Osteogenesis and aging: lessons from mesenchymal stem cells

The Hallmarks of Aging

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The amazing osteocyte

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Fate decision of mesenchymal stem cells: adipocytes or osteoblasts?

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Single-layer graphene oxide nanosheets induce proliferation and Osteogenesis of single-cell hBMSCs encapsulated in Alginate Microgels

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Quercetin regulates ERα mediated differentiation of BMSCs through circular RNA

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Myocardin-Related Transcription Factor A (MRTF-A) Regulates the Balance between Adipogenesis and Osteogenesis of Human Adipose Stem Cells

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Suffruticosol A elevates osteoblast differentiation targeting BMP2‐Smad /1/5/ 8‐RUNX2 in pre‐osteoblasts

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Sulfurous thermal waters stimulate the osteogenic differentiation of human mesenchymal stromal cells – An in vitro study

Gambari, L., Grigolo, B., Filardo, G., & Grassi, F. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110344 · Cited by 17

Regulatory cellular and molecular networks in the bone microenvironment during aging

Zhang, L., Wang, Z., Zhang, Y., Ji, R., Li, Z., Zou, J., & Gao, B. (2024) · Life Medicine · doi:10.1093/lifemedi/lnae019 · Cited by 19

Biomechanical Basis for Bone Healing and Osseointegration of Implants in Sinus Grafts

Stacchi, C., Coyac, B. R., & Helms, J. A. (2024) · Clinical Implant Dentistry and Related Research · doi:10.1111/cid.13424 · Cited by 17

Biomaterials targeting senescent cells for bone regeneration: State-of-the-art and future perspectives

Wu, H., Zhang, Q., Zhu, J., Wu, L., Xiao, Y., & Yang, X. (2025) · Bioactive Materials · doi:10.1016/j.bioactmat.2025.09.002 · Cited by 18

Consumption of Phytoestrogens Affects Bone Health by Regulating Estrogen Metabolism

Tomczyk‐Warunek, A., Winiarska‐Mieczan, A., Blicharski, T., Blicharski, R., Kowal, F., Pano, I. T., Tomaszewska, E., & Muszyński, S. (2024) · Journal of Nutrition · doi:10.1016/j.tjnut.2024.05.026 · Cited by 17

Effects of physical exercise on the prevention of stem cells senescence

Valenti, M. T., Carbonare, L. D., Dorelli, G., & Mottes, M. (2019) · Stem Cell Reviews and Reports · doi:10.1007/s12015-019-09928-w · Cited by 15

Biological Mechanisms of Paeonoside in the Differentiation of Pre-Osteoblasts and the Formation of Mineralized Nodules

Park, K.-R., Lee, J. Y., Cho, M., Hong, J. T., & Yun, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22136899 · Cited by 14

Targeted delivery of liposomal senolytics to alleviate cellular senescence-induced bone loss

Li, R., Wei, Y., Xiong, C., Wang, J., Lin, Y., Deng, R., Qin, H., Yang, C., Li, N., Zheng, G., et al. (2024) · Fundamental Research · doi:10.1016/j.fmre.2024.12.010 · Cited by 17

Senescence of bone marrow mesenchymal stromal cells: a narrative review of mechanisms, functional consequences, and rejuvenation strategies for age-related disorders

Zhang, W., Xie, Y., & Wang, B. (2025) · Stem Cell Research & Therapy · doi:10.1186/s13287-025-04874-6 · Cited by 14

Installation of click-type functional groups enable the creation of an additive manufactured construct for the osteochondral interface

Beeren, I. A. O., Dijkstra, P. J., Lourenço, A. F. H., Sinha, R., Gomes, D. B., Liu, H., Bouvy, N. D., Baker, M. B., Camarero‐Espinosa, S., & Moroni, L. (2022) · Biofabrication · doi:10.1088/1758-5090/aca3d4 · Cited by 14

Electrospunned nanofiber membranes of PTH-related peptide loaded biopolymers for osteoporotic bone defect repair

Chen, R., Wang, J., Chen, L., Li, Z., Feng, Q., Chen, F., Hao, Z., Chen, T., Shi, G., Zhang, Q., et al. (2024) · Materials & Design · doi:10.1016/j.matdes.2024.113179 · Cited by 14

TMARg, a Novel Anthraquinone Isolated from Rubia cordifolia Nakai, Increases Osteogenesis and Mineralization through BMP2 and β-Catenin Signaling

Park, K., Lee, J. Y., Kim, B., Kang, S. W., & Yun, H. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21155332 · Cited by 15

Current and emerging histomorphometric and imaging techniques for assessing age‐at‐death and cortical bone quality

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Mesenchymal stem cells prevent ovariectomy-induced osteoporosis formation in mice through intraosseous vascular remodeling.

