Osteogenesis and aging: lessons from mesenchymal stem cells

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Mesenchymal Stem Cell Senescence and Rejuvenation: Current Status and Challenges

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LRRc17 controls BMSC senescence via mitophagy and inhibits the therapeutic effect of BMSCs on ovariectomy-induced bone loss

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The costs and benefits of senotherapeutics for human health

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Hydrogels and Bioprinting in Bone Tissue Engineering: Creating Artificial Stem‐Cell Niches for In Vitro Models

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Molecular Basis of Bone Aging

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Prospect of Stem Cell Therapy and Regenerative Medicine in Osteoporosis

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Deciphering the Relevance of Bone ECM Signaling

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Osteoporosis and the Potential of Cell-Based Therapeutic Strategies

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The implications of bone marrow adipose tissue on inflammaging

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Dysfunction of metabolic activity of bone marrow mesenchymal stem cells in aged mice

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Aging and Mesenchymal Stem Cells: Basic Concepts, Challenges and Strategies

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Mesenchymal Stem Cells: Allogeneic MSC May Be Immunosuppressive but Autologous MSC Are Dysfunctional in Lupus Patients

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Long-term mechanical loading is required for the formation of 3D bioprinted functional osteocyte bone organoids

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Biphasic regulation of osteoblast development via the ERK MAPK–mTOR pathway

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Stem Cell-Laden Hydrogel-Based 3D Bioprinting for Bone and Cartilage Tissue Engineering

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The Role of the Kynurenine Pathway in the Pathophysiology of Frailty, Sarcopenia, and Osteoporosis

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Bone regeneration in osteoporosis: opportunities and challenges

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Crucial Role of Lamin A/C in the Migration and Differentiation of MSCs in Bone

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Advances in the roles of ATF4 in osteoporosis

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The role of the haematopoietic stem cell niche in development and ageing

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The Role of Adipose Stem Cells in Bone Regeneration and Bone Tissue Engineering

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The Potential Influence of Bone-Derived Modulators on the Progression of Alzheimer’s Disease

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The effect of aging on the biological and immunological characteristics of periodontal ligament stem cells

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Kynurenine Promotes RANKL-Induced Osteoclastogenesis In Vitro by Activating the Aryl Hydrocarbon Receptor Pathway

Eisa, N. H., Reddy, S. V., Elmansi, A. M., Kondrikova, G., Kondrikov, D., Shi, X.-M., Novince, C. M., Hamrick, M. W., McGee-Lawrence, M. E., Isales, C. M., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21217931 · Cited by 55

Phytochemical Compounds Involved in the Bone Regeneration Process and Their Innovative Administration: A Systematic Review

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Reiterative infusions of MSCs improve pediatric osteogenesis imperfecta eliciting a pro‐osteogenic paracrine response: TERCELOI clinical trial

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The biological function of BMAL1 in skeleton development and disorders

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Age-related changes in human bone marrow mesenchymal stromal cells: morphology, gene expression profile, immunomodulatory activity and miRNA expression

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Aging and Mesenchymal Stem Cells: Therapeutic Opportunities and Challenges in the Older Group

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Inflammatory Microenvironment Accelerates Bone Marrow Mesenchymal Stem Cell Aging

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Muscle-Derived Extracellular Vesicles Improved Disuse-Induced Osteoporosis by Rebalancing Bone Formation and Bone Resorption

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TRAF4 acts as a fate checkpoint to regulate the adipogenic differentiation of MSCs by activating PKM2

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Adult mesenchymal stem cells: is there a role for purine receptors in their osteogenic differentiation?

