DNA methylation changes of whole blood cells in response to active smoking exposure in adults: a systematic review of DNA methylation studies

Aspirin plus Clopidogrel as Secondary Prevention after Stroke or Transient Ischemic Attack: A Systematic Review and Meta-Analysis

Zhang, Q., Wang, C., Zheng, M., Li, Y., Li, J., Zhang, L., Shang, X., & Yan, C. (2014) · Cerebrovascular Diseases · doi:10.1159/000369778 · Cited by 11,609

Projections of Global Mortality and Burden of Disease from 2002 to 2030

Mathers, C. D., & Loncar, D. (2006) · PLoS Medicine · doi:10.1371/journal.pmed.0030442 · Cited by 11,386

DNA methylation arrays as surrogate measures of cell mixture distribution

Houseman, E. A., Accomando, W. P., Koestler, D. C., Christensen, B. C., Marsit, C. J., Nelson, H. H., Wiencke, J. K., & Kelsey, K. T. (2012) · BMC Bioinformatics · doi:10.1186/1471-2105-13-86 · Cited by 3,175

Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease

Lohmueller, K. E., Pearce, C. L., Pike, M., Lander, E. S., & Hirschhorn, J. N. (2003) · Nature Genetics · doi:10.1038/ng1071 · Cited by 1,900

Evaluation of the endorsement of the preferred reporting items for systematic reviews and meta-analysis (PRISMA) statement on the quality of published systematic review and meta-analyses

Panic, N., Leoncini, E., de Belvis, G., Ricciardi, W., & Boccia, S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0083138 · Cited by 883

Tobacco smoking leads to extensive genome-wide changes in DNA methylation

Zeilinger, S., Kühnel, B., Klopp, N., Baurecht, H., Kleinschmidt, A., Gieger, C., Weidinger, S., Lattka, E., Adamski, J., Peters, A., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0063812 · Cited by 824

Tobacco-smoking-related differential DNA methylation: 27K discovery and replication

Breitling, L. P., Yang, R., Korn, B., Burwinkel, B., & Brenner, H. (2011) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2011.03.003 · Cited by 640

Epigenome-wide association study in the European Prospective Investigation into Cancer and Nutrition (EPIC-Turin) identifies novel genetic loci associated with smoking

Shenker, N. S., Polidoro, S., van Veldhoven, K., Sacerdote, C., Ricceri, F., Birrell, M. A., Belvisi, M. G., Brown, R., Vineis, P., & Flanagan, J. M. (2013) · Human Molecular Genetics · doi:10.1093/hmg/dds488 · Cited by 396

Cigarette smoking and DNA methylation

Lee, K. W. K., & Pausová, Z. (2013) · Frontiers in Genetics · doi:10.3389/fgene.2013.00132 · Cited by 384

Dynamics of smoking-induced genome-wide methylation changes with time since smoking cessation

Guida, F., Sandanger, T. M., Castagné, R., Campanella, G., Polidoro, S., Palli, D., Krogh, V., Tumino, R., Sacerdote, C., Panico, S., et al. (2015) · Human Molecular Genetics · doi:10.1093/hmg/ddu751 · Cited by 331

Social-Science Genomics: Progress, Challenges, and Future Directions

Benjamin, D., Cesarini, D., Turley, P., & Young, A. S. (2024) · doi:10.3386/w32404 · Cited by 20

Novel DNA Methylation Sites Influence GPR15 Expression in Relation to Smoking

Haase, T., Müller, C., Krause, J., Röthemeier, C., Stenzig, J., Kunze, S., Waldenberger, M., Münzel, T. F., Pfeiffer, N., Wild, P. S., et al. (2018) · Biomolecules · doi:10.3390/biom8030074 · Cited by 19

Identification of gene expression predictors of occupational benzene exposure

Schiffman, C., McHale, C. M., Hubbard, A., Zhang, L., Thomas, R., Vermeulen, R. C. H., Li, G., Shen, M., Rappaport, S. M., Yin, S., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0205427 · Cited by 19

Epigenome-wide association studies for breast cancer risk and risk factors.

