CoChat
Sign Up
Cited by 38

The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.

Recent progress and perspectives on the mechanisms underlying Asbestos toxicity

Kuroda, Akio·2021·Genes and Environment
DOI 10.1186/s41021-021-00215-0PMC PMC8507173
Open this paper in CoChat — free account

Abstract

Most cases of mesothelioma are known to result from exposure to asbestos fibers in the environment or occupational ambient air. The following questions regarding asbestos toxicity remain partially unanswered: (i) why asbestos entering the alveoli during respiration exerts toxicity in the pleura; and (ii) how asbestos causes mesothelioma, even though human mesothelial cells are easily killed upon exposure to asbestos. As for the latter question, it is now thought that the frustrated phagocytosis of asbestos fibers by macrophages prolongs inflammatory responses and gives rise to a “mutagenic microenvironment” around mesothelial cells, resulting in their malignant transformation. Based on epidemiological and genetic studies, a carcinogenic model has been proposed in which BRCA1-associated protein 1 mutations are able to suppress cell death in mesothelial cells and increase genomic instability in the mutagenic microenvironment. This leads to additional mutations, such as CDKN2A [p16], NF2, TP53, LATS2, and SETD2, which are associated with mesothelioma carcinogenesis. Regarding the former question, the receptors involved in the intracellular uptake of asbestos and the mechanism of transfer of inhaled asbestos from the alveoli to the pleura are yet to be elucidated. Further studies using live-cell imaging techniques will be critical to fully understanding the mechanisms underlying asbestos toxicity.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1186/s41021-021-00215-0

Cites

7 of 7 references verified0 citation errors · 0 not checkable

Statistics

Figures

Fig. 1 Electron micrograph of asbestos. Amosite, obtained from the Japan Association for Working Environment Measurement (Tokyo, Japan), was observed by field emission scanning electron microscopy (Ultra Plus, Carl Zeiss)
Fig. 1 Electron micrograph of asbestos. Amosite, obtained from the Japan Association for Working Environment Measurement (Tokyo, Japan), was observed by field emission scanning electron microscopy (Ultra Plus, Carl Zeiss)CC BY · PubMed Central
Fig. 2 Frustrated phagocytosis. Fluorescently labeled asbestos (red) was phagocytosed by RAW264.7 cells. The actin cytoskeletons and nuclei were stained with Actin Green™ 488 (green) and 4′,6-diamidino-2-phenylindole (blue), respectively. This image was taken using a confocal laser scanning microscope [81]. Scale bar = 10 μm. This figure has been reproduced from the open-access article [81]
Fig. 2 Frustrated phagocytosis. Fluorescently labeled asbestos (red) was phagocytosed by RAW264.7 cells. The actin cytoskeletons and nuclei were stained with Actin Green™ 488 (green) and 4′,6-diamidino-2-phenylindole (blue), respectively. This image was taken using a confocal laser scanning microscope [81]. Scale bar = 10 μm. This figure has been reproduced from the open-access article [81]CC BY · PubMed Central
Fig. 3 A model of the carcinogenesis of mesothelioma in an asbestos-induced mutagenic microenvironment. Phagocytosed asbestos induces a mutagenic microenvironment rich in Fe (II), IL-1ß, ROS, and HMGB1 [16, 17, 19, 27, 46, 50–52]. The BAP1 mutation contributes to the suppression of mesothelial cell death and the accumulation of additional mutations associated with mesothelioma carcinogenesis [69]. Abbreviations: IL-1ß: Interleukin-1ß; ROS, reactive oxygen species; HMGB1, high mobility group box-1 protein; BAP1, BRCA1-associated protein 1
Fig. 3 A model of the carcinogenesis of mesothelioma in an asbestos-induced mutagenic microenvironment. Phagocytosed asbestos induces a mutagenic microenvironment rich in Fe (II), IL-1ß, ROS, and HMGB1 [16, 17, 19, 27, 46, 50–52]. The BAP1 mutation contributes to the suppression of mesothelial cell death and the accumulation of additional mutations associated with mesothelioma carcinogenesis [69]. Abbreviations: IL-1ß: Interleukin-1ß; ROS, reactive oxygen species; HMGB1, high mobility group box-1 protein; BAP1, BRCA1-associated protein 1CC BY · PubMed Central
Fig. 4 Transport of asbestos fibers from the alveoli to the pleura
Fig. 4 Transport of asbestos fibers from the alveoli to the pleuraCC BY · PubMed Central