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Epigenetic regulation of bone remodeling and bone metastasis

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Loss of ASAP1 in mice impairs adipogenic and osteogenic differentiation of mesenchymal progenitor cells through dysregulation of FAK/Src and AKT signaling

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Senescent cells: A therapeutic target for osteoporosis

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Electromagnetic field treatment increases purinergic receptor P2X7 expression and activates its downstream Akt/GSK3β/β-catenin axis in mesenchymal stem cells under osteogenic induction

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PLGA–collagen–ECM hybrid scaffolds functionalized with biomimetic extracellular matrices secreted by mesenchymal stem cells during stepwise osteogenesis- co -adipogenesis

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Nanohydroxyapatite (nHAp) Doped with Iron Oxide Nanoparticles (IO), miR-21 and miR-124 Under Magnetic Field Conditions Modulates Osteoblast Viability, Reduces Inflammation and Inhibits the Growth of Osteoclast – A Novel Concept for Osteoporosis Treatment: Part 1

Marycz, K., Śmieszek, A., Marcinkowska, K. A., Sikora, M., Turlej, E., Sobierajska, P., Patej, A., Bieńko, A., & Wiglusz, R. J. (2021) · International Journal of Nanomedicine · doi:10.2147/ijn.s303412 · Cited by 41

Nicotinamide enhances osteoblast differentiation through activation of the mitochondrial antioxidant defense system

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Short‐Duration High Frequency MegaHertz‐Order Nanomechanostimulation Drives Early and Persistent Osteogenic Differentiation in Mesenchymal Stem Cells

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The role of resveratrol in bone marrow‐derived mesenchymal stem cells from patients with osteoporosis

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GAS5 protects against osteoporosis by targeting UPF1/SMAD7 axis in osteoblast differentiation

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What doesn't kill you makes you stranger: Dipeptidyl peptidase-4 (CD26) proteolysis differentially modulates the activity of many peptide hormones and cytokines generating novel cryptic bioactive ligands

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Deterioration of hematopoietic autophagy is linked to osteoporosis

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Radiographic Evaluation of Bone Remodeling after Additively Manufactured Subperiosteal Jaw Implantation (AMSJI) in the Maxilla: A One-Year Follow-Up Study

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The impact of ageing mechanisms on musculoskeletal system diseases in the elderly

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Bone marrow stromal cells (BMSCs CD45 ‐ /CD44 + /CD73 + /CD90 + ) isolated from osteoporotic mice SAM/P6 as a novel model for osteoporosis investigation

Sikora, M., Śmieszek, A., & Marycz, K. (2021) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16667 · Cited by 35

The Signalling Effects of Photobiomodulation on Osteoblast Proliferation, Maturation and Differentiation: A Review

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Hydroxyapatite Use in Spine Surgery—Molecular and Clinical Aspect

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Loss of Notch signaling in skeletal stem cells enhances bone formation with aging

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Mesenchymal stem cells and dental implant osseointegration during aging: from mechanisms to therapy

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Photobiomodulation: An Effective Approach to Enhance Proliferation and Differentiation of Adipose-Derived Stem Cells into Osteoblasts

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Nicotinamide mononucleotide attenuates glucocorticoid‑induced osteogenic inhibition by regulating the SIRT1/PGC‑1α signaling pathway

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Human Fibroblasts as a Model for the Study of Bone Disorders

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Multiomics profiling reveals VDR as a central regulator of mesenchymal stem cell senescence with a known association with osteoporosis after high-fat diet exposure

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Hypoxia-inducible factor-2α mediates senescence-associated intrinsic mechanisms of age-related bone loss

Lee, S. Y., Park, K. H., Lee, G., Kim, S., Song, W., Kwon, S., Koh, J., Huh, Y. H., & Ryu, J. (2021) · Experimental & Molecular Medicine · doi:10.1038/s12276-021-00594-y · Cited by 32

FGFR2 accommodates osteogenic cell fate determination in human mesenchymal stem cells

Zhang, Y., Ling, L., Ajayakumar, A. A. D. O., Eio, M. Y., van Wijnen, A. J., Nurcombe, V., & Cool, S. M. (2022) · Gene · doi:10.1016/j.gene.2022.146199 · Cited by 30

Reciprocal Effect of Environmental Stimuli to Regulate the Adipogenesis and Osteogenesis Fate Decision in Bone Marrow-Derived Mesenchymal Stem Cells (BM-MSCs)

Xu, X., Zhao, L., Terry, P., & Chen, J. (2023) · Cells · doi:10.3390/cells12101400 · Cited by 31

Osteoporosis and Alzheimer´s disease (or Alzheimer´s disease and Osteoporosis)

Wanionok, N. E., Morel, G. R., & Fernández, J. M. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102408 · Cited by 31

