Positive Breast Cancer
Krop, I. E., & Winer, E. P. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-0541 · Cited by 105 · see citing works
Targeting the PI3K/Akt/mTOR Pathway for Breast Cancer Therapy
Cidado, J. R., & Park, B. H. (2012) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1007/s10911-012-9264-2 · Cited by 104 · see citing works
Neoadjuvant Therapy as a Platform for Drug Development and Approval in Breast Cancer
Bardia, A., & Baselga, J. M. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-0916 · Cited by 102 · see citing works
Dual Blockade of HER2 in HER2-Overexpressing Tumor Cells Does Not Completely Eliminate HER3 Function
Garrett, J. T., Sutton, C. R., Kuba, M. G., Cook, R. S., & Arteaga, C. L. (2012) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-12-2024 · Cited by 99 · see citing works
Self-citation
Low PTEN levels and PIK3CA mutations predict resistance to neoadjuvant lapatinib and trastuzumab without chemotherapy in patients with HER2 over-expressing breast cancer
Rimawi, M. F., Angelis, C. D., Contreras, A., Pareja, F. G., Geyer, F. C., Burke, K. A., Herrera, S., Wang, T., Mayer, I. A., Forero, A., et al. (2017) · Breast Cancer Research and Treatment · doi:10.1007/s10549-017-4533-9 · Cited by 98 · see citing works
Self-citation
circCDYL2 promotes trastuzumab resistance via sustaining HER2 downstream signaling in breast cancer
Ling, Y., Liang, G., Lin, Q., Fang, X., Luo, Q., Cen, Y., Mehrpour, M., Hamaï, A., Liu, Z., Shi, Y., et al. (2022) · Molecular Cancer · doi:10.1186/s12943-021-01476-7 · Cited by 97 · see citing works
β2-AR signaling controls trastuzumab resistance-dependent pathway
Liu, D., Yang, Z., Wang, T., Yang, Z., Chen, H., Hu, Y., Hu, C., Guo, L., Deng, Q., Liu, Y., et al. (2015) · Oncogene · doi:10.1038/onc.2015.58 · Cited by 95 · see citing works
Tumor suppressor PTEN in breast cancer: heterozygosity, mutations and protein expression.
Kechagioglou, P., Papi, R. M., Provatopoulou, X., Kalogera, E., Papadimitriou, E., Grigoropoulos, P., Nonni, A., Zografos, G., Kyriakidis, D. A., & Gounaris, A. (2014) · PubMed · Cited by 95 · see citing works
HER2 + breast cancers evade anti-HER2 therapy via a switch in driver pathway
Smith, A. E., Ferraro, E., Safonov, A. M., Morales, C. B., Arenas, E. J., Li, Q., Kulick, A. R., Ross, D. S., Solit, D. B., de Stanchina, E., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-27093-y · Cited by 93 · see citing works
Targeting the HER/EGFR/ErbB Family to Prevent Breast Cancer
Howe, L. R., & Brown, P. H. (2011) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-11-0334 · Cited by 92 · see citing works
Outcome impact of PIK3CA mutations in HER2-positive breast cancer patients treated with trastuzumab
Cizkova, M., Dujaric, M. E., Lehmann‐Che, J., Scott, V., Tembo, O., Asselain, B. J. R., Pierga, J., Marty, M. E., de Crémoux, P., Spyratos, F., et al. (2013) · British Journal of Cancer · doi:10.1038/bjc.2013.164 · Cited by 90 · see citing works
Overcoming resistance and restoring sensitivity to HER2-targeted therapies in breast cancer
Sharial, M. S. N. M., Crown, J. P., & Hennessy, B. T. (2012) · Annals of Oncology · doi:10.1093/annonc/mds200 · Cited by 90 · see citing works
HSP90 as a platform for the assembly of more effective cancer chemotherapy
