Osteogenesis and aging: lessons from mesenchymal stem cells

The Hallmarks of Aging

López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982

Sox9 Modulates Proliferation and Expression of Osteogenic Markers of Adipose-Derived Stem Cells (ASC)

Stöckl, S., Göttl, C., Grifka, J. K., & Grässel, S. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350089 · Cited by 4,670

Mechanisms of fatty acid-induced inhibition of glucose uptake.

Boden, G., Chen, X., Ruiz, J., White, J. V., & Rossetti, L. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117252 · Cited by 3,720

The Novel Zinc Finger-Containing Transcription Factor Osterix Is Required for Osteoblast Differentiation and Bone Formation

Nakashima, K., Zhou, X., Kunkel, G., Zhang, Z., Deng, J. M., Behringer, R. R., & de Crombrugghe, B. (2002) · Cell · doi:10.1016/s0092-8674(01)00622-5 · Cited by 3,608

Birth and Death of Bone Cells: Basic Regulatory Mechanisms and Implications for the Pathogenesis and Treatment of Osteoporosis

Manolagas, S. C. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.2.0395 · Cited by 2,639

Mesenchymal stem cells reside in virtually all post-natal organs and tissues

Meirelles, L. D. S., Chagastelles, P. C., & Nardi, N. B. (2006) · Journal of Cell Science · doi:10.1242/jcs.02932 · Cited by 2,472

The amazing osteocyte

Bonewald, L. F. (2011) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.320 · Cited by 2,287

Aging is associated with decreased maximal life span and accelerated senescence of bone marrow stromal cells,

Stenderup, K. (2003) · Bone · doi:10.1016/j.bone.2003.07.005 · Cited by 1,207

PPARγ: a Nuclear Regulator of Metabolism, Differentiation, and Cell Growth

Rosen, E. D., & Spiegelman, B. M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.r100034200 · Cited by 1,178

Fate decision of mesenchymal stem cells: adipocytes or osteoblasts?

Chen, Q., Shou, P., Zheng, C., Jiang, M., Cao, G., Yang, Q., Cao, J., Xie, N., Velletri, T., Zhang, X., et al. (2016) · Cell Death & Differentiation · doi:10.1038/cdd.2015.168 · Cited by 1,156

Additional file 3 of HSPB7 oppositely regulates human mesenchymal stromal cell-derived osteogenesis and adipogenesis

Zhang, S., van de Peppel, J., Koedam, M., van Leeuwen, J. P. T. M., & van der Eerden, B. C. J. (2023) · Figshare · doi:10.6084/m9.figshare.22807406

Additional file 2 of HSPB7 oppositely regulates human mesenchymal stromal cell-derived osteogenesis and adipogenesis

Zhang, S., van de Peppel, J., Koedam, M., van Leeuwen, J. P. T. M., & van der Eerden, B. C. J. (2023) · Figshare · doi:10.6084/m9.figshare.22807403

Additional file 5 of ALPL regulates pro-angiogenic capacity of mesenchymal stem cells through ATP-P2X7 axis controlled exosomes secretion

Dong, J., Zhao, W., Zhao, J., Chen, J., Liu, P., Zheng, X., Li, D., Xue, Y., & Zhou, H. (2024) · Figshare · doi:10.6084/m9.figshare.26705757

Additional file 6 of HSPB7 oppositely regulates human mesenchymal stromal cell-derived osteogenesis and adipogenesis

Zhang, S., van de Peppel, J., Koedam, M., van Leeuwen, J. P. T. M., & van der Eerden, B. C. J. (2023) · Figshare · doi:10.6084/m9.figshare.22807415

Additional file 4 of HSPB7 oppositely regulates human mesenchymal stromal cell-derived osteogenesis and adipogenesis

Zhang, S., van de Peppel, J., Koedam, M., van Leeuwen, J. P. T. M., & van der Eerden, B. C. J. (2023) · Figshare · doi:10.6084/m9.figshare.22807409

Additional file 2 of ALPL regulates pro-angiogenic capacity of mesenchymal stem cells through ATP-P2X7 axis controlled exosomes secretion