Effects of miRNAs, lncRNAs and circRNAs on osteoporosis as regulatory factors of bone homeostasis (Review)

Li, Z., Xue, H., Tan, G., & Xu, Z. (2021) · Molecular Medicine Reports · doi:10.3892/mmr.2021.12428 · Cited by 29

Bone marrow mesenchymal stem cell’s exosomes as key nanoparticles in osteogenesis and bone regeneration: specific capacity based on cell type

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Exercise improved bone health in aging mice: a role of SIRT1 in regulating autophagy and osteogenic differentiation of BMSCs

Zhu, C., Ding, H., Shi, L., Zhang, S., Tong, X., Huang, M., Liu, L., Guan, X., Zou, J., Yuan, Y. J., et al. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1156637 · Cited by 28

Limonoid Triterpene, Obacunone Increases Runt-Related Transcription Factor 2 to Promote Osteoblast Differentiation and Function

Park, K.-R., Kim, S., Cho, M., & Yun, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052483 · Cited by 29

Dietary organosulfur compounds: Emerging players in the regulation of bone homeostasis by plant-derived molecules

Gambari, L., Grigolo, B., & Grassi, F. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.937956 · Cited by 25

Advances in the interaction between endoplasmic reticulum stress and osteoporosis

Zhong, M., Wu, Z., Chen, Z., Ren, Q., & Zhou, J. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115134 · Cited by 29

Aged mesenchymal stem cells and inflammation: from pathology to potential therapeutic strategies

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Xeno-Free Condition Enhances Therapeutic Functions of Human Wharton’s Jelly-Derived Mesenchymal Stem Cells against Experimental Colitis by Upregulated Indoleamine 2,3-Dioxygenase Activity

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Effects of Chinese Herbal Medicines on the Risk of Overall Mortality, Readmission, and Reoperation in Hip Fracture Patients

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Age-related increase of kynurenine enhances miR29b-1-5p to decrease both CXCL12 signaling and the epigenetic enzyme Hdac3 in bone marrow stromal cells

Elmansi, A. M., Hussein, K. A., Mas, S., Periyasamy‐Thandavan, S., Aguilar‐Perez, A., Kondrikova, G., Kondrikov, D., Eisa, N. H., Pierce, J. L., Kaiser, H., et al. (2020) · Bone Reports · doi:10.1016/j.bonr.2020.100270 · Cited by 28

IRF2‐mediated upregulation of lncRNA HHAS1 facilitates the osteogenic differentiation of bone marrow‐derived mesenchymal stem cells by acting as a competing endogenous RNA

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Calycosin-7-O-β-Glucoside Isolated from Astragalus membranaceus Promotes Osteogenesis and Mineralization in Human Mesenchymal Stem Cells

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LncRNA RAD51-AS1 Regulates Human Bone Marrow Mesenchymal Stem Cells via Interaction with YBX1 to Ameliorate Osteoporosis

Li, B., Wang, J., Xu, F., Wang, Q., Liu, Q., Wang, G., Miao, D., & Sun, Q. (2022) · Stem Cell Reviews and Reports · doi:10.1007/s12015-022-10408-x · Cited by 26

Pro-Osteogenic and Anti-Inflammatory Synergistic Effect of Orthosilicic Acid, Vitamin K2, Curcumin, Polydatin and Quercetin Combination in Young and Senescent Bone Marrow-Derived Mesenchymal Stromal Cells

Giordani, C., Matacchione, G., Giuliani, A., Valli, D., Scarpa, E. S., Antonelli, A., Sabbatinelli, J., Giacchetti, G., Sabatelli, S., Olivieri, F., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24108820 · Cited by 26

The miR-665/SOST Axis Regulates the Phenotypes of Bone Marrow Mesenchymal Stem Cells and Osteoporotic Symptoms in Female Mice

Zeng, X., Yuan, X., Liao, H., Wei, Y., Wu, Q., Zhu, X., Li, Q., Chen, S., & Hu, M. (2024) · American Journal Of Pathology · doi:10.1016/j.ajpath.2024.07.022 · Cited by 26

Adipocyte- and Monocyte-Mediated Vicious Circle of Inflammation and Obesity (Review of Cellular and Molecular Mechanisms)