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 7 references

Research works printed but not linked: 74

  1. Davis JM, Beckett ST, Bolton RE, Collings P, Middleton AP. Mass and number of fibres in the pathogenesis of asbestos-related lung disease in rats. Br J Cancer. 1978;37(5):673–88. https://doi.org/10.1038/bjc.1978.105. · DOI
  2. Suzuki Y, Yuen SR, Ashley R. Short, thin asbestos fibers contribute to the development of human malignant mesothelioma: pathological evidence. Int J Hyg Environ Health. 2005;208(3):201–10. https://doi.org/10.1016/j.ijheh.2005.01.015. · DOI · Paper page
  3. Kanarek MS. Mesothelioma from chrysotile asbestos: update. Ann Epidemiol. 2011;21(9):688–97. https://doi.org/10.1016/j.annepidem.2011.05.010. · DOI
  4. Wagner JC, Sleggs CA, Marchand P. Diffuse pleural mesothelioma and asbestos exposure in the North Western Cape Province. Occup Environ Med. 1960;17(4):260–71. https://doi.org/10.1136/oem.17.4.260. · DOI · Paper page
  5. Park EK, Takahashi K, Jiang Y, Movahed M, Kameda T. Elimination of asbestos use and asbestos-related diseases: an unfinished story. Cancer Sci. 2012;103(10):1751–5. https://doi.org/10.1111/j.1349-7006.2012.02366.x. · DOI
  6. Gordon RE, Fitzgerald S, Millette J. Asbestos in commercial cosmetic talcum powder as a cause of mesothelioma in women. Int J Occup Environ Health. 2014;20(4):318–32. https://doi.org/10.1179/2049396714Y.0000000081. · DOI
  7. Moline J, Bevilacqua K, Alexandri M, Gordon RE. Mesothelioma associated with the use of cosmetic talc. J Occup Environ Med. 2020;62(1):11–7. https://doi.org/10.1097/JOM.0000000000001723. · DOI
  8. Furuya S, Chimed-Ochir O, Takahashi K, David A, Takala J. Global Asbestos Disaster. Int J Environ Res Public Health. 2018;15(5):1000. https://doi.org/10.3390/ijerph15051000. · DOI
  9. Bariş B, Demir AU, Shehu V, Karakoca Y, Kisacik G, Bariş YI. Environmental fibrous zeolite (erionite) exposure and malignant tumors other than mesothelioma. J Environ Pathol Toxicol Oncol. 1996;15:183–9.
  10. Carbone M, Baris YI, Bertino P, Brass B, Comertpay S, Dogan AU, et al. Erionite exposure in North Dakota and Turkish villages with mesothelioma. Proc Natl Acad Sci U S A. 2011;108(33):13618–23. https://doi.org/10.1073/pnas.1105887108. · DOI · Paper page
  11. Carbone M, Emri S, Dogan AU, Steele I, Tuncer M, Pass HI, et al. A mesothelioma epidemic in Cappadocia: scientific developments and unexpected social outcomes. Nat Rev Cancer. 2007;7(2):147–54. https://doi.org/10.1038/nrc2068. · DOI
  12. Larson D, Powers A, Ambrosi JP, Tanji M, Napolitano A, Flores EG, et al. Investigating palygorskite's role in the development of mesothelioma in southern Nevada: insights into fiber-induced carcinogenicity. J Toxicol Environ Health, Part B. 2016;19(5-6):213–30. https://doi.org/10.1080/10937404.2016.1195321. · DOI
  13. Sanchez VC, Pietruska JR, Miselis NR, Hurt RH, Kane AB. Biopersistence and potential adverse health impacts of fibrous nanomaterials: what have we learned from asbestos? Wiley Interdiscip Rev: Nanomed Nanobiotechnol. 2009;1(5):511–29. https://doi.org/10.1002/wnan.41. · DOI · Paper page
  14. Olofsson K, Mark J. Specificity of asbestos-induced chromosomal aberrations in short-term cultured human mesothelial cells. Cancer Genet Cytogenet. 1989;41(1):33–9. https://doi.org/10.1016/0165-4608(89)90105-2. · DOI
  15. Yang H, Bocchetta M, Kroczynska B, Elmishad AG, Chen Y, Liu Z, et al. TNF-α inhibits asbestos-induced cytotoxicity via a NF-κB-dependent pathway, a possible mechanism for asbestos-induced oncogenesis. Proc Natl Acad Sci U S A. 2006;103(27):10397–402. https://doi.org/10.1073/pnas.0604008103. · DOI · Paper page
