Prevalence of adjustment disorder among cancer patients, and the reach, effectiveness, cost-utility and budget impact of tailored psychological treatment: study protocol of a randomized controlled trial
Open accessAbstract
Background: Information on the prevalence of adjustment disorders among cancer patients and the value of psychological interventions in this group of patients is limited. This study investigates the prevalence of adjustment disorders among cancer patients as well as the reach, effectiveness, cost-utility and budget impact of a tailored psychological intervention. Method: This study consists of two parts. Part 1 is an observational study among a representative group of mixed cancer patients after cancer treatment on the prevalence of adjustment disorder as well as the uptake (i.e. reach) of psychological treatment. In Part 2, patients diagnosed with an adjustment disorder are invited to participate in a randomized controlled trial. Patients will be randomized to the intervention (access to the tailored psychological intervention) or control group (waitlist period of 6 months). The psychological intervention consists of three modules: one module containing psycho-education (3 sessions, all patients) and two additional modules (maximum of 6 sessions per module) provided as continuum, in case needed. Module 2 and 3 can consist of several evidence-based interventions (e.g. group interventions, mindfulness, eHealth) The primary outcome is psychological distress (HADS). Secondary outcomes are mental adjustment to cancer (MAC) and health-related quality of life (EORTC QLQ-C30). To assess the cost-utility and budget impact, quality of life (EQ-5D-5 L) and costs (iMCQ and iPCQ) will be measured. Measures will be completed at baseline and 3 and 6-months after randomization. Discussion: This study will provide data of the prevalence of adjustment disorders and the reach, effectiveness, cost-utility and budget impact of a tailored psychological intervention. Trial registration: Netherlands Trial Register identifier:NL7763. Registered on 3 June 2019.
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Due to the COVID-19 pandemic, the study had to stop recruiting patients earlier than planned, resulting in 200 patients with breast, prostate, and head and neck cancer instead of the planned 3000 patients with various types of cancer.
“A limitation is that, due to the COVID-19 pandemic, we had to stop recruiting patients earlier than planned, which resulted in 200 patients with breast, prostate, and head and neck cancer instead of the planned 3000 patients with various types of cancer [14].”
From Adjustment disorder in cancer patients after treatment: prevalence and acceptance of psychological treatment (2022) · cites this paper as [14]
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Cites
Bray, F., Ferlay, J., Soerjomataram, I., Siegel, R. L., Torre, L. A., & Jemal, A. (2018) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21492 · Cited by 84,109 · see citing works
von Elm, E., Altman, D. G., Egger, M., Pocock, S. J., Gøtzsche, P. C., Vandenbroucke, J. P., & Initiative, F. T. S. (2007) · PLoS Medicine · doi:10.1371/journal.pmed.0040296 · Cited by 23,020 · see citing works
Aaronson, N. K., Ahmedzai, S., Bergman, B., Bullinger, M., Cull, A., Duez, N. J., Filiberti, A., Flechtner, H., Fleishman, S. B., Haes, J. C. J. M. D., et al. (1993) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/85.5.365 · Cited by 16,005 · see citing works
Methods for the Economic Evaluation of Health Care Programmes
