The DOI matches its Crossref record; 106 of the 106 references it cites were found in a registry or an index.
5-Hydroxymethylfurfural (HMF) levels in honey and other food products: effects on bees and human health
Open accessAbstract
An organic compound known as 5-hydroxymethylfurfural (HMF) is formed from reducing sugars in honey and various processed foods in acidic environments when they are heated through the Maillard reaction. In addition to processing, storage conditions affect the formation HMF, and HMF has become a suitable indicator of honey quality. HMF is easily absorbed from food through the gastrointestinal tract and, upon being metabolized into different derivatives, is excreted via urine. In addition to exerting detrimental effects (mutagenic, genotoxic, organotoxic and enzyme inhibitory), HMF, which is converted to a non-excretable, genotoxic compound called 5-sulfoxymethylfurfural, is beneficial to human health by providing antioxidative, anti-allergic, anti-inflammatory, anti-hypoxic, anti-sickling, and anti-hyperuricemic effects. Therefore, HMF is a neo-forming contaminant that draws great attention from scientists. This review compiles updated information regarding HMF formation, detection procedures, mitigation strategies and effects of HMF on honey bees and human health.
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Cites
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Cited by
Zeineldin, M., Esmael, A., Al-Hindi, R. R., Alharbi, M. G., Ashenafi Bekele, D., & Teklemariam, A. D. (2023) · Life · doi:10.3390/life13020503 · Cited by 27
Active Polylactic Acid (PLA) Films Incorporating Almond Peel Extracts for Food Preservation
Martin-Perez, L., Contreras, C., Chiralt, A., & Gonzalez-Martinez, C. (2025) · Molecules · doi:10.3390/molecules30091988 · Cited by 11
Metadata
- Authors
- Shapla, U. M., Solayman, M., Alam, N., Khalil, M. I., & Gan, S. H.
- Venue
- Chemistry Central Journal
- Published
- 2018-04-04
- Volume
- 12
- Issue
- 1
- Pages
- 35-35
- ISSN
- 1752-153X (ISSN-L)
- OpenAlex
- W2796200857
- Cited by
- 584
- References
- 106
- FWCI
- 34.21
- Type
- journal article
- Language
- en
- Open access
- gold
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- Shapla, U. M., Solayman, M., Alam, N., Khalil, M. I., & Gan, S. H. (2018). 5-Hydroxymethylfurfural (HMF) levels in honey and other food products: effects on bees and human health. Chemistry Central Journal. https://doi.org/10.1186/s13065-018-0408-3
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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