Wang, W.-Z., Wang, Y.-H., Tang, Z., Chen, Y., Liu, Z., Duan, H., Zhong, Z.-Y., & He, F. (2021) · Biochemical and Biophysical Research Communications - BBRC · doi:10.1016/j.bbrc.2021.10.033 · Cited by 10

Cell and Cell-Free Therapies to Counteract Human Premature and Physiological Aging: MSCs Come to Light

Infante, A., & Rodríguez, C. I. (2021) · Journal of Personalized Medicine · doi:10.3390/jpm11101043 · Cited by 14

Hydroxytyrosol-rich extract from olive juice as an additive in gilthead sea bream juveniles fed a high-fat diet: Regulation of somatic growth

Balbuena-Pecino, S., Montblanch, M., García-Meilán, I., Fontanillas, R., Gallardo, Á., Gutiérrez, J., Navarro, I., & Capilla, E. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.966175 · Cited by 14

Tailor-made oligonucleotide-loaded lipid-polymer nanosystems designed for bone gene therapy

García‐García, P., Briffault, E., Landín, M., Évora, C., Díaz‐Rodríguez, P., & Delgado, A. (2021) · Drug Delivery and Translational Research · doi:10.1007/s13346-021-00926-5 · Cited by 14

Osteogenic differentiation of mesenchymal stem cell spheroids: A microfluidic device and electrochemiluminescence imaging study

Hiramoto, K., Konno, A., Nashimoto, Y., Hirano‐Iwata, A., Ino, K., & Shiku, H. (2024) · Electrochimica Acta · doi:10.1016/j.electacta.2024.144291 · Cited by 13

Paeonolide as a Novel Regulator of Core-Binding Factor Subunit Alpha-1 in Bone-Forming Cells

Park, K., Lee, J. Y., Cho, M., Hong, J. T., & Yun, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094924 · Cited by 13

Evaluation of the Age- and Sex-Related Changes of the Osteogenic Differentiation Potentials of Healthy Bone Marrow-Derived Mesenchymal Stem Cells

Lee, H., Lee, H., Na, C., Song, I., Ryu, J., & Park, J. (2021) · Medicina · doi:10.3390/medicina57060520 · Cited by 14

HA15 alleviates bone loss in ovariectomy-induced osteoporosis by targeting HSPA5

Han, C., Xie, K., Yang, C., Zhang, F., Liang, Q., Lan, C., Chen, J., Huang, K., Liu, J., Li, K., et al. (2021) · Experimental Cell Research · doi:10.1016/j.yexcr.2021.112781 · Cited by 13

Regulation of the mesenchymal stem cell fate by interleukin-17: Implications in osteogenic differentiation

Krstić, J., Mojsilović, S. B., Mojsilović, S. S., & Santibanez, J. F. (2021) · World Journal of Stem Cells · doi:10.4252/wjsc.v13.i11.1696 · Cited by 13

Curculigoside Ameliorates Bone Loss by Influencing Mesenchymal Stem Cell Fate in Aging Mice

Wang, N., Li, Z., Li, S., Li, Y., Gao, L., Bao, X., Wang, K., Liu, C., Xue, P., & Liu, S. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.767006 · Cited by 13

Osteoinductive activity of bisdemethoxycurcumin and its synergistic protective effect with human amniotic mesenchymal stem cells against ovariectomy-induced osteoporosis mouse model

Wei, J., Luo, Y., Xu, Y., & Xiao, J. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112605 · Cited by 13

Microenvironment-responsive hydrogels for spatiotemporal delivery of epigallocatechin gallate and BMP-2 to promote osteoporotic bone defect repair

Xiao, P., Shi, G., Lu, Z., Liu, S., Huang, C., Zhao, Y., Wang, L., Wang, Z., Zhang, H., Liu, Y., et al. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.102290 · Cited by 12

Multi-omics analysis of bone marrow mesenchymal stem cell differentiation differences in osteoporosis

Feng, K., Yu, M., Lou, X., Wang, D., Wang, L., & Ren, W. (2023) · Genomics · doi:10.1016/j.ygeno.2023.110668 · Cited by 12