Drummond, M. E., Sculpher, M. J., Torrance, G. W., O’Brien, B. J., & Stoddart, G. L. (2005) · doi:10.1093/oso/9780198529446.001.0001 · Cited by 13,648 · see citing works
CONSORT 2010 Statement: updated guidelines for reporting parallel group randomised trials
the CONSORT Group, Schulz, K. F., Altman, D. G., & Moher, D. (2010) · BMC Medicine · doi:10.1186/1741-7015-8-18 · Cited by 13,371 · see citing works
von Elm, E., Altman, D. G., Egger, M., Pocock, S. J., Gøtzsche, P. C., & Vandenbroucke, J. P. (2014) · International Journal of Surgery · doi:10.1016/j.ijsu.2014.07.013 · Cited by 9,909 · see citing works
Mitchell, A. J., Chan, M., Bhatti, H., Halton, M., Grassi, L., Johansen, C., & Meader, N. (2011) · The Lancet Oncology · doi:10.1016/s1470-2045(11)70002-x · Cited by 2,449 · see citing works
SPINHOVEN, P., ORMEL, J., SLOEKERS, P. P. A., KEMPEN, G. I. J. M., SPECKENS, A. E. M., & HEMERT, A. M. V. (1997) · Psychological Medicine · doi:10.1017/s0033291796004382 · Cited by 2,158 · see citing works
Dutch Tariff for the Five-Level Version of EQ-5D
M. Versteegh, M., M. Vermeulen, K., M. A. A. Evers, S., de Wit, G. A., Prenger, R., & A. Stolk, E. (2016) · Value in Health · doi:10.1016/j.jval.2016.01.003 · Cited by 1,113 · see citing works
Sullivan, S., Mauskopf, J., Augustovski, F., Caro, J., Lee, K. M., Minchin, M., Orlewska, E., Penna, P., Barrios, J. R. R., & Shau, W. (2014) · Value in Health · doi:10.1016/j.jval.2013.08.2291 · Cited by 1,069 · see citing works
Economic burden of cancer across the European Union: a population-based cost analysis
Luengo-Fernández, R., Leal, J., Gray, A. M., & Sullivan, R. J. (2013) · The Lancet Oncology · doi:10.1016/s1470-2045(13)70442-x · Cited by 1,010 · see citing works
Quality of life research within the EORTC—the EORTC QLQ-C30
Fayers, P. M., & Bottomley, A. (2002) · European Journal of Cancer · doi:10.1016/s0959-8049(01)00448-8 · Cited by 928 · see citing works
Faller, H., Schuler, M., Richard, M., Heckl, U., Weis, J., & Küffner, R. (2013) · Journal of Clinical Oncology · doi:10.1200/jco.2011.40.8922 · Cited by 912 · see citing works
What are the unmet supportive care needs of people with cancer? A systematic review
Harrison, J. D., Young, J. M., Price, M. A., Butow, P. N., & Solomon, M. J. (2009) · Supportive Care in Cancer · doi:10.1007/s00520-009-0615-5 · Cited by 905 · see citing works
Physical and psychological long-term and late effects of cancer
Stein, K., Syrjala, K. L., & Andrykowski, M. A. (2008) · Cancer · doi:10.1002/cncr.23448 · Cited by 772 · see citing works
Development of a questionnaire measure of adjustment to cancer: the MAC scale
Watson, M., Greer, S., Young, J., Inayat, Q., Burgess, C., & Robertson, B. (1988) · Psychological Medicine · doi:10.1017/s0033291700002026 · Cited by 666 · see citing works
Four-Week Prevalence of Mental Disorders in Patients With Cancer Across Major Tumor Entities
Mehnert, A., Brähler, E., Faller, H., Härter, M., Keller, M., Schulz, H., Wegscheider, K., Weis, J., Boehncke, A., Hund, B., et al. (2014) · Journal of Clinical Oncology · doi:10.1200/jco.2014.56.0086 · Cited by 649 · see citing works
Screening for Distress and Unmet Needs in Patients With Cancer: Review and Recommendations
Carlson, L. E., Waller, A., & Mitchell, A. J. (2012) · Journal of Clinical Oncology · doi:10.1200/jco.2011.39.5509 · Cited by 550 · see citing works
Tuinman, M. A., Gazendam‐Donofrio, S. M., & Hoekstra‐Weebers, J. E. (2008) · Cancer · doi:10.1002/cncr.23622 · Cited by 404 · see citing works
