An acceptance and commitment therapy-based intervention for opioid use disorder risk in individuals with cancer: A treatment development study
Open accessAbstract
This paper describes the iterative development of an evidence-based behavioral intervention for individuals with cancer at risk for opioid use disorder, using the National Institutes of Health Stage Model for Behavioral Intervention Development. Adult patients with cancer from an outpatient palliative care clinic at an academic cancer center, with moderate to high risk of opioid misuse, were enrolled in a treatment development study that aimed to increase psychological flexibility. In this intervention, psychological flexibility is the posited mechanism of change for reduction of opioid use disorder risk. Patients completed baseline (pre-intervention) assessments, a six-session behavioral intervention based in Acceptance and Commitment Therapy, post-intervention assessments, and a semi-structured exit interview. Ten patients with moderate to high risk of opioid misuse completed the intervention. Patients rated the intervention as highly acceptable and were generally highly satisfied. Patients reported finding the coping skills helpful (e.g., mindfulness, cognitive defusion) and reported a preference for more sessions. These treatment development efforts have implications for the development and design of acceptance- and mindfulness-based, targeted interventions for individuals with cancer, receiving palliative care and at risk for opioid use disorder. Specifically, this six-session behavioral intervention to increase psychological flexibility was acceptable to patients and ready to be studied in a pilot RCT.
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Survey length was directly assessed in the feasibility phase of this study.
“Of note, survey length was directly assessed in the feasibility phase of this study.15”
From Study protocol for a pilot randomised controlled trial of a virtually delivered behavioural intervention (ACTION) for adults with cancer at risk for opioid use disorder (2024) · cites this paper as [15]
The Method > Patient Feedback and Results > Feasiblity Results passages say the study assessed feasibility through completion of pre- and post-intervention questionnaires. They do not report directly assessing survey length or the time needed to complete the questionnaires (no page numbers provided). (LLM, conf=0.84)
Experimental — accuracy not yet measuredIn a prior feasibility trial, participants preferred virtual delivery because it was convenient and lowered barriers to research participation.
“Participants also preferred virtual delivery, particularly because it was convenient and lowered barriers to research participation.15”
In a prior feasibility trial, participants were satisfied with the coping skills learnt.
“Participants were satisfied with the coping skills learnt”
In a prior feasibility trial, participants reported that the intervention fostered accountability and normalised internal experiences.
“reported that the intervention fostered accountability and normalised internal experiences (eg, feelings, thoughts, memories)”
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Yusufov, M., Pirl, W. F., Greer, J. A., Mazzola, E., Dalrymple, K. L., Tulsky, J. A., Braun, I. M., & McHugh, R. K. (2024) · BMJ Open · doi:10.1136/bmjopen-2024-096546 · Cited by 1 · see citing works
Self-citation
- Authors
- Yusufov, M., McHugh, R. K., Greer, J. A., Dalrymple, K. L., Sannes, T. S., Braun, I. M., Tulsky, J. A., & Pirl, W. F.
- Affiliations
- Harvard University (US)
- Brown University (US)
- Corresponding author
- Yusufov, Miryam
- ORCID
- Venue
- Journal of Contextual Behavioral Science
- Publisher
- Elsevier BV
- Published
- 2023-04
- Volume
- 28
- Pages
- 226-234
- ISSN
- 2212-1447 (ISSN-L)
- PMC
- PMC10270682
- OpenAlex
- W4366977900
- Cited by
- 3
- References
- 68
- Citations by year
- 2026: 2 · 2024: 1
- FWCI
- 0.87
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Contextual Behavioral Science (acceptedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (K08CA259538)
- National Institutes of Health
- Topics
- Social Sciences › Psychology › Clinical Psychology › Mindfulness and Compassion Interventions
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Opioid Use
- Keywords
- acceptance and commitment therapy, opioid use disorder, cancer patients, opioid misuse risk, psychological flexibility, palliative care, treatment acceptability, mindfulness, coping strategies
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