Engineering of extracellular matrix from human iPSC-mesenchymal progenitors to enhance osteogenic capacity of human bone marrow stromal cells independent of their age

Hanetseder, D., Levstek, T., Teuschl, A., Frank, J. K., Schaedl, B., Redl, H. R., & Marolt, D. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1214019 · Cited by 13

Evaluating the role of biological age in osteoporosis risk among middle-aged and older adults: A nationwide perspective

Zhu, G., Guo, B., & Liang, J. (2024) · Bone · doi:10.1016/j.bone.2024.117255 · Cited by 13

Advancements in regenerative medicine: a comprehensive review of stem cell and growth factor therapies for osteoarthritis

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Effects of different physical factors on osteogenic differentiation

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Deciphering the chromatin spatial organization landscapes during BMMSC differentiation

Teng, Z., Zhu, Y., Lin, D., Hao, Q., Yue, Q., Yu, X., Sun, S., Jiang, L., & Lu, S. (2023) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2023.01.009 · Cited by 11

Chidamide suppresses adipogenic differentiation of bone marrow derived mesenchymal stem cells via increasing REEP2 expression

Zhang, X., Liu, L., Liu, X., Huang, Q., Liu, L., Liu, H., Ren, S., Wei, P., Cheng, P., Yao, M., et al. (2023) · iScience · doi:10.1016/j.isci.2023.106221 · Cited by 11

Injectable pH and Thermo-Responsive Hydrogel Scaffold with Enhanced Osteogenic Differentiation of Preosteoblasts for Bone Regeneration

King, J. L., Shrivastava, R., Shah, P. D., Maturavongsadit, P., & Benhabbour, S. R. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15092270 · Cited by 11

A Multifunctional Therapeutic Strategy Using P7C3 as A Countermeasure Against Bone Loss and Fragility in An Ovariectomized Rat Model of Postmenopausal Osteoporosis

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Osteoking inhibits apoptosis of BMSCs in osteoporotic rats via PI3K/AKT signaling pathway

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Jabuticaba peel extract modulates adipocyte and osteoblast differentiation of MSCs from healthy and osteoporotic rats

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Pore Extractor 2D: An ImageJ toolkit for quantifying cortical pore morphometry on histological bone images, with application to intraskeletal and regional patterning

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A multimodal 3D imaging approach of pore networks in the human femur to assess age‐associated vascular expansion and Lacuno‐Canalicular reduction

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The Role of Melanotransferrin (CD228) in the regulation of the differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells (hBM-MSC)

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Vanillin Promotes Osteoblast Differentiation, Mineral Apposition, and Antioxidant Effects in Pre-Osteoblasts

Yun, H., Kim, E., Kwon, Y.-J., & Park, K. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16040485 · Cited by 10

Enhanced PDGFR/Wnt/β-catenin activity of mesenchymal stem cells with high migration ability rescue bone loss of osteoporosis

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Effects of Laser Application on Alveolar Bone Mesenchymal Stem Cells and Osteoblasts: An In Vitro Study

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The Journey of SCAPs (Stem Cells from Apical Papilla), from Their Native Tissue to Grafting: Impact of Oxygen Concentration

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Impact of exogenous hydrogen peroxide on osteogenic differentiation of broiler chicken compact bones derived mesenchymal stem cells

Tompkins, Y. H., Liu, G., & Kim, W. K. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1124355 · Cited by 10

Association between Donor Age and Osteogenic Potential of Human Adipose Stem Cells in Bone Tissue Engineering

Sattar, M. A., Lingens, L. F., Guillaume, V. G. J., Götzl, R., Beier, J. P., & Ruhl, T. (2024) · Current Issues in Molecular Biology · doi:10.3390/cimb46020092 · Cited by 10

Specific concentration of hyaluronan amide derivative induces osteogenic mineralization of human mesenchymal stromal cells: Evidence of RUNX2 and COL1A1 genes modulation

Paolella, F., Gabusi, E., Manferdini, C., Schiavinato, A., & Lisignoli, G. (2019) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.36780 · Cited by 10

Global and local fat effects on bone mass and quality in obesity

Dai, X., Liu, B., Hou, Q., Dai, Q.-J., Wang, D., Xie, B., Sun, Y., & Wang, B. (2023) · Bone & Joint Research · doi:10.1302/2046-3758.129.bjr-2023-0102.r1 · Cited by 8

