The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Comparison of exosomes secreted by induced pluripotent stem cell-derived mesenchymal stem cells and synovial membrane-derived mesenchymal stem cells for the treatment of osteoarthritis
Open accessAbstract
BACKGROUND: Osteoarthritis (OA) is the most common joint disease worldwide. In the past decade, mesenchymal stem cells (MSCs) have been used widely for the treatment of OA. A potential mechanism of MSC-based therapies has been attributed to the paracrine secretion of trophic factors, in which exosomes may play a major role. In this study, we aimed to compare the effectiveness of exosomes secreted by synovial membrane MSCs (SMMSC-Exos) and exosomes secreted by induced pluripotent stem cell-derived MSCs (iMSC-Exos) on the treatment of OA. METHODS: Induced pluripotent stem cell-derived MSCs and synovial membrane MSCs were characterized by flow cytometry. iMSC-Exos and SMMSC-Exos were isolated using an ultrafiltration method. Tunable resistive pulse-sensing analysis, transmission electron microscopy, and western blots were used to identify exosomes. iMSC-Exos and SMMSC-Exos were injected intra-articularly in a mouse model of collagenase-induced OA and the efficacy of exosome injections was assessed by macroscopic, histological, and immunohistochemistry analysis. We also evaluated the effects of iMSC-Exos and SMMSC-Exos on proliferation and migration of human chondrocytes by cell-counting and scratch assays, respectively. RESULTS: The majority of iMSC-Exos and SMMSC-Exos were approximately 50-150 nm in diameter and expressed CD9, CD63, and TSG101. The injection of iMSC-Exos and SMMSC-Exos both attenuated OA in the mouse OA model, but iMSC-Exos had a superior therapeutic effect compared with SMMSC-Exos. Similarly, chondrocyte migration and proliferation were stimulated by both iMSC-Exos and SMMSC-Exos, with iMSC-Exos exerting a stronger effect. CONCLUSIONS: The present study demonstrated that iMSC-Exos have a greater therapeutic effect on OA than SMMSC-Exos. Because autologous iMSCs are theoretically inexhaustible, iMSC-Exos may represent a novel therapeutic approach for the treatment of OA.
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Cites
Paracrine Mechanisms of Mesenchymal Stem Cell-Based Therapy: Current Status and Perspectives
Liang, X., Ding, Y., Zhang, Y., Tse, H.-F., & Lian, Q. (2014) · Cell Transplantation · doi:10.3727/096368913x667709 · Cited by 909
Exosomes: Vehicles of Intercellular Signaling, Biomarkers, and Vectors of Cell Therapy
Kourembanas, S. (2015) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021014-071641 · Cited by 761
Cited by
Mesenchymal stem cell secretome: toward cell-free therapeutic strategies in regenerative medicine
Vizoso, F., Eiro, N., Cid, S., Schneider, J., & Perez-Fernandez, R. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18091852 · Cited by 1,363
Clinical applications of stem cell-derived exosomes
Tan, F., Li, X., Wang, Z., Li, J., Shahzad, K., & Zheng, J. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01704-0 · Cited by 708
Mesenchymal stem cell-derived exosomes: a new therapeutic approach to osteoarthritis?
Mianehsaz, E., Mirzaei, H. R., Mahjoubin-Tehran, M., Rezaee, A., Sahebnasagh, R., Pourhanifeh, M. H., Mirzaei, H., & Hamblin, M. R. (2019) · Stem Cell Research & Therapy · doi:10.1186/s13287-019-1445-0 · Cited by 274
The tissue origin effect of extracellular vesicles on cartilage and bone regeneration
Li, Q., Yu, H., Sun, M., Yang, P., Hu, X., Ao, Y., & Cheng, J. (2021) · Acta Biomaterialia · doi:10.1016/j.actbio.2021.02.039 · Cited by 172
Self-citationMa, Z.-J., Yang, J.-J., Lu, Y.-B., Liu, Z.-Y., & Wang, X.-X. (2020) · World Journal of Stem Cells · doi:10.4252/wjsc.v12.i8.814 · Cited by 155
Exosomes: a tool for bone tissue engineering
Huber, J., Griffin, M. F., Longaker, M. T., & Quarto, N. (2022) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2020.0246 · Cited by 41
Lang, H.-L., Zhao, Y.-Z., Xiao, R.-J., Sun, J., Chen, Y., Hu, G.-W., & Xu, G.-H. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.350205 · Cited by 33
Self-citationGerami, M. H., Khorram, R., Rasoolzadegan, S., Mardpour, S., Nakhaei, P., Hashemi, S., Al-Naqeeb, B. Z. T., Aminian, A., & Samimi, S. (2023) · European Journal of Medical Research · doi:10.1186/s40001-023-01034-5 · Cited by 27
RetractedBuitrago, J. C., Morris, S. L., Backhaus, A., Kaltenecker, G., Kaipa, J. M., Girard, C., Schneider, S., & Gruber, J. (2024) · Scientific Reports · doi:10.1038/s41598-024-75956-3 · Cited by 21
Scalzone, A., Sanjurjo-Rodríguez, C., Berlinguer-Palmini, R., Dickinson, A. M., Jones, E., Wang, X.-N., & Crossland, R. E. (2024) · Bioengineering · doi:10.3390/bioengineering11040388 · Cited by 16
Metadata
- Authors
- Zhu, Y., Wang, Y., Zhao, B., Niu, X., Hu, B., Li, Q., Zhang, J., Ding, J., Chen, Y., & Wang, Y.
- Venue
- Stem Cell Research & Therapy
- Published
- 2017-03-09
- Volume
- 8
- Issue
- 1
- Pages
- 64-64
- ISSN
- 1757-6512 (ISSN-L)
- OpenAlex
- W2591763108
- Cited by
- 446
- References
- 2
- FWCI
- 28.87
- Type
- journal article
- Language
- en
- Open access
- gold
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