Тодосенко, Н. М., Хазиахматова, О. Г., Malashchenko, V. V., Yurova, K. A., Bograya, M., Beletskaya, M., Vulf, M. A., Mikhailova, L. V., Minchenko, A., Soroko, I., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241512259 · Cited by 28

An Injectable Black Phosphorus Hydrogel for Rapid Tooth Extraction Socket Healing

Guo, F., Li, J., Chen, Z., Wang, T., Wang, R., Wang, T., Bian, Y., Du, Y., Yuan, H., Pan, Y., et al. (2024) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.4c03278 · Cited by 23

Protective effects and network analysis of natural compounds obtained from Radix dipsaci, Eucommiae cortex, and Rhizoma drynariae against RANKL-induced osteoclastogenesis in vitro

Cheng, C., Lin, J. C.-F., Tsai, F., Chen, C., Chiou, J., Chou, C.-H., Li, T., Lin, T., Liao, C., Huang, S., et al. (2019) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2019.112074 · Cited by 23

Gold nanoparticles biosynthesized by Nocardiopsis dassonvillei NCIM 5124 enhance osteogenesis in gingival mesenchymal stem cells

Bennur, T., Javdekar, V., Tomar, G. B., & Zinjarde, S. (2020) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-020-10508-z · Cited by 23

Dense carbon-nanotube coating scaffolds stimulate osteogenic differentiation of mesenchymal stem cells

Mori, H., Ogura, Y., Enomoto, K., Hara, M., Maurstad, G., Stokke, B. T., & Kitamura, S. (2020) · PLoS ONE · doi:10.1371/journal.pone.0225589 · Cited by 22

Bone marrow mesenchymal stem cells’ osteogenic potential: superiority or non-superiority to other sources of mesenchymal stem cells?

Farashah, M. S. G., Mohammadi, A., Javadi, M., Rad, J. S., Shakouri, S. K., Meshgi, S., & Roshangar, L. (2023) · Cell and Tissue Banking · doi:10.1007/s10561-022-10066-w · Cited by 24

Chitosan/collagen/Mg, Se, Sr, Zn-substituted calcium phosphate scaffolds for bone tissue engineering applications: A growth factor free approach

Ressler, A., Ohlsbom, R., Žužić, A., Gebraad, A., Frankberg, E. J., Pakarinen, T.-K., Ivanković, H., Miettinen, S., & Ivanković, M. (2023) · European Polymer Journal · doi:10.1016/j.eurpolymj.2023.112129 · Cited by 21

Surface Chemistry Dictates the Osteogenic and Antimicrobial Properties of Palladium‐, Platinum‐, and Titanium‐Based Bulk Metallic Glasses

Lackington, W. A., Wiestner, R., Pradervand, E., Schweizer, P., Zuber, F., Ren, Q., Stoica, M., Löffler, J. F., & Rottmar, M. (2023) · Advanced Functional Materials · doi:10.1002/adfm.202302069 · Cited by 21

Andrographolide promotes proliferative and osteogenic potentials of human placenta-derived mesenchymal stem cells through the activation of Wnt/β-catenin signaling

Phunikom, N., Boonmuen, N., Kheolamai, P., Suksen, K., Manochantr, S., Tantrawatpan, C., & Tantikanlayaporn, D. (2021) · Stem Cell Research & Therapy · doi:10.1186/s13287-021-02312-x · Cited by 21

Bmi‐1 Epigenetically Orchestrates Osteogenic and Adipogenic Differentiation of Bone Marrow Mesenchymal Stem Cells to Delay Bone Aging

Zhao, J., Chen, A., Wang, R., Qiu, D., Chen, H., Li, J., Zhang, J., Wang, T., Wang, Y., Lin, Y., et al. (2024) · Advanced Science · doi:10.1002/advs.202404518 · Cited by 20

Interferon-gamma regulates the levels of bone formation effectors in a stage-dependent manner

Lai, J.-H., Hsu, Y.-P., Yang, C.-H., Chen, Y., Liu, C.-C., & Chen, S. (2022) · Molecular Biology Reports · doi:10.1007/s11033-022-07993-y · Cited by 20