Osteoimmunology: Interactions With the Immune System in Spinal Fusion

Bergin, S. M., Crutcher, C. L., Keeler, C., Rocos, B., Haglund, M. M., Guo, H. M., Gottfried, O. N., Richardson, W. J., & Than, K. D. (2023) · The International Journal of Spine Surgery · doi:10.14444/8556 · Cited by 9

Curcumin controls the senescence of adipose-derived mesenchymal stem cells via the FoxO3/autophagy signaling pathway to enhance joint homeostasis for osteoarthritis therapy

Zhang, R., Huang, L., Jin, M., Kou, H., Ma, J., Zhang, W., & Ma, J. (2025) · Stem Cell Research & Therapy · doi:10.1186/s13287-025-04836-y · Cited by 11

Pyruvate dehydrogenase kinase 4 promotes osteoblastic potential of BMP9 by boosting Wnt/β-catenin signaling in mesenchymal stem cells

Yang, Y., Luo, H., Deng, Y., Yao, X., Zhang, J., Su, Y., & He, B. (2022) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2022.106341 · Cited by 9

Effect of Rotary Swaging on Mechanical and Operational Properties of Zn–1%Mg and Zn–1%Mg–0.1%Ca Alloys

Martynenko, N. S., Anisimova, N. Y., Rybalchenko, G. V., Rybalchenko, O. V., Serebryany, V. N., Zheleznyi, M. V., Shinkareva, M., Gorbenko, A. D., Temralieva, D. R., Lukyanova, E. A., et al. (2023) · Metals · doi:10.3390/met13081386 · Cited by 9

Effect of the Pulsed Electromagnetic Field Treatment in a Rat Model of Senile Osteoporosis In Vivo

Zhou, J., Wang, J., Qu, M., Huang, X., Yin, L., Liao, Y., Huang, F., Ning, P., Zhong, P., & Zeng, Y. (2022) · Bioelectromagnetics · doi:10.1002/bem.22423 · Cited by 9

High Concentrations of Polyelectrolyte Complex Nanoparticles Decrease Activity of Osteoclasts

Kauschke, V., Hessland, F. M., Vehlow, D., Müller, M., Heiß, C., & Lips, K. S. (2019) · Molecules · doi:10.3390/molecules24122346 · Cited by 9

Bioactive Self‐Regulated Liquified Microcompartments to Bioengineer Bone‐Like Microtissues

Pinho, A. R., Gomes, M. C., Costa, D. C. S., & Mano, J. F. (2023) · Small · doi:10.1002/smll.202305029 · Cited by 8

Apoptotic vesicles inhibit bone marrow adiposity via wnt/β-catenin signaling

Zhu, Y., Liu, Y., Yang, K., Wu, W., Cheng, Y., Ding, Y., Gu, R., Liu, H., Zhang, X., & Liu, Y. (2025) · Regenerative Therapy · doi:10.1016/j.reth.2025.03.012 · Cited by 8

Research progress on mesenchymal stem cell‑derived exosomes in the treatment of osteoporosis induced by knee osteoarthritis (Review)

Xue, H., Shen, X.-L., Wang, Z., Bi, H., Xu, H., Wu, J., Cui, R., & Liu, M.-W. (2025) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2025.5601 · Cited by 11

Osteogenic Differentiation Triggered by Intracellular Magnetoelectric Stimulation of Core–Shell Nanotransducers under Remotely Applied Magnetic Fields

Mendes, M. C., Martins, E. A. G., Chernozem, R. V., Chernozem, P. V., Custódio, C. A., Анатольевич, С. Р., Kholkin, A. L., Silva, A. S., & Mano, J. F. (2025) · ACS Nano · doi:10.1021/acsnano.5c10509 · Cited by 8

Cellular senescence and aging in bone

Mohan, M., Muthusami, S., Selvamurugan, N., Narasimhan, S., Kumaran, R., & Ramachandran, I. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-820071-1.00013-x · Cited by 8

Regulation of Adipose-Derived Stem Cell Activity by Melatonin Receptors in Terms of Viability and Osteogenic Differentiation

Skubis-Sikora, A., Sikora, B., Małysiak, W., Wieczorek, P., & Czekaj, P. (2023) · Pharmaceuticals · doi:10.3390/ph16091236 · Cited by 8

