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Advances in mesenchymal stem cell exosomes: a review
Open accessAbstract
Stem cells can be used for regenerative medicine and as treatments for disease. The application of tissue engineering-related transplantation, stem cells, and local changes in the microenvironment is expected to solve major medical problems. Currently, most studies focus on tissue repair and regeneration, and mesenchymal stem cells (MSCs) are among the most common research topics. MSCs are applicable as seed cells, and they represent one of the current hot topics in regenerative medicine research. However, due to storage limitations and because cell senescence occurs during in vitro expansion, their clinical application is challenging. Exosomes, which are secreted by MSCs through paracrine signalling, not only have the same effects as MSCs, but they also have the advantages of targeted delivery, low immunogenicity, and high repairability. This article reviews the acquisition methods, characteristics, biological functions, and clinical applications of exosomes.
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“EVs can be obtained from MSCs using various methods, including ultracentrifugation, which provides a substantial amount of EVs with consistent purity and reproducibility, allowing for reliable in vitro and in vivo studies [30,36,45,46,47,48].”
From Mesenchymal Stem/Stromal Cells: Immunomodulatory and Bone Regeneration Potential after Tumor Excision in Osteosarcoma Patients (2023) · cites this paper as [46]
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Metadata
- Authors
- Tang, Y., Zhou, Y., & Li, H.-J.
- Affiliations
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Venue
- Stem Cell Research & Therapy
- Published
- 2021-01-19
- Volume
- 12
- Issue
- 1
- Pages
- 71-71
- ISSN
- 1757-6512 (ISSN-L)
- PMC
- PMC7814175
- OpenAlex
- W3124390790
- Cited by
- 327
- References
- 85
- Citations by year
- 2026: 33 · 2025: 88 · 2024: 70 · 2023: 64 · 2022: 53 · 2021: 19
- FWCI
- 5.51
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Stem Cell Research & Therapy (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (31700154)
- Chinese Academy of Medical Sciences Medicine and Health Technology Innovation Project (2016-I2M-3-026)
- Major Science and Technology Special Project of Yunnan Province (2018ZF006)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
- Health Sciences › Dentistry › Periodontics › Periodontal Regeneration and Treatments
- Keywords
- mesenchymal stem cells, exosomes, paracrine signaling, regenerative medicine, tissue engineering, cellular senescence, targeted delivery, immunogenicity
- MeSH terms
- Paracrine Communication, Tissue Engineering, Regenerative Medicine, Mesenchymal Stem Cell Transplantation, Exosomes, Mesenchymal Stem Cells
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