Fitch, M. I. (2008) · Canadian Oncology Nursing Journal · doi:10.5737/1181912x181614 · Cited by 403 · see citing works
Panel, N. I. O. H. S.-O.-T.-S. (2003) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djg014 · Cited by 396 · see citing works
Panel, N. I. O. H. S.-O.-T.-S. (2004) · JNCI Monographs · doi:10.1093/jncimonographs/djg014 · Cited by 394 · see citing works
Screening for Psychological Distress in Japanese Cancer Patients
Kugaya, A., Akechi, T., Okuyama, T., Okamura, H., & Uchitomi, Y. (1998) · Japanese Journal of Clinical Oncology · doi:10.1093/jjco/28.5.333 · Cited by 367 · see citing works
The assessment of fatigue: Psychometric qualities and norms for the Checklist individual strength
Worm-Smeitink, M., Gielissen, M., Bloot, L., van Laarhoven, H. W. M., van Engelen, B. G. M., van Riel, P., Bleijenberg, G., Nikolaus, S., & Knoop, H. (2017) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2017.05.007 · Cited by 360 · see citing works
Gielissen, M. F. M., Verhagen, S., Witjes, F., & Bleijenberg, G. (2006) · Journal of Clinical Oncology · doi:10.1200/jco.2006.06.8270 · Cited by 349 · see citing works
Vodermaier, A., & Millman, R. D. (2011) · Supportive Care in Cancer · doi:10.1007/s00520-011-1251-4 · Cited by 332 · see citing works
Kugaya, A., Akechi, T., Okuyama, T., Nakano, T., Mikami, I., Okamura, H., & Uchitomi, Y. (2000) · Cancer · doi:10.1002/1097-0142(20000615)88:12 · Cited by 309 · see citing works
Comparing the Standard EQ-5D Three-Level System with a Five-Level Version
Janssen, M. F., Birnie, E., Haagsma, J. A., & Bonsel, G. J. (2008) · Value in Health · doi:10.1111/j.1524-4733.2007.00230.x · Cited by 275 · see citing works
van den Berg, S. W., Gielissen, M. F. M., Custers, J. A. E., van der Graaf, W. T. A., Ottevanger, P. B., & Prins, J. B. (2015) · Journal of Clinical Oncology · doi:10.1200/jco.2013.54.9386 · Cited by 201 · see citing works
Self-citationvan de Wal, M., Thewes, B., Gielissen, M., Speckens, A., & Prins, J. (2017) · Journal of Clinical Oncology · doi:10.1200/jco.2016.70.5301 · Cited by 195 · see citing works
Self-citationAkizuki, N., Yamawaki, S., Akechi, T., Nakano, T., & Uchitomi, Y. (2005) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2004.04.016 · Cited by 189 · see citing works
Validation of the French ‘multidimensional fatigue inventory’ (MFI 20)
Gentile, S., Delarozière, J.-C., FAVRE, F., Sambuc, R., & MARCO, J. L. S. (2003) · European Journal of Cancer Care · doi:10.1046/j.1365-2354.2003.00295.x · Cited by 187 · see citing works
Akizuki, N., Akechi, T., Nakanishi, T., Yoshikawa, E., Okamura, M., Nakano, T., Murakami, Y., & Uchitomi, Y. (2003) · Cancer · doi:10.1002/cncr.11358 · Cited by 184 · see citing works
Abrahams, H. J. G., Gielissen, M. F. M., Donders, R. R. T., Goedendorp, M. M., van der Wouw, A. J., Verhagen, C. A. H. H. V. M., & Knoop, H. (2017) · Cancer · doi:10.1002/cncr.30815 · Cited by 165 · see citing works
Brebach, R., Sharpe, L., Costa, D. S. J., Rhodes, P., & Butow, P. (2016) · Psycho-Oncology · doi:10.1002/pon.4099 · Cited by 139 · see citing works
Schellekens, M. P. J., van den Hurk, D. G. M., Prins, J. B., Donders, A. R. T., Molema, J., Dekhuijzen, R., van der Drift, M. A., & Speckens, A. E. M. (2017) · Psycho-Oncology · doi:10.1002/pon.4430 · Cited by 138 · see citing works
Self-citationEfficacy of meaning-centered group psychotherapy for cancer survivors: a randomized controlled trial
van der Spek, N., Vos, J., van Uden-Kraan, C. F., Breitbart, W., Cuijpers, P., Holtmaat, K., Witte, B. I., Tollenaar, R. A. E. M., & Verdonck-de Leeuw, I. M. (2017) · Psychological Medicine · doi:10.1017/s0033291717000447 · Cited by 135 · see citing works
