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Cited by 14Urological Disorders and TreatmentsSexual Differentiation and DisordersHypothalamic control of reproductive hormones

Normative penile anthropometry in term newborns in Kumasi, Ghana: a cross-sectional prospective study

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Asafo-Agyei, Serwah Bonsu, Ameyaw, Emmanuel, Chanoine, Jean-Pierre, Nguah, Samuel Blay·2017·International Journal of Pediatric Endocrinology
DOI 10.1186/s13633-017-0042-1PMC PMC5270225
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Abstract

BACKGROUND: Genital measurements are a useful adjunct in the early detection of various endocrine conditions including hypopituitarism and disorders of sexual differentiation. Standards for genital sizes have been published but racial/ethnic differences exist. This study was done to establish norms for genital sizes in term Ghanaian male newborns. METHODS: This was a cross-sectional study of all apparently well full-term newborns of postnatal age < 48 h and birth weight between 2.5 and 4.0 kg delivered at Komfo Anokye Teaching Hospital within the study period. Anthropometric and genital parameters were documented for study subjects as well as parental socio-demographic indices. RESULTS: < 0.001 for both). CONCLUSIONS: Using the conventional definition of micropenis as stretched penile length (SPL) < 2.5 standard deviation (SD) below the mean and macropenis as an SPL > 2.5 SD, a Ghanaian term newborn may warrant investigation if he has an MPL < 2.1 cm or > 4.4 cm.

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  • The coordinated increase of both parameters supports the concept that penile growth occurs in a proportional manner.

    “The coordinated increase of both parameters supports the concept that penile growth occurs in a proportional manner [26-28].”

    From Stretched Penile Length and Penile Circumference in Pediatric Population of Pakistan: A Cross-Sectional Single-Center Study (2026) · cites this paper as [26]

    The Discussion (page unavailable) reports that penile length and width were both positively associated with newborn body length, which offers limited support for a coordinated pattern. It does not establish that penile length and width increase proportionally with each other or track penile growth over time; the study measured term newborns at one point. (LLM, conf=0.83)