Static magnetic field: A potential tool of controlling stem cells fates for stem cell therapy in osteoporosis

Wang, J., & Shang, P. (2022) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2022.12.007 · Cited by 20

The Role of SOX Transcription Factors in Ageing and Age-Related Diseases

Stevanović, M. J., Lazic, A., Schwirtlich, M., & Ninković, D. S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24010851 · Cited by 19

Differentiation Potential of Synovial Mesenchymal Stem Cells Isolated From Hip Joints Affected by Femoroacetabular Impingement Syndrome Versus Osteoarthritis

Murata, Y., Uchida, S., Utsunomiya, H., Hatakeyama, A., Nakashima, H., Mori, T., Yamanaka, Y., Tsukamoto, M., Sekiya, I., Huard, J., et al. (2020) · Arthroscopy The Journal of Arthroscopic and Related Surgery · doi:10.1016/j.arthro.2020.03.016 · Cited by 20

Chikungunya Virus Infection Impairs the Function of Osteogenic Cells

Roy, E., Shi, W., Duan, B., & Reid, S. P. (2020) · mSphere · doi:10.1128/msphere.00347-20 · Cited by 22

Reduced osteoclast-derived apoptotic bodies in bone marrow characterizes the pathological progression of osteoporosis

Wu, Y., Ai, H., Xi, Y., Yin, P., Qu, Y., Xu, J., Dou, C., & Luo, F. (2023) · Cell Death Discovery · doi:10.1038/s41420-023-01434-w · Cited by 19

The senolytic agent ABT263 ameliorates osteoporosis caused by active vitamin D insufficiency through selective clearance of senescent skeletal cells

Yang, C., Qiao, W., Xue, Q., Goltzman, D., Miao, D., & Zhan, D. (2024) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2024.08.012 · Cited by 20

Suitability and limitations of mesenchymal stem cells to elucidate human bone illness

Mitxitorena, I., Infante, A., Gener, B., & Rodríguez, C. I. (2019) · World Journal of Stem Cells · doi:10.4252/wjsc.v11.i9.578 · Cited by 20

Switch-on mode of bioenergetic channels regulated by curcumin-loaded 3D composite scaffold to steer bone regeneration

Wei, J., Zhang, X., Zhang, Z., Ding, X., Li, Y., Zhang, Y., Jiang, X., Zhang, H., Lai, H., & Shi, J. (2022) · Chemical Engineering Journal · doi:10.1016/j.cej.2022.139165 · Cited by 19

Bone Marrow Stromal Stem Cell Fate Decision: A Potential Mechanism For Bone Marrow Adipose Increase with Aging-related Osteoporosis

Li, T., Lu, L., & Meng, Y. (2022) · Current Molecular Medicine · doi:10.2174/1566524023666221025104629 · Cited by 16

Mesenchymal stem cell aging: Mechanisms and influences on skeletal and non-skeletal tissues

Liu, H., Xia, X., & Li, B. (2015) · Experimental Biology and Medicine · doi:10.1177/1535370215591828 · Cited by 91

AGE RELATED CHANGES IN BONE MARROW MESENCHYMAL STROMAL CELLS: A POTENTIAL IMPACT ON OSTEOPOROSIS AND OSTEOARTHRITIS DEVELOPMENT

Ganguly, P., El‐Jawhari, J. J., Giannoudis, P. V., Burska, A. N., Ponchel, F., & Jones, E. (2017) · Cell Transplantation · doi:10.3727/096368917x694651 · Cited by 22

AGE RELATED CHANGES IN BONE MARROW MESENCHYMAL STROMAL CELLS: A POTENTIAL IMPACT ON OSTEOPOROSIS AND OSTEOARTHRITIS DEVELOPMENT

Ganguly, P., El‐Jawhari, J. J., Giannoudis, P. V., Burska, A. N., Ponchel, F., & Jones, E. (2017) · Cell Transplantation · doi:10.1177/0963689717721201 · Cited by 236

Mechanisms and therapeutic strategies linking mesenchymal stem cells senescence to osteoporosis

Tong, Y., Tu, Y., Wang, J., Liu, X., Su, Q., Wang, Y., & Wang, W. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1625806 · Cited by 13