IMTA Productivity Cost Questionnaire (IPCQ)
Bouwmans, C. A. M., Krol, M., Brouwer, W. B. F., Severens, J. L., Koopmanschap, M. A., & Hakkaart, L. (2014) · Value in Health · doi:10.1016/j.jval.2014.08.1791 · Cited by 132 · see citing works
Lydiatt, W. M., Denman, D., McNeilly, D. P., Puumula, S. E., & Burke, W. J. (2008) · Archives of Otolaryngology - Head and Neck Surgery · doi:10.1001/archotol.134.5.528 · Cited by 102 · see citing works
The HADS and the DT for screening psychosocial distress of cancer patients in Taiwan
Wang, G., Hsu, S., Feng, A., Chiu, C., Shen, J., Lin, Y., & Cheng, C. (2011) · Psycho-Oncology · doi:10.1002/pon.1952 · Cited by 100 · see citing works
Adjustment Disorder with Depressed Mood
Baumeister, H., Maercker, A., & Casey, P. (2009) · Psychopathology · doi:10.1159/000207455 · Cited by 92 · see citing works
Mental Adjustment to Cancer Scale<sup>©</sup>: psychometric properties in a large cancer cohort
Watson, M., & Homewood, J. (2008) · Psycho-Oncology · doi:10.1002/pon.1345 · Cited by 90 · see citing works
Leeuw, I. M. V., de Bree, R., Keizer, A. L., Houffelaar, T., Cuijpers, P. J., van der Linden, M. H., & Leemans, C. R. (2009) · Oral Oncology · doi:10.1016/j.oraloncology.2009.01.012 · Cited by 90 · see citing works
Self-citationWillems, R. A., Mesters, I., Lechner, L., Kanera, I. M., & Bolman, C. A. W. (2017) · Journal of Cancer Survivorship · doi:10.1007/s11764-017-0625-0 · Cited by 80 · see citing works
Krebber, A. M. H., Jansen, F., Lissenberg-Witte, B. I., Cuijpers, P. J., de Bree, R., Becker‐Commissaris, A., Smit, E. F., van Straten, A., Eeckhout, A. M., Beekman, A. T. F., et al. (2016) · Annals of Oncology · doi:10.1093/annonc/mdw230 · Cited by 74 · see citing works
Self-citationHernández Blázquez, M., & Cruzado, J. A. (2016) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2016.05.010 · Cited by 70 · see citing works
Economic evaluations of psychosocial interventions in cancer: a systematic review
Dieng, M., Cust, A. E., Kasparian, N. A., Mann, G. J., & Morton, R. L. (2016) · Psycho-Oncology · doi:10.1002/pon.4075 · Cited by 66 · see citing works
Waller, A. E., Williams, A. M., Groff, S. L., Bultz, B. D., & Carlson, L. E. (2011) · Psycho-Oncology · doi:10.1002/pon.2102 · Cited by 63 · see citing works
Ryan, D. A., Gallagher, P., Wright, S., & Cassidy, E. M. (2012) · Psycho-Oncology · doi:10.1002/pon.2042 · Cited by 62 · see citing works
Passik, S. D., Kirsh, K. L., Donaghy, K. B., Theobald, D., Lundberg, J. C., Holtsclaw, E., & Dugan, W. (2001) · Journal of Pain and Symptom Management · doi:10.1016/s0885-3924(00)00264-5 · Cited by 59 · see citing works
Burm, R., Thewes, B., Rodwell, L., Kievit, W., Speckens, A., van de Wal, M., & Prins, J. (2019) · BMC Cancer · doi:10.1186/s12885-019-5615-3 · Cited by 55 · see citing works
Self-citationÖzalp, E., Soygür, H., Cankurtaran, E. Ş., Turhan, L., Akbıyık, D. İ., & Geyik, P. Ö. (2007) · Psycho-Oncology · doi:10.1002/pon.1286 · Cited by 49 · see citing works
Hosaka, T., Awazu, H., Aoki, T., Okuyama, T., & Yamawaki, S. (1999) · International Journal of Psychiatry in Clinical Practice · doi:10.3109/13651509909024758 · Cited by 39 · see citing works
A review on cost-effectiveness and cost-utility of psychosocial care in cancer patients
Jansen, F., van Zwieten, V., Coupé, V. M. H., Leemans, C. R., & Leeuw, I. M. V. (2016) · Asia-Pacific Journal of Oncology Nursing · doi:10.4103/2347-5625.182930 · Cited by 39 · see citing works