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  1. [1]Phillip M De Boer C Pilpel D Karplus M Sofer S Clitoral and penile sizes of full term newborns in two different ethnic groups J Pediatr Endocrinol Metab 1996 9 175 9 10.1515/JPEM.1996.9.5.519 8887140 · DOI
  2. [2]Lee P Mazur T Danish R Amrhein J Blizzard R Money J Micropenis I. Criteria, etiologies and classification Johns Hopkins Med J 1980 146 156 63 7366061
  3. [3]Feldman KW Smith DW Fetal phallic growth and penile standards for newborn male infants J Pediatr 1975 86 395 8 10.1016/S0022-3476(75)80969-3 1113226 · DOI · Paper page
  4. [4]Salisbury DM Leonard JV Dezateux CA Savage MO Micropenis: an important early sign of congenital hypopituitarism Br Med J (Clin Res Ed) 1984 288 621 2 10.1136/bmj.288.6417.621 PMC1444359 6421404 · DOI
  5. [5]Ameeta Mehta A Datta MT Brook CGD Clayton PE Brown RS Congenital disorders of the hypothalamic–pituitary axis Brook’s Clinical Pediatric Endocrinology 2005 5 Oxford Blackwell Publishing Ltd 67 89
  6. [6]Tuladhar R Davis PG Batch J Doyle LW Establishment of a normal range of penile length in preterm infants J Paediatr Child Health 1998 34 471 3 10.1046/j.1440-1754.1998.00278.x 9767514 · DOI
  7. [7]Conte FA Grumbach MM Gardner DG Shoback D Disorders of sexual determination and differentiation Greenspan’s Basic & Clinical Endocrinology 2011 9 New York The McGraw-Hill Companies 479 526
  8. [8]Hatipoğlu N Kurtoğlu S Micropenis: etiology, diagnosis and treatment approaches J Clin Res Pediatr Endocrinol 2013 5 217 23 10.4274/Jcrpe.1135 24379029 PMC3890219 · DOI
  9. [9]Kaiser GL Symptoms and signs in Pediatric surgery 2005 New York Springer 565 79
  10. [10]Thorén M Schenck-Gustafsson K DeCola PR Pfaff DW Pisetsky DS Adrenal disorders, female androgen deficiency, hirsutism, and endocrine hypertension Handbook of Clinical Gender Medicine 2012 Basel Karger 317 26
  11. [11]Kido Y Gordon CT Sakazume S Bdira EB Dattani M Wilson LC Further characterization of atypical features in auriculocondylar syndrome caused by recessive PLCB4 mutations Am J Med Genet A 2013 161A 2339 46 10.1002/ajmg.a.36066 23913798 · DOI
  12. [12]Makhoul IR Aviram-Goldring A Paperna T Sujov P Rienstein S Smolkin T Caudal dysplasia sequence with penile enlargement: case report and a potential pathogenic hypothesis Am J Med Genet 2001 99 54 8 10.1002/1096-8628(20010215)99:1<54::AID-AJMG1124>3.0.CO;2-F 11170094 · DOI
  13. [13]Praduch DA Schlegel PN Sarafoglou K Hoffmann G Roth KS Courtney H Male hypogonadism Pediatric Endocrinology and Inborn Errors of Metabolism 2009 New York The McGraw Hill Companies 575 600
  14. [15]Schonfeld WA Primary and secondary sexual characteristics: study of their development in males from birth through maturity, with biometric study of penis and testes Am J Dis Child 1943 65 535 49 10.1001/archpedi.1943.02010160019003 · DOI
  15. [16]Flatau E Josefsberg Z Reisner SH Bialik O Laron Z Letter: Penile size in the newborn infant J Pediatr 1975 87 663 4 10.1016/S0022-3476(75)80877-8 1159603 · DOI
  16. [17]Cheng PK Chanoine JP Should the definition of micropenis vary according to ethnicity? Horm Res 2001 55 278 81 11805431
  17. [18]Lian WB Lee WR Ho LY Penile length of newborns in Singapore J Pediatr Endocrinol Metab 2000 13 55 62 10.1515/JPEM.2000.13.1.55 10689638 · DOI
  18. [19]Lee JH Ji YH Lee SK Hwang HH Ryu DS Kim KS Change in penile length in children: preliminary study Korean J Urol 2012 53 870 4 10.4111/kju.2012.53.12.870 23301133 PMC3531642 · DOI
  19. [20]Kutlu AO Normative data for penile length in Turkish newborns J Clin Res Pediatr Endocrinol 2010 2 107 10 10.4274/jcrpe.v2i3.107 21274323 PMC3005681 · DOI
  20. [21]Akın Y Ercan O Telatar B Tarhan F Penile size in term newborn infants Turk J Pediatr 2011 53 3 301 7 21980812
  21. [22]Ting TH Wu LL Penile length of term newborn infants in multiracial Malaysia Singapore Med J 2009 50 8 817 21 19710983
  22. [23]Fok TF Hon KL So HK Wong E Ng PC Chang A Normative data of penile length for term Chinese newborns Biol Neonate 2005 87 242 5 10.1159/000083420 15665508 · DOI · Paper page
  23. [24]Jarrett OO Ayoola OO Jonsson B Albertsson-Wikland K Ritzen EM Penile size in healthy Nigerian newborns: country-based reference values and international comparisons Acta Paediatr 2014 103 4 442 6 10.1111/apa.12517 24289753 · DOI
  24. [25]Dubowitz LMS Dubowitz V Goldberg C Clinical assessment of gestational age in the newborn infant J Pediatr 1970 77 1 10 10.1016/S0022-3476(70)80038-5 5430794 · DOI
