Cited by 336Mesenchymal stem cell researchBone Metabolism and DiseasesBone health and osteoporosis research

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Osteogenesis and aging: lessons from mesenchymal stem cells

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Infante, Arantza, Rodríguez, Clara I.·2018·Stem Cell Research & Therapy

DOI 10.1186/s13287-018-0995-xPMC PMC6158877

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Abstract

Aging is a high risk factor for the development of osteoporosis, a multifactorial age-related progressive disease characterized by reduced bone mass and increased risk of fractures. At the cellular level, the mesenchymal stem cell pool in the bone marrow niche shows a biased differentiation into adipogenesis at the cost of osteogenesis. This differentiation shift leads to decreased bone formation, contributing to the etiology of osteoporosis. This review will focus on the most recent/relevant molecular findings driving this functional impairment of mesenchymal stem cells in the aging process.

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Fig. 1 Osteogenic differentiation of MSCs. The MSC population proliferates actively at the initial stages of osteogenesis. As MSCs commit to osteoblasts their proliferation rate decreases while they start expressing osteogenic markers such as alkaline phosphatase secreted by early osteoblasts (matrix maturation phase) and osteocalcin secreted by late osteoblasts (mineralization phase). At the end of the bone forming phase, they can become BLCs or osteocytes or undergo apoptosisCC BY · PubMed Central

Fig. 2 Age-related alterations of a number of cell-intrinsic factors can shift MSC differentiation to adipogenesis. Cell-extrinsic factors such as young paracrine factors and ECM, rapamycin, and resveratrol have been proven to restore osteogenic potential of aged MSCs through modulation of these impaired cell-intrinsic factorsCC BY · PubMed Central

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Authors: Infante, A., & Rodríguez, C. I.
Affiliations: BioCruces Health research Institute (ES)
ORCID: Infante, Arantza
Rodríguez, Clara I.
Venue: Stem Cell Research & Therapy
Publisher: Springer Science and Business Media LLC
Published: 2018-09-26
Volume: 9
Issue: 1
Pages: 244-244
ISSN: 1757-6512 (ISSN-L)
DOI: 10.1186/s13287-018-0995-x
PMC: PMC6158877
OpenAlex: W2893485895
Cited by: 334
References: 59
Citations by year: 2026: 28 · 2025: 45 · 2024: 54 · 2023: 54 · 2022: 53 · 2021: 49 · 2020: 35 · 2019: 15
FWCI: 3.65
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (tdm)
Locations: Stem Cell Research & Therapy (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, other-oa)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Instituto de Salud Carlos III (PI15/00820)
Basque Country Government (KK-2018/00031)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Keywords: bone formation, aging, mesenchymal stem cells, osteoporosis, bone marrow microenvironment, adipogenesis, osteogenic differentiation, molecular mechanisms of aging
MeSH terms: Aging, Bone Marrow Cells, Cell Differentiation, Humans, Osteogenesis, Adipogenesis, Stem Cell Niche, Mesenchymal Stem Cells

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Osteogenesis and aging: lessons from mesenchymal stem cells

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