Dong, J., Zhao, W., Zhao, J., Chen, J., Liu, P., Zheng, X., Li, D., Xue, Y., & Zhou, H. (2024) · Figshare · doi:10.6084/m9.figshare.26705748

Additional file 7 of HSPB7 oppositely regulates human mesenchymal stromal cell-derived osteogenesis and adipogenesis

Zhang, S., van de Peppel, J., Koedam, M., van Leeuwen, J. P. T. M., & van der Eerden, B. C. J. (2023) · Figshare · doi:10.6084/m9.figshare.22807418

Additional file 5 of HSPB7 oppositely regulates human mesenchymal stromal cell-derived osteogenesis and adipogenesis

Zhang, S., van de Peppel, J., Koedam, M., van Leeuwen, J. P. T. M., & van der Eerden, B. C. J. (2023) · Figshare · doi:10.6084/m9.figshare.22807412

Additional file 1 of ALPL regulates pro-angiogenic capacity of mesenchymal stem cells through ATP-P2X7 axis controlled exosomes secretion

Dong, J., Zhao, W., Zhao, J., Chen, J., Liu, P., Zheng, X., Li, D., Xue, Y., & Zhou, H. (2024) · Figshare · doi:10.6084/m9.figshare.26705745

Additional file 3 of ALPL regulates pro-angiogenic capacity of mesenchymal stem cells through ATP-P2X7 axis controlled exosomes secretion

Dong, J., Zhao, W., Zhao, J., Chen, J., Liu, P., Zheng, X., Li, D., Xue, Y., & Zhou, H. (2024) · Figshare · doi:10.6084/m9.figshare.26705751

Additional file 4 of The effect of aging on the biological and immunological characteristics of periodontal ligament stem cells

Li, X., Zhang, B., Wang, H., Zhao, X., Zhang, Z., Ding, G., & Wei, F. (2020) · Figshare · doi:10.6084/m9.figshare.12737325

The Notch signaling pathway as a mechanism for regulation of osteogenic differentiation

Perepletchikova, D. A., Smirnova, D. V., Azarkina, K., Semenikchin, V. A., & Malashicheva, A. (2025) · Регенерация органов и тканей. · doi:10.60043/2949-5938-2024-4-68-80

Cardiolipin Remodeling as a Regulatory Switch in Osteogenesis: Insights from Multimodal Metabolic Imaging and Molecular ProfilingPreprint

Iftesum, M., Guttula, P. K., Agrawal, K., Kundu, S. S., Das, S., Donnarumma, F., Devireddy, R. V., & Gartia, M. R. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.22.696122

A Novel Bone Shield to Improve Skeletal Health during Space Exploration and for Disuse Conditions on Earth

Wei, F., Ngo, C., Neal, C. J., Kolanthai, E., Schwartzman, J. D., Omer, M., Dore, J., Aziz, A., Jimenez‐Chavez, L., Pugazhendhi, A. S., et al. (2026) · Advanced Healthcare Materials · doi:10.1002/adhm.202503961

Maternal dibutyl benzene-1,2-dicarboxylate exposure accelerates bone marrow mesenchymal stem cells senescence to induce skeletal retardation in male offspring mice

Zhang, Y., Wang, K., Lu, J., Wang, R., Pan, C., Ma, T., & Ma, F. (2026) · Toxicology Letters · doi:10.1016/j.toxlet.2026.111843

Biological properties of iron oxide nanoparticles and bone morphogenetic protein 2 functionalized biomaterials for bone tissue engineering, from a molecular perspective: A review

Arias‐Acevedo, M., Patiño-González, E., Orozco, C. P. O., Arango-Varela, S. S., & Uribe, D. (2026) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2026.108110

Genetically reprogrammed BMSCs with Lamin B1 depletion enhance bone regeneration for osteoporosis therapy

Fu, X., Huo, S., Cao, C., Hsu, H., Huang, J., Lei, Y., Li, J., Liu, P., Zeng, J., Lin, S., et al. (2026) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2026.1803514