Johansson, A., & Flanagan, J. M. (2017) · PubMed · Cited by 19

Refinement of cg05575921 demethylation response in nascent smoking

Dawes, K., Andersen, A. M., Papworth, E., Hundley, B., Hutchens, N., Manawy, H. E., Becker, A., Sampson, L., Philibert, W., Gibbons, F. X., et al. (2020) · Clinical Epigenetics · doi:10.1186/s13148-020-00882-w · Cited by 19

Methylome and transcriptome signature of bronchoalveolar cells from multiple sclerosis patients in relation to smoking

Ringh, M. V., Hagemann-Jensen, M., Needhamsen, M., Kullberg, S., Wahlström, J., Grünewald, J., Brynedal, B., Jagodic, M., Ekström, T. J., Öckinger, J., et al. (2020) · Multiple Sclerosis Journal · doi:10.1177/1352458520943768 · Cited by 18

Rotating night work, lifestyle factors, obesity and promoter methylation in BRCA1 and BRCA2 genes among nurses and midwives

Pepłońska, B., Bukowska, A., Wieczorek, E., Lesicka, M., Zienolddiny, S., & Reszka, E. (2017) · PLoS ONE · doi:10.1371/journal.pone.0178792 · Cited by 18

Global methylation profiles in buccal cells of long-term smokers and moist snuff consumers

Jessen, W. J., Borgerding, M. F., & Prasad, G. L. (2018) · Biomarkers · doi:10.1080/1354750x.2018.1466367 · Cited by 17

Accelerated DNA Methylation Aging in U.S. Military Veterans: Results From the National Health and Resilience in Veterans Study

Tamman, A. J. F., Montalvo‐Ortiz, J. L., Southwick, S. M., Krystal, J. H., Levy, B. R., & Pietrzak, R. H. (2019) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2019.01.001 · Cited by 18

Saliva DNA Methylation Detects Nascent Smoking in Adolescents

Dawes, K., Andersen, A. M., Vercande, K., Papworth, E., Philibert, W., Beach, S. R. H., Gibbons, F. X., Gerrard, M., & Philibert, R. A. (2019) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2018.0176 · Cited by 18

Social Epigenomics: Conceptualizations and Considerations for Oral Health

Gomaa, N. A. (2022) · Journal of Dental Research · doi:10.1177/00220345221110196 · Cited by 16

Genome-Wide Methylation Profiling in 229 Patients With Crohn’s Disease Requiring Intestinal Resection: Epigenetic Analysis of the Trial of Prevention of Post-operative Crohn’s Disease (TOPPIC)

Ventham, N. T., Kennedy, N. A., Kalla, R., Adams, A. T., Noble, A. J., Ennis, H., Arnott, I. D., Cahill, A., Smith, M., Ahmad, T., et al. (2023) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2023.06.001 · Cited by 16

Inference of tobacco and alcohol consumption habits from DNA methylation analysis of blood

Ambroa-Conde, A., de Cal, M. C., Gómez‐Tato, A., Robinson, O., Mosquera‐Miguel, A., de la Puente, M., Ruiz-Ramírez, J., Phillips, C., Lareu, M. V., & Freire-Aradas, A. (2024) · Forensic Science International Genetics · doi:10.1016/j.fsigen.2024.103022 · Cited by 17

Effects of smoking on genome-wide DNA methylation profiles: A study of discordant and concordant monozygotic twin pairs

van Dongen, J., Willemsen, G. A. H. M., de Geus, E. J. C., Boomsma, D. I., & Neale, M. C. (2023) · eLife · doi:10.7554/elife.83286 · Cited by 19

Changes at global and site-specific DNA methylation of MLH1 gene promoter induced by waterpipe smoking in blood lymphocytes and oral epithelial cells

Sabi, S. H., Khabour, O. F., Alzoubi, K. H., Cobb, C. O., & Eissenberg, T. (2020) · Inhalation Toxicology · doi:10.1080/08958378.2020.1754972 · Cited by 16

CpG site-specific methylation as epi-biomarkers for the prediction of health risk in PAHs-exposed populations

Ye, L., He, Z., Li, D., Chen, L., Chen, S., Guo, P., Yu, D., Ma, L., Niu, Y., Duan, H., et al. (2022) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2022.128538 · Cited by 17

Sex-dichotomous effects of NOS1AP promoter DNA methylation on intracranial aneurysm and brain arteriovenous malformation

Wang, Z., Zhao, J., Sun, J., Nie, S., Li, K., Gao, F., Zhang, T., Duan, S., Di, Y., Huang, Y., et al. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.04.016 · Cited by 16

A comparison of reference-based algorithms for correcting cell-type heterogeneity in Epigenome-Wide Association StudiesPreprint

Teschendorff, A. E., Breeze, C. E., Zheng, S., & Beck, S. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/101709 · Cited by 16

Using DNA methylation to validate an electronic medical record phenotype for smoking

McGinnis, K. A., Justice, A. C., Tate, J. P., Kranzler, H. R., Tindle, H. A., Becker, W. C., Concato, J., Gelernter, J. E., Li, B., Zhang, X., et al. (2018) · Addiction Biology · doi:10.1111/adb.12670 · Cited by 15

Differential Regulation of Human Surfactant Protein A Genes, SFTPA1 and SFTPA2, and Their Corresponding Variants

Floros, J., & Tsotakos, N. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.766719 · Cited by 16

Altered Global 5-Hydroxymethylation Status in Hidradenitis Suppurativa: Support for an Epigenetic Background

Hessam, S., Sand, M. S., Lang, K., Käfferlein, H. U., Scholl, L., Gambichler, T., Skrygan, M., Brüning, T., Stockfleth, E., & Bechara, F. G. (2017) · Dermatology · doi:10.1159/000478043 · Cited by 15

Precision behavioral medicine: Implications of genetic and genomic discoveries for behavioral weight loss treatment.