Whitesell, L. J., & Lin, N. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2011.12.006 · Cited by 84 · see citing works
Stem Cells and Cellular Origins of Breast Cancer: Updates in the Rationale, Controversies, and Therapeutic Implications
Zhou, J., Chen, Q., Zou, Y., Chen, H., Qi, L., & Chen, Y. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.00820 · Cited by 80 · see citing works
Current Status of Anti–Human Epidermal Growth Factor Receptor 2 Therapies: Predicting and Overcoming Herceptin Resistance
Chung, A. P., Cui, X., Audeh, W., & Giuliano, A. E. (2013) · Clinical Breast Cancer · doi:10.1016/j.clbc.2013.04.001 · Cited by 77 · see citing works
Autophagy-related gene 12 (ATG12) is a novel determinant of primary resistance to HER2-targeted therapies: Utility of transcriptome analysis of the autophagy interactome to guide breast cancer treatment
Cufí, S., Vázquez‐Martín, A., Oliveras‐Ferraros, C., Corominas-Faja, B., Urruticoechea, A., Martı́n-Castillo, B., & Menéndez, J. A. (2012) · Oncotarget · doi:10.18632/oncotarget.742 · Cited by 75 · see citing works
Trastuzumab or lapatinib with standard chemotherapy for HER2-positive breast cancer: results from the GEICAM/2006-14 trial
Alba, E., Albanell, J., de la Haba-Rodríguez, J., Barnadas, A., Calvo, L., Sánchez‐Rovira, P., Ramos, M., Rojo, F., Burgués, O., Carrasco, E., et al. (2014) · British Journal of Cancer · doi:10.1038/bjc.2013.831 · Cited by 73 · see citing works
Hybrid Capture–Based Genomic Profiling of Circulating Tumor DNA from Patients with Advanced Cancers of the Gastrointestinal Tract or Anus
Schrock, A. B., Pavlick, D. C., Klempner, S. J., Chung, J., Forcier, B., Welsh, A. W., Young, L., Leyland-Jones, B., Bordoni, R. E., Carvajal, R. D., et al. (2018) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-17-3103 · Cited by 71 · see citing works
Beyond trastuzumab: New treatment options for HER2-positive breast cancer
Saini, K. S., Azim, H. A., Metzger, O., Loi, S., Sotiriou, C. P., de Azambuja, E., & Piccart, M. J. (2011) · The Breast · doi:10.1016/s0960-9776(11)70289-2 · Cited by 71 · see citing works
Anti-HER2 therapy in metastatic breast cancer: many choices and future directions
Wynn, C., & Tang, S. (2022) · Cancer and Metastasis Reviews · doi:10.1007/s10555-022-10021-x · Cited by 68 · see citing works
Developments in Ki67 and other biomarkers for treatment decision making in breast cancer
Sheri, A., & Dowsett, M. (2012) · Annals of Oncology · doi:10.1093/annonc/mds307 · Cited by 68 · see citing works
Oncogenic cooperation between PI3K/Akt signaling and transcription factor Runx2 promotes the invasive properties of metastatic breast cancer cells
Pande, S., Browne, G., Padmanabhan, S., Zaidi, S. K., Lian, J. B., van Wijnen, A. J., Stein, J. L., & Stein, G. S. (2013) · Journal of Cellular Physiology · doi:10.1002/jcp.24339 · Cited by 67 · see citing works
De-escalation of treatment in HER2-positive breast cancer: Determinants of response and mechanisms of resistance
Veeraraghavan, J., Angelis, C. D., Reis-Filho, J. S., Pascual, T., Prat, A., Rimawi, M. F., Osborne, C. K., & Schiff, R. (2017) · The Breast · doi:10.1016/j.breast.2017.06.022 · Cited by 67 · see citing works
Self-citation
Molecular determinants of trastuzumab efficacy: What is their clinical relevance?