Synthesis of bioactive surfaces for the control of stem cells differentiation

Prouvé, É. (2021) · theses.fr (ABES) · doi:10.70675/e6e40875z38c9z479ezb35fz53ede1161671

Peptides de l’immunité innée (défensines et cathélicidines) : expression dans les contextes d’obésité et de diabète de type 2, et lien avec la régulation fonctionnelle des adipocytes médullaires et l’os

Paquet, A. (2024) · theses.fr (ABES) · doi:10.70675/e3a1b1e8zfab0z4399zad38z5669589d1e7a

The TLR10–Vitamin D Axis Facilitates Osteogenic Differentiation of Mesenchymal Stem Cells In Vitro

Stierschneider, A., Neuditschko, B., Fischer, I., Hellmann, E., Zimmermann, D., Prohaska, K., Milchram, L., Herzog, F., & Wiesner, C. (2026) · Cells · doi:10.3390/cells15080697

Rh3R Attenuates RANKL‐Induced Osteoclast Differentiation and F‐Actin Ring Formation via the Suppression of c‐Fos/NFATc1 Signaling in Primary Murine Cells

Yun, H., Kim, S. H., Lee, J., & Park, K.-R. (2026) · Journal of Cellular Physiology · doi:10.1002/jcp.70174

Adobe-inspired hydrogel with antibacterial and angiogenic functions for osteoporotic bone defect repair

Guo, Q., Li, Z., Chen, R., Wang, Y., Shi, G., Zhu, M., He, W., Liu, H., Jian, C., & Zhu, S. (2026) · Materials & Design · doi:10.1016/j.matdes.2026.116148

Dysregulated JAK2 signaling delays fracture healing by enhancing STAT3/NF-κB signaling and inhibiting BMP2-mediated osteogenesis

Zhang, C., Zhang, X., Luo, Y., Jin, L., Dong, T., Cao, X. C., Tian, K., Zhang, Z., Zhang, J., Li, J., et al. (2026) · Life Sciences · doi:10.1016/j.lfs.2026.124648

Magnetic nanohydroxyapatite–peptide silk fibroin hydrogel induces osteogenesis in canine periodontal ligament stem cells revealed by proteomic analysis

Purbantoro, S. D., Scatena, M., Taephatthanasagon, T., Rodprasert, W., Somparn, P., Nanthawong, S., Makjaroen, J., Jantaratana, P., Mahanonda, R., Sa‐Ard‐Iam, N., et al. (2026) · Veterinary Quarterly · doi:10.1080/01652176.2026.2672558

Raman spectroscopic fingerprinting uncovers a multi-scale structural–mechanical–transcriptomic coupling landscape in osteoporosis

Wang, J., Lu, Y., Zhou, X., Huang, L., Li, X., Kou, X., Cao, Y., & Yang, Y. (2026) · Frontiers in Endocrinology · doi:10.3389/fendo.2026.1860651

Single‑cell Transcriptomic Profiling of Bone Marrow Mesenchymal Stem Cells Reveals Lineage Heterogeneity and Dysregulated Osteoblast Genes in Osteoporosis Versus Osteoarthritis

Wang, H., Zhuang, C., Ma, T., & Lin, H. (1970) · Current Gene Therapy · doi:10.2174/0115665232482401260522115907

Correlation between postural balance and quality of life in older women with low bone density: a cross-sectional study

Silva, B. S., Vieira, J. F., Hirama, M. L., da Silva, V. C., Alonso, A. C., & Brech, G. C. (2026) · Fisioterapia e Pesquisa · doi:10.1590/1809-2950/e24015326en

Correlação do equilíbrio postural com a qualidade de vida em idosas com baixa densidade óssea: estudo transversal

Silva, B. S., Vieira, J. F., Hirama, M. L., da Silva, V. C., Alonso, A. C., & Brech, G. C. (2026) · Fisioterapia e Pesquisa · doi:10.1590/1809-2950/e24015326pt

Metabolic phenotype and patient characteristics associate with inter-donor variability of osteogenic differentiation in human adipose stem cells

Sattar, M. A., Beier, J. P., & Ruhl, T. (2026) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2026.102728