McCaffery, J. M. (2018) · American Psychologist · doi:10.1037/amp0000253 · Cited by 15

AHRR Methylation is a Significant Predictor of Mortality Risk in Framingham Heart Study

Philibert, R. A., Dogan, M. V., Mills, J. A., & Long, J. D. (2019) · Journal of Insurance Medicine · doi:10.17849/insm-48-1-1-11.1 · Cited by 15

Using Cg05575921 methylation to predict lung cancer risk: a potentially bias-free precision epigenetics approach

Philibert, R. A., Dawes, K., Moody, J., Hoffman, R. M., Sieren, J. C., & Long, J. D. (2022) · Epigenetics · doi:10.1080/15592294.2022.2108082 · Cited by 14

Impact of confounding by leukocyte composition on associations of leukocyte DNA methylation with common risk factors

Heiss, J. A., & Brenner, H. (2017) · Epigenomics · doi:10.2217/epi-2016-0154 · Cited by 13

Crosstalk between Environmental Inflammatory Stimuli and Non-Coding RNA in Cancer Occurrence and Development

Xu, T., Xie, M., Jing, X., Cui, J., Wu, X., & Shu, Y. (2021) · Cancers · doi:10.3390/cancers13174436 · Cited by 14

Epigenetics: A link between toxicants and diseases

Romano, A. D. R. R., Pagiatakis, C., Gornati, R., Bernardini, G., & Papait, R. (2025) · iScience · doi:10.1016/j.isci.2025.112613 · Cited by 13

Smoke-induced SAV1 Gene Promoter Hypermethylation Disrupts YAP Negative Feedback and Promotes Malignant Progression of Non-small Cell Lung Cancer

Liu, T., Guo, W., Luo, K., Li, L., Dong, J., Liu, M., Shi, X., Wang, Z., Zhang, J., Yin, J., et al. (2022) · International Journal of Biological Sciences · doi:10.7150/ijbs.73428 · Cited by 13

Epigenetic age acceleration mediates the association between smoking and diabetes-related outcomes

Chang, X.-Y., & Lin, W. (2023) · Clinical Epigenetics · doi:10.1186/s13148-023-01512-x · Cited by 13

Prediction of smoking by multiplex bisulfite PCR with long amplicons considering allele-specific effects on DNA methylation

Kondratyev, N. V., Golov, A. K., Алфимова, М. В., Лежейко, Т. В., & Голимбет, В. Е. (2018) · Clinical Epigenetics · doi:10.1186/s13148-018-0565-1 · Cited by 13

Blood‐derived DNA methylation predictors of mortality discriminate tumor and healthy tissue in multiple organs

Zhang, Y., Bewerunge‐Hudler, M., Schick, M., Burwinkel, B., Herpel, E., Hoffmeister, M., & Brenner, H. (2020) · Molecular Oncology · doi:10.1002/1878-0261.12738 · Cited by 13

Cellular expression of epigenetic markers and oxidative stress in periodontitis lesions of smokers and non‐smokers

Dionigi, C., Larsson, L., Difloe‐Geisert, J. C., Zitzmann, N. U., & Berglundh, T. (2022) · Journal of Periodontal Research · doi:10.1111/jre.13030 · Cited by 13

Prenatal smoke exposure induces persistent Cyp2a5 methylation and increases nicotine metabolism in the liver of neonatal and adult male offspring

Lkhagvadorj, K., Meyer, K. F., Verweij, L. P., Kooistra, W., Reinders-Luinge, M., Dijkhuizen, H. W., de Graaf, I. A. M., Plösch, T., & Hylkema, M. N. (2020) · Epigenetics · doi:10.1080/15592294.2020.1782655 · Cited by 14

Epigenome-wide DNA methylation in unipolar depression: predictive biomarker of antidepressant treatment response?