De, P. K. R., Hasmann, M., & Leyland-Jones, B. R. (2013) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2013.02.006 · Cited by 66 · see citing works
A randomized, controlled phase II trial of neoadjuvant ado-trastuzumab emtansine, lapatinib, and nab-paclitaxel versus trastuzumab, pertuzumab, and paclitaxel in HER2-positive breast cancer (TEAL study)
Patel, T. A., Ensor, J., Creamer, S. L., Boone, T., Rodriguez, A. A., Niravath, P. A., Darcourt, J. G., Meisel, J. L., Li, X., Zhao, J., et al. (2019) · Breast Cancer Research · doi:10.1186/s13058-019-1186-0 · Cited by 66 · see citing works
Self-citation
Double-Blind, Placebo-Controlled, Multicenter, Randomized, Phase IIB Neoadjuvant Study of Letrozole-Lapatinib in Postmenopausal Hormone Receptor–Positive, Human Epidermal Growth Factor Receptor 2–Negative, Operable Breast Cancer
Guarneri, V., Generali, D., Frassoldati, A., Artioli, F., Boni, C., Cavanna, L., Tagliafico, E., Maiorana, A., Bottini, A., Cagossi, K., et al. (2014) · Journal of Clinical Oncology · doi:10.1200/jco.2013.51.4737 · Cited by 61 · see citing works
Targeting the PI3K Pathway for Cancer Therapy
Sadeghi, N., & Gerber, D. E. (2012) · Future Medicinal Chemistry · doi:10.4155/fmc.12.56 · Cited by 60 · see citing works
Trastuzumab: a novel standard option for patients with HER-2-positive advanced gastric or gastro-oesophageal junction cancer
Okines, A. F. C., & Cunningham, D. (2012) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756283x12450246 · Cited by 60 · see citing works
Targeting Bcl-2 in Herceptin-Resistant Breast Cancer Cell Lines
Crawford, A. C., & Nahta, R. (2011) · Current pharmacogenomics and personalized medicine (Online)/Current pharmacogenomics and personalized medicine · doi:10.2174/187569211796957584 · Cited by 55 · see citing works
Hotspot mutations in PIK3CA associate with first-line treatment outcome for aromatase inhibitors but not for tamoxifen
Ramirez-Ardila, D. E., Helmijr, J., Look, M. P., Lurkin, I., Ruigrok-Ritstier, K., Laere, S. V., Dirix, L. Y., Sweep, F. C. G. J., Span, P. N., Linn, S. C., et al. (2013) · Breast Cancer Research and Treatment · doi:10.1007/s10549-013-2529-7 · Cited by 54 · see citing works
Biomarkers of drugs targeting HER ‐family signalling in cancer
Montemurro, F., & Scaltriti, M. (2013) · The Journal of Pathology · doi:10.1002/path.4269 · Cited by 54 · see citing works
The predictive role of phosphatase and tensin homolog (PTEN) loss, phosphoinositol-3 (PI3) kinase (PIK3CA) mutation, and PI3K pathway activation in sensitivity to trastuzumab in HER2-positive breast cancer: a meta-analysis
Wang, Y., Liu, Y., Du, Y., Yin, W., & Lu, J. (2013) · Current Medical Research and Opinion · doi:10.1185/03007995.2013.794775 · Cited by 53 · see citing works
Resistance to Anti-HER2 Therapies in Breast Cancer
Rimawi, M. F., Angelis, C. D., & Schiff, R. (2015) · American Society of Clinical Oncology Educational Book · doi:10.14694/edbook_am.2015.35.e157 · Cited by 52 · see citing works
Self-citation
Identification of novel determinants of resistance to lapatinib in ERBB2-amplified cancers
Wetterskog, D., Shiu, K.-K., Chong, I. Y.-S., Meijer, T. G., Mackay, A. G., Lambros, M. B. K., Cunningham, D., Reis-Filho, J. S., Lord, C. J., & Ashworth, A. (2013) · Oncogene · doi:10.1038/onc.2013.41 · Cited by 51 · see citing works
Deciphering and Targeting Oncogenic Mutations and Pathways in Breast Cancer
Santarpia, L., Bottai, G., Kelly, C. M., Győrffy, B., Székely, B., & Pusztai, L. (2016) · The Oncologist · doi:10.1634/theoncologist.2015-0369 · Cited by 51 · see citing works
Integrin α3β1–CD151 complex regulates dimerization of ErbB2 via RhoA
Novitskaya, V., Romańska, H., Kordek, R., Potemski, P., Kusińska, R., Parsons, M., Odintsova, E., & Berditchevski, F. (2013) · Oncogene · doi:10.1038/onc.2013.231 · Cited by 50 · see citing works
Will PI3K pathway inhibitors be effective as single agents in patients with cancer?
