Cited by 330Extracellular vesicles in diseaseMesenchymal stem cell researchPeriodontal Regeneration and Treatments

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Advances in mesenchymal stem cell exosomes: a review

Open access

Tang, Yaya, Zhou, Yan, Li, Hong-Jun·2021·Stem Cell Research & Therapy

DOI 10.1186/s13287-021-02138-7PMC PMC7814175

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Abstract

Stem cells can be used for regenerative medicine and as treatments for disease. The application of tissue engineering-related transplantation, stem cells, and local changes in the microenvironment is expected to solve major medical problems. Currently, most studies focus on tissue repair and regeneration, and mesenchymal stem cells (MSCs) are among the most common research topics. MSCs are applicable as seed cells, and they represent one of the current hot topics in regenerative medicine research. However, due to storage limitations and because cell senescence occurs during in vitro expansion, their clinical application is challenging. Exosomes, which are secreted by MSCs through paracrine signalling, not only have the same effects as MSCs, but they also have the advantages of targeted delivery, low immunogenicity, and high repairability. This article reviews the acquisition methods, characteristics, biological functions, and clinical applications of exosomes.

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Fig. 1 Exosome biogenesis and secretionCC BY · PubMed Central

Fig. 2 Three types of extracellular vesiclesCC BY · PubMed Central

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Authors: Tang, Y., Zhou, Y., & Li, H.-J.
Affiliations: Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
Venue: Stem Cell Research & Therapy
Publisher: Springer Science and Business Media LLC
Published: 2021-01-19
Volume: 12
Issue: 1
Pages: 71-71
ISSN: 1757-6512 (ISSN-L)
DOI: 10.1186/s13287-021-02138-7
PMC: PMC7814175
OpenAlex: W3124390790
Cited by: 327
References: 85
Citations by year: 2026: 33 · 2025: 88 · 2024: 70 · 2023: 64 · 2022: 53 · 2021: 19
FWCI: 5.51
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0 (tdm)
creativecommons.org/licenses/by/4.0 (vor)
Locations: Stem Cell Research & Therapy (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: National Natural Science Foundation of China (31700154)
Chinese Academy of Medical Sciences Medicine and Health Technology Innovation Project (2016-I2M-3-026)
Major Science and Technology Special Project of Yunnan Province (2018ZF006)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
Health Sciences › Dentistry › Periodontics › Periodontal Regeneration and Treatments
Keywords: mesenchymal stem cells, exosomes, paracrine signaling, regenerative medicine, tissue engineering, cellular senescence, targeted delivery, immunogenicity
MeSH terms: Paracrine Communication, Tissue Engineering, Regenerative Medicine, Mesenchymal Stem Cell Transplantation, Exosomes, Mesenchymal Stem Cells

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