Schiele, M. A., Crespo Salvador, O., Lipovsek, J., Schwarte, K., Schlosser, P., Zwanzger, P., Arolt, V., Baune, B. T., Köttgen, A., & Domschke, K. (2024) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyae045 · Cited by 13

DNA methylation changes in response to active smoking exposure are associated with leukocyte telomere length among older adults

Gao, X., Mons, U., Zhang, Y., Breitling, L. P., & Brenner, H. (2016) · European Journal of Epidemiology · doi:10.1007/s10654-016-0210-2 · Cited by 12

ADHD genetic burden associates with older epigenetic age: mediating roles of education, behavioral and sociodemographic factors among older adults

Arpawong, T. E., Klopack, E. T., Kim, J. K., & Crimmins, E. M. (2023) · Clinical Epigenetics · doi:10.1186/s13148-023-01484-y · Cited by 14

Artificial intelligence-based epigenomic, transcriptomic and histologic signatures of tobacco use in oral squamous cell carcinoma

Viet, C. T., Asam, K. R., Yu, G., Dyer, E., Kochanny, S. E., Thomas, C. M., Callahan, N. F., Morlandt, A. B., Cheng, A. C., Patel, A., et al. (2024) · npj Precision Oncology · doi:10.1038/s41698-024-00605-x · Cited by 12

Frequent DNA methylation changes in cancerous and noncancerous lung tissues from smokers with non-small cell lung cancer

Daniūnaitė, K., Šeštokaitė, A., Kubiliūtė, R., Stuopelytė, K., Kettunen, E., Husgafvel‐Pursiainen, K., & Jarmalaitė, S. (2020) · Mutagenesis · doi:10.1093/mutage/geaa022 · Cited by 12

Inflammatory biomarker relationships with helper T cell GPR15 expression and cannabis and tobacco smoking

Andersen, A. M., Lei, M., Beach, S. R. H., & Philibert, R. A. (2020) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2020.110326 · Cited by 12

Data Analysis of DNA Methylation Epigenome-Wide Association Studies (EWAS): A Guide to the Principles of Best Practice

Bhat, B. A., & Jones, G. T. (2022) · Methods in molecular biology · doi:10.1007/978-1-0716-2140-0_2 · Cited by 12

Cigarette smoking related DNA methylation in peripheral leukocytes and cardiovascular risk in young adults

Sabogal, C., Su, S., Tingen, M. S., Kapuku, G. K., & Wang, X. (2019) · International Journal of Cardiology · doi:10.1016/j.ijcard.2019.11.103 · Cited by 12

Active and secondhand smoke exposure throughout life and DNA methylation in breast tumors

Callahan, C. L., Bonner, M. R., Nie, J., Wang, Y., Tao, M., Shields, P. G., Marian, C., Eng, K. H., Trevisan, M., & Freudenheim, J. L. (2019) · Cancer Causes & Control · doi:10.1007/s10552-018-1102-4 · Cited by 12

Epigenetic Analyses of Alcohol Consumption in Combustible and Non-Combustible Nicotine Product Users

Dawes, K., Sampson, L., Reimer, R. A., Miller, S., Philibert, R. A., & Andersen, A. M. (2021) · Epigenomes · doi:10.3390/epigenomes5030018 · Cited by 11

A comprehensive analysis of AHRR gene as a candidate for cleft lip with or without cleft palate

Linnenkamp, B. D. W., Raskin, S., Elífio-Esposito, S., & Herai, R. H. (2020) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2020.108319 · Cited by 11

Cancer-related changes and low-to-moderate exposure to welding fumes: A longitudinal study

Dauter, U. M., Alhamdow, A., Cediel-Ulloa, A., Gliga, A. R., Albin, M. C., & Bröberg, K. (2021) · Scandinavian Journal of Work Environment & Health · doi:10.5271/sjweh.3988 · Cited by 11

Novel blood-based hypomethylation of SH3BP5 is associated with very early-stage lung adenocarcinoma

Qiao, R., Zhong, R., Liu, C., Di, F., Zhang, Z., Wang, L., Tian, X., Wang, Y., Dai, L., Gu, W., et al. (2021) · Genes & Genomics · doi:10.1007/s13258-021-01190-0 · Cited by 11

Genome-wide methylation data improves dissection of the effect of smoking on body mass index

Amador, C., Zeng, Y., Barber, M., Walker, R. M., Campbell, A., McIntosh, A. M., Evans, K. L., Porteous, D. J., Hayward, C., Wilson, J. F., et al. (2021) · PLoS Genetics · doi:10.1371/journal.pgen.1009750 · Cited by 10

DNA Methylation Biomarkers Of Myocardial Infarction And Cardiovascular DiseasePreprint

Fernández‐Sanlés, A., Sayols-Baixeras, S., Subirana, I., Sentı́, M., Pérez-Fernández, S., de Moura, M. C., Esteller, M., Marrugat, J., & Elosúa, R. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/707315 · Cited by 11

An integrative machine learning approach to discovering multi-level molecular mechanisms of obesity using data from monozygotic twin pairs

Kibble, M., Khan, S. A., Ammad-ud-din, M., Bollepalli, S., Palviainen, T., Kaprio, J. A., Pietiläinen, K. H., & Ollikainen, M. (2020) · Royal Society Open Science · doi:10.1098/rsos.200872 · Cited by 10