Dietary ω-3 Fatty Acid Supplementation Improves Murine Sickle Cell Bone Disease and Reprograms Adipogenesis

Valenti, M. T., Mattè, A., Federti, E., Puder, M., Anez‐Bustillos, L., Deiana, M., Cheri, S., Minoia, A., Brugnara, C., Paolo, M. L. D., et al. (2021) · Antioxidants · doi:10.3390/antiox10050799 · Cited by 8

The Cross-Talk between Myeloid and Mesenchymal Stem Cells of Human Bone Marrow Represents a Biomarker of Aging That Regulates Immune Response and Bone Reabsorption

Perico, M. E., Maluta, T., Conti, G., Vella, A., Provezza, L., Cestari, T., Cao, G. D., Segalla, L., Tecchio, C., Benedetti, F. M., et al. (2021) · Cells · doi:10.3390/cells11010001 · Cited by 8

In vitro evaluation of bone cell response to novel 3D ‐printable nanocomposite biomaterials for bone reconstruction

Haghpanah, Z., Mondal, D., Momenbeitollahi, N., Mohsenkhani, S., Zarshenas, K., Jin, Y., Watson, M., Willett, T. L., & Gorbet, M. (2024) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.37719 · Cited by 7

Phosvitin phosphopeptides alleviate the inhibitory effect of oxidative stress on osteoblast function through FoxO/Wnt signaling

Liu, W., Abou-Elsoud, M., Salama, M., Ding, L., Cai, Z., Ahn, D. U., Shu, D., & Huang, X. (2024) · Food Bioscience · doi:10.1016/j.fbio.2024.104622 · Cited by 7

PPP3R1 Promotes MSCs Senescence by Inducing Plasma Membrane Depolarization and Increasing Ca2+ Influx

Li, M., Gong, W., Chen, J., Zhang, Y., Ma, Y., & Tu, X. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054421 · Cited by 9

Targeted Proteomic Profiling Revealed Roles of Small GTPases during Osteogenic Differentiation

Yang, Y., Soh, R., Vera-Colón, M. K. M., Huang, M. S., Nieden, N. I. Z., & Wang, Y. (2023) · Analytical Chemistry · doi:10.1021/acs.analchem.2c05781 · Cited by 8

Extract of Artemisia dracunculus L. Modulates Osteoblast Proliferation and Mineralization

Scott, M. C., Bourgeois, A., Yu, Y., Burk, D. H., Smith, B. J., & Floyd, Z. E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241713423 · Cited by 8

Anti-aging Related Activities and Health Benefits of Licochalcone A: A Review

Ara, I., Turcio, R., Islam, T., Hossain, M. S., & Hasan, M. K. (2023) · Clinical Complementary Medicine and Pharmacology · doi:10.1016/j.ccmp.2023.100125 · Cited by 10

Layer by layer assembly of strontium substituted nanowire hydroxyapatite and hybrid of carbon derivatives as potential biomaterial for bone metastasis treatment

Sistanipour, E., Meshkini, A., & Oveisi, H. (2023) · Colloids and Surfaces A Physicochemical and Engineering Aspects · doi:10.1016/j.colsurfa.2023.132947 · Cited by 7

Characterization of mesenchymal stem cells in mucolipidosis type II (I-cell disease)

Köse, S., Aerts‐Kaya, F., Kuşkonmaz, B., & Uçkan, D. (2019) · TURKISH JOURNAL OF BIOLOGY · doi:10.3906/biy-1902-20 · Cited by 7

Enhanced osteoinductive capacity of poly(lactic-co-glycolic) acid and biphasic ceramic scaffolds by embedding simvastatin

Sordi, M. B., Curtarelli, R. B., Mantovani, I. F., Moreira, A. C., Fernandes, C. P., da Cruz, A. C. C., & Magini, R. D. S. (2021) · Clinical Oral Investigations · doi:10.1007/s00784-021-04240-9 · Cited by 7

Osteo-modulatory potential of biologically synthesized cis-resveratrol passivated gold nanoparticles

Gupta, A., Madhyastha, H., Kumar, A., & Singh, S. (2024) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2024.124637 · Cited by 6

FXR Activation Accelerates Early Phase of Osteoblast Differentiation Through COX-2-PGE2-EP4 Axis in BMP-2-Induced Mouse Mesenchymal Stem Cells

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Shilajit Boosts Osteogenic Ability of Mesenchymal Stem Cells for Regeneration of Rat Bone Defect

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