Advances in mesenchymal stem cell exosomes: a review
Open accessAbstract
Stem cells can be used for regenerative medicine and as treatments for disease. The application of tissue engineering-related transplantation, stem cells, and local changes in the microenvironment is expected to solve major medical problems. Currently, most studies focus on tissue repair and regeneration, and mesenchymal stem cells (MSCs) are among the most common research topics. MSCs are applicable as seed cells, and they represent one of the current hot topics in regenerative medicine research. However, due to storage limitations and because cell senescence occurs during in vitro expansion, their clinical application is challenging. Exosomes, which are secreted by MSCs through paracrine signalling, not only have the same effects as MSCs, but they also have the advantages of targeted delivery, low immunogenicity, and high repairability. This article reviews the acquisition methods, characteristics, biological functions, and clinical applications of exosomes.
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EVs can be obtained from MSCs using various methods, including ultracentrifugation, which provides a substantial amount of EVs with consistent purity and reproducibility.
“EVs can be obtained from MSCs using various methods, including ultracentrifugation, which provides a substantial amount of EVs with consistent purity and reproducibility, allowing for reliable in vitro and in vivo studies [30,36,45,46,47,48].”
From Mesenchymal Stem/Stromal Cells: Immunomodulatory and Bone Regeneration Potential after Tumor Excision in Osteosarcoma Patients (2023) · cites this paper as [46]
The Exosome isolation methods section describes several methods and says a double-ultracentrifugation protocol with 30% sucrose has high yield and slightly lower contamination. It does not establish consistent purity or reproducibility for ultracentrifugation; the Differential centrifugation subsection says a three-time protocol fails to achieve good purity. Page numbers are not available in our copy. (LLM, conf=0.86)
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- Authors
- Tang, Y., Zhou, Y., & Li, H.-J.
- Affiliations
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Corresponding author
- Li, Hong-Jun
- Venue
- Stem Cell Research & Therapy
- Published
- 2021-01-19
- Volume
- 12
- Issue
- 1
- Pages
- 71-71
- ISSN
- 1757-6512 (ISSN-L)
- PMC
- PMC7814175
- OpenAlex
- W3124390790
- Cited by
- 327
- References
- 85
- Citations by year
- 2026: 33 · 2025: 88 · 2024: 70 · 2023: 64 · 2022: 53 · 2021: 19
- FWCI
- 5.51
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Stem Cell Research & Therapy (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (31700154)
- Chinese Academy of Medical Sciences Medicine and Health Technology Innovation Project (2016-I2M-3-026)
- Major Science and Technology Special Project of Yunnan Province (2018ZF006)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Health Sciences › Medicine › Urology › Periodontal Regeneration and Treatments
- Keywords
- mesenchymal stem cells, exosomes, paracrine signaling, regenerative medicine, tissue engineering, cellular senescence, targeted delivery, immunogenicity
- MeSH terms
- Paracrine Communication, Tissue Engineering, Regenerative Medicine, Mesenchymal Stem Cell Transplantation, Exosomes, Mesenchymal Stem Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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