  16. Wang Y, Faux SP, Hallden G, Kirn DH, Houghton CE, Lemoine NR, et al. Interleukin-1β and tumour necrosis factor-alpha promote the transformation of human immortalised mesothelial cells by erionite. Int J Oncol. 2004;25(1):173–8.
  17. Xu A, Wu LJ, Santella RM, Hei TK. Role of oxyradicals in mutagenicity and DNA damage induced by crocidolite asbestos in mammalian cells. Cancer Res. 1999;59(23):5922–6.
  18. Qi F, Okimoto G, Jube S, Napolitano A, Pass HI, Laczko R, et al. Continuous exposure to chrysotile asbestos can cause transformation of human mesothelial cells via HMGB1 and TNF-α signaling. Am J Pathol. 2013;183(5):1654–66. https://doi.org/10.1016/j.ajpath.2013.07.029. · DOI
  19. Lehnert BE. Defense mechanisms against inhaled particles and associated particle-cell interactions. In: Guthrie Jr GD, Mossman BT, editors. Health effects of mineral dusts. Berlin, Boston: De Gruyter; 2018. p. 427–70. https://doi.org/10.1515/9781501509711-017. · DOI
  20. Oberdörster G. Macrophage-associated responses to chrysotile. Ann Occup Hyg. 1994;38(4):601–15. https://doi.org/10.1093/annhyg/38.4.601. · DOI
  21. Schinwald A, Murphy FA, Prina-Mello A, Poland CA, Byrne F, Movia D, et al. The threshold length for fiber-induced acute pleural inflammation: shedding light on the early events in asbestos-induced mesothelioma. Toxicol Sci. 2012;128(2):461–70. https://doi.org/10.1093/toxsci/kfs171. · DOI · Paper page
  22. Dörger M, Münzing S, Allmeling AM, Messmer K, Krombach F. Differential responses of rat alveolar and peritoneal macrophages to man-made vitreous fibers in vitro. Environ Res. 2001;85(3):207–14. https://doi.org/10.1006/enrs.2001.4234. · DOI
  23. Schinwald A, Donaldson K. Use of back-scatter electron signals to visualise cell/nanowires interactions in vitro and in vivo; frustrated phagocytosis of long fibres in macrophages and compartmentalisation in mesothelial cells in vivo. Part Fibre Toxicol. 2012;9(1):34. https://doi.org/10.1186/1743-8977-9-34. · DOI
  24. Stanton MF, Layard M, Tegeris A, Miller E, May M, Morgan E, et al. Relation of particle dimension to carcinogenicity in amphibole asbestoses and other fibrous minerals. J Natl Cancer Inst. 1981;67(5):965–75.
  25. Dostert C, Pétrilli V, Van Bruggen R, Steele C, Mossman BT, Tschopp J. Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica. Science. 2008;320(5876):674–7. https://doi.org/10.1126/science.1156995. · DOI · Paper page
  26. Poland CA, Duffin R, Kinloch I, Maynard A, Wallace WA, Seaton A, et al. Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot study. Nat Nanotechnol. 2008;3(7):423–8. https://doi.org/10.1038/nnano.2008.111. · DOI · Paper page
  27. Palomäki J, Välimäki E, Sund J, Vippola M, Clausen PA, Jensen KA, et al. Long, needle-like carbon nanotubes and asbestos activate the NLRP3 inflammasome through a similar mechanism. ACS Nano. 2011;5(9):6861–70. https://doi.org/10.1021/nn200595c. · DOI
  28. Franklin BS, Mangan MS, Latz E. Crystal formation in inflammation. Annu Rev Immunol. 2016;34(1):173–202. https://doi.org/10.1146/annurev-immunol-041015-055539. · DOI
  29. Donaldson K, Murphy FA, Duffin R, Poland CA. Asbestos, carbon nanotubes and the pleural mesothelium: a review of the hypothesis regarding the role of long fibre retention in the parietal pleura, inflammation and mesothelioma. Part Fibre Toxicol. 2010;7(1):5. https://doi.org/10.1186/1743-8977-7-5. · DOI · Paper page
  30. Mulay SR, Anders HJ. Crystallopathies. N Engl J Med. 2016;374(25):2465–76. https://doi.org/10.1056/NEJMra1601611. · DOI