Comparative Bioinformatics Analysis of Transcriptomic Signatures and Regulatory Networks in BM-MSCs and UCB-MSCs: Molecular Insights for Regenerative Medicine

KARAKUŞ, A. (2026) · Afyon Kocatepe University Journal of Sciences and Engineering · doi:10.35414/akufemubid.1850855

Bone as a Biomarker of Ageing and Senescence: Connecting Musculoskeletal Health to Longevity via Diet, Nutrition and Exercise

Beaumont, H., Guest, S., Pathak, S., Premjit, Y., Jones, E., & Ganguly, P. (2026) · Biology · doi:10.3390/biology15161377

Diet and Lipidomics Mediated Regulation of Mesenchymal Stem Cell Function: Diet, Omics and Stem Cell Connection

Gökcen, B. B., Atabılen, B., Çelik, M. N., Aksoy, Z. B., Raposa, B. L., & Ağagündüz, D. (2026) · Biomolecules · doi:10.3390/biom16081216

3D-Printed and Biofabricated Scaffolds for Osteoporotic Bone Defect Repair: Mechanical Adaptation, Redox Control, Senescence Modulation and Osteoimmunomodulation

Mosaid, S. M., Jihad, Y., Pepper, N., Elnemr, M., Marudanayagam, A., & Lee, P. Y. (2026) · Bioengineering · doi:10.3390/bioengineering13091088

Photobiomodulation-Mediated Modulation of TGF-β/Smad Signaling in Stem Cell–Driven Osteogenesis

Agommuo, S. C., Roets, B., & Crous, A. (2026) · Cellular Reprogramming · doi:10.1177/21524971261497225

Methylmalonic Acid in Skeletal Aging and Osteoporosis: Linking Vitamin B12 Metabolism to Mitochondrial Dysfunction

Ji, T., Pei, T., Yang, J., Wan, T., Zhang, Y., Ma, X., He, M., Gu, T., Lu, R., & Guo, W. (2026) · Calcified Tissue International · doi:10.1007/s00223-026-01622-7

A self-organized tri-lineage bone model in liquefied microcapsules captures matrix dynamics in early remodeling

Pinho, A. R., Henriques, M. C., Gomes, M. C., & Mano, J. F. (2026) · Cell stem cell · doi:10.1016/j.stem.2026.09.014

Bone Marrow Stromal Stem Cell Fate Decision: A Potential Mechanism For Bone Marrow Adipose Increase with Aging-related Osteoporosis

Li, T., Lu, L., & Meng, Y. (2022) · Current Molecular Medicine · doi:10.2174/1566524023666221025104629 · Cited by 16

Mesenchymal stem cell aging: Mechanisms and influences on skeletal and non-skeletal tissues

Liu, H., Xia, X., & Li, B. (2015) · Experimental Biology and Medicine · doi:10.1177/1535370215591828 · Cited by 91

AGE RELATED CHANGES IN BONE MARROW MESENCHYMAL STROMAL CELLS: A POTENTIAL IMPACT ON OSTEOPOROSIS AND OSTEOARTHRITIS DEVELOPMENT

Ganguly, P., El‐Jawhari, J. J., Giannoudis, P. V., Burska, A. N., Ponchel, F., & Jones, E. (2017) · Cell Transplantation · doi:10.3727/096368917x694651 · Cited by 22

AGE RELATED CHANGES IN BONE MARROW MESENCHYMAL STROMAL CELLS: A POTENTIAL IMPACT ON OSTEOPOROSIS AND OSTEOARTHRITIS DEVELOPMENT

Ganguly, P., El‐Jawhari, J. J., Giannoudis, P. V., Burska, A. N., Ponchel, F., & Jones, E. (2017) · Cell Transplantation · doi:10.1177/0963689717721201 · Cited by 236

Mechanisms and therapeutic strategies linking mesenchymal stem cells senescence to osteoporosis

Tong, Y., Tu, Y., Wang, J., Liu, X., Su, Q., Wang, Y., & Wang, W. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1625806 · Cited by 13