Hypomethylation of AHRR (cg05575921) Is Related to Smoking Status in the Mexican Mestizo Population

Bravo-Gutiérrez, O. A., Falfán‐Valencia, R., Ramírez‐Venegas, A., Sansores, R. H., Hernández-Zenteno, R. D. J., Hernández‐Pérez, A., García‐Gómez, L., Osio-Echánove, J., Abarca‐Rojano, E., & Pérez-Rubio, G. (2021) · Genes · doi:10.3390/genes12081276 · Cited by 10

A Review of High-Dimensional Mediation Analyses in DNA Methylation Studies

Zhang, H., Hou, L., & Liu, L. (2021) · Methods in molecular biology · doi:10.1007/978-1-0716-1994-0_10 · Cited by 9

No association between peripheral serotonin-gene-related DNA methylation and brain serotonin neurotransmission in the healthy and depressed state

Bruzzone, S. E. P., Ozenne, B., Fisher, P. M., Ortega, G., Jensen, P. S., Dam, V. H., Svarer, C., Knudsen, G. M., Lesch, K., & Frøkjær, V. G. (2024) · Clinical Epigenetics · doi:10.1186/s13148-024-01678-y · Cited by 10

False data, positive results in neurobiology: moving beyond the epigenetics of blood and saliva samples in mental disorders

Cariaga-Martínez, A. E., & Alelú‐Paz, R. (2016) · Journal of Negative Results in BioMedicine · doi:10.1186/s12952-016-0064-x · Cited by 10

Epigenetic changes in peripheral leucocytes as biomarkers in intrauterine growth retardation rat

Xu, X., Xu, S., Fu, L.-C., Hu, Q., Lv, Y., & Du, L. (2016) · Biomedical Reports · doi:10.3892/br.2016.775 · Cited by 9

The influence of human leukocyte antigen-DRB1*15:01 and its interaction with smoking in MS development is dependent on DQA1*01:01 status

Hedström, A. K., Hössjer, O., Hillert, J. A., Stridh, P., Kockum, I. S., Olsson, T. P., & Alfredsson, L. S. (2019) · Multiple Sclerosis Journal · doi:10.1177/1352458519877685 · Cited by 10

Causal Mediation Analysis for Integrating Exposure, Genomic, and Phenotype Data

Yang, H., Liu, Z., Wang, R., Lai, E., Schwartz, J. D., Baccarelli, A., Huang, Y., & Lin, X. (2024) · Annual Review of Statistics and Its Application · doi:10.1146/annurev-statistics-040622-031653 · Cited by 9

Epigenome-wide association analyses of active injection drug use

Shu, C., Jaffe, A. E., Sabunciyan, S., Ji, H., Astemborski, J. A., Sun, J., Bakulski, K. M., Sosnowski, D. W., Mehta, S. H., Kirk, G. D., et al. (2022) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2022.109431 · Cited by 10

Relationships of Long-Term Smoking and Moist Snuff Consumption With a DNA Methylation Age Relevant Smoking Index: An Analysis in Buccal Cells

Nwanaji‐Enwerem, J. C., Cárdenas, A., Chai, P. R., Weisskopf, M. G., Baccarelli, A., & Boyer, E. W. (2018) · Nicotine & Tobacco Research · doi:10.1093/ntr/nty156 · Cited by 9

Changes in global DNA methylation and hydroxymethylation in oral mucosa according to tobacco smoke exposure

Emilia, A. G., Marcu, A., Moatăr, A. I., Samoilă, C., Podariu, A. C., Șeclăman, E. P., & Marian, C. (2020) · Journal of International Medical Research · doi:10.1177/0300060520954677 · Cited by 9

Epigenetic prediction of complex traits and mortality in a cohort of individuals with oropharyngeal cancer

Langdon, R., Beynon, R. A., Ingarfield, K., Marioni, R. E., McCartney, D. L., Martin, R. M., Ness, A., Pawlita, M., Waterboer, T., Relton, C. L., et al. (2020) · Clinical Epigenetics · doi:10.1186/s13148-020-00850-4 · Cited by 9

Heterogeneity of thymic output in the elderly and its association with sex and smoking

Sandhar, B. S., Vyas, V. S., Harding, D., Ragazzini, R., Bonfanti, P., Marelli‐Berg, F. M., Bell, C. G., Chain, B., & Longhi, M. P. (2025) · JCI Insight · doi:10.1172/jci.insight.189008 · Cited by 10

Mortality and morbidity risk prediction for older former smokers based on a score of smoking history: evidence from UK Biobank and ESTHER cohorts