Self-citationJansen, F., Krebber, A. M. H., Coupé, V. M. H., Cuijpers, P. J., de Bree, R., Becker‐Commissaris, A., Smit, E. F., van Straten, A., Eeckhout, G. M., Beekman, A. T. F., et al. (2017) · Journal of Clinical Oncology · doi:10.1200/jco.2016.68.8739 · Cited by 38 · see citing works
Self-citationSinger, S., Meyer, A., Wienholz, S., Briest, S., Brown, A., Dietz, A., Binder, H., Jonas, S., Papsdorf, K., Stolzenburg, J., et al. (2014) · Cancer · doi:10.1002/cncr.28716 · Cited by 31 · see citing works
Braeken, A. P. B. M., Kempen, G. I. J. M., Watson, M., Houben, R. M. A., van Gils, F. C. J. M., & Lechner, L. (2009) · Psycho-Oncology · doi:10.1002/pon.1628 · Cited by 25 · see citing works
Garssen, B., Van der Lee, M., Van der Poll, A., Ranchor, A. V., Sanderman, R., & Schroevers, M. J. (2016) · Psychology & Health · doi:10.1080/08870446.2016.1204447 · Cited by 17 · see citing works
Effect of radiotherapy on psychiatric disorder in patients with head and neck cancer
Unal, D., Orhan, O., Özsoy, S., Beşirli, A., Eroğlu, C., & Kaplan, B. (2016) · Indian Journal of Cancer · doi:10.4103/0019-509x.180816 · Cited by 4 · see citing works
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- [35]Vercoulen JHMM, Alberets M, Blijenberg G. De checklist individual strength (CIS). Gedragstherapie. 1999;32:31–6.
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Van Beek, F. E., Wijnhoven, L. M. A., Custers, J. A. E., Holtmaat, K., De Rooij, B. H., Horevoorts, N. J. E., Aukema, E. J., Verheul, S., Eerenstein, S. E. J., Strobbe, L., et al. (2022) · Supportive Care in Cancer · doi:10.1007/s00520-021-06530-0 · Cited by 26 · see citing works
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- Authors
- van Beek, F. E., Wijnhoven, L. M. A., Jansen, F., Custers, J. A. E., Aukema, E. J., Coupé, V. M. H., Cuijpers, P., van der Lee, M. L., Lissenberg-Witte, B. I., Wijnen, B., Prins, J. B., & Verdonck-de Leeuw, I. M.
- Affiliations
- Radboud University Nijmegen (NL)
- Amsterdam Public Health (NL)
- Amsterdam University Medical Centers (NL)
- Trimbos Institute (NL)
- ORCID
- Venue
- BMC Psychology
- Published
- 2019-12
- Volume
- 7
- Issue
- 1
- Pages
- 89-89
- ISSN
- 2050-7283 (ISSN-L)
- PMC
- PMC6929410
- OpenAlex
- W2996349402
- Cited by
- 13
- References
- 59
- Citations by year
- 2025: 3 · 2024: 3 · 2023: 1 · 2022: 1 · 2021: 4 · 2020: 1
- FWCI
- 0.63
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- BMC Psychology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- VU Research Portal (submittedVersion, other-oa)
- Radboud Repository (Radboud University) (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Funders
- ZonMw (856001005)
- Topics
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Health Systems, Economic Evaluations, Quality of Life
- Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Economic and Financial Impacts of Cancer
- Keywords
- adjustment disorder, cancer patients, psychological intervention, prevalence, psychological distress, mental adjustment to cancer, health-related quality of life, cost-utility analysis, budget impact, psychoeducation, mindfulness, e-health, group intervention
- MeSH terms
- Adjustment Disorders, Adult, Clinical Protocols, Cost-Benefit Analysis, Female, Humans, Male, Neoplasms, Netherlands, Psychotherapy, Psychotherapy, Group, Quality of Life, Research Design, Prevalence, Randomized Controlled Trials as Topic, Treatment Outcome, Telemedicine, Mindfulness, Observational Studies as Topic
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