  31. Rock KL, Kataoka H, Lai JJ. Uric acid as a danger signal in gout and its comorbidities. Nat Rev Rheumatol. 2013;9(1):13–23. https://doi.org/10.1038/nrrheum.2012.143. · DOI
  32. Broz P, Dixit VM. Inflammasomes: mechanism of assembly, regulation and signalling. Nat Rev Immunol. 2016;16(7):407–20. https://doi.org/10.1038/nri.2016.58. · DOI · Paper page
  33. Gross O, Thomas CJ, Guarda G, Tschopp J. The inflammasome: an integrated view. Immunol Rev. 2011;243(1):136–51. https://doi.org/10.1111/j.1600-065X.2011.01046.x. · DOI · Paper page
  34. Latz E, Xiao TS, Stutz A. Activation and regulation of the inflammasomes. Nat Rev Immunol. 2013;13(6):397–411. https://doi.org/10.1038/nri3452. · DOI · Paper page
  35. Rathinam VA, Fitzgerald KA. Inflammasome complexes: emerging mechanisms and effector functions. Cell. 2016;165(4):792–800. https://doi.org/10.1016/j.cell.2016.03.046. · DOI
  36. Nakayama M. Macrophage recognition of crystals and nanoparticles. Front Immunol. 2018;9:103. https://doi.org/10.3389/fimmu.2018.00103. · DOI
  37. Thakur SA, Hamilton RF Jr, Holian A. Role of scavenger receptor a family in lung inflammation from exposure to environmental particles. J Immunotoxicol. 2008;5(2):151–7. https://doi.org/10.1080/15476910802085863. · DOI
  38. Murthy S, Larson-Casey JL, Ryan AJ, He C, Kobzik L, Carter AB. Alternative activation of macrophages and pulmonary fibrosis are modulated by scavenger receptor, macrophage receptor with collagenous structure. FASEB J. 2015;29(8):3527–36. https://doi.org/10.1096/fj.15-271304. · DOI
  39. Tsugita M, Morimoto N, Tashiro M, Kinoshita K, Nakayama M. SR-B1 is a silica receptor that mediates canonical Inflammasome activation. Cell Rep. 2017;18(5):1298–311. https://doi.org/10.1016/j.celrep.2017.01.004. · DOI
  40. Omori S, Tsugita M, Hoshikawa Y, Morita M, Ito F, Yamaguchi SI, et al. Tim4 recognizes carbon nanotubes and mediates phagocytosis leading to granuloma formation. Cell Rep. 2021;34(6):108734. https://doi.org/10.1016/j.celrep.2021.108734. · DOI
  41. Kawanishi S, Ohnishi S, Ma N, Hiraku Y, Murata M. Crosstalk between DNA damage and inflammation in the multiple steps of carcinogenesis. Int J Mol Sci. 2017;18(8):1808. https://doi.org/10.3390/ijms18081808. · DOI
  42. Blake DJ, Bolin CM, Cox DP, Cardozo-Pelaez F, Pfau JC. Internalization of Libby amphibole asbestos and induction of oxidative stress in murine macrophages. Toxicol Sci. 2007;99(1):277–88. https://doi.org/10.1093/toxsci/kfm166. · DOI
  43. Okada S, Hamazaki S, Toyokuni S, Midorikawa O. Induction of mesothelioma by intraperitoneal injections of ferric saccharate in male Wistar rats. Br J Cancer. 1989;60(5):708–11. https://doi.org/10.1038/bjc.1989.344. · DOI · Paper page
  44. Galluzzi L, Vitale I, Aaronson SA, Abrams JM, Adam D, Agostinis P, et al. Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. Cell Death Differ. 2018;25(3):486–541. https://doi.org/10.1038/s41418-017-0012-4. · DOI · Paper page
  45. Stockwell BR, Angeli JPF, Bayir H, Bush AI, Conrad M, Dixon SJ, et al. Ferroptosis: a regulated cell death Nexus linking metabolism, redox biology, and disease. Cell. 2017;171(2):273–85. https://doi.org/10.1016/j.cell.2017.09.021. · DOI · Paper page
  46. Testa JR, Cheung M, Pei J, Below JE, Tan Y, Sementino E, et al. Germline BAP1 mutations predispose to malignant mesothelioma. Nat Genet. 2011;43(10):1022–5. https://doi.org/10.1038/ng.912. · DOI · Paper page
  47. Nasu M, Emi M, Pastorino S, Tanji M, Powers A, Luk H, et al. High incidence of somatic BAP1 alterations in sporadic malignant mesothelioma. J Thorac Oncol. 2015;10(4):565–76. https://doi.org/10.1097/JTO.0000000000000471. · DOI
