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Molecular approach to a patient’s tailored diagnosis of the oral allergy syndrome

Alessandri, Claudia, Ferrara, Rosetta, Bernardi, Maria Livia, Zennaro, Danila, Tuppo, Lisa, Giangrieco, Ivana, Ricciardi, Teresa, Tamburrini, Maurizio, Ciardiello, Maria Antonietta, Mari, Adriano·2020·Clinical and Translational Allergy
DOI 10.1186/s13601-020-00329-8PMC PMC7298840
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Fig. 1 Overview of the relationships between OAS, PFAS, class 1 and class 2 food allergens
Fig. 1 Overview of the relationships between OAS, PFAS, class 1 and class 2 food allergensCC BY · PubMed Central
Fig. 2 Comparison of amino acid sequence identity percentage between different allergens. Bar colors highlight the plant source of allergens, namely green, brown, yellow, red and light grey are for pollen, seed, fruit, root and latex, respectively. The similarity searches were performed with the Allergome Aligner tool, using the Blast algorithm on the Allergome platform (https://www.allergome.org). The amino acid sequence of Bet v 1.0101 (b and c), Bet v 2.0101 (a) and Cry j GRP (d) were used as query sequences. The allergens shown in a and b were selected as representative of the large number of homologs found in the database. When many homologs were found, that giving the highest identity with the query sequence was selected and shown in the figure. c represents a representative selection of Bet v 1 isoallergens/isoforms found in the Allergome database. The sequence identity values of GRP (d) were obtained with the algorithm CLUSTALO on the Uniprot website (https://www.uniprot.org) and they are referred to mature proteins lacking the signal peptide. Cup s 7 was not included because its complete sequence was not available. Additional details on the allergens shown in the Figure are reported in Additional file 1: Tables S1, S2, S3 and S4
Fig. 2 Comparison of amino acid sequence identity percentage between different allergens. Bar colors highlight the plant source of allergens, namely green, brown, yellow, red and light grey are for pollen, seed, fruit, root and latex, respectively. The similarity searches were performed with the Allergome Aligner tool, using the Blast algorithm on the Allergome platform (https://www.allergome.org). The amino acid sequence of Bet v 1.0101 (b and c), Bet v 2.0101 (a) and Cry j GRP (d) were used as query sequences. The allergens shown in a and b were selected as representative of the large number of homologs found in the database. When many homologs were found, that giving the highest identity with the query sequence was selected and shown in the figure. c represents a representative selection of Bet v 1 isoallergens/isoforms found in the Allergome database. The sequence identity values of GRP (d) were obtained with the algorithm CLUSTALO on the Uniprot website (https://www.uniprot.org) and they are referred to mature proteins lacking the signal peptide. Cup s 7 was not included because its complete sequence was not available. Additional details on the allergens shown in the Figure are reported in Additional file 1: Tables S1, S2, S3 and S4CC BY · PubMed Central
Fig. 3 Schematic representation of cross-reactivity occurring between profilins (upper O-ring) and between Bet v 1-related allergenic proteins (lower O-ring) contained in pollens and plant foods. Red and green lines connecting allergy sources indicate single and double cross-reaction relationships, respectively. Arrowheads indicate the direction of data collection. The two pictures were generated on January 2020 by the Allergome software which uses information contained in the own database [53] (https://www.allergome.org)
Fig. 3 Schematic representation of cross-reactivity occurring between profilins (upper O-ring) and between Bet v 1-related allergenic proteins (lower O-ring) contained in pollens and plant foods. Red and green lines connecting allergy sources indicate single and double cross-reaction relationships, respectively. Arrowheads indicate the direction of data collection. The two pictures were generated on January 2020 by the Allergome software which uses information contained in the own database [53] (https://www.allergome.org)CC BY · PubMed Central
Fig. 4 Schematic representation of the class 1 plant food allergens that may cause OAS and/or trigger allergic reactions in other organs and apparatus. These allergens may even induce severe anaphylaxis
Fig. 4 Schematic representation of the class 1 plant food allergens that may cause OAS and/or trigger allergic reactions in other organs and apparatus. These allergens may even induce severe anaphylaxisCC BY · PubMed Central
Fig. 5 Sensitizations detected in 39 patients IgE-positive to at least one of the three analyzed GRP. The columns indicate, in order, patients sensitized to all the three GRP, those bi-sensitized to Cup s 7 and Pru p 3, to Cup s 7 and Pun g 7, to Pru p 7 and Pun g 7 and those monosensitized to Cup s 7, to Pru p 7 and to Pun g 7
Fig. 5 Sensitizations detected in 39 patients IgE-positive to at least one of the three analyzed GRP. The columns indicate, in order, patients sensitized to all the three GRP, those bi-sensitized to Cup s 7 and Pru p 3, to Cup s 7 and Pun g 7, to Pru p 7 and Pun g 7 and those monosensitized to Cup s 7, to Pru p 7 and to Pun g 7CC BY · PubMed Central

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Metadata

Authors
Alessandri, C., Ferrara, R., Bernardi, M. L., Zennaro, D., Tuppo, L., Giangrieco, I., Ricciardi, T., Tamburrini, M., Ciardiello, M. A., & Mari, A.
ORCID
Alessandri, Claudia
Venue
Clinical and Translational Allergy
Publisher
Wiley
Published
2020-06-17
Volume
10
Issue
1
ISSN
2045-7022
DOI
10.1186/s13601-020-00329-8
PMC
PMC7298840
Cited by
54
References
1
Language
en
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CoChat. (2026). Citation check: Molecular approach to a patient’s tailored diagnosis of the oral allergy syndrome. https://app.cochat.ai/papers/10.1186/s13601-020-00329-8
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Alessandri, C., Ferrara, R., Bernardi, M. L., Zennaro, D., Tuppo, L., Giangrieco, I., Ricciardi, T., Tamburrini, M., Ciardiello, M. A., & Mari, A. (2020). Molecular approach to a patient’s tailored diagnosis of the oral allergy syndrome. Clinical and Translational Allergy. https://doi.org/10.1186/s13601-020-00329-8