Garrett, J. T., Chakrabarty, A., & Arteaga, C. L. (2011) · Oncotarget · doi:10.18632/oncotarget.409 · Cited by 49 · see citing works
Self-citation
Regulation of anti-apoptotic signaling by Kruppel-like factors 4 and 5 mediates lapatinib resistance in breast cancer
Farrugia, M. K., Sharma, S. B., Lin, C.-C., McLaughlin, S. L., Vanderbilt, D. B., Ammer, A. G., Salkeni, M. A., Stoilov, P., Agazie, Y. M., Creighton, C. J., et al. (2015) · Cell Death and Disease · doi:10.1038/cddis.2015.65 · Cited by 48 · see citing works
Association of PIK3CA Mutation Status before and after Neoadjuvant Chemotherapy with Response to Chemotherapy in Women with Breast Cancer
Yuan, H., Chen, J., Liu, Y., Ouyang, T., Li, J., Wang, T., Fan, Z., Fan, T., Lin, B., & Xie, Y. (2015) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-14-3354 · Cited by 45 · see citing works
Src and CXCR4 are involved in the invasiveness of breast cancer cells with acquired resistance to lapatinib
Luca, A. D., D’Alessio, A., Gallo, M., Maiello, M. R., Bode, A. M., & Normanno, N. (2013) · Cell Cycle · doi:10.4161/cc.26899 · Cited by 44 · see citing works
The Role of PTEN in Tumor Angiogenesis
Rodriguez, S., & Huynh‐Do, U. (2011) · Journal of Oncology · doi:10.1155/2012/141236 · Cited by 44 · see citing works
Advances in systemic therapy for metastatic breast cancer: future perspectives
Corona, S. P., Sobhani, N., Ianza, A., Roviello, G., Mustacchi, G., Bortul, M., Zanconati, F., & Generali, D. (2017) · Medical Oncology · doi:10.1007/s12032-017-0975-5 · Cited by 44 · see citing works
Emerging roles for mammalian target of rapamycin inhibitors in the treatment of solid tumors and hematological malignancies
Khokhar, N. Z., Altman, J. K., & Platanias, L. C. (2011) · Current Opinion in Oncology · doi:10.1097/cco.0b013e32834b892d · Cited by 43 · see citing works
The Potential Role of Aerobic Exercise to Modulate Cardiotoxicity of Molecularly Targeted Cancer Therapeutics
Scott, J. M., Gilchrist, S. C., Mackey, J. R., Douglas, P. S., Haykowsky, M. J., & Jones, L. W. (2013) · The Oncologist · doi:10.1634/theoncologist.2012-0226 · Cited by 42 · see citing works
Inhibition of Cell Proliferation and Metastasis by Scutellarein Regulating PI3K/Akt/NF-κB Signaling through PTEN Activation in Hepatocellular Carcinoma
Ha, S. E., Kim, S. M., Vetrivel, P., Kim, H. H., Bhosale, P. B., Heo, J., Lee, H. J., & Kim, G. S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168841 · Cited by 43 · see citing works
A combinatorial biomarker predicts pathologic complete response to neoadjuvant lapatinib and trastuzumab without chemotherapy in patients with HER2+ breast cancer
Veeraraghavan, J., Angelis, C. D., Mao, R., Wang, T., Herrera, S., Pavlick, A. C., Contreras, A., Nuciforo, P. G., Mayer, I. A., Forero-Torres, A., et al. (2019) · Annals of Oncology · doi:10.1093/annonc/mdz076 · Cited by 42 · see citing works
Self-citation
Benefit to neoadjuvant anti-human epidermal growth factor receptor 2 (HER2)-targeted therapies in HER2-positive primary breast cancer is independent of phosphatase and tensin homolog deleted from chromosome 10 (PTEN) status