  48. Guo G, Chmielecki J, Goparaju C, Heguy A, Dolgalev I, Carbone M, et al. Whole-exome sequencing reveals frequent genetic alterations in BAP1, NF2, CDKN2A, and CUL1 in malignant pleural mesothelioma. Cancer Res. 2015;75(2):264–9. https://doi.org/10.1158/0008-5472.CAN-14-1008. · DOI
  49. Lo Iacono M, Monica V, Righi L, Grosso F, Libener R, Vatrano S, et al. Targeted next-generation sequencing of cancer genes in advanced stage malignant pleural mesothelioma: a retrospective study. J Thorac Oncol. 2015;10(3):492–9. https://doi.org/10.1097/JTO.0000000000000436. · DOI
  50. Bueno R, Stawiski EW, Goldstein LD, Durinck S, De Rienzo A, Modrusan Z, et al. Comprehensive genomic analysis of malignant pleural mesothelioma identifies recurrent mutations, gene fusions and splicing alterations. Nat Genet. 2016;48(4):407–16. https://doi.org/10.1038/ng.3520. · DOI
  51. Yoshikawa Y, Emi M, Nakano T, Gaudino G. Mesothelioma developing in carriers of inherited genetic mutations. Transl Lung Cancer Res. 2020;9(Suppl 1):S67–76. https://doi.org/10.21037/tlcr.2019.11.15. · DOI
  52. Hmeljak J, Sanchez-Vega F, Hoadley KA, Shih J, Stewart C, Heiman D, et al. Integrative molecular characterization of malignant pleural mesothelioma. Cancer Discov. 2018;8(12):1548–65. https://doi.org/10.1158/2159-8290.CD-18-0804. · DOI · Paper page
  53. Jean D, Jaurand MC. Mesotheliomas in genetically engineered mice unravel mechanism of mesothelial carcinogenesis. Int J Mol Sci. 2018;19(8):2191. https://doi.org/10.3390/ijms19082191. · DOI
  54. Dey A, Seshasayee D, Noubade R, French DM, Liu J, Chaurushiya MS, et al. Loss of the tumor suppressor BAP1 causes myeloid transformation. Science. 2012;337(6101):1541–6. https://doi.org/10.1126/science.1221711. · DOI
  55. Yu H, Pak H, Hammond-Martel I, Ghram M, Rodrigue A, Daou S, et al. Tumor suppressor and deubiquitinase BAP1 promotes DNA double-strand break repair. Proc Natl Acad Sci U S A. 2014;111(1):285–90. https://doi.org/10.1073/pnas.1309085110. · DOI
  56. Bononi A, Giorgi C, Patergnani S, Larson D, Verbruggen K, Tanji M, et al. BAP1 regulates IP3R3-mediated ca(2+) flux to mitochondria suppressing cell transformation. Nature. 2017;546(7659):549–53. https://doi.org/10.1038/nature22798. · DOI
  57. Bononi A, Yang H, Giorgi C, Patergnani S, Pellegrini L, Su M, et al. Germline BAP1 mutations induce a Warburg effect. Cell Death Differ. 2017;24(10):1694–704. https://doi.org/10.1038/cdd.2017.95. · DOI · Paper page
  58. Zhang Y, Shi J, Liu X, Feng L, Gong Z, Koppula P, et al. BAP1 links metabolic regulation of ferroptosis to tumour suppression. Nat Cell Biol. 2018;20(10):1181–92. https://doi.org/10.1038/s41556-018-0178-0. · DOI
  59. Affar EB, Carbone M. BAP1 regulates different mechanisms of cell death. Cell Death Dis. 2018;9(12):1151. https://doi.org/10.1038/s41419-018-1206-5. · DOI
  60. Xue J, Patergnani S, Giorgi C, Suarez J, Goto K, Bononi A, et al. Asbestos induces mesothelial cell transformation via HMGB1-driven autophagy. Proc Natl Acad Sci U S A. 2020;117(41):25543–52. https://doi.org/10.1073/pnas.2007622117. · DOI
  61. Carbone M, Adusumilli PS, Alexander HR Jr, Baas P, Bardelli F, Bononi A, et al. Mesothelioma: scientific clues for prevention, diagnosis, and therapy. CA Cancer J Clin. 2019;69(5):402–29. https://doi.org/10.3322/caac.21572. · DOI · Paper page