  25. [27]Laron Z Klinger B Effect of insulin-like growth factor-1 treatment on serum androgens and testicular and penile size in males with Laron syndrome (primary growth hormone resistance) Eur J Endocrinol 1998 138 176 80 10.1530/eje.0.1380176 9506862 · DOI
  26. [28]Maimoun L Philibert P Cammas B Audran F Bouchard P Fenichel P Phenotypical, biological, and molecular heterogeneity of 5α-reductase deficiency: an extensive international experience of 55 patients J Clin Endocrinol Metab 2011 96 297 307 10.1210/jc.2010-1024 21147889 · DOI
  27. [31]Matsuo N Ishii T Takayama J Miwa M Hasegawa T Reference standard of penile size and prevalence of buried penis in Japanese newborn male infants Endocr J 2014 61 9 894 53 10.1507/endocrj.EJ14-0069 24931740 · DOI
  28. [32]Al-Herbish AS Standard penile size for normal full term newborns in the Saudi population Saudi Med J 2002 23 314 6 11938424
  29. [33]Sutan-Assin M Rukman J Dahlan A Penile dimensions of newborn infants Paediatr Indones 1989 29 7–8 146 50 2812828
  30. [34]Moelyo AG Widyastuti M Penile length of newborns and children in Surakarta, Indonesia Paediatr Indones 2013 53 65 9 10.14238/pi53.2.2013.65-9 · DOI · Paper page
  31. [35]Kholy ME Hamza RT Saleh M Elsedfy H Penile length and genital anomalies in Egyptian male newborns: epidemiology and influence of endocrine disruptors JPEM 2013 26 509 13 10.1515/jpem-2012-0350 23509209 · DOI
  32. [36]Romano-Riquer SP Hernandez-Avila M Gladen BC Cupul-Uicab LA Longnecker MP Reliability and determinants of anogenital distance and penis dimensions in male newborns from Chiapas, Mexico Paediatr Perinat Epidemiol 2007 21 219 28 10.1111/j.1365-3016.2007.00810.x 17439530 PMC3653615 · DOI
  33. [37]Carlsen SM Jacobsen G Bjerve KS Androgen levels in pregnant women decrease with increasing maternal age Scand J Clin Lab Invest 2003 63 23 6 10.1080/00365510310000457 12729066 · DOI
  34. [38]Troisi R Potischman N Roberts J Siiteri P Daftary A Sims C Associations of maternal and umbilical cord hormone concentrations with maternal, gestational and neonatal factors (United States) Cancer Causes Control 2003 14 347 55 10.1023/A:1023934518975 12846366 · DOI
  35. [39]Gitau R Adams D Fisk NM Glover V Fetal plasma testosterone correlates positively with cortisol Arch Dis Child Fetal Neonatal Ed 2005 90 F166 9 10.1136/adc.2004.049320 15724043 PMC1721847 · DOI · Paper page
  36. [40]Mohamed MH Abdoua RM Hamzab MT Husseina MMS Penile length and cord total and free testosterone in full term male Egyptian neonates Gaz Egypt Paediatr Assoc 2015 63 58 62 10.1016/j.epag.2015.03.002 · DOI
  37. [41]Kaijser M Jacobsen G Granath F Cnattingius S Ekbom A Maternal age, anthropometrics and pregnancy oestriol Paediatr Perinat Epidemiol 2002 16 149 53 10.1046/j.1365-3016.2002.00397.x 12064269 · DOI
  38. [42]Alaee E Gharib MJ Fouladinejad M Penile length and anogenital distance in male newborns from different Iranian ethnicities in Golestan province Iran Red Crescent Med J 2014 16 1 4 10.5812/ircmj.16729 PMC4341348 25763234 · DOI
  39. [43]Backeljauw PF Dattani MT Cohen P Rosenfeld RG Sperling MA Disorders of growth hormone/insulin-like growth factor secretion and action Pediatric Endocrinology 2014 4 Philadelphia Elsevier 338

Cited by

Sorted by citations

Authors
Asafo-Agyei, S. B., Ameyaw, E., Chanoine, J.-P., & Nguah, S. B.
Affiliations
  • Komfo Anokye Teaching Hospital (GH)
  • University of British Columbia (CA)
ORCID
Venue
International Journal of Pediatric Endocrinology
Publisher
Springer Science and Business Media LLC
Published
2017-01-26
Volume
2017
Issue
1
Pages
2-2
ISSN
  • 1687-9848 (ISSN-L)
  • 1687-9856
DOI
10.1186/s13633-017-0042-1
PMC
PMC5270225
OpenAlex
W2581514062
Cited by
14
References
3
Citations by year
2026: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 3 · 2020: 3 · 2019: 2 · 2018: 1
FWCI
2.30
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • International Journal of Pediatric Endocrinology (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • cIRcle (University of British Columbia) (submittedVersion, cc-by)
Funders
  • European Society for Paediatric Endocrinology
  • Global Pediatric Endocrinology and Diabetes
Topics
  • Health Sciences › Medicine › Urology › Urological Disorders and Treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords
neonates, stretched penile length, micropenis, hypopituitarism, sex differentiation disorders

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