Gao, X., Huang, N., Jiang, M., Holleczek, B., Schöttker, B., Huang, T., & Brenner, H. (2022) · Age and Ageing · doi:10.1093/ageing/afac154 · Cited by 8

Postnatal Smoke Exposure Further Increases the Hepatic Nicotine Metabolism in Prenatally Smoke Exposed Male Offspring and Is Linked with Aberrant Cyp2a5 Methylation

Lkhagvadorj, K., Zeng, Z., Meyer, K. F., Verweij, L. P., Kooistra, W., Reinders-Luinge, M., Dijkhuizen, H. W., de Graaf, I. A. M., Plösch, T., & Hylkema, M. N. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms22010164 · Cited by 8

An Examination of Risk Factors for Tobacco and Cannabis Smoke Exposure in Adolescents Using an Epigenetic Biomarker

Andersen, A. M., Gerrard, M., Gibbons, F. X., Beach, S. R. H., & Philibert, R. A. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.688384 · Cited by 8

Association of DNA methylation in circulating CD4+T cells with short-term PM2.5 pollution waves: A quasi-experimental study of healthy young adults

Jiang, M., Wang, X., Gao, X., Cárdenas, A., Baccarelli, A., Guo, X., Huang, J., & Wu, S. (2022) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2022.113634 · Cited by 8

Longitudinal analysis of epigenome-wide DNA methylation reveals novel smoking-related loci in African Americans

Liu, J., Zhao, W., Ammous, F., Turner, S. T., Mosley, T. H., Zhou, X., & Smith, J. A. (2019) · Epigenetics · doi:10.1080/15592294.2019.1581589 · Cited by 8

Epigenetic Epidemiology as a Tool to Understand the Role of Immunity in Chronic Disease

Nelson, H. H., & Kelsey, K. T. (2016) · Epigenomics · doi:10.2217/epi-2016-0055 · Cited by 8

Epigenetic aging in Williams syndrome

Okazaki, S., Kimura, R., Otsuka, I., Tomiwa, K., Funabiki, Y., Hagiwara, M., Murai, T., & Hishimoto, A. (2022) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.13613 · Cited by 7

“Gestaltomics”: Systems Biology Schemes for the Study of Neuropsychiatric Diseases

Gutiérrez-Nájera, N., Reséndis-Antonio, O., & Nicolini, H. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00286 · Cited by 8

Regularized estimation in sparse high-dimensional multivariate regression, with application to a DNA methylation study

Zhang, H., Zheng, Y., Yoon, G., Zhang, Z., Gao, T., Joyce, B. T., Zhang, W., Schwartz, J. D., Vokonas, P., Colicino, E., et al. (2017) · Statistical Applications in Genetics and Molecular Biology · doi:10.1515/sagmb-2016-0073 · Cited by 7

Vitamin D status and epigenetic-based mortality risk score: strong independent and joint prediction of all-cause mortality in a population-based cohort study

Gao, X., Zhang, Y., Schöttker, B., & Brenner, H. (2018) · Clinical Epigenetics · doi:10.1186/s13148-018-0515-y · Cited by 7

LINE-1 methylation mediates the inverse association between body mass index and breast cancer risk: A pilot study in the Lebanese population

Awada, Z., Bouaoun, L., Nasr, R., Tfayli, A., Cuenin, C., Akika, R., Boustany, R., Makoukji, J., Tamim, H., Zgheib, N. K., et al. (2021) · Environmental Research · doi:10.1016/j.envres.2021.111094 · Cited by 6

Age-Related Macular Degeneration: From Epigenetics to Therapeutic Implications

Farkas, M. H., & DeAngelis, M. M. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-66014-7_9 · Cited by 7

RNA sequencing to predict response to TNF-α inhibitors reveals possible mechanism for nonresponse in smokers

Cuppen, B. V. J., Rossato, M., Fritsch-Stork, R. D. E., Concepcion, A. N., Linn-Rasker, S. P., Bijlsma, J. W. J., van Laar, J. M., Lafeber, F. P. J. G., & Radstake, T. R. D. J. (2018) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2018.1480937 · Cited by 7

DNA methylation-based semen age prediction using the markers identified in Koreans and Europeans

Lee, J. E., Cho, S., So, M. H., & Lee, H. Y. (2025) · Forensic Science International Genetics · doi:10.1016/j.fsigen.2025.103243 · Cited by 8

Variation in Arterial Stiffness and Markers of Oxidative Stress in Patients with Type 2 Diabetes Mellitus from Different Ethnic Groups

Zitouni, K., Steyn, M., Lewis, J. E. A., Kelly, F. J., Cook, P. R., & Earle, K. (2025) · Antioxidants · doi:10.3390/antiox14070858 · Cited by 6

A variability in response of osteoclasts to zoledronic acid is mediated by smoking-associated modification in the DNA methylome