  62. Otsuki T, Matsuzaki H, Lee S, Kumagai-Takei N, Yamamoto S, Hatayama T, et al. Environmental factors and human health: fibrous and particulate substance-induced immunological disorders and construction of a health-promoting living environment. Environ Health Prev Med. 2016;21(2):71–81. https://doi.org/10.1007/s12199-015-0499-6. · DOI
  63. Kumagai-Takei N, Lee S, Srinivas B, Shimizu Y, Sada N, Yoshitome K, et al. The Effects of Asbestos Fibers on Human T Cells. Int J Mol Sci. 2020;21(19). · DOI
  64. Cugell DW, Kamp DW. Asbestos and the pleura: a review. Chest. 2004;125(3):1103–17. https://doi.org/10.1378/chest.125.3.1103. · DOI
  65. Suzuki Y, Kohyama N. Translocation of inhaled asbestos fibers from the lung to other tissues. Am J Ind Med. 1991;19(6):701–4. https://doi.org/10.1002/ajim.4700190603. · DOI
  66. Dodson RF, O'Sullivan MF, Huang J, Holiday DB, Hammar SP. Asbestos in extrapulmonary sites: omentum and mesentery. Chest. 2000;117(2):486–93. https://doi.org/10.1378/chest.117.2.486. · DOI
  67. Miserocchi G, Sancini G, Mantegazza F, Chiappino G. Translocation pathways for inhaled asbestos fibers. Environ Health. 2008;7(1):4. https://doi.org/10.1186/1476-069X-7-4. · DOI
  68. Jensen CG, Jensen LC, Rieder CL, Cole RW, Ault JG. Long crocidolite asbestos fibers cause polyploidy by sterically blocking cytokinesis. Carcinogenesis. 1996;17(9):2013–21. https://doi.org/10.1093/carcin/17.9.2013. · DOI
  69. Wang NS, Jaurand MC, Magne L, Kheuang L, Pinchon MC, Bignon J. The interactions between asbestos fibers and metaphase chromosomes of rat pleural mesothelial cells in culture. A scanning and transmission electron microscopic study. Am J Pathol. 1987;126(2):343–9.
  70. Gianoncelli A, Kourousias G, Cammisuli F, Cassese D, Rizzardi C, Radillo O, et al. Combined use of AFM and soft X-ray microscopy to reveal fibres' internalization in mesothelial cells. Analyst. 2017;142(11):1982–92. https://doi.org/10.1039/C6AN02661C. · DOI
  71. Kuroda A, Alexandrov M, Nishimura T, Ishida T. Rapid on-site detection of airborne asbestos fibers and potentially hazardous nanomaterials using fluorescence microscopy-based biosensing. Biotechnol J. 2016;11(6):757–67. https://doi.org/10.1002/biot.201500438. · DOI
  72. Kuroda A, Nishimura T, Ishida T, Hirota R, Nomura K. Detection of chrysotile asbestos by using a chrysotile-binding protein. Biotechnol Bioeng. 2008;99(2):285–9. https://doi.org/10.1002/bit.21588. · DOI
  73. Ishida T, Fujihara N, Nishimura T, Funabashi H, Hirota R, Ikeda T, et al. Live-cell imaging of macrophage phagocytosis of asbestos fibers under fluorescence microscopy. Genes Environ. 2019;41(1):14. https://doi.org/10.1186/s41021-019-0129-4. · DOI
  74. Ishida T, Alexandrov M, Nishimura T, Minakawa K, Hirota R, Sekiguchi K, et al. Evaluation of sensitivity of fluorescence-based asbestos detection by correlative microscopy. J Fluoresc. 2012;22(1):357–63. https://doi.org/10.1007/s10895-011-0967-3. · DOI

Cited by

Sorted by citations

See all 38

Metadata

Authors
Kuroda, A.
Venue
Genes and Environment
Publisher
Springer Science and Business Media LLC
Published
2021-10-12
Volume
43
Issue
1
ISSN
1880-7062
DOI
10.1186/s41021-021-00215-0
PMC
PMC8507173
Cited by
38
References
7
Language
en
Licence
Funders
  • environmental restoration and conservation agency (JPMEERF201950001)
  • japan society for the promotion of science (19H04291)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Recent progress and perspectives on the mechanisms underlying Asbestos toxicity. https://app.cochat.ai/papers/10.1186/s41021-021-00215-0
The paper
Kuroda, A. (2021). Recent progress and perspectives on the mechanisms underlying Asbestos toxicity. Genes and Environment. https://doi.org/10.1186/s41021-021-00215-0