Cited by 84Autophagy in Disease and TherapyComputational Drug Discovery MethodsUbiquitin and proteasome pathways

HAMdb: a database of human autophagy modulators with specific pathway and disease information

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Wang, Ning-Ning, Dong, Jie, Zhang, Lin, Ouyang, Defang, Cheng, Yan, Chen, Alex F., Lu, Ai-Ping, Cao, Dong-Sheng·2018·Journal of Cheminformatics

Abstract

Autophagy is an important homeostatic cellular recycling mechanism responsible for degrading unnecessary or dysfunctional cellular organelles and proteins in all living cells. In addition to its vital homeostatic role, this degradation pathway also involves in various human disorders, including metabolic conditions, neurodegenerative diseases, cancers and infectious diseases. Therefore, the comprehensive understanding of autophagy process, autophagy-related modulators and corresponding pathway and disease information will be of great help for identifying the new autophagy modulators, potential drug candidates, new diagnostic and therapeutic targets. In recent years, some autophagy databases providing structural and functional information were developed, but the specific databases covering autophagy modulator (proteins, chemicals and microRNAs)-related target, pathway and disease information do not exist. Hence, we developed an online resource, Human Autophagy Modulator Database (HAMdb, http://hamdb.scbdd.com ), to provide researchers related pathway and disease information as many as possible. HAMdb contains 796 proteins, 841 chemicals and 132 microRNAs. Their specific effects on autophagy, physicochemical information, biological information and disease information were manually collected and compiled. Additionally, lots of external links were available for more information covering extensive biomedical knowledge. HAMdb provides a user-friendly interface to query, search, browse autophagy modulators and their comprehensive related information. HAMdb will help researchers understand the whole autophagy process and provide detailed information about related diseases. Furthermore, it can give hints for the identification of new diagnostic and therapeutic targets and the discovery of new autophagy modulators. In a word, we hope that HAMdb has the potential to promote the autophagy research in pharmacological and pathophysiological area.

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  • A handful of autophagy-related online resources have already been created collecting functional, structural and biological information: THANATOS, HADb, and HAMdb.

    “Indeed, a handful of autophagy-related resources, available on-line, have been already created collecting diverse data type including functional, structural and biological information: Autophagy, Necrosis, ApopTosis OrchestratorS (THANATOS, http://thanatos.biocuckoo.org) [16], Human Autophagy Database (HADb, http://www.autophagy.lu/), and Human Autophagy Modulator Database (HAMdb, http://hamdb.scb”

    From A gene toolbox for monitoring autophagy transcription (2021) · cites this paper as [17]

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Authors
Wang, N.-N., Dong, J., Zhang, L., Ouyang, D., Cheng, Y., Chen, A. F., Lu, A.-P., & Cao, D.-S.
Affiliations
  • Central South University of Forestry and Technology (CN)
  • University of Macau (MO)
  • Central South University (CN)
  • Third Xiangya Hospital (CN)
Venue
Journal of Cheminformatics
Published
2018-07-31
Volume
10
Issue
1
Pages
34-34
ISSN
1758-2946 (ISSN-L)
OpenAlex
W2886257261
Cited by
83
References
37
Citations by year
2026: 10 · 2025: 10 · 2024: 21 · 2023: 15 · 2022: 12 · 2021: 7 · 2020: 6 · 2019: 2
FWCI
2.93
Type
journal article
Language
en
Open access
Locations
  • Journal of Cheminformatics (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Key Basic Research Program (2015CB910700)
  • National Natural Science Foundation of China (81402853, 81501619)
Topics
  • Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
  • Physical Sciences › Computer Science › Computational Theory and Mathematics › Computational Drug Discovery Methods
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
Keywords
autophagy, autophagy modulators, autophagy-related proteins, microRNA, autophagy-related diseases, biological pathways, therapeutic target

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