Nuciforo, P. G., Aura, C. M., Holmes, E. M., Prudkin, L., Jimenez, J., Martinez, P., Ameels, H., de la Peña, L., Ellis, C., Eidtmann, H., et al. (2015) · Annals of Oncology · doi:10.1093/annonc/mdv175 · Cited by 41 · see citing works
Neoadjuvant Trastuzumab and Pyrotinib for Locally Advanced HER2-Positive Breast Cancer (NeoATP): Primary Analysis of a Phase II Study
Yin, W., Wang, Y., Wu, Z., Ye, Y., Zhou, L., Xu, S., Lin, Y., Du, Y., Yan, T., Yang, F., et al. (2022) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-22-0446 · Cited by 41 · see citing works
Enhanced PI3K p110α Signaling Confers Acquired Lapatinib Resistance That Can Be Effectively Reversed by a p110α-Selective PI3K Inhibitor
Brady, S. W., Zhang, J., Seok, D., Wang, H., & Yu, D. (2013) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-13-0518 · Cited by 40 · see citing works
Down-regulation of miR-543 expression increases the sensitivity of colorectal cancer cells to 5-Fluorouracil through the PTEN/PI3K/AKT pathway
Liu, G., Zhou, J., & Dong, M. (2019) · Bioscience Reports · doi:10.1042/bsr20190249 · Cited by 40 · see citing works
Analysis of PIK3CA exon 9 and 20 mutations in breast cancers using PCR-HRM and PCR-ARMS: Correlation with clinicopathological criteria
Harlé, A., Lion, M., Lozano, N., Husson, M., Harter, V., Génin, P., & Merlin, J. (2013) · Oncology Reports · doi:10.3892/or.2013.2229 · Cited by 38 · see citing works
Biomarkers of cetuximab resistance in patients with head and neck squamous cell carcinoma
Leblanc, O., Vacher, S., Lecerf, C., Jeannot, E., Klijanienko, J., Berger, F., Hoffmann, C., Calugaru, V., Badois, N., Chilles, A., et al. (2020) · Cancer Biology and Medicine · doi:10.20892/j.issn.2095-3941.2019.0153 · Cited by 38 · see citing works
Targeting HER2 in solid tumors: Unveiling the structure and novel epitopes
Liu, X., Song, Y., Cheng, P., Liang, B., & Xing, D. (2024) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2024.102826 · Cited by 37 · see citing works
Molecular markers for breast cancer diagnosis, prognosis and targeted therapy
Lang, J. E., Wecsler, J. S., Press, M. F., & Tripathy, D. (2014) · Journal of Surgical Oncology · doi:10.1002/jso.23732 · Cited by 37 · see citing works
Blockade of the HER Family of Receptors in the Treatment of HER2-Positive Metastatic Breast Cancer
Sachdev, J. C., & Jahanzeb, M. (2011) · Clinical Breast Cancer · doi:10.1016/j.clbc.2011.07.001 · Cited by 37 · see citing works

PI3 kinase activation and response to trastuzumab or lapatinib in HER-2 overexpressing locally advanced breast cancer (LABC).
Migliaccio, I., Gutiérrez, M. T., Wu, M., Wong, H., Pavlick, A. C., Hilsenbeck, S., Horlings, H. M., Rimawi, M., Berns, K., Bernards, R., et al. (2009) · Cancer Research · doi:10.1158/0008-5472.sabcs-34 · Cited by 30 · see citing works
Self-citation
Activated Phosphoinositide 3-Kinase/AKT Signaling Confers Resistance to Trastuzumab but not Lapatinib
O’Brien, N. A., Browne, B. C., Chow, L., Wang, Y., Ginther, C., Arboleda, J., Duffy, M. J., Crown, J. P., O’Donovan, N., & Slamon, D. J. (2010) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-09-1171 · Cited by 324 · see citing works
An evaluation of PI3K pathway activation on the efficacy of both trastuzumab and lapatinib.
Hu, X., Wang, L. P., Zhang, Q. L., Zhang, J., Guo, H., Sun, S., Wang, B. Y., Jia, Z., Shao, Z. M., & Wang, Z. H. (2011) · Journal of Clinical Oncology · doi:10.1200/jco.2011.29.15_suppl.541
Abstract 613: Increased PI3K/AKT activity, which confers resistance to trastuzumab, can be overcome by lapatinib
O’Brien, N. A., Wang, Y., Chow, L., Wilcox, K., Browne, B. C., Crown, J. P., Arboleda, J., Ginther, C., Duffy, M. J., O’Donovan, N., et al. (2010) · Cancer Research · doi:10.1158/1538-7445.am10-613
PI3K pathway activation results in low efficacy of both trastuzumab and lapatinib
Wang, L., Zhang, Q., Zhang, J., Sun, S., Guo, H., Jia, Z. Y., Wang, B., Shao, Z., Wang, Z., & Hu, X. (2011) · BMC Cancer · doi:10.1186/1471-2407-11-248 · Cited by 146 · see citing works

Authors: Dave, B., Migliaccio, I., Gutierrez, M. C., Wu, M.-F., Chamness, G. C., Wong, H., Narasanna, A., Chakrabarty, A., Hilsenbeck, S. G., Huang, J., Rimawi, M., Schiff, R., Arteaga, C., Osborne, C. K., & Chang, J. C.
Affiliations: Houston Methodist (US)
ORCID: Migliaccio, Ilenia
Wu, Meng-Fen
Wong, Helen
Chakrabarty, Anindita
Hilsenbeck, Susan G.
Huang, Jian
Rimawi, Mothaffar
Schiff, Rachel
Arteaga, Carlos
Osborne, C. Kent
Chang, Jenny C.
Venue: Journal of Clinical Oncology
Publisher: American Society of Clinical Oncology (ASCO)
Published: 2011-01-10
Volume: 29
Issue: 2
Pages: 166-173
ISSN: 0732-183X (ISSN-L)
1527-7755
DOI: 10.1200/jco.2009.27.7814
PMC: PMC3058274
OpenAlex: W2109189228
Cited by: 252
References: 28
Citations by year: 2026: 1 · 2025: 10 · 2024: 7 · 2023: 15 · 2022: 10 · 2021: 7 · 2020: 12 · 2019: 14 · 2018: 10 · 2017: 17 · 2016: 15 · 2015: 32 · 2014: 21 · 2013: 34 · 2012: 21
FWCI: 12.66
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Journal of Clinical Oncology (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Breast Cancer Research Foundation
GlaxoSmithKline
National Cancer Institute (P50 CA 50183, R01CA112305)
Medical Research and Materiel Command
Topics: Health Sciences › Medicine › Oncology › HER2/EGFR in Cancer Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Lung Cancer Treatments and Mutations
Keywords: PTEN loss, PIK3CA mutation, trastuzumab resistance, lapatinib, HER2-positive breast cancer, locally advanced breast cancer, PI3 kinase pathway, MAPK signaling, Akt phosphorylation, pathological complete response, neoadjuvant therapy
MeSH terms: Trastuzumab, Docetaxel, Lapatinib, Adult, Aged, Antibodies, Monoclonal, Antineoplastic Combined Chemotherapy Protocols, Breast Neoplasms, Enzyme Activation, Female, Humans, Middle Aged, Mutation, Quinazolines, Transfection, Clinical Trials, Phase II as Topic, Receptor, ErbB-2, Erb-b2 Receptor Tyrosine Kinases, Phosphatidylinositol 3-Kinases, Neoadjuvant Therapy, RNA, Small Interfering, Taxoids, Cell Line, Tumor, PTEN Phosphohydrolase, Class I Phosphatidylinositol 3-Kinases, Antibodies, Monoclonal, Humanized

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Loss of phosphatase and tensin homolog or phosphoinositol-3 kinase activation and response to trastuzumab or lapatinib in human epidermal growth factor receptor 2-overexpressing locally advanced breast cancers

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