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Cited by 37Mindfulness and Compassion InterventionsCancer survivorship and carePalliative Care and End-of-Life Issues

Acceptance and commitment therapy for adults with advanced cancer (CanACT): study protocol for a feasibility randomised controlled trial

Open access
Low, Joseph, Serfaty, Marc, Davis, Sarah, Vickerstaff, Victoria, Gola, Anna, Omar, Rumana Z., King, Michael, Tookman, Adrian +3 more·2016·Trials
DOI 10.1186/s13063-016-1169-8PMC PMC4750179
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Abstract

BACKGROUND: One-third of people with cancer experience psychological distress and may suppress distressing thoughts, emotions, and concerns, leading to further problems. Conventional psychological treatments reduce distress by problem solving, but in advanced cancer, when ill health is progressive and death may be approaching, physical and psychological difficulties are complex and have no simple solutions. Acceptance and Commitment Therapy encourages acknowledgement and acceptance of mental experiences, increasing people's ability to work with problems that cannot be solved. Previous pilot work in advanced cancer confirms that distress can be associated with an avoidance of experiencing uncomfortable thoughts and emotions. METHODS/DESIGN: This feasibility randomised controlled trial of Acceptance Commitment Therapy aims to establish parameters for a larger trial. Fifty-four participants with advanced cancer will be randomly allocated to up to eight sessions (each 1 hour) of Acceptance Commitment Therapy or a talking control. Participants will be recruited from those attending outpatient services and hospice day care at three specialist palliative care units in North and East London, United Kingdom. The primary outcome is a measure of functioning in four areas of life (physical, social/family, emotional, and general activity) using the Functional Assessment of Cancer Therapies--General questionnaire at 3 months after randomisation. Secondary outcomes are (i) acceptance using the Acceptance and Action Questionnaire; (ii) psychological distress using the Kessler Psychological Distress Scale; (iii) physical functioning using a timed walk and sit-to-stand test; and (iv) quality of life measures including the Euroqol-5 Dimensions and ICECAP Supportive Care measures. Qualitative data will be collected at 3 months to explore the participants' experiences of the trial and therapy. Data will be collected on the costs of care. DISCUSSION: Data generated on the recruitment, retention, and experience of the interventions and the usefulness of the outcome measures will inform the adaptations required and whether changes in function are consistent with existing data when planning for a sufficiently powered randomised controlled trial. TRIAL REGISTRATION: ISRCTN13841211 (registered 22 July 2015).

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  • ACT-based internet-interventions are emerging and some positive preliminary results have been published.

    “More recently, ACT-based internet-interventions are emerging and some positive preliminary results have been published (Low et al., 2016; Köhle et al., 2015; Arch and Mitchell, 2016; Mujcic et al., 2018; Köhle et al., 2017).”

    From A guided internet-delivered individually-tailored ACT-influenced cognitive behavioural intervention to improve psychosocial outcomes in breast cancer survivors (iNNOVBC): Study protocol (2019) · cites this paper as Low et al., 2016

    The Background reports published ACT studies with useful pilot data in cancer settings and better outcomes in other health-related interventions. It does not identify those interventions as internet-based or report positive preliminary results specifically for internet-delivered ACT. The Interventions section instead describes the planned CanACT sessions as usually face to face. (LLM, conf=0.78)

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Authors
Low, J., Serfaty, M., Davis, S., Vickerstaff, V., Gola, A., Omar, R. Z., King, M., Tookman, A., Austen, J. S. J., Turner, K., & Jones, L.
Affiliations
  • University College London (GB)
  • Marie Curie (GB)
Corresponding author
Low, Joseph
ORCID
Venue
Trials
Publisher
Springer Science and Business Media LLC
Published
2016-02-11
Volume
17
Issue
1
Pages
77-77
ISSN
1745-6215 (ISSN-L)
DOI
10.1186/s13063-016-1169-8
PMC
PMC4750179
OpenAlex
W2260058051
Cited by
37
References
46
Citations by year
2024: 5 · 2023: 5 · 2022: 2 · 2020: 7 · 2019: 7 · 2018: 6 · 2017: 2 · 2016: 3
FWCI
8.03
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Trials (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • UCL Discovery (University College London) (submittedVersion)
Funders
National Institute for Health Research (PB-PG-1111-26043)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Mindfulness and Compassion Interventions
  • Health Sciences › Medicine › Oncology › Cancer survivorship and care
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Palliative Care and End-of-Life Issues
Keywords
acceptance and commitment therapy, advanced cancer, psychological distress, palliative care, hospice care, acceptance, quality of life, physical function, psychological intervention, trial recruitment and retention, costs of care
MeSH terms
Adult, Clinical Protocols, Data Interpretation, Statistical, Humans, Neoplasms, Patient Selection, Acceptance and Commitment Therapy

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