Tan, Q., Møller, A. M. J., Qiu, C., Madsen, J. S., Shen, H., Bechmann, T., Delaissé, J., Kristensen, B. W., Deng, H., Karasik, D., et al. (2023) · Clinical Epigenetics · doi:10.1186/s13148-023-01449-1 · Cited by 6

Epigenome-wide association study of total nicotine equivalents in multiethnic current smokers from three prospective cohorts

Huang, B. Z., Binder, A. M., Quon, B. K., Patel, Y. M., Lum‐Jones, A., Tiirikainen, M., Murphy, S. E., Loo, L. W. M., Maunakea, A. K., Haiman, C. A., et al. (2024) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2024.01.012 · Cited by 6

Predicting risk of lung function impairment and all-cause mortality using a DNA methylation-based classifier of tobacco smoke exposure

Eckhardt, C. M., Wu, H., Prada, D., Vokonas, P., Sparrow, D., Hou, L., Schwartz, J. D., & Baccarelli, A. (2022) · Respiratory Medicine · doi:10.1016/j.rmed.2022.106896 · Cited by 6

Effect of menopausal hormone therapy on methylation levels in early and late postmenopausal women

Hilser, J. R., Hartiala, J., Sriprasert, I., Kono, N., Cai, Z., Karim, R., DeYoung, J. A., Mack, W. J., Hodis, H. N., & Allayee, H. (2022) · Clinical Epigenetics · doi:10.1186/s13148-022-01311-w · Cited by 6

Short-term smoking cessation leads to a universal decrease in whole blood genomic DNA methylation in patients with a smoking history

Shang, J., Nie, X., Qi, Y., Zhou, J., & Qi, Y. (2023) · World Journal of Surgical Oncology · doi:10.1186/s12957-023-03099-2 · Cited by 6

Relationship between Alzheimer's disease-associated SNPs within the CLU gene, local DNA methylation and episodic verbal memory in healthy and schizophrenia subjects

Алфимова, М. В., Kondratyev, N. V., Golov, A. K., & Голимбет, В. Е. (2018) · Psychiatry Research · doi:10.1016/j.psychres.2018.12.134 · Cited by 6

Epigenome‐Wide Tobacco‐Related Methylation Signature Identification and Their Multilevel Regulatory Network Inference for Lung Adenocarcinoma

Dong, Y., Li, M., He, Q., Tong, Y.-F., Gao, H., Zhang, Y.-Z., Wu, Y., Hu, J., Zhang, N., & Song, K. (2020) · BioMed Research International · doi:10.1155/2020/2471915 · Cited by 6

Unraveling the causal impact of smoking and its DNA methylation signatures on cardiovascular disease: Mendelian randomization and colocalization analysis

Cao, S., Zeng, Y., Pang, K., Chen, M., Guo, R., Wu, N., Fang, C., Deng, H., Zhang, X., Xie, X., et al. (2025) · Clinical Epigenetics · doi:10.1186/s13148-024-01808-6 · Cited by 6

SNP-by-CpG Site Interactions in ABCA7 Are Associated with Cognition in Older African Americans

Chaar, D., Nguyen, K. A., Wang, Y.-Z., Ratliff, S. M., Mosley, T. H., Kardia, S. L. R., Smith, J. A., & Zhao, W. (2022) · Genes · doi:10.3390/genes13112150 · Cited by 5

Picking the Right Fruit: Intersecting Chronic Obstructive Pulmonary Disease Genome-Wide Association Study Discoveries with Epigenetics

Ortega, V. E. (2018) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201801-0084ed · Cited by 5

Risk Biomarkers Enable Precision in Public Health

Ollier, W., Muir, K. R., Lophatananon, A., Verma, A., & Yuille, M. (2018) · Personalized Medicine · doi:10.2217/pme-2017-0068 · Cited by 5

Biomarkers in IPF

Yunt, Z. X., Aschner, Y., & Brown, K. M. (2018) · Elsevier eBooks · doi:10.1016/b978-0-323-54431-3.00010-x · Cited by 5

A Droplet Digital PCR Assay for Smoking Predicts All-Cause Mortality

Andersen, A. M., Ryan, P. T., Gibbons, F. X., Simons, R. L., Long, J. D., & Philibert, R. A. (2018) · Journal of Insurance Medicine · doi:10.17849/insm-47-4-1-10.1 · Cited by 5

Mediation analysis method review of high throughput data

Han, Q., Wang, Y., Sun, N., Chu, J., Hu, W., & Shen, Y. (2023) · Statistical Applications in Genetics and Molecular Biology · doi:10.1515/sagmb-2023-0031 · Cited by 4

A validated restriction enzyme ddPCR cg05575921 (AHRR) assay to accurately assess smoking exposure

Fitzgerald, S., Bhat, B., Print, C. G., & Jones, G. T. (2024) · Clinical Epigenetics · doi:10.1186/s13148-024-01659-1 · Cited by 2

Neighborhood environment associations with cognitive function and structural brain measures in older African Americans

Chaar, D., Tu, L., Moore, K., Du, J., Opsasnick, L. A., Ratliff, S. M., Mosley, T. H., Kardia, S. L. R., Zhao, W., Zhou, X., et al. (2025) · BMC Medicine · doi:10.1186/s12916-024-03845-7 · Cited by 5

The effect of maternal prenatal tobacco smoking on offspring academic achievement: A systematic review and meta-analysis

Duko, B., Bedaso, A., Dachew, B. A., Newnham, E. A., Gebremedhin, A. T., Tessema, G. A., Einarsdóttir, K., Alati, R., & Pereira, G. F. (2024) · Addictive Behaviors · doi:10.1016/j.addbeh.2024.107985 · Cited by 4

Rationale, Study Design, and Cohort Characteristics for the Markers for Environmental Exposures (MEE) Study

Lucia, R. M., Huang, W., Alvarez, A., Thampy, D., Elyasian, M., Hidajat, A., Yang, K. J., Forman, D., Pebdani, A., Masunaka, I. K., et al. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17051774 · Cited by 4

Identification of tissue-specific and common methylation quantitative trait loci in healthy individuals using MAGAR

Scherer, M., Gasparoni, G., Rahmouni, S., Shashkova, T., Arnoux, M., Louis, E. J., Nostaeva, A. V., Avalos, D., Dermitzakis, E. T., Aulchenko, Y. S., et al. (2021) · Epigenetics & Chromatin · doi:10.1186/s13072-021-00415-6 · Cited by 3

PTSD and physiology: The long-term effects of PTSD and relation to epigenetics, physical health, and chronic diseases

Reed, K., Cleveland, S., Thomas, J. L., Hsu, A., Jeong, A., Nguyen, J., Patel, A., Zhang, S., & Sumner, J. A. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-823039-8.00016-2 · Cited by 4

Influence of the environment, gender, and hormones on systemic lupus erythematosus: A narrative review

Duran-Barragán, S., Bátiz-Andrade, J. P., Valenzuela-Marrufo, R. A., & Alarcón, G. S. (2021) · Revista Colombiana de Reumatología · doi:10.1016/j.rcreu.2021.02.008 · Cited by 4

Differential methylation as a mediator of COVID-19 susceptibilityPreprint

Steyaert, S., Trooskens, G., Delanghe, J., & Criekinge, W. V. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.08.14.251538 · Cited by 4

Cigarette smoke and biological age induce degenerative heterogeneity in retinal pigment epitheliumPreprint

Singh, K., Jin, Y. O., Hu, M.-W., Palazzo, I., Cano, M., Hoang, T. V., Bhutto, I. A., Wang, S., Sinha, D., Blackshaw, S., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.01.27.635096 · Cited by 4

Biological age and diet: Measuring the impact of lifestyle on a 6CpG-epigenetic clock

Bordoni, L., Malinowska, A. M., Petracci, I., Chmurzyńska, A., & Gabbianelli, R. (2022) · Nutrition and Healthy Aging · doi:10.3233/nha-220160 · Cited by 3

Additional file 1: Table S1. of DNA methylation changes of whole blood cells in response to active smoking exposure in adults: a systematic review of DNA methylation studies

Gao, X., Jia, M., Zhang, Y., Breitling, L. P., & Brenner, H. (2015) · Figshare · doi:10.6084/m9.figshare.c.3626948_d1

REVIEW

(2016)

DNA methylation and smoking in Korean adults: epigenome-wide association study

Lee, M. K., Hong, Y., Kim, S., London, S. J., & Kim, W. J. (2016) · Clinical Epigenetics · doi:10.1186/s13148-016-0266-6 · Cited by 51

Abstract 3647: Dose-dependent alteration of CpG methylation in AHRR and GFI1 in mononuclear cell DNA of smokers.

Wang, X., Pittman, G. S., Su, D., Adamski, K. N., Campbell, M. R., Joubert, B. R., Huang, Z. Y., Hoyo, C., Murphy, S. K., London, S., et al. (2013) · Cancer Research · doi:10.1158/1538-7445.am2013-3647 · Cited by 1

Epigenome-450K-wide methylation signatures of active cigarette smoking: The Young Finns Study

Mishra, P. P., Hanninen, I., Raitoharju, E., Marttila, S., Mishra, B. H., Mononen, N., Kahonen, M., Hurme, M., Raitakari, O. T., Toronen, P., et al. (2022